Clinical trials: Colitis
Ulcerative Colitis, Inflammatory Bowel Disease
Assessment of Disease Activity in Ulcerative Colitis by Endoscopic Ultrasound
In this cross-sectional study patients with active or quiescent ulcerative colitis will be studied to determine the utility of endoscopic ultrasound measurements of rectal wall blood flow and thickness as reliable indices of…
- Trial name
- NCT01852760
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Crohn's Disease
Imuran Dosing in Crohn's Disease Study
This study will compare two different dosing methods of azathioprine (IMURAN) in participants with Crohn's disease who are currently taking steroids (e.g. prednisone or budesonide)or who have just started steroids.
- Trial name
- NCT00113503
- Testing
- Azathioprine weight-based dose, Azathioprine individualised dose
- Where
- 15 sites in United States, Canada
- Volunteers
- 50 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
AssessIUS Scores inUC Versus Colonoscopy
Comparative Accuracy of Activity Scores of Intestinal Ultrasound and Colonoscopy in Monitoring Ulcerative Colitis Activity
Our study aimed to assess simple sonographic activity scores and Colonoscopy for active UC patients
- Trial name
- IUS/IBD (NCT07115524)
- Volunteers
- 200 people
- Sponsor
- Assiut University
Ulcerative Colitis, Postoperative Complications
TAMIS-IPAA vs. Lap-IPAA for Ulcerative Colitiis
The objective of this RCT is to compare the postoperative outcome of transanal versus transabdominal minimally invasive proctectomy with ileal pouch-annal anastomosis in patients with ulcerative colitis.
- Conditions
- Ulcerative Colitis, Postoperative Complications, Ileal Pouch
- Trial name
- NCT03536988
- Testing
- TAMIS-IPAA, Lap-IPAA
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Jinling Hospital, China
Pouchitis, Inflammatory Bowel Diseases
Faecal Microbiota Transplantation From Normal Pouch Function Donor in the Treatment of Chronic Pouchitis
Patients with chronic pouchitis is disabled by bloody diarrhoea and abdominal pain often followed by fever. Pouchitis is an inflammation in a pouch, a reservoir formed by the small intestine in the management of the chronic…
- Conditions
- Pouchitis, Inflammatory Bowel Diseases, Ulcerative Colitis
- Trial name
- NCT04820413
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 3 people
- Sponsor
- Ole Thorlacius-Ussing, MD, DMSc, Professor of Surgery
Ulcerative Colitis (UC)
Efficacy and Safety of Vedolizumab Combined With Upadacitinib in Patients With Ulcerative Colitis
It's of great importance to effectively induce and maintain disease remission in patients with moderate to severe ulcerative colitis (UC).
- Trial name
- NCT06095596
- Testing
- Upadacitinib, Vedolizumab
- Where
- China
- Volunteers
- 334 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Ulcerative Colitis
Basiliximab Maintenance in Ulcerative Colitis
Primary Objective Safety: assess the safety of basiliximab 40 mg, given every 4 weeks, in subjects with ulcerative colitis who completed previous basiliximab studies.
- Trial name
- NCT01061996
- Testing
- Basiliximab
- Where
- United Kingdom
- Volunteers
- 88 people
- Sponsor
- Cerimon Pharmaceuticals
Clostridium Enterocolitis, Pseudomembranous Colitis
Compassionate Use of Nitazoxanide for the Treatment of Clostridium Difficile Infection
The purpose of this study is for compassionate use of nitazoxanide in the treatment of diarrheal disease due to Clostridium difficile infection when the patient has failed previous treatment with metronidazole or vancomycin.
- Trial name
- NCT00304356
- Testing
- Nitazoxanide
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Daniel M. Musher MD
Ulcerative Colitis, Ultrasound Therapy; Complications
Sonographic Assessment in Severe Ulcerative Colitis Patients Admitted for Intravenous Corticosteroids and Eligible for Infliximab Rescue Therapy; a Prospective Clinician-blinded Observational Study Protocol.
Introduction Acute severe ulcerative colitis (ASUC) occurs in 15-25 % of all ulcerative colitis (UC) patients. Initial treatment with intravenous corticosteroids fails in 30-50 % of patients, for whom the next line of treatment…
- Trial name
- SUCCES (NCT03942861)
- Testing
- Solu-Medrol
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital at Herlev
Crohn's Disease, IBD
A Study to Evaluate the Safety and Efficacy of Ustekinumab in Patients With Moderately to Severely Active Crohn's Disease Who Have Failed or Are Intolerant to Tumor Necrosis Factor (TNF) Antagonist Therapy (UNITI-1)
This study (UNITI-1) will compare the effects (both positive and negative) of an initial treatment with ustekinumab to placebo over 8 weeks, in patients with moderately to severely active Crohn's disease who have either failed or…
- Conditions
- Crohn's Disease, IBD, Colitis, Inflammatory Bowel Disease
- Trial name
- NCT01369329
- Testing
- Group 2 ustekinumab 130 mg, Group 3: ustekinumab approximately 6 mg/kg
- Where
- 175 sites in United States, Australia and 21 more
- Volunteers
- 769 people
- Sponsor
- Janssen Research & Development, LLC
Ulcerative Colitis
A Study To Investigate The Safety And Efficacy Of CP- 690,550 In Patients With Moderate And Severe Ulcerative Colitis.
The hypothesis of the study is that at least one dose of CP 690 550 is superior to placebo (inactive drug) in inducing remission in patients with moderate to severe ulcerative colitis.
- Trial name
- NCT00787202
- Testing
- CP- 690 550
- Where
- 59 sites in Belgium, Brazil and 15 more
- Volunteers
- 195 people
- Sponsor
- Pfizer
Crohn Disease, Colitis, Ulcerative
Paricipant Preferences in the Treatment of Inflammatory Bowel Disease (IBD) in Europe
The purpose of this survey is to describe Crohn's disease (CD) participants' as well as ulcerative colitis (UC) participants' preferences towards the attributes of treatment with advanced therapies for IBD, including safety and…
- Conditions
- Crohn Disease, Colitis, Ulcerative, Inflammatory Bowel Diseases
- Trial name
- NCT04597905
- Where
- France
- Volunteers
- 686 people
- Sponsor
- Takeda
Ulcerative Colitis, Diet Habit
Reduced Sulfur Diet in Ulcerative Colitis Patients
A)Background: Approximately 44% of patients with Inflammatory bowel disease have Ulcerative colitis(UC) which is a lifelong, chronic disease, starting in early adulthood, where the colon becomes inflamed and ulcerated due to a…
- Trial name
- UCS (NCT04474561)
- Testing
- Reduced sulfur diet
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University of Calgary
Ulcerative Colitis
Propionyl-L-Carnitine Hydrochloride in Patients With Mild Ulcerative Colitis; Efficacy, Safety and Tolerability Study
The aim of the trial is to test safety, tolerability and efficacy of Propionyl-L-carnitine modified release tablets 1g/die in reducing the symptoms of the disease with respect to the proportion of patients with disease remission…
- Trial name
- NCT01567956
- Testing
- Propionyl-L-Carnitine
- Where
- 58 sites in Austria, France and 6 more
- Volunteers
- 150 people
- Sponsor
- sigma-tau i.f.r. S.p.A.
Ulcerative Colitis
Open-Label Adalimumab for Ulcerative Colitis Patients
This is an open-label study of 20 patients designed to demonstrate the safety, tolerability and preliminary evidence of benefit of adalimumab in the treatment of subjects with Ulcerative Colitis, both in patients who have never…
- Trial name
- NCT00421642
- Testing
- Adalimumab
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Chronic Inflammatory Bowel Disease
Impact of a Structured Therapeutic Education Session on the Practice of Adapted Physical Activity in Chronic Inflammatory Bowel Diseases
Chronic inflammatory bowel diseases (IBD; including Crohn's disease and ulcerative colitis) significantly impact patients' quality of life.
- Trial name
- ETAP-MICI (NCT07305454)
- Testing
- Inflammatory Bowek Disk Questionnaires, Short-International Physical Activity Questionnaries
- Where
- France
- Volunteers
- 71 people
- Sponsor
- University Hospital, Toulouse
Inflammatory Bowel Disease, Colitis, Ulcerative
A Study to Observe Real-world Evidence of Guselkumab Treatment in Participants With Ulcerative Colitis and Crohn's Disease in the United Kingdom (UK)
The purpose of this study is to evaluate the clinical effectiveness (how well the treatment works) of Guselkumab, by lines of treatment and subpopulations, and what are the outcomes of treatment (clinical outcomes) in adult…
- Conditions
- Inflammatory Bowel Disease, Colitis, Ulcerative, Crohn's Disease
- Trial name
- GUSTO-UK (NCT07242248)
- Where
- United Kingdom
- Volunteers
- 220 people
- Sponsor
- Janssen-Cilag Ltd.
Crohn's Disease, Ulcerative Colitis
Expanded Access to Vedolizumab for Children and Teenagers With Ulcerative Colitis or Crohn's Disease in the USA
The expanded access program (EAP) allows people to gain access to an unlicensed treatment on compassionate grounds. This EAP provides children and teenagers with Ulcerative Colitis (UC) or Crohn's Disease (CD) who completed the…
- Trial name
- NCT06856135
- Testing
- Vedolizumab IV
- Where
- 3 sites in United States
- Sponsor
- Takeda
Inflammatory Bowel Disease
Bone Marrow Stromal Cells for Inflammatory Bowel Diseases
Background: Bone marrow stromal cells (BMSCs) are cells that can develop into other tissue types, including bone, cartilage, marrow, and blood cells.
- Trial name
- NCT01851343
- Testing
- Bone Marrow Stromal Cell (BMSC) Infusion
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ulcerative Colitis
Study of the Efficacy and Safety of AMT-101 in Combination With Adalimumab in Subjects With Ulcerative Colitis (MARKET)
Randomized, Placebo-controlled, Double-blind, Parallel-group, Multicenter, Phase 2a Study of the Efficacy and Safety of Oral AMT-101 in Combination With Adalimumab in Subjects with Moderate to Severe Ulcerative Colitis.
- Trial name
- NCT05372939
- Testing
- AMT-101 (oral), Humira (adalimumab)
- Where
- 18 sites in Georgia, Netherlands and 2 more
- Volunteers
- 51 people
- Sponsor
- Applied Molecular Transport