Clinical trials: Colon Cancer Surveillance
Rectal Cancer, LARS - Low Anterior Resection Syndrome
Personalized Care Pathways for Bowel Symptoms in Rectal Cancer Patients_contributing Factors (Treatable)
Colorectal cancer is the 2nd and 3rd most common cancer in respectively women and men, of which about 40% is located in the rectum.
- Conditions
- Rectal Cancer, LARS - Low Anterior Resection Syndrome, Active Surveillance
- Trial name
- Treatable (NCT06914245)
- Testing
- Electronic bowel diary, Faecal Incontinence Quality of Life questionnaire (FIQL), EuroQoL 5 dimensions, 5 levels (EQ-5D-5L)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- KU Leuven
Colon Polyp, Adenoma
Six Versus Twelve Month Index Follow-up After Large Colon Polyp Resection
The study will compare the use of a 6-month follow-up vs a 12-month follow-up after the removal of a large non-pedunculated polyp 20-50mm in size and without high grade dysplasia.
- Conditions
- Colon Polyp, Adenoma, Serrated Polyp, Recurrence, Local Neoplasm
- Trial name
- STARLING (NCT07198945)
- Testing
- 6-month follow-up, 12-month follow-up
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 546 people
- Sponsor
- Indiana University
Colorectal Cancer
Assessment of Frequency of Surveillance After Curative Resection in Patients With Stage II and III Colorectal Cancer
The aim is to conduct a prospective multicentre randomised study comparing two different control regimens after resection for colorectal cancer stage II - III.
- Trial name
- NCT00225641
- Testing
- CT-scan, CEA, X-ray of lungs
- Where
- Denmark
- Volunteers
- 2,500 people
- Sponsor
- Bispebjerg Hospital
Familial Adenomatous Polyposis
A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis
The purpose of this study is to determine the efficacy and safety of a personalized surveillance and intervention protocol for duodenal and gastric polyposis in patients with familial adenomatous polyposis (FAP)
- Trial name
- NCT04677998
- Testing
- Personalized surveillance and intervention protocol
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Colorectal Cancer
Anastomotic Safety and Surveillance Using Real-time Enhanced Sensing Using xBar
Purpose: To evaluate the effect of xBar system utilization on clinical outcomes during recovery following colorectal surgery.
- Trial name
- ASSURE (NCT07337590)
- Testing
- xBar™ System
- Where
- 6 sites in United States
- Volunteers
- 80 people
- Sponsor
- Exero Medical Ltd.
Lynch Syndrome
High Definition White-Light Colonoscopy vs. Chromoendoscopy for Surveillance of Lynch Syndrome.
Adenomas in Lynch syndrome have an accelerated progression to colorectal cancer (CRC) which might occur despite a regular follow-up.
- Trial name
- EndoLynch (NCT02951390)
- Testing
- High-definition white-light endoscopy
- Where
- Spain
- Volunteers
- 280 people
- Sponsor
- Hospital Clinic of Barcelona
Colon Rectal Cancer, Surgical Site Infection
Surveillance and Implementation of a Bundle of Care to Reduce Surgical Site Infection in Colorectal Surgery (CCR-VINCat)
The Nosocomial Infection Surveillance Program in Catalonia (VINCat) monitors surgical site infection (SSI) in elective colorectal surgery since 2007 in 55 public and private acute care hospitals.
- Trial name
- CCR-VINCat (NCT04496635)
- Testing
- Implementation of a bundle of care
- Where
- Spain
- Volunteers
- 60,000 people
- Sponsor
- Hospital de Granollers
Stage III Colorectal Cancer, Circulating Tumor DNA
Evaluation of Circulating Tumor DNA Guided Surveillance Strategy of Stage III Colorectal Cancer: an Open, Prospective, Randomized Controlled Cohort Study
For patients with stage III colon cancers, radical resection of primary tumor followed by adjuvant chemotherapy is currently the standard treatment.
- Trial name
- NCT05161585
- Testing
- ctDNA dynamic monitoring
- Where
- China
- Volunteers
- 316 people
- Sponsor
- Fudan University
Colorectal Cancer Recurrent, Colorectal Cancer
Early-Onset Colorectal Cancer Recurrence
Survivors of early-onset colorectal cancer (diagnosed before age 50) may experience colorectal cancer recurrence several years after curative-intent treatments, but clinical guidelines provide unclear guidance on endoscopic…
- Conditions
- Colorectal Cancer Recurrent, Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenocarcinoma
- Trial name
- ENCORE (NCT06271980)
- Testing
- ENCORE
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- City of Hope Medical Center
Screening Colonoscopy, Surveillance Colonoscopy
Study to Evaluate the Diagnostic Performance of of MAGENTIQ-COLO During Colonoscopy.
This is an international, multicenter, study to evaluate the diagnostic performance of the CADx polyp sizing modality of the MAGENTIQ-COLO.
- Trial name
- NCT06568523
- Testing
- MAGENTIQ-COLO.
- Where
- 5 sites in United States, Israel and 1 more
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Magentiq Eye LTD
Familial Pancreatic Cancer, BRCA1 Mutation
Registry of Subjects at Risk of Pancreatic Cancer
IRFARPC is a multicenter national registry designed to study the diagnosis and predisposing factors of subjects with an inherited increased risk for pancreatic cancer.
- Conditions
- Familial Pancreatic Cancer, BRCA1 Mutation, BRCA2 Mutation, Lynch Syndrome
- Trial name
- IRFARPC (NCT04095195)
- Testing
- MRCP, Endoultrasonography
- Where
- 4 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Associazione Italiana per lo Studio del Pancreas
Gut Microbiota, Colorectal Cancer
Gut Mucosal Microbiota is Associated With Colorectal Cancer Relapse
Colonic microbiome has been found to contribute to the development of colorectal cancer. We speculate that gut microbiota related to colorectal cancer relapse after curative treatment.
- Trial name
- NCT03385213
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Colonoscopy, Colorectal Cancer Screening
Robotic Colonoscopy Using the Triton 4.0 System in Adults for Screening, Surveillance, and Diagnosis of Lower Gastrointestinal Conditions
This study is a prospective, single-arm, non-randomized, single site first-in-human study and will be conducted in two phases, where Phase A will serve to evaluate the safety of the Triton 4.0 System to perform screening…
- Conditions
- Colonoscopy, Colorectal Cancer Screening, Colorectal Neoplasms, Gastrointestinal Endoscopy
- Trial name
- CARE I (NCT06935734)
- Testing
- Diagnostic Colonoscopy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Neptune Medical
Colon Cancer, Rectal Cancer
Comparison of Two Bundles of Care to Reduce Surgical Site Infection in Colorectal Surgery (CCR-VINCat 2)
There is controversy about the maximum number of elements to be included in a surgical site infection (SSI) prevention bundle and the possibility of its implementation at a multi-center level.
- Conditions
- Colon Cancer, Rectal Cancer, Surgical Site Infection
- Trial name
- CCR-VINCat2 (NCT06244836)
- Testing
- Implementation of a bundle of care
- Where
- Spain
- Volunteers
- 32,205 people
- Sponsor
- Hospital de Granollers
Colorectal Neoplasms
Fecal Immunochemical Test for Post-polypectomy Surveillance to Reduce Unnecessary eNdoscopy
This is an observational study in a clinical setting to estimate the prevalence of advanced colorectal neoplasia (ACN) at colonoscopy in those with a history of low or high risk polyps or a family history of CRC/polyps and to…
- Trial name
- FIT2RUN (NCT05396560)
- Where
- Canada
- Volunteers
- 3,000 people
- Sponsor
- University of Calgary
Colonic Polyp, Colonic Neoplasms
Validation of Aer-O-Scope Colonoscope System Cecal Intubation
61 subjects (male or female) between the ages of 45 and 75 will undergo colonoscopy. The primary outcome is Cecal Intubation
- Conditions
- Colonic Polyp, Colonic Neoplasms, Colonic Diseases, Colon Adenoma
- Trial name
- NCT03949777
- Testing
- Aer-O-Scope Colonoscopy
- Where
- Israel
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- GI View Ltd.
Colorectal Cancer
T1 Colorectal Cancer After Local Excision: Decision Between Surgery and Active Surveillance (T1LDA Trial)
The goal of this two-arm clinical trial is to compare additional surgery with active surveillance in patients with high-risk pT1 colorectal cancer after local excision.
- Trial name
- T1LDA (NCT07900620)
- Testing
- Additional surgery
- Where
- 14 sites in Finland
- Volunteers
- 500 people
- Sponsor
- Tampere University Hospital
Colorectal Neoplasms
Stivarga Regulatory Post-Marketing Surveillance Study in Korea
To investigate and collect post-marketing data on the safety of Stivarga in real world practice in its registered indication(s) as required by Health Authority.
- Trial name
- StivargaPMS (NCT02106858)
- Testing
- Regorafenib (Stivarga,BAY73-4506)
- Where
- South Korea
- Volunteers
- 316 people
- Sponsor
- Bayer
Cancer Colorectal
Identification of High Risk People for Colorectal Cancer and Evaluation of a Specific Surveillance System
Colorectal cancer is one the most frequent cancer in developed countries. In France, it rank third with 43000 new cases in 2015.
- Trial name
- ISIRECC (NCT02931825)
- Testing
- Reminder letter
- Where
- France
- Volunteers
- 7,101 people
- Sponsor
- University Hospital, Tours
LARS - Low Anterior Resection Syndrome, Rectal Cancer Surgery
Improving Functional Outcomes and Quality of Life in Patients With Rectal Cancer After Surgery With Intensified Follow-up & Surveillance
The goal of this clinical study is to gain further insights into the treatment of patients with Low Anterior Resection Syndrome (LARS) symptoms after rectal resection.
- Conditions
- LARS - Low Anterior Resection Syndrome, Rectal Cancer Surgery, Rectal Cancer, Quality of Life (QOL)
- Trial name
- iRECOVER (NCT06936774)
- Testing
- Intensified follow-up program
- Where
- 5 sites in Switzerland
- Volunteers
- 140 people
- Sponsor
- University Hospital, Basel, Switzerland