Clinical trials: Colonic Polyp
Colorectum
Prospective Trial of Metformin - Chemoprevention Role
The goal of this clinical research study is to learn if metformin extended release (ER) can prevent colonic adenomas from becoming cancerous. Metformin ER will be compared to a placebo.
- Trial name
- NCT01550900
- Testing
- Metformin ER
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer, Colon Cancer
Pilot Study of Colon Cancer Screening Tests
Colon cancer is the second leading cause of cancer death in North America. These deaths are preventable with proper screening. Fecal occult blood testing, virtual colonoscopy, and standard (optical) colonoscopy are all options…
- Conditions
- Colorectal Cancer, Colon Cancer, Adenomatous Polyps
- Trial name
- NCT00865527
- Testing
- Fecal occult blood test, Virtual colonoscopy, Optical colonoscopy
- Where
- Canada
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Colorectal Cancer, Colorectal Adenoma
The Implementation of Genetic Risk for Colorectal Cancer Screening
The goal of this study is to investigate genetic risk for colorectal cancer utilizing polygenic risk scores (PRS) for adults over 45 who have not received their first colonoscopy. The main questions it hopes to address are: 1.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Polyp
- Trial name
- PRO-GENE-COLON (NCT07621757)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Colonic Polyp
Real Life AI in Polyp Detection
The objective of this study is to compare the polyp detection rate (PDR) of endoscopists unaware of a commercially available artificial intelligence (AI) device for polyp detection during colonoscopy and the PDR of endoscopists…
- Trial name
- RELIANT (NCT04335318)
- Testing
- AI-assisted colonoscopy
- Where
- Germany
- Volunteers
- 230 people
- Sponsor
- Wuerzburg University Hospital
Polyp of Colon, Crohn Disease
Lesion Size Measurement During Gastrointestinal Endoscopies
The goal of this prospective observational study is to assess the accuracy and reliability of laser readings obtained through AccuMeasure, in comparison to other measurements performed by gastroenterologists.
- Trial name
- AccuMeasure (NCT07770425)
- Where
- Canada
- Volunteers
- 3,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colon Polyp
Collecting Recorded Videos of Colonoscopy Tests
The study shall mainly help to better evaluate the performance the APDS device and secondly it may help to assess the potential of the future alpha version of the device to be a useful and effective for the detection of colon…
- Trial name
- NCT03937063
- Testing
- Collecting recorded videos of Colonoscopy screening tests
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Magentiq Eye LTD
Familial Adenomatous Polyposis (FAP)
Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis
The main goal of this clinical trial is to learn if the drug eRapa works to slow down the progression of disease in patients diagnosed with Familial Adenomatous Polyposis (FAP). Researchers will compare eRapa to Placebo.
- Trial name
- SERENTA (NCT06950385)
- Testing
- eRapa (encapsulated rapamycin)
- Where
- 29 sites in United States, Denmark and 5 more
- Volunteers
- 168 people
- Sponsor
- Rapamycin Holdings Inc.
Colonic Polyp
Trainee Participation Increases Colon Adenoma Detection Rate
Previous studies that examined whether the presence of an additional observer, more specifically a GI fellow, during colonoscopy can enhance detection of all polyps and adenomas yielded conflicting results.
- Trial name
- ADR (NCT03908229)
- Testing
- Trainee colonoscopy, Experienced physician colonoscopy
- Where
- 4 sites in Italy
- Volunteers
- 812 people
- Sponsor
- Ospedali Riuniti di Foggia
Familial Adenomatous Polyposis (FAP)
Expanded Access to 0.5 mg eRapa for Familial Adenomatous Polyposis
This expanded access program provides 0.5 mg eRapa (encapsulated rapamycin) to patients with familial adenomatous polyposis (FAP) who have no satisfactory alternative treatment options and are not eligible to participate in a…
- Trial name
- eRapa-FAP (NCT07689942)
- Testing
- eRapa (encapsulated rapamycin)
- Sponsor
- Biodexa Pharmaceuticals
Colonic Polyp, Colonoscopy
Cold Snare Endoscopic Mucosal Resection Trial
This study compares different approaches to endoscopic mucosal resection (EMR) of large non-pedunculated colorectal polyps (≥20mm) in a 2 x 2 randomized design.
- Conditions
- Colonic Polyp, Colonoscopy, Complication, Recurrence
- Trial name
- LPS-II (NCT03865537)
- Testing
- Cold snare EMR, Hot snare EMR, Eleview injection
- Where
- United States
- Volunteers
- 990 people
- Sponsor
- White River Junction Veterans Affairs Medical Center
Colorectal Cancer, Polyp of Colon
Hybrid-sensor Breath Analysis for Colorectal Cancer Screening
The aim of this project is to promote the breath volatile marker concept for colorectal cancer (CRC) screening by advancing developing the application of a novel hybrid analyzer for the purpose.
- Trial name
- HYCOR (NCT05173077)
- Testing
- Identification of specific VOCs in CRC tissue surgery material, Secondary validation study in general CRC screening settings, Breath sampling for VOC detection
- Where
- Latvia
- Volunteers
- 3,000 people
- Sponsor
- University of Latvia
Colonic Polyp, Colon Cancer
Improving Outpatient Colonoscopy Bowel Prep With the Orton Score
Colonoscopy is a common endoscopic procedure which the UVA Gastroenterology \& Hepatology department performs on a daily basis for both screening/surveillance and diagnostic/therapeutic intent.
- Trial name
- NCT04093557
- Testing
- Orton Score, Typical Standard of Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Virginia
Multiple Polyps Right Colon, Large Polyp Right Colon
Megachannel Device for Advanced Colonoscopy
Megachannel is a newly developed colonic access system allowing rapid and multiple passes of the colonoscope to the right colon.
- Conditions
- Multiple Polyps Right Colon, Large Polyp Right Colon, Suspected Polyp Right Colon
- Trial name
- NCT00987896
- Testing
- Colonoscopy with Megachannel™ device loaded
- Where
- Austria
- Volunteers
- 41 people
- Sponsor
- Medical University of Vienna
Colorectal Carcinoma, Familial Adenomatous Polyposis
An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis
This open-label phase II trial tests how well TPST-1495 works in reducing the number of polyps in the small bowel and colon in patients with familial adenomatous polyposis (FAP).
- Trial name
- NCT06557733
- Testing
- Biopsy Procedure, Biospecimen Collection, EP2/EP4 Antagonist TPST-1495
- Where
- 4 sites in United States
- Volunteers
- 38 people
- Sponsor
- National Cancer Institute (NCI)
Adenomatous Polyp, Colorectal Cancer
Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI
The purpose of this study is to find out whether METFORMIN decreases protein markers in colorectal tissue. This is a phase IIA study of the pharmacodynamics, safety and tolerability of Metformin in decreasing colorectal mucosa in…
- Conditions
- Adenomatous Polyp, Colorectal Cancer, Obesity
- Trial name
- NCT01312467
- Testing
- metformin hydrochloride
- Where
- 4 sites in United States, Canada
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)
Polyps
Evaluation of an Endoscopic Suturing System for Tissue Apposition in Colonic Polypectomy
The purpose of this study is to show that the surgical site in the bowel wall can be sewn closed in the colon or intestine, with a new sewing device after removal of a benign polyp according to standard of care.
- Trial name
- NCT00553436
- Testing
- Tissue Apposition System (TAS) Device
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Ethicon Endo-Surgery
Polyp, Colonic, Bleeding
Clip Placement Following Colonic Endoscopic Mucosal Resection (EMR)
Study design: A national, multi-center, patient-blinded, randomized clinical trial. Study population: Patients undergoing EMR with a moderate to severe risk (right sided colon, ≥2cm) of developing Delayed Bleeding (DB).
- Trial name
- CLIPPER (NCT03309683)
- Testing
- Olympus Quick Clip Pro - Single Use Repositionable Clips
- Where
- 2 sites in Netherlands
- Volunteers
- 356 people
- Sponsor
- Radboud University Medical Center
Colorectal Neoplasms
Impact of Experience on Results With the Third Eye Retroscope
The Third Eye Retroscope is a device that can be used with a colonoscope to improve the ability of a physician to see areas of the colon that may be hidden from the view of the colonoscope.
- Trial name
- NCT00969124
- Testing
- Third Eye Retroscope
- Where
- 9 sites in United States
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Avantis Medical Systems
Cancer Colon, Polyp of Colon
Clinical Trial Verifying C-REX LapAid and C-REX DMH/DMHC
In colorectal surgery, hand suturing and stapling are routine methods for performing intestinal anastomoses, and these methods appear to be similar in terms of clinical safety.
- Trial name
- NCT03179358
- Testing
- C-REX Ring-locking Procedure
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Carponovum AB
Polyp of Colon
Prevention of Post-Polypectomy Colorectal Bleeding by Clips in Patients on Anticoagulants
This observational study aims to retrospectively determine if clips can prevent post-polypectomy bleeding in adults who have received restarted anticoagulants after a colorectal polypectomy, using a large, single-center patient…
- Trial name
- PiCAnt (NCT07007598)
- Testing
- Hemostatic clip
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- Helios Kliniken Schwerin