Clinical trials: Cognitive Impairments, Mild
MCI, MCI-AD, Early Stage Alzheimer's Disease
Efficacy and Safety of Dimethyl Fumarate Among Patients with Mild Cognitive Impairment and Dementia Due to Alzheimer's Disease
The goal of this clinical trial is to assess the degree of improvement in cognitive functions, including memory, attention, thinking, executive and language functions in diagnosed patients MCI and AD taking dimethyl fumarate 480…
- Conditions
- MCI, MCI-AD, Early Stage Alzheimer's Disease, Alzheimer's Disease
- Trial name
- NCT06850597
- Testing
- dimethyl fumarate
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Dementia, Alzheimer Disease 1
Study of APH-1105 in Patients With Mild to Moderate Alzheimer's Disease
This is a Phase 2 study assessing the safety, tolerability and efficacy of intranasal delivery of APH-1105 for the treatment of mild to moderate Alzheimer's in adult.
- Conditions
- Dementia, Alzheimer Disease 1, Alzheimer Disease 2, Alzheimer Disease 3
- Trial name
- NCT03806478
- Testing
- APH-1105
- Volunteers
- 60 people
- Sponsor
- Aphios
Healthy Aging, Memory Disorders in Old Age
Noninvasive Temporal Interference Stimulation: Modulating Associative Memory by Targeting Deep-brain Targets
Alzheimer's disease and its preclinical stages are characterized by progressive neurodegenerative changes in the hippocampi and default mode network resulting in dysfunctions in episodic memory and its central part the…
- Conditions
- Healthy Aging, Memory Disorders in Old Age, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- Deep-HiPs (NCT05805215)
- Testing
- Non-invasive Temporal Interference stimulation and Face-name association training task targeting the hippocampus, Non-invasive Temporal Interference stimulation and Face-name association training task targeting the Precuneus
- Where
- Czechia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Healthy Test Persons, Mild Cognitive Impairment
Identification of Predictors for Early Cognitive Decline in Men
The research program explores how aging influences brain function in test-persons from a Danish birth cohort of men born in 1953.
- Conditions
- Healthy Test Persons, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT03290040
- Where
- Denmark
- Volunteers
- 564 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Mild Dementia, Mild Cognitive Impairment
The Swedish BioFINDER - Memory Clinic Study
The diagnosis of diseases causing memory difficulties or dementia is often challenging. Without the use of advanced methods such as cerebrospinal fluid tests, approximately 25-30% do not receive a correct diagnosis today.
- Conditions
- Mild Dementia, Mild Cognitive Impairment, SCD, Alzheimer Disease
- Trial name
- Validate (NCT06122415)
- Testing
- Plasma Amyloid Probability Score 2 (APS 2) score, Plasma ptau217/nptau217, Plasma ptau217
- Where
- Sweden
- Volunteers
- 1,200 people
- Sponsor
- Skane University Hospital
Mild Cognitive Impairment, Alzheimer Disease
Epilepsy in Alzheimer's Disease: Effect on Disease Progression
This is a long-term, prospective, interventional study to investigate the role and prevalence of subclinical epileptiform activity in the hippocampus in patients with mild cognitive impairment (MCI) due to Alzheimer's disease…
- Trial name
- EADP (NCT04131491)
- Testing
- Lumbar puncture
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Dementia, Alzheimer Disease
Evaluation of Alteration by Magnetic Resonance Imaging (MRI) in Dementia Among Elderly Subjects
Capturing the earliest stages of Dementia especially Alzheimer's Disease (AD) is a great challenge. Until now the NINCDS-ADRDA and the DSM criteria for AD were largely used as diagnostic standards in research.
- Trial name
- AMIMAGE (NCT00951197)
- Testing
- Neuroimaging
- Where
- France
- Volunteers
- 318 people
- Sponsor
- University Hospital, Bordeaux
Mild Cognitive Impairment, Subjective Cognitive Decline
Under-Represented Communities Diagnosed With SCD or MCI Through Tele-Cog
The purpose of this study is to establish a longitudinal cohort of older adults with Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI): 1) at heightened risk for dementia, and 2) from…
- Trial name
- NCT06542458
- Testing
- Assessments, Neuroimaging volumetric measures, Biofluid samples
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ohio State University
Mild Cognitive Impairment
Computer-Based Therapy for Mild Cognitive Impairment
The purpose of this study is to determine the neuropsychological and neurophysiological impacts of a computer-based training program designed to improve the cognitive performance of patients with mild cognitive impairment (MCI).
- Trial name
- NCT00319943
- Testing
- Computer-based training for Mild Cognitive Impairment (MCI)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Posit Science Corporation
Dementia, Alzheimer Disease
The Music, Sleep and Dementia Study
The specific aims of this studyare to examine the 1) feasibility; 2) acceptability; and 3) preliminary efficacy of a tailored music intervention in home-dwelling older adults with dementia suffering from sleep disruption.
- Conditions
- Dementia, Alzheimer Disease, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder
- Trial name
- NCT04157244
- Testing
- Tailored music listening intervention
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Mild to Moderate Alzheimer Disease, Cognitive Impairment
An Efficacy and Safety Study of Sodium Oligo-mannurarate (GV-971) Capsule for the Treatment of Alzheimer's Disease
The primary purpose of this study is to determine the efficacy and safety of Sodium Oligo-mannurarate (GV-971) in 36-week treatment of mild to moderate Alzheimer's disease.
- Trial name
- NCT02293915
- Testing
- Sodium oligo-mannurarate 900mg
- Where
- 16 sites in China
- Volunteers
- 818 people
- Sponsor
- Shanghai Greenvalley Pharmaceutical Co., Ltd.
Alzheimer's Disease
Risk Evaluation and Education for Alzheimer's Disease
The purpose of this study is to determine the characteristics of those who obtain genetic susceptibility testing for Alzheimer's disease with APOE disclosure and to study the psychological and behavioral consequences of providing…
- Trial name
- REVEAL I (NCT00571025)
- Testing
- APOE Disclosure
- Where
- 3 sites in United States
- Volunteers
- 301 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Cognitive Decline, Mild Cognitive Impairment
The Effects of Chicken Extract and a Peptide Supplement for the Prevention of Cognitive Decline in Non-demented Elderly Adults
This trial investigates the effect of a chicken extract supplement and a peptide supplement on cognitive function and potential mechanisms of action of cognitive decline during ageing, among non-demented elderly adults using a…
- Conditions
- Cognitive Decline, Mild Cognitive Impairment, Aging
- Trial name
- NCT04555655
- Testing
- Chicken extract supplement, Peptide Supplement
- Where
- 3 sites in Taiwan
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Brand's Suntory Asia
Mild Cognitive Impairment (MCI), Sarcopenia
Project Gnosis: the Neurophysical and Psychosocial Health Outcomes of Tai Chi for Older Adults with Cognitive Concerns or Mild Cognitive Impairment
Mild Cognitive Impairment (MCI) in older adults is linked to muscle loss (sarcopenia) and can lead to dementia, with pain further impacting cognitive and physical performance.
- Trial name
- NCT06828926
- Testing
- Tai Chi
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ohio University
Alzheimer Disease, Cognitive Impairment, Mild
Comparing Smartphone Technology and a Memory Strategy on Improving Prospective Memory in Alzheimer's Disease
Alzheimer's disease is a debilitating condition for patients and their caregivers marked by hallmark cognitive symptoms (e.g., memory loss) as well as an impact on quality of life.
- Conditions
- Alzheimer Disease, Cognitive Impairment, Mild, Dementia, Mild
- Trial name
- NCT03384043
- Testing
- Smartphone Personal Assistant, Implementation Intention
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Baylor University
Dementia Alzheimers
Feasibility Study of Game Technology in the Early Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease
This study will test G:DATA, a simple computer game designed to diagnose Alzheimer's Disease, in three different groups of people, some of whom have Alzheimer's Disease.
- Trial name
- G:DATA (NCT06047340)
- Testing
- G:DATA, dementia screen videogame
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ascentys Ltd
Subjective Memory Loss in Older Persons
Study of the Effects of Cerefolin NAC on Inflammation Blood Markers in Older Individuals With Memory Complaints
The purpose of this six-month research study is to determine if Cerefolin NAC reduces levels of substances in the blood that may be associated with thinking ability and the health of brain cells in subjects with memory concerns…
- Trial name
- NCT00597376
- Testing
- Cerefolin NAC (a medical food)
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Rush University Medical Center
Mild Cognitive Impairment
Mindfulness Based Stress Reduction for Adults With Mild Cognitive Impairment
The investigators are investigating the benefits of a mind/body intervention, Mindfulness Based Stress Reduction, for adults with Mild Cognitive Impairment.
- Trial name
- NCT01605448
- Testing
- Mindfulness Based Stress Reduction (MBSR)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Beth Israel Deaconess Medical Center
Mild Cognitive Impairment, So Stated, Mild Dementia
Cognitive/Physical Computer-Game Blended Training of Elderly: Neuroscientific LLM Studies
The study involved Information and Communication Technologies (ICT) and more specifically computer exercises blended with game activities.
- Conditions
- Mild Cognitive Impairment, So Stated, Mild Dementia, Healthy
- Trial name
- LLM-AUTH (NCT02313935)
- Testing
- LLM, FFA, Brain Fitness
- Volunteers
- 581 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Mild Cognitive Impairment (MCI)
AI-Supported Cognitive Rehabilitation for Older Adults With Mild Cognitive Impairment
Mild cognitive impairment (MCI) is associated with increased risk of progression to dementia, highlighting the need for accessible interventions to support cognitive health.
- Trial name
- ReMind-AI (NCT07474038)
- Testing
- AI-Supported Cognitive Rehabilitation
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Kaiser Permanente
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