Clinical trials: Colon Cancer
Pancreatic Cancer, Metastatic Castration-resistant Prostate Cancer
Study of NGM120 in Subjects With Advanced Solid Tumors, Pancreatic Cancer, and Prostate Cancer Using Combination Therapy
Study of NGM120 in subjects with advanced solid tumors and pancreatic cancer (Part 1 and 2) and metastatic castration resistant prostate cancer (Part 3).
- Conditions
- Pancreatic Cancer, Metastatic Castration-resistant Prostate Cancer, Bladder Cancer, Melanoma
- Trial name
- NCT04068896
- Testing
- NGM120 30mg, NGM120 100mg, NGM120 30mg with Gemcitabine and Abraxane
- Where
- 20 sites in United States
- Volunteers
- 89 people
- Sponsor
- NGM Biopharmaceuticals, Inc
Colorectal Cancer
Adjuvant Chemotherapy Combined With Huaier Granule for Treating High-risk Stage II, Stage III Colorectal Cancer
A randomized, paralleled control clinical study investigating Huaier Granule for prevention of recurrence and metastasis of colorectal cancer after radical surgery, to evaluate the efficacy and safety.
- Trial name
- NCT02785146
- Testing
- Huaier Granule, Oxaliplatin, Calcium folinate
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Colorectal Cancer
The Effect of a Virtual Navigator on Colorectal Cancer Patient Empowerment
For individuals diagnosed with colorectal cancer, exposure to up-to-date cancer information and support as well as guidance to access the most appropriate health care services is crucial for cancer self-management and support.
- Trial name
- NCT01549327
- Testing
- Oncology Interactive Navigator, Routine Care
- Where
- 4 sites in Canada
- Volunteers
- 129 people
- Sponsor
- McGill University
Hypoxia, Gastric Cancer
Capnographic Monitoring in Gastrointestinal Endoscopy for Elderly Patients
Hypoxia is the most common adverse event in gastrointestinal endoscopes sedated with propofol and sufentanil, especially in elderly people.
- Conditions
- Hypoxia, Gastric Cancer, Gastric Polyp, Colon Polyp
- Trial name
- CapnoGI (NCT05030870)
- Testing
- Capnography monitoring, Standard monitoring
- Where
- 3 sites in China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Right-sided Colon Cancer, Right-sided Colon Adenoma
Preoperative Endoscopic Treatment With Fosfomycin and Metronidazole in Patients With Right-sided Colon Cancer and Colon Adenoma (MEFO-trial)
Clinical studies have shown that patients with right-sided colon cancer have reduced progression-free and overall survival compared to patients with left-sided colon cancer.
- Trial name
- MEFO (NCT04312360)
- Testing
- therapeutic endoscopy with metronidazole and fosfomycin disodium
- Where
- 2 sites in Denmark
- Volunteers
- 28 people
- Sponsor
- Zealand University Hospital
Colorectal Cancer
Faecal Immunochemical Test and Urine Volatile Compounds in Adenoma Detection
Bowel cancer can arise from polyps, which can become cancerous. Polyps are little outgrowths within the lining of the bowel (similar to skin warts).
- Trial name
- FASt (NCT04146662)
- Testing
- Faecal immunochemical test
- Where
- United Kingdom
- Volunteers
- 360 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Colorectal Cancer
Adaptive Intervention to Maximize Colorectal Screening in Safety Net Populations
The goal of this study is to find the best ways to increase colorectal cancer (CRC) screening.
- Trial name
- AIMSS (NCT03100461)
- Testing
- I2, Health Education
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Colorectal Cancer, Metastatic Colorectal Cancer
Regorafenib and Nivolumab in Mismatch Repair (MMR) Refractory Colorectal Cancer
The main purpose of this study is to test the safety, tolerable side effects, and determine the highest tolerable dose of the combination of Regorafenib and Nivolumab.
- Conditions
- Colorectal Cancer, Metastatic Colorectal Cancer, Colon Cancer
- Trial name
- NCT03712943
- Testing
- Regorafenib, Nivolumab
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Locally Advanced Rectal Cancer
Assess the Efficacy of Radiotherapy and Sequential Chemotherapy and AK104 Before TME Surgery for Local CRC（AK104-IIT-13）
This study is a single-arm, open-label, multicenter clinical study to evaluate the efficacy and safety of preoperative short-course radiotherapy combined with AK104 and chemotherapy + TME surgery in patients with advanced rectal…
- Trial name
- AK104-IIT-13 (NCT05794750)
- Testing
- AK104 injection, TME surgery, Capecitabine
- Volunteers
- 50 people
- Sponsor
- JIN JING
Pancreatic Cancer, Breast Cancer
Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors
Study of NGM831 as Monotherapy and in Combination with Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors
- Conditions
- Pancreatic Cancer, Breast Cancer, Gastric Cancer, Non-small Cell Lung Cancer
- Trial name
- NCT05215574
- Testing
- NGM831, NGM831 plus pembrolizumab (KEYTRUDA®), NGM831 and NGM438 plus pembrolizumab (KEYTRUDA®)
- Where
- 9 sites in United States
- Volunteers
- 130 people
- Sponsor
- NGM Biopharmaceuticals, Inc
Uterine Cervical Neoplasms, Triple Negative Breast Neoplasms
A Phase II Study of GV20-0251 in Combination With Anti-PD-1 Monoclonal Antibodies in Patients With Unresectable, Locally Advanced, or Metastatic Solid Tumors.
This is a Phase 2 study of GV20-0251 in combination with anti-PD-1 monoclonal antibodies (including tislelizumab and toripalimab) for the treatment of participants with unresectable, locally advanced, or metastatic solid tumors…
- Conditions
- Uterine Cervical Neoplasms, Triple Negative Breast Neoplasms, Prostatic Neoplasms, Squamous Cell Carcinoma of Head and Neck
- Trial name
- NCT07623642
- Testing
- GV20-0251, anti-PD-1 monoclonal antibodies
- Where
- 2 sites in China
- Volunteers
- 227 people
- Sponsor
- GV20 Therapeutics
Colo-rectal Cancer, Nutrition Disorders
Effect of Prehabilitation on the Lean Mass Index (IMM) in ERAS PROGRAMM.
The implementation of prehabilitation in patients operated on for colon cancer in a multimodal rehabilitation regimen improves the values of the "lean body mass" or lean mass index, positively influencing the results of clinical…
- Trial name
- PRERAS (NCT03618329)
- Testing
- Prehabilitation
- Volunteers
- 130 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Colorectal Cancer
A Phase 2 Study of Tomudex & Iressa as Second Line Chemotherapy in Subjects With Colorectal Carcinoma
The primary objective of this study is to compare the activity of raltitrexed and ZD1839 versus raltitrexed alone as second line chemotherapy in subjects with colorectal carcinoma by estimating progression free survival (PFS) in…
- Trial name
- NCT00234429
- Testing
- Gefitinib, raltitrexed
- Where
- 9 sites in Spain
- Volunteers
- 74 people
- Sponsor
- AstraZeneca
Metastatic Solid Tumor, Colorectal Cancer
Surufatinib in Combination With Tislelizumab in Subjects With Advanced Solid Tumors
This open-label, phase Ib/II study of surufatinib in combination with tislelizumab will evaluate the safety, tolerability, PK and efficacy in patients with advanced solid tumors.
- Conditions
- Metastatic Solid Tumor, Colorectal Cancer, Neuroendocrine Tumors, Small Cell Lung Cancer
- Trial name
- NCT04579757
- Testing
- Surufatinib and Tislelizumab _ Part 1, Surufatinib and Tislelizumab _ Part 2
- Where
- 18 sites in United States
- Volunteers
- 87 people
- Sponsor
- Hutchmed
Colonic Polyps, Adenomatous Polyps
Linked-Color Imaging Versus Indigo Carmine Pump Spraying on the Colorectal Adenoma Detection Rate
Detection and removal of polyps during colonoscopy is crucial for the prevention of colorectal cancer. Indigo carmine spraying up to the colonic mucosa could probably increase the adenoma detection rate, but considering the long…
- Conditions
- Colonic Polyps, Adenomatous Polyps, Adenoma Detection Rate, Chromoendoscopy
- Trial name
- NCT06961149
- Testing
- Chromoendoscopy with indigo carmine solution spray, Linked-color imaging endoscopy
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Shandong University
Radical Right Hemicolectomy
Novel Ileocecal Valve-Sparing Anastomosis in Laparoscopic Right Hemicolectomy
This is a single-center retrospective cohort study conducted by the Department of General Surgery at the Second Affiliated Hospital of Army Medical University (Xinqiao Hospital).
- Trial name
- NCT07095985
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Army Medical University, China
Colorectal Neoplasm
Stenting and Resection for Stage IV Colorectal Cancer Endoscopic Stenting and Colorectal Resection in Stage IV
Patients with Stage IV obstructing colorectal cancer and unresectable liver metastses, with general and local conditions not a risk for coliorectal resection, will be randomized to have either endoscopic stenting or colorectal…
- Trial name
- NCT03451643
- Testing
- ENDOSCOPIC PLACEMENT OF EXPANDABLE STENT
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University of Roma La Sapienza
KRAS Altered Advanced or Metastatic Solid Tumors
AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors
The purpose of this first-in-human study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of AMG 410 when administered alone or in combination with other agents in…
- Trial name
- NCT07094113
- Testing
- AMG 410, Pembrolizumab, Panitumumab
- Where
- 39 sites in United States, Australia and 12 more
- Volunteers
- 434 people
- Sponsor
- Amgen
Quality of Life, Colorectal Neoplasms
Direct Improvement of Quality of Life Using a Tailored Pathway With Quality of Life Diagnosis and Therapy: Randomised Trial in Colorectal Cancer Patients
The purpose of the study is to determine whether a quality of life pathway with defined diagnostic and therapeutic options improves quality of life in colorectal cancer patients during follow-up.
- Trial name
- DIQOL (NCT02321813)
- Testing
- quality of life pathway
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- Tumor Center Regensburg
Advanced Solid Tumor, Non-Small Cell Lung Cancer
A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations
A first in human study to evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of BLU-924 / SAR449336, a pan-KRAS inhibitor, in participants with advanced Pancreatic Cancer, Non-Small Cell Lung Cancer, or…
- Conditions
- Advanced Solid Tumor, Non-Small Cell Lung Cancer, Colorectal Neoplasms, Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT07629960
- Testing
- BLU-924
- Where
- 16 sites in United States, Spain
- Volunteers
- 265 people
- Sponsor
- Blueprint Medicines Corporation