Clinical trials: Colonic Polyps
Familial Adenomatous Polyposis
The Chemopreventive Effect of Metformin in Patients With Familial Adenomatous Polyposis: Double Blinded Randomized Controlled Study
Familial adenomatous polyposis (FAP) leads to adenomas and eventual adenocarcinomas in colon and less frequently, duodenum. Chemopreventive strategies have been studied in FAP patients to delay the development of adenomas and…
- Trial name
- NCT01725490
- Testing
- Metformin
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Yonsei University
Ulcerative Colitis, Crohn Disease
Evaluation of the Diagnostic Value of microRNAs for Inflammatory Bowel Diseases
The purpose of this study is to assess the diagnostic value of microRNAs in IBD colon (ulcerative colitis or Crohn's disease) in adults as compared to healthy controls (and non-IBD colitis)
- Conditions
- Ulcerative Colitis, Crohn Disease, Healthy, Non-IBD Colitis
- Trial name
- MicroMICI (NCT02020382)
- Testing
- qPCR diagnostic KIT of microRNAS
- Where
- 5 sites in France
- Volunteers
- 325 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Neoplasms
CHOICE: Communicating Health Options Through Information and Cancer Education
The purpose of this study is to determine the effectiveness of a two-component intervention, that combines academic detailing at the medical practice level and distribution of decision aids at the patient level, on adherence to…
- Trial name
- NCT00134589
- Testing
- Academic Detailing (Medical Practices)+Decision Aids (Patients)
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Right Colon Adenoma Miss Rate, Right Colon Hyperplastic Polyp Miss Rate
Right Colon Polyp Miss Rates of Water Exchange and Carbon Dioxide Insufflation Colonoscopy
This will be a prospective randomized controlled trial comparing CO2 insufflation and WE in terms of right colon combined adenoma miss rate (AMR) and hyperplastic polyp miss rate (HPMR) by tandem inspection.
- Trial name
- NCT03845933
- Testing
- Colon polypectomy
- Where
- Taiwan
- Volunteers
- 262 people
- Sponsor
- Evergreen General Hospital, Taiwan
Colorectal Cancer, Polyps
Vitamin D/Calcium Polyp Prevention Study
Extensive experimental and observational data suggest that intake of calcium and of vitamin D exert protective effects on colorectal neoplasia.
- Conditions
- Colorectal Cancer, Polyps, Adenomas
- Trial name
- NCT00153816
- Testing
- Calcium Carbonate, Vitamin D3
- Where
- 11 sites in United States, Puerto Rico
- Volunteers
- 2,813 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Diverticulitis, Colon Polyps
Early Post-Op Recovery After Partial Large Bowel Resection
The purpose of this trial is to gather information on the postoperative recovery time and hospital length of stay experienced by patients having laparoscopic surgeries.
- Conditions
- Diverticulitis, Colon Polyps, Colorectal Cancer
- Trial name
- NCT00492193
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- University Hospitals Cleveland Medical Center
Colonic Polyp
Evaluation of a Double Balloon Interventional Platform (DiLumen) for Complex Colonic ESD
The purpose of this randomized study is to compare ESD procedural time and cost facilitated with a dual balloon accessory device versus ESD procedures performed without the accessory device.
- Trial name
- NCT03846609
- Testing
- double balloon interventional platform (DiLumen), no double balloon interventional platform (DiLumen)
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Mercy Medical Center
Familial Adenomatous Polyposis (FAP), Pouches, Ileoanal
Evaluation of the Ileo-anal Pouch in FAP (ENDOPOL)
This international, multi-centre randomised controlled trial will compare dye-based chromoendoscopy with virtual chromoendoscopy, using NBI/BLI, for adenoma detection during routine surveillance pouchoscopy in adults with…
- Trial name
- ENDOPOL (NCT07726771)
- Testing
- Chromoendoscopy (Indigo Carmine), Virtual Chromoendoscopy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- London North West Healthcare NHS Trust
Colon Carcinoma, Colonic Polyps
Measuring the Spectrum of Tissues During Endoscopy
Lesions, polyps and other abnormalities in the gastrointestinal (GI) tract have a different composition compared to the normal mucose. The investigators plan to gather spectroscopic information from these features.
- Conditions
- Colon Carcinoma, Colonic Polyps, Intestinal Polyps
- Trial name
- NCT00996619
- Testing
- An optical fiber, inside the work channel of an endoscope, is added to the endoscopic examination
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Post Polypectomy Bleeding in Anticoagulated Patients, Gastrointestinal Hemorrhage
Hemorrhage Following Small Polyp Resection in the Colon in Anticoagulated Patients
One of the well-known of complications post colonic polypectomy is bleeding usually occuring in the 2-week period following the procedure. Patients treated with oral anticoagulation (e.g.
- Trial name
- NCT02375646
- Testing
- Warfarin, LMW Heparin
- Volunteers
- 286 people
- Sponsor
- Hadassah Medical Organization
Familial Adenomatous Polyposis (FAP)
Preventive Anti-inflammatory Diet to Reduce Gastro-intestinal Inflammation in FAP Patients: a Prospective Pilot Study
Preventive anti-inflammatory diet to reduce gastro-intestinal inflammation in FAP patients: a prospective pilot study
- Trial name
- FAPPER (NCT04552405)
- Testing
- Anti-inflammatory Diet
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Colorectal Cancer, Colorectal Adenoma
Comparison of Expression of Carcinogenesis-related Molecular Markers in the Patients With Colon Cancer and Polyp
A study of carcinogenesis-related molecular markers in the patients with colorectal cancer and colorectal adenoma.
- Trial name
- NCT05638542
- Where
- South Korea
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Colorectal Cancer Screening, Colon Adenomatous Polyp
Ambient Lighting During Colonoscopy and Its Effect on Adenoma Detection Rate and Eye Fatigue
A retrospective and prospective study to determine if the use of ambient lighting during screening colonoscopy is well tolerated and if ambient lighting will help physicians maintain adenoma detection rates while decreasing…
- Trial name
- NCT04441242
- Testing
- Ambient lighting, Low lighting
- Where
- United States
- Volunteers
- 1,109 people
- Sponsor
- Wake Forest University Health Sciences
Colorectal Cancer
Development of a New Simplified Tool to Predict LNPCPs Histology and Assess the Risk of Submucosal Invasive Cancer. The Colorectal Regular-Irregular Score
Colorectal cancer (CRC) is the third most common malignancy worldwide and the second leading cause of cancer related death. It can be prevented by endoscopic detection and complete resection of colorectal polyps.
- Trial name
- CRIS (NCT07584486)
- Testing
- Learning tool (CRIS/JNET), Learning tool (JNET/CRIS)
- Where
- Belgium
- Volunteers
- 764 people
- Sponsor
- University Hospital, Ghent
Familial Adenomatous Polyposis, FAP
Turmeric Supplementation on Polyp Number and Size in Patients With Familial Adenomatous Polyposis.
A Phase 2, randomized, double blind, placebo controlled trial for the effectivness of wholistic turmeric supplementation on polyp burden mong patients with Familial Adenomatouse Polyposis (FAP).
- Conditions
- Familial Adenomatous Polyposis, FAP, FAP Gene Mutation
- Trial name
- NCT03061591
- Testing
- Wholistic Turmeric capsules
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Colorectal Cancer, Colo-rectal Cancer
Study Comparing the Contribution of G-Eye Combined With CAD-Eye Versus High-definition Colonoscopy With CAD-Eye in the Detection of Colonic Lesions After a Positive Immunological Test in the Context of Organized Colorectal Cancer (BENEFIT)
The incidence of colorectal cancer (CRC) is high in France, with approximately 45,000 new cases per year. The fecal immunochemical test (FIT) is used for screening for this cancer.
- Trial name
- BENEFIT (NCT07502469)
- Testing
- Colonoscopy
- Where
- France
- Volunteers
- 341 people
- Sponsor
- Elsan
Familial Adenomatous Polyposis
Azithromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis
Colorectal cancer (CRC) is a leading cause for cancer related mortality in the western world with a lifetime risk of 6%. Etiology is complex, while genetic background significantly affects the risk.
- Trial name
- FAP (NCT04454151)
- Testing
- Azithromycin Tablets
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Colon Cancer, Rectal Cancer
Clinical Study-evaluate Performance&Safety "Aer-O-Scope" in Colon of Low Risk Patients
A double center study to evaluate the safety and efficacy of the Aer-O-Scope in traveling through the colon in low risk subjects.
- Trial name
- NCT00867724
- Testing
- Aer-O-Scope Colonoscopy
- Where
- Israel
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- GI View Ltd.
Colonic Polyp, Gastrointestinal Neoplasms
Clinical Study on Continuous Suture of Endoscopic Mucosal Defects
The use of clips to completely clip mucosal defects after ESD/EMR can reduce postoperative adverse events, but the rate of incomplete mucosal defects closure is high.
- Trial name
- NCT05190042
- Testing
- Cotinuous suture, Clips
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Crohn's Disease, Ulcerative Colitis
An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy
The purpose of this study is to find out if guided fluid administration with the esophageal monitor is superior to standard fluid administration and whether use of the hetastarch or lactated ringers offers different benefits with…
- Conditions
- Crohn's Disease, Ulcerative Colitis, Rectal Cancer, Colon Cancer
- Trial name
- NCT00467922
- Testing
- Hextend, Lactated Ringers
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Corewell Health West