Clinical trials: Cold Exposure
Obsessive Compulsive Disorder
Application of Vagal Stimulation in Exposure and Response Prevention for Obsessive Compulsive Disorder
Obsessive Compulsive Disorder (OCD) is a condition associated with recurrent intrusive distressing thoughts, images and urges compelling the person to perform neutralizing acts or thoughts to the extent of significantly…
- Trial name
- NCT02196090
- Testing
- Exposure and Response Prevention, Cold face gel mask
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- King's College London
Body Temperature, Hypothermia
Core Body Temperature Measurement During Hot and Cold Environmental Exposure
Accurate measurement of core body temperature at the scene of an accident is critical for both diagnosis and treatment/triage decisions for hypothermic patients.
- Trial name
- NCT01793337
- Testing
- Exposure to cold environmental temperature (-20°C)
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Institute of Mountain Emergency Medicine
Cold Exposure
The Influence of Race and MitoQ Supplementation on Skin Blood Flow in the Cold
Individuals who operate in cold weather are at risk of developing cold injuries, for example, frostbite. They also often experience a loss of hand function and joint mobility due to a decrease in skin temperature and blood flow.
- Trial name
- NCT06784531
- Testing
- Mitoquinone mesylate (MitoQ), Cold Water Hand Immersion, Cold Air Exposure
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Cold Exposure
The Effect of Cold Exposure on Energy Expenditure
Cold-induced thermogenesis, or the increase in energy expenditure upon cold exposure, indicates metabolic stress, as such, cold-induced thermogenesis may signal an appropriate stimulus to improve metabolic health.
- Trial name
- NCT05107570
- Testing
- Cold exposure
- Where
- Netherlands
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Hypertension
L-citrulline Supplementation & Cold Exposure
Cardiovascular disease (CVD) is considered the primary cause of death in the developed world. Large scale epidemiological studies indicate that prevalence of hypertension along with adverse cardiovascular events peak during the…
- Trial name
- NCT01462591
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Florida State University
Hypertension
Cardiovascular Responses to Cold in Hypertension
Wintertime is associated with increased morbidity and mortality and a majority is related to cardiovascular causes, such as myocardial infarctions, heart failures, and strokes.
- Trial name
- ColdHTN (NCT02007031)
- Where
- 2 sites in Finland
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Oulu
Solid Tumors, Solid Malignancies
Controlled Cold Exposure Combined With PD-1/PD-L1 Immunotherapy in Solid Tumors (NIVALIS)
This is a single-center, prospective, single-arm, open-label phase I exploratory study that plans to enroll 24 participants with solid malignancies.
- Conditions
- Solid Tumors, Solid Malignancies, Cold Exposure, Immunotherapy
- Trial name
- NIVALIS (NCT07538479)
- Testing
- Controlled Cold Exposure, Investigator-Selected Standard PD-1/PD-L1 Inhibitor-Based Therapy
- Where
- China
- Volunteers
- 24 people
- Sponsor
- West China Hospital
Cold Exposure
Omega-3 Fatty Acids as Regulators of Brown Adipose Tissue During Cold Exposure
This clinical trial will assess the whether fish oil supplementation can modulate brown fat activation, shivering, thermal comfort and skin blood flow during cold exposure.
- Trial name
- NCT05822141
- Testing
- Fish Oil
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Delayed Onset Muscle Soreness (DOMS), Inflammation
Effects of Immediate and Delayed Repeated Cold Exposure After Physical Exertion
The goal of this clinical trial is to learn if applying cold therapy can reduce swelling, inflammation, and pain after physical activity in adults who experience muscle soreness (Delayed Onset Muscle Soreness, or DOMS).
- Conditions
- Delayed Onset Muscle Soreness (DOMS), Inflammation, Muscle Pain, Muscle Damage
- Trial name
- NCT06813690
- Testing
- Cold Therapy with Axanova Cold Hot Pearls Maxi Pack
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Brown Adipose Tissue, Cold Exposure
Intermittent Cold Exposure and Brown Adipose Tissue Hyperplasia
This clinical trial explores how repeated short-term cold exposure impacts the molecular and physiological function of brown adipose tissue (BAT), a thermogenic organ associated with improved cardiometabolic health.
- Conditions
- Brown Adipose Tissue, Cold Exposure, 18F-FDG PET/CT
- Trial name
- ICEBATH (NCT07048405)
- Testing
- Cooling, Biopsies, Injection of 18F-FDG
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Healthy Volunteers
Showers and Stress
The study investigates whether repeated exposure to cold showers can improve the ability to cope with and respond to stress. In particular, it examines both the psychophysiological effects of cold showers and the role of…
- Trial name
- S A S (NCT07611422)
- Testing
- Positive expectation about the effects of cold and warm showers, No expectation regarding the exposure to cold water and/or to warm showers
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Hand Injuries and Disorders
Cross-cultural Adaptation and Validation of the CISS and the PWES Questionnaire in Patients With Hand Pathologies.
The primary objective of the study is to do translation, cross-cultural adaptation and validation of the CISS and PWES questionnaire in French. No available translation exist in French.
- Trial name
- NCT04646343
- Testing
- administration of F-CISS and F-PWES pre version, administration of definitive version of F-CISS and F-PWES plus F-DASH, F-HFS and F-SF 36
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Clinique Romande de Readaptation
Healthy Adult Participants
The Effect of Cold Exposure on Physiological Markers
The goal of this observational study is to examine how different physiological markers change over a two-day period after long-duration whole-body cold-water immersion in healthy young men and women.
- Trial name
- NCT07504718
- Testing
- Cold water immerssion
- Where
- Lithuania
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Thermoregulation, Cold Exposure
Effect of Pre-cooling on Whole-body Heat Loss During Exercise-heat Stress
Endurance exercise performance declines in hot environments as core body temperature increases. To enhance performance, body pre-cooling strategies, such as cold-water immersion have been employed to lower resting core…
- Conditions
- Thermoregulation, Cold Exposure, Heat Stress, Exercise
- Trial name
- NCT06670339
- Testing
- No Cooling, Pre-Cooling
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Cold Exposure
Cold Water Exposure's Effects on Physical and Mental Health
An interest in cold-water immersion (CWI) to elicit diverse physiological effects has been prevalent for centuries. CWI typically consists of bodily exposure to water at temperatures ranging from 5-10º C for various durations.
- Trial name
- NCT06667193
- Testing
- Cold Water Immersion (CWI) - Cold Tub Immersion (CI), Cold Water Immersion (CWI) - Cold Shower (CS)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Northern Colorado
Particularly Partial-body Cryostimulation
Effect of Cryostimulation on Selected Motor Skills in Soccer Players
A randomized study was conducted during two training periods. The first stage of a 5-day cryostimulation procedure took place in November 2022, during the training period after the end of the league season.
- Trial name
- NCT06812819
- Testing
- Cryostimulation is a form of cooling the body using low temperatures without causing tissue damage. The stimulus effect is achieved at temperatures below - 110⁰C, in a short time of 1-3 minutes. The p
- Where
- Poland
- Volunteers
- healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Hypertension
L-citrulline Supplementation, Cold Exposure, & Post-Exercise Muscle Ischemia
Cardiovascular disease (CVD) continues to be the major cause of morbidity and mortality in western countries. It has been shown that CVD events are known to be higher in the winter than in the summer.
- Trial name
- NCT02104375
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Florida State University
Healthy
Inuit and Cold Exposure
Brown adipose tissue (BAT) produces heat through non-shivering thermogenesis. It is activated by cold exposure, and when activated it utilizes fatty acids and glucose in order to produce heat.
- Trial name
- ICE (NCT05884177)
- Testing
- Short-term cold exposure
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Stig Andersen
Psoriasis, Stress
Non-pharmacological Mitigation of Psoriasis
In the past few years, research has provided evidence for a possibility of dampening immune system by one's will after undergoing a specific training program.
- Conditions
- Psoriasis, Stress, Inflammation, Depression
- Trial name
- NCT04745429
- Testing
- breathing exercises, cold exposure and meditation
- Where
- Poland
- Volunteers
- 38 people
- Sponsor
- Medical University of Lodz
Hypoxia, Altitude, Cold Exposure
Effects of Physical Training in Altered Environmental Conditions on Exercise Performance
The main objective of the study is to evaluate the physiological-biochemical effects of physical training under artificially altered climatic conditions (using a hypoxic thermoclimatic chamber) in particular to determine the…
- Conditions
- Hypoxia, Altitude, Cold Exposure, Heat Exposure
- Trial name
- NCT06159374
- Testing
- exercise and environmental conditions
- Where
- Poland
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland