Clinical trials: Colonization
Bacterial Infections
A Study of Doripenem in Infants Less Than 12 Weeks of Age
The purpose of this study is to measure drug levels of doripenem in blood samples collected before and after administration of doripenem to infants less than 12 weeks of age who are hospitalized and documented, presumed to have…
- Trial name
- NCT01381848
- Testing
- Doripenem
- Where
- 13 sites in United States, Belgium and 1 more
- Volunteers
- 52 people
- Sponsor
- Janssen Research & Development, LLC
Underweight, Wasting
Preventing Infant Malnutrition With Early Supplementation
Background: Worldwide, more than 50 million children under 5 years of age are wasted (weight-for-length/height Z-score (WLZ) <-2) and over 150 million children under 5 are stunted (length/height-for-age Z-score (LAZ) <-2); such…
- Conditions
- Underweight, Wasting, Stunting, Breastfeeding
- Trial name
- PRIMES (NCT04704076)
- Testing
- ESVS, Exclusive breastfeeding
- Where
- 2 sites in Guinea-Bissau, Uganda
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Covid19
Safety and Efficacy of Intranasal Application of GX-03 as a Treatment and Prevention for COVID-19.
Phase 2b clinical trial to evaluate the safety and efficacy of intranasal application of GX-03 as a treatment and prevention for COVID-19.
- Trial name
- NCT04951349
- Testing
- GX-03, Petrolatum ointment
- Where
- 3 sites in Panama
- Volunteers
- 85 people
- Sponsor
- Turn Therapeutics
ARDS, Human, Catheter Infection
Prone Position Impact in ARDS Patients on the Incidence of Central Venous Catheter Colonization
Catheter colonization, catheter-associated infection and catheter-associated bacteremia are a major challenge for resuscitation unit.
- Trial name
- ILCDV (NCT03405038)
- Where
- France
- Volunteers
- 202 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Antibiotic Resistant Infection, Nosocomial Infection
Inulin for Infections in the Intensive Care Unit
Normal gut bacteria prevent colonization and subsequent infection with MDR organisms (MDROs) through competition for resources and other mechanisms.
- Conditions
- Antibiotic Resistant Infection, Nosocomial Infection, Pathogen Transmission, Nutrition Disorders
- Trial name
- NCT03865706
- Testing
- Inulin Oral Suspension, Broad-spectrum antibiotics
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Columbia University
MRSA
Community-Assoc. S. Aureus Colonization and Recurrent Infection in Pts With Uncomplicated S. Aureus Skin Abscesses
Infections due to S. aureus are a major healthcare burden. Currently there is not an effective way to prevent S. aureus infection.
- Trial name
- CIRCUS (NCT02690415)
- Testing
- Antibiotics Given, Antibiotics not given
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Southern Illinois University
Microbial Colonization, Dysbiosis
Determination of Vaginal Colonization and the Effect of an Oral Probiotic (PROSALVAG)
The aim of this study is to determine the efficacy of an oral nutraceutical with probiotics in restore vaginal health.
- Conditions
- Microbial Colonization, Dysbiosis, Fertility Issues
- Trial name
- PROSALVAG (NCT05176535)
- Testing
- FertyBiotic Balance
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Fertypharm
S.Mutans Colonization in Adults With Fixed Orthodontic Appliance
Changes in Streptococcus Mutans Colonization With Different Oral Hygiene Protocols in Adult Patients With Fixed Orthodontic Appliance
Fixed orthodontic appliances increase the rate of plaque accumulation around orthodontic brackets and gingival margins. It was also found that the amount of plaque accumulation and S.mutans level around banded orthodontic…
- Trial name
- NCT05016713
- Testing
- Chlorhexidine mouthwash, Interdental brush, Fluoride-based toothpaste
- Where
- Egypt
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Cairo University
Microbial Colonization, Antibiotic Side Effect
Autoflor -Lyophilized Capsulated Autological FMT to Restore Gut Microbiome After Treatment With Antibiotics
In this clinical trial, our aim is to assess the effect of auto-FMT (Fecal microbiome transplantation) on the intestinal microbiota, after a course of antibiotics. 30 healthy adults are recruited.
- Trial name
- FMT (NCT06250413)
- Testing
- FMT, Amox Clav
- Where
- Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Otto Helve
Pneumonia, Ventilator-Associated
Effect of Gravity on Tracheal Colonization During Mechanical Ventilation in Infants
Ventilator-associated pneumonia (VAP) is the leading cause of death among all nosocomial infections in ventilated patients. Once intubated, the risk of pneumonia in hospitalized patients is increased 3-10 fold; almost 90% of…
- Trial name
- NCT00491660
- Testing
- supine positioning, lateral positioning
- Volunteers
- 60 people
- Sponsor
- Cairo University
Newborns, Oral Hygiene
Effect of Oral Hygienization in Newborn on Candida Spp Colonization
Oral hygiene is one of the most accessible and well-known strategies for the prevention of dental caries. The benefits of this practice after tooth eruption are well established in the literature.
- Conditions
- Newborns, Oral Hygiene, Candidiasis, Oral, Behavior
- Trial name
- NCT04410250
- Testing
- oral hygiene
- Where
- Brazil
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Federal University of the Valleys of Jequitinhonha and Mucuri
Environmental Enteric Dysfunction (EED)
Maternal Probiotic Intervention to Improve Gut Health - Trial II - Burkina Faso (MPIGH-II)
Burden: Environmental Enteric Dysfunction (EED) is an enteropathic condition characterized by altered gut permeability, infiltration of immune cells and changes in villous architecture and cell differentiation.
- Trial name
- MPIGH-II (NCT07134790)
- Testing
- VE818, Oral Vancomycin
- Where
- Burkina Faso
- Volunteers
- 144 people
- Sponsor
- University Ghent
Microbial Colonization, Infected Wound
Compare Wound Sampling Methods Efficacy in Microbiology Culture
Slough was a visible indicator of biofilm, which was the most available specimen from acute and chronic wounds. However, studies believed that slough were poorly accurate, and that the Levine swab was more recommended for…
- Conditions
- Microbial Colonization, Infected Wound, Slough
- Trial name
- NCT06460025
- Where
- China
- Volunteers
- 131 people
- Sponsor
- Peking University Third Hospital
Surgical Site Infection, Microbial Colonization
Broad-spectrum Antibiotic Prophylaxis in Tumor and Infected Orthopedic Surgery
The perioperative antibiotic prophylaxis is evidence-based in orthopedic surgery. While its duration ranges from a single dose to three doses throughout the world, the choice of the prophylactic agents is undisputed.
- Conditions
- Surgical Site Infection, Microbial Colonization, Antibiotic Resistant Infection
- Trial name
- BAPTIST (NCT05502380)
- Testing
- Standard antibiotic prophylaxis
- Where
- Switzerland
- Volunteers
- 1,100 people
- Sponsor
- Balgrist University Hospital
Microbial Colonization
Microbial Colonization of Dairy Free Oral Probiotics
The aim of this study is to evaluate the colonization efficacy of probiotic lozenges containing dairy and dairy free probiotic Streptococcus salivarius M18, in healthy adults
- Trial name
- NCT05375396
- Testing
- Streptococcus salivarius M18 lozenges, Streptococcus salivarius M18 dairy free lozenges
- Where
- New Zealand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- John Hale
Ventilator Associated Pneumonia
Efficacy Study of Colistimethate Sodium Inhalation in Patients With Ventilator-associated Pneumonia
There might be additional benefit on clinical outcomes from adjunctive colistimethate sodium inhalation as therapy for multidrug resistant Gram-negative ventilator-associated pneumonia.
- Trial name
- NCT01975350
- Where
- Taiwan
- Volunteers
- 49 people
- Sponsor
- National Taiwan University Hospital
Dental Caries
Study on Use of Xylitol-wipes to Prevent Dental Caries
Mutans streptococci (MS) and lactobacillus species (LB) are the two groups of infectious cariogenic (caries-causing) bacteria most strongly associated with dental caries (dental decay).
- Trial name
- WIPE (NCT01468727)
- Testing
- xylitol wipe
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infection, Bacterial
Colonization of Bile Ducts and Infectious Complications in Cephalic Duodenopancreatectomy
Cephalic duodenopancreatectomy is part of the curative treatment for pancreatic cancer of the head and peri-ampullary area. The mortality of the procedure is around 5%, with a morbidity ranging from 30 to 50%.
- Trial name
- NCT04555252
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Central Hospital, Nancy, France
Methicillin-resistant Staphylococcus Aureus, Skin Diseases, Infectious
MRSA Colonization and Control in the Dallas County Jail
The goal of this 3-year project is to control the spread of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in the Dallas County Jail.
- Conditions
- Methicillin-resistant Staphylococcus Aureus, Skin Diseases, Infectious, Soft Tissue Infections
- Trial name
- NCT00785200
- Testing
- Chlorhexidine, Water
- Where
- United States
- Volunteers
- 4,194 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Multi-Drug Resistant Organism Colonization
Response to Emerging Antimicrobial Resistance With Containment Microbiota Therapy (REACT)
REACT is a phase two, open-label, randomized, controlled trial of microbiota therapy (MT) to reduce colonization with multi-drug resistant organisms (MDRO).
- Trial name
- NCT06321536
- Testing
- Allogeneic Microbiota in Glycerol (9%) (AMG)
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Emory University