Clinical trials: Colitis, Ulcerative
Ulcerative Colitis
Thermography in Surveillance of Ulcerative Colitis
Ulcerative colitis represents a chronic condition occurring in relapsing and remitting fashion with uncertain outcome and requires lifelong treatment with considerable side effects.
- Trial name
- Thermo (NCT02149043)
- Testing
- Thermography, Colonoscopy
- Where
- Croatia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Hospital Dubrava
Colitis,Ulcerative
Anti-tumor Necrosis Factor in Patients With Ulcerative Colitis in Clinical Remission: to Continue or Not?
The primary objective is to assess if discontinuation of anti- tumor necrosis factor alpha (TNF) treatment in ulcerative colitis patients in sustained clinical remission, with the option to restart treatment in the case of…
- Trial name
- BIOSTOP (NCT03011268)
- Testing
- Discontinuation of anti-TNF treatment, Continuation of anti-TNF treatment
- Where
- 19 sites in Norway
- Volunteers
- 174 people
- Sponsor
- Helse Møre og Romsdal HF
Pouchitis, UC - Ulcerative Colitis
Oral Aeromonas sp. MTB Phage Therapy for Pouchitis in Patients With Ulcerative Colitis (UC)
The goal of this single-arm, prospective clinical trial is to assess the clinical efficacy and safety of oral Aeromonas sp. MTB-specific phage therapy in adult participants aged 18-70 years with pouchitis following ileal…
- Trial name
- NCT07878026
- Testing
- MTB-targeted phage therapy
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Jinling Hospital, China
Colitis, Ulcerative, Crohn Disease
Extended Access Program of Vedolizumab IV in Ulcerative Colitis and Crohn's Disease
The purpose of this study is to monitor ongoing safety in participants with ulcerative colitis (UC) and Crohn's disease (CD) and to provide access to vedolizumab for qualifying participants who, in the opinion of the…
- Trial name
- NCT02743806
- Testing
- Vedolizumab
- Where
- 78 sites in Australia, Bulgaria and 16 more
- Volunteers
- 331 people
- Sponsor
- Takeda
Crohn Disease, Polyposis
Clinical Database of Colorectal Robotic Surgery
Evaluation of robot Da Vinci Xi by determining its learning curve.The operating time will be defined by patient then the operating average will be calculated.
- Conditions
- Crohn Disease, Polyposis, Ulcerative Colitis, Diverticulitis
- Trial name
- ROBOT CR (NCT04013152)
- Testing
- Clinical database
- Where
- 4 sites in France
- Volunteers
- 1,800 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Colitis, Ulcerative
An Analysis of the Relationship Between the Genetic Polymorphisms of Plasminogen Activator Inhibitor-1 and Ulcerative Colitis in Chinese Patients
From January 2019 to February 2025, diagnosed ulcerative colitis(UC) patients and gender- and age-matched normal controls were enrolled from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical…
- Trial name
- NCT06961435
- Testing
- Vedolizumab
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Ulcerative Colitis
Safety and Pharmacokinetic Study of LYC-30937 in Subjects With Active Ulcerative Colitis
The purpose of this study to assess the pharmacokinetic profile in patients with active ulcerative colitis and compare it to the experience in healthy volunteers.
- Trial name
- NCT02818543
- Testing
- LYC-30937
- Where
- 2 sites in Hungary
- Volunteers
- 6 people
- Sponsor
- Lycera Corp.
Ulcerative Colitis (UC), Colorectal Cancer (CRC)
Smart Pill for Measuring Gut Health in Colon Inflammation and Colon Cancer
The goal of this observational pilot study with invasive measurements is to explore whether an ingestible sensor pill can be of use in diagnosis or monitoring of disease in patients with ulcerative colitis or colorectal cancer.
- Trial name
- SPIRIT (NCT07046468)
- Testing
- Ingestion of sensor capsule (twice), Device evaluation questionnaire, Wearing device
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center
Crohns Disease, Ulcerative Colitis
Integrative Gastroenterology - an Observational Trial
This study aims to test, if a two-week integrative therapy in an internal medicine ward will improve symptoms, disability and quality of life in patients with inflammatory bowel disease or irritable bowel syndrome.a It shall…
- Conditions
- Crohns Disease, Ulcerative Colitis, Irritable Bowel Syndrome
- Trial name
- InteGast (NCT02476643)
- Testing
- Integrative Therapy
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Universität Duisburg-Essen
Ulcerative Colitis
ADAPT Adacolumn Pediatric Trial in Ulcerative Colitis
Children aged up to 18 years with moderately active Ulcerative Colitis (PUCAI:35-64) will receive one weekly Adacolumn® apheresis treatment over 5 consecutive weeks, followed by up to 3 optional Adacolumn® apheresis treatments…
- Trial name
- NCT00781638
- Testing
- Adacolumn®
- Volunteers
- 24 people
- Sponsor
- Otsuka Frankfurt Research Institute GmbH
Ulcerative Colitis
Long-term Outcome of Patients With Acute Ulcerative Colitis After First Course of Intravenous Corticosteroids
All episodes of patients with acute UC admitted to Tampere University Hospital and treated with intravenous corticosteroids between January 2007 and January 2016 were identified from patient records and reviewed.
- Trial name
- NCT04564638
- Testing
- Corticosteroid
- Volunteers
- 217 people
- Sponsor
- Tampere University Hospital
Ulcerative Colitis
Linked Color Imaging vs. White Light for Colorectal Dysplasia in Ulcerative Colitis
The purpose of the study is to determine whether a new colonoscopic viewing technique called Linked color imaging(LCI) helps endoscopists detect more dysplasia lesions in ulcerative colitis patients than conventional colonoscopy…
- Trial name
- NCT02772406
- Testing
- Linked Color Imaging, white light imaging
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Ulcerative Colitis
A Randomized, Multicenter Open Label Study Comparing Early Administration of Azathioprine Plus IFX to Steroids Plus Azathioprine for Acute Severe Colitis
PHASE : IV TYPE OF STUDY : With direct benefit. DESCRIPTIVE : Multicentre, randomized, open label study. INCLUSION CRITERIA : Acute severe ulcerative colitis.
- Trial name
- ACTIVE (NCT02425852)
- Testing
- Azathioprine, Infliximab, Prednisolone
- Where
- 16 sites in France
- Volunteers
- 65 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Ulcerative Colitis (UC)
The Effects of a Modified Mediterranean Diet on Ulcerative Colitis Patients
Ulcerative colitis is a chronic disease with a significant impact on quality of life where a substantial proportion of patients fails to achieve disease remission.
- Trial name
- OLIVE-UC-1 (NCT07857447)
- Testing
- Modified Mediterranean Diet, Standard Nutritional Guidance
- Where
- Croatia
- Volunteers
- 62 people
- Sponsor
- University Hospital Sestre Milosrdnice
Ulcerative Colitis
Study to Assess Change in Disease Activity of Risankizumab Treatment in Japanese Participants With Moderate to Severe Ulcerative Colitis
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).
- Trial name
- RISE UP (NCT07136116)
- Where
- 29 sites in Japan
- Volunteers
- 200 people
- Sponsor
- AbbVie
Ulcerative Colitis
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181 in Healthy Subjects and Subjects With Mild to Moderate Ulcerative Colitis
To assess the safety and tolerability of single subcutaneous (SC) and intravenous (IV) doses of AMG 181 in healthy subjects and of a single SC dose in subjects with mild to moderate ulcerative colitis (UC)
- Trial name
- NCT01164904
- Testing
- Amg 181
- Where
- 10 sites in United States, Australia and 1 more
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Amgen
Mild to Moderate Ulcerative Colitis
A Study of SPH3127 in the Treatment of Mild to Moderate Ulcerative Colitis
To preliminarily evaluate the clinical efficacy of the renin inhibitor SPH3127 Tablets in patients with mild to moderate ulcerative colitis with placebo as a control and determine the recommended dose.
- Trial name
- NCT05770609
- Testing
- SPH3127 Tablets with Dose A, SPH3127 Tablets with Dose B
- Where
- 25 sites in China
- Volunteers
- 53 people
- Sponsor
- Shanghai Pharmaceuticals Holding Co., Ltd
Inflammatory Bowel Diseases, Ulcerative Colitis
Personalized B-fructan Diet in Inflammatory Bowel Disease Patients
This study aims to examine patient tolerability of personalized dietary fibre consumption recommendations (high-pectin diet versus high-B-fructan diet based on personalized responses), provided by an IBD dietician, based on our…
- Trial name
- NCT05615779
- Testing
- Randomized B-fructan diet, Personalized pectin diet, Personalized B-fructan diet
- Where
- 2 sites in Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Ulcerative Colitis, Postoperative Complications
TAMIS-IPAA vs. Lap-IPAA for Ulcerative Colitiis
The objective of this RCT is to compare the postoperative outcome of transanal versus transabdominal minimally invasive proctectomy with ileal pouch-annal anastomosis in patients with ulcerative colitis.
- Conditions
- Ulcerative Colitis, Postoperative Complications, Ileal Pouch
- Trial name
- NCT03536988
- Testing
- TAMIS-IPAA, Lap-IPAA
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Jinling Hospital, China