Clinical trials: Cohort Studies
Alzheimer Disease, Neurodegenerative Diseases
Cognitive Impairment Cohort Study of the Elderly Population in YuGarden
The goal of this prospective observational research with an 8-year follow-up is to study the cognitive changes in the elderly in YuGarden community, Shanghai, China.
- Conditions
- Alzheimer Disease, Neurodegenerative Diseases, Cognitive Impairment, Mild Cognitive Impairment
- Trial name
- NCT06325527
- Where
- China
- Volunteers
- 1,872 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Healthy
A Phase 1, First-in-human Study of MORF-440 (LY4292009) in Healthy Participants
The purpose of this study is to evaluate the safety and tolerability of single ascending doses of MORF-440 administered to healthy participants single-ascending dose (SAD) and maximum ascending dose (MAD) substudy.
- Trial name
- NCT06977880
- Testing
- LY4292009
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company)
Hip Fracture (First Incidence of)
Diet and Hip Fracture Risk in the United Kingdom Women's Cohort
Hip fracture is a common serious injury in older women that reduces quality of life and can lead to premature death. In the United Kingdom, hip fractures are estimated to account for 1.5 million hospital bed days used per year…
- Trial name
- NCT05081466
- Testing
- Dietary pattern, Fruit and vegetable intake, Meat intake
- Where
- United Kingdom
- Volunteers
- 35,372 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Ischemic Stroke, Ischemic Cerebrovascular Disease
Clinical Evaluation of New Biomarkers for Ischemic Cerebrovascular Disease
The goal of this single-center prospective observational study is to identify and evaluate new biomarkers for ischemic cerebrovascular disease (ICVD) to aid in early diagnosis, individualized treatment planning, and prognosis…
- Trial name
- NCT06890702
- Testing
- biomaker levels
- Where
- 2 sites in China
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Leber Congenital Amaurosis
Genetic Decryption of Leber Congenital Amaurosis (LCA) in a Large Cohort of Independent Families.
The main objectives of this study are: 1. Improve genetic counseling by establishment of prevalences of each of genetic subtypes within a expanded population of patients with LCA taking into account ethnicity of families. 2.
- Trial name
- GENPHENACL (NCT02970266)
- Where
- France
- Volunteers
- 659 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Arterial Stiffness, Oral Health
Predication of Arterial Stiffness in Healthy Adults by Oral Health and Chewing Assessments
INN.oral.HEALTH is an sub-study embedded in the Innsbruck Health Promotion Program (INN.HEALTH). The study investigates whether oral health, oral structure, and oral function provide additional information for understanding…
- Conditions
- Arterial Stiffness, Oral Health, Mastication, Deglutition
- Trial name
- INNoralHEALTH (NCT07736222)
- Testing
- Dentition and Occlusal Status Assessment, Oral Health Assessment Tool, Maximum Bite Force Measurement
- Where
- Austria
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- VASCage GmbH
Long Covid
Validation of Biomarkers for Long COVID in the LIINC Viral Immunopathogenesis and Persistence Repeat Donor Cohort (VIPER)
The purpose of this study is to better understand the biological changes associated with Long COVID and to identify laboratory tests (biomarkers) that may help diagnose the condition and measure how it changes over time.
- Trial name
- VIPER (NCT07770022)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy
Effects of Food on Oxycodone Pharmacokinetics in Healthy Volunteers
To estimate the effect of food on the pharmacokinetics and relative bioavailability of oxycodone following oral administration of single 40 mg doses of PF 00345439 Formulation K taken whole or after chewing in healthy volunteers.
- Trial name
- NCT02117583
- Testing
- Oxycodone
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Pain Therapeutics
Alzheimer Disease, Mild Cognitive Impairment
ADRC Clinical Cohort (Alzheimer's Disease)
The purpose of the study is to establish a clinical cohort for the Duke/UNC Alzheimer's Disease Research Center (ADRC). The cohort will be composed of subjects ages 25 to 44 at enrollment with normal cognition and subjects ages…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia
- Trial name
- NCT06703541
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Duke University
Cadasil
AusCADASIL: An Australian Cohort of CADASIL
The aim of this project is to establish an Australian cohort of patients diagnosed with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL).
- Trial name
- NCT06148051
- Where
- 5 sites in Australia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Perminder Sachdev
HPV-Related Cervical Carcinoma, Physician-Patient Relations
An Observational Study of GP Verbal Reminders Upon Cervical Screening
Cervical cancer screening is offered to all women in the United Kingdom (UK) between the ages of 24.5 and 64 years of age. The majority of screening is performed in primary care and the rate remains stubbornly below 80%, despite…
- Trial name
- VRCS (NCT04970394)
- Testing
- Cervical Screening Reminder
- Where
- United Kingdom
- Volunteers
- 724 people, healthy volunteers welcome
- Sponsor
- Dr. Faizan Awan
Respiratory Syncytial Virus
A Prospective, Epidemiological Study to Assess the Disease Burden of Respiratory Syncytial Virus Associated, Suspected Lower Respiratory Tract Infections in Newborns, From 0 to 2 Years of Age and Risk of Development of Wheeze and Asthma From 0 to 6 Years of Age
The purpose of this study is to assess the incidence and associated healthcare utilization of RSV-associated, suspected LRTI in a general population of infants from birth up to 2 years of age, and also to assess the accuracy of a…
- Trial name
- NCT01995175
- Testing
- Nasal swab sampling, Blood sampling, Diary cards
- Where
- 23 sites in United States, Argentina and 6 more
- Volunteers
- 2,409 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
RSV Infections, Lower Respiratory Tract Infections
Real-World Effectiveness of Nirsevimab Against RSV-Related and All-Cause Respiratory Tract Infections in Chinese Infants
A multicenter, retrospective cohort study based on clinical data from seven tertiary hospitals in China will be undertaken. The study aims to evaluate the real-world effectiveness of Nirsevimab in preventing Respiratory Syncytial…
- Trial name
- NCT07382219
- Testing
- Nirsevimab
- Where
- 7 sites in China
- Volunteers
- 816 people, healthy volunteers welcome
- Sponsor
- Han Tongyan
Venous Thromboses, Venous Thromboembolism
The Risk of Venous Thromboembolism in Systemic Inflammatory Disorders: a United Kingdom (UK) Matched Cohort Study
Blood clots occurring in the legs and in the lungs are relatively common; they occur in around 3 in a 1000 people per year. They can cause disability and are also potentially life threatening.
- Conditions
- Venous Thromboses, Venous Thromboembolism, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- NCT03835780
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 266,890 people, healthy volunteers welcome
- Sponsor
- Momentum Data
Long COVID, COVID-19 Pandemic
Long COVID and Its Associations With Health Outcomes in Older Adults
The Peking University Health Cohort in Anning, Yunnan (PKUHC-AN) is a prospective cohort study carried out in Anning, Yunnan. The primary aim of this study is to investigate the impact of COVID-19 on older adults' health, and to…
- Conditions
- Long COVID, COVID-19 Pandemic, Elderly Infection, Vaccine Reaction
- Trial name
- NCT05825651
- Testing
- no interventions
- Where
- China
- Volunteers
- 11,527 people, healthy volunteers welcome
- Sponsor
- Peking University
Whooping Cough
The Safety of Boostrix Following Routine Immunization of Pregnant Women
The purpose of this study was to assess the safety of Boostrix administered on or after the first day of the 27th week of pregnancy by conducting a post-marketing study that provided safety information to the public and…
- Trial name
- NCT03463577
- Testing
- Safety assessment following routine immunization with Boostrix
- Where
- United States
- Volunteers
- 65,783 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Second Primary Colorectal Cancer
Impact of 10 Different Prior Cancer History on Survival of Patients Who Underwent Surgery for Second Primary Colorectal Cancer: a Population-based Cohort Study
In this study, the investigators collected data with the SEER*Stat software version 8.4.1 (accession number: 20377-Nov2021). The patients with confirmed diagnoses of CRC (site code C18.0-20.9 and C26.0) between 2004 and 2013 were…
- Trial name
- NCT06189547
- Testing
- different prior cancer history type
- Where
- China
- Volunteers
- 82,770 people, healthy volunteers welcome
- Sponsor
- Guangzhou Medical University
Male Circumcision, HIV Prevention
Cohort Field Study to Assess the Safety and Efficacy of the PrePex Device for Non-Surgical Circumcision When Performed by Nurses
A range of observational and epidemiological studies have shown that the lifetime risk of HIV infection can be reduced by 70% through male circumcision.
- Trial name
- NCT01434628
- Testing
- PrePex™ device
- Where
- Rwanda
- Volunteers
- 590 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
Coma, Disorder of Consciousness
Development of a Point of Care System for Automated Coma Prognosis
Electroencephalogram/event-related potentials (EEG/ERP) data will be collected from 50 participants in coma or other disorder of consciousness (DOC; i.e., Unresponsive Wakefulness Syndrome [UWS] or Minimally Conscious State…
- Conditions
- Coma, Disorder of Consciousness, Minimally Conscious State, Vegetative State
- Trial name
- NCT03826407
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McMaster University
Perinatal Mental Health, Reproductive Behavior
Women's Reproductive Choices and Mental Health During Pregnancy and After Birth in Wartime Ukraine
The goal of this observational study is to learn how war affects reproductive decisions and perinatal mental health in Ukrainian women.
- Conditions
- Perinatal Mental Health, Reproductive Behavior, Women, Cohort Studies
- Trial name
- NCT07551934
- Testing
- Psychological Assessment, Routine Clinical Data Collection
- Where
- Ukraine
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Taras Shevchenko National University of Kyiv
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