Clinical trials: Cognitive Performance
Aging, Cognitive Function Abnormal
Executive Functioning Training Study
Cognitive aging in people with HIV (PWH) is of increasing concern for several reasons: 1) between 52%-59% of PWH experience cognitive impairment known as HIV-Associated Neurocognitive Disorder (HAND) which impacts everyday…
- Conditions
- Aging, Cognitive Function Abnormal, Cognitive Performance, Cognitive Training
- Trial name
- EFT (NCT05598047)
- Testing
- Executive Functioning Training
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cognitive Performance
Home Operations Utilizing Stimulation
This project will utilize a home-operated stimulator in 1) a healthy young adult population and 2) a healthy older adult population to provide a proof of concept of home-use of transcutaneous vagal nerve stimulation (tVNS).
- Trial name
- NCT04484285
- Testing
- Transcutaneous Vagal Nerve Stimulation (tVNS)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Florida
Healthy, Brain Stimulation
Effects of Transcranial Electrical Stimulation on Task Performance in Healthy Adults
The objective of this randomized, double-blind, sham-controlled, crossover study is to evaluate the effects of transcranial electrical stimulation (tES) on complex cognitive task performance in healthy adult volunteers.
- Conditions
- Healthy, Brain Stimulation, Transcranial Direct Current Stimulation (tDCS), Cognition
- Trial name
- BRAIN-STIM (NCT06995560)
- Testing
- Active Transcranial Electrical Stimulation
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Mild Cognitive Impairment
Application of Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance
Loss of slow wave sleep (SWS) is common in mild cognitive impairment (MCI) and Alzheimer's disease, and is thought to worsen thinking, memory and brain degeneration.
- Trial name
- NCT03112902
- Testing
- Application of Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Marijuana Abuse
The Effect of Prescription Medications in Marijuana Users
A subset of heavy marijuana users have trouble quitting marijuana use and the number of those seeking treatment for problems related to marijuana is increasing.
- Trial name
- NCT00893074
- Testing
- Dronabinol 30mg/day, Dronabinol 60mg/day, Dronabinol 120mg/day
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cognitive Performance, Brain Structure
Rhythm Experience and Africana Culture Trial
REACT is a randomized intervention to examine the benefits of African Dance as a method to increase physical activity behaviors in older adults.
- Trial name
- REACT (NCT03771716)
- Testing
- African Dance, African Cultural Immersion
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Schizophrenia, Schizoaffective Disorder
Assessing the Effects of Fanapt® on Social Cognition in Schizophrenia
The study looks at whether treatment with iloperidone (Fanapt) is associated with improvements in social cognition in individuals who have been recently diagnosed with schizophrenia or schizoaffective disorder.
- Trial name
- NCT01929889
- Testing
- Iloperidone
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Northwestern University
Cognitive and Cerebral Blood Flow Effects of Resveratrol
The Cognitive and Cerebral Blood Flow Effects of Resveratrol
Research shows that resveratrol is able to induce vasodilation (and therefore blood flow) by interacting with nitric oxide (NO).
- Trial name
- NCT01010009
- Testing
- Trans- resveratrol
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Cognitive Measures, Driving Simulator Performance
Phenytoin and Driving Safety: A Randomized, Controlled Cross-Over Study
Automobile driving is a crucial aspect of everyday life, yet vehicular crashes represent a serious public health problem. Patients with epilepsy are at elevated risk for automobile crashes, causing great personal suffering and…
- Trial name
- NCT00581893
- Testing
- Phenytoin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Multiple Sclerosis
Cognitive Markers in Prodromal MS
The focus of this work is the evaluation of a measure of cognitive functioning- intra-individual variability (IIV) - derived from a computer-based continuous reaction time (RT) task (Cogstate) as an early marker of prodromal MS.
- Trial name
- NCT05543915
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Major Depressive Disorder
The BIomarker Guided (BIG) Study for Depression
Cognitive impairments contribute significantly to psychosocial dysfunction in major depressive disorder (MDD) and respond poorly to conventional antidepressants, yet selective treatments targeted to these impairments are lacking.
- Trial name
- NCT04181736
- Testing
- Guanfacine Tablets
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Stanford University
Multiple Sclerosis
Efficacy and Safety of 4-aminopyridine on Cognitive Performance and Motor Function of Patients With Multiple Sclerosis
Twenty four relapsing-remitting multiple sclerosis (RRMS) patients over the age of 18, with similar degree of disability, and with an evolution of at last 6 months, who are in first-line immunomodulatory therapy and have a stable…
- Trial name
- NCT02280096
- Testing
- 4-aminopyridine
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Caffeine
The Effects of e+Shots Energy Beverage on Mental Energy
The aim of the research project is to determine the changes in motivation to perform mental and physical tasks, feelings of vigor and fatigue, mental task vigilance and fine motor function after consumption of a commercially…
- Trial name
- NCT03850275
- Testing
- Intervention/treatment
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Clarkson University
Cocaine Use Disorders, HIV
Project IMPACT: Improving Memory Performance by Applying Cognitive Training
The purpose of this study is to examine the effects of a cognitive training program in persons with Human Immunodeficiency Virus (HIV) infection who have used cocaine.
- Trial name
- NCT02909101
- Testing
- Active Cognitive Training (ACT), Control Training (CON)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Duke University
Caloric Restriction, Exercise
Trial of Testosterone Undecanoate for Optimizing Performance During Military Operations
The objective of this study is to determine the effects of a single dose of testosterone undecanoate during and in recovery from simulated operational stress.
- Conditions
- Caloric Restriction, Exercise, Sleep
- Trial name
- OPS II (NCT04120363)
- Testing
- Testosterone Undecanoate, Sesame Oil
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Insomnia, Primary Insomnia
Impact of Hyperarousal on Simple and Complex Cognitive Task Performance Among Insomnia Sufferers
The purpose of this study is to learn more about people with insomnia disorder and cognitive impairment. Cognitive impairment is difficulty with mental abilities such as thinking, knowing and remembering.
- Conditions
- Insomnia, Primary Insomnia, Chronic Insomnia
- Trial name
- NCT02290405
- Testing
- Multiple Sleep Latency Test (MSLT)
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Jack Edinger, PhD
Cognition, Stress Reaction
rTMS to Enhance Cognitive Performance and Promote Resilience
The purpose of this study is to determine the most effective dose of brief, non-invasive brain stimulation (repetitive transcranial magnetic stimulation, rTMS) for improving cognitive functions such as attention and memory as…
- Trial name
- NCT04123496
- Testing
- rTMS
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Expectancy Versus Pharmacotherapy Effect of Adderall
Neuroimaging the Expectancy Versus Pharmacotherapy Effect of Adderall on Cognitive Performance
The purpose of this balanced-placebo design study is to pilot a larger study to further explore the current evidence that stimulant medications are not cognitive enhancers, despite this rampant belief in young adults.
- Trial name
- NCT03530631
- Testing
- Adderall
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Seasonal Allergic Rhinitis
Fluticasone Furoate Treatment of Daytime Somnolence and Cognitive Performance in Seasonal Allergic Rhinitis
The hypothesis is that treating hay fever patients who had daytime sleepiness and slowed thinking because of the hay fever will improve when treated with an effective anti-hay fever medication, an intranasal steroid, that is will…
- Trial name
- NCT00997620
- Testing
- Fluticasone furoate Nasal Spray 110 mcg
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Western Sky Medical Research
Healthy
Chronic Resveratrol Supplementation in Healthy Humans
The effects of chronic resveratrol supplementation have yet to be investigated in healthy humans. It is hypothesised that the effects will be different to those seen in acute supplementation.
- Trial name
- NCT01640197
- Testing
- Resveratrol
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northumbria University