Clinical trials: Cognitive Flexibility
Cognition Improvement
Tinkering to Flex Ur Brain (Tinker-FUN): A Cognitive Flexibility Pilot Program for Community Dwelling Older Adults
The Tinker-FUN program is a cognitive flexibility intervention designed to help older adults adapt to aging and live independently.
- Trial name
- NCT07128498
- Testing
- Tinker-Fun
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Florida
Emotional Processing
Losartan and Emotional Learning
This study explores the effects of single-dose losartan (50mg) versus placebo on emotional processing in healthy volunteers.
- Trial name
- NCT06628154
- Testing
- Losartan potassium 50mg
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Cognitive Flexibility, Emotional Regulation
The STRENGTHEN Study
This study uses two different types of interventions including electrical brain stimulation delivered during sleep, and brief, daily meditation training.
- Trial name
- NCT06267521
- Testing
- Healthy Minds Program, Stimulation in Lab, MRI Scanner
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cognitive Performance in Major Depression
Cognitive Flexibility in Major Depression in the Course of Pharmacological and Psychotherapeutic Treatment
Cognitive deficits in major depression seem explicable by the well-recognized concept of impaired neuroplasticity in mood disorders.
- Trial name
- Decoflex (NCT00993876)
- Testing
- citalopram, reboxetine, interpersonal psychotherapy
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Zentrum für Integrative Psychiatrie
Health Behavior
ACTyourCHANGE Study Protocol. Promoting Healthy Lifestyle With ACT for Obesity
Background: as treatment of choice in promoting psychological flexibility, Acceptance and Commitment Therapy (ACT) was found to be effective in several conditions, and among different populations, including weight management in…
- Trial name
- ACTyourCHANGE (NCT04474509)
- Testing
- FACT Module Engagement, FACT Module Openness, FACT Module Awareness
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Istituto Auxologico Italiano
Dementia, Memory, Short-Term
Evaluation of the Effect of Memory-based Reminiscence Therapy
The main objective of this study is to examine the effects of memory-based recall therapy applied to elderly adults diagnosed with Stage 0, 1, and 2 dementia on their mental state, psychological flexibility, and cognitive…
- Trial name
- NCT07073443
- Testing
- Experimental: Memory Therapy Group
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Kahramanmaraş İstiklal University
Alcohol Use Disorder Cognitive Decline
NEUROPSYCHOLOGICAL REHABILITATION FOR ALCOHOL USE DISORDERS
This investigation will take place between September 2024 and June 2025, with the objective of analyzing executive deficits and the impact of Neuropsychological Rehabilitation on Alcohol Use Disorder, comparing different…
- Trial name
- AUD (NCT06933186)
- Testing
- Neuropsychological rehabilitation, Weekly therapeutic groups
- Where
- Portugal
- Volunteers
- 48 people
- Sponsor
- University of Lisbon
Spastic Diplegic Cerebral Palsy
Effects of Transcranial Direct Current Stimulation Combined With Virtual Reality on Balance and Executive Functions in Children With Spastic Diplegic Cerebral Palsy
Children with spastic diplegic cerebral palsy commonly experience difficulties with balance and may also have challenges involving attention, working memory, cognitive flexibility, and inhibitory control.
- Trial name
- NCT07829770
- Testing
- Active Transcranial Direct Current Stimulation, Virtual Reality Rehabilitation, Conventional Physical Therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Pain, Postoperative
Flexibility of Cognition And Persistent Pain
This observational study aims to determine the association between preoperative cognitive flexibility and the risk of developing PPSP by preoperative administration of cognitive tests.
- Trial name
- FlexCAPP (NCT02579538)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Eating Disorders, Hypoestrogenemia
The Role of Estrogen in the Neurobiology of Eating Disorders
This is a randomized, double blind, placebo-controlled study of the effects of transdermal estradiol versus placebo on cognitive flexibility, reward processing, and eating disorder pathology in hypoestrogenemic female adolescents…
- Trial name
- NCT03740204
- Testing
- 17-β estradiol transdermal patches with cyclic progesterone
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Emotional Distress
The Role of Cognitive Flexibility in Mindfulness Intervention: a Functional Near-infrared Spectroscopy Study
This study hopes to: explore the relationship between mindfulness mediation experiences and emotional distress and cognitive flexibility levels.
- Trial name
- NCT06103149
- Testing
- Mindfulness Intervention for Emotional Distress(MIED)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xinghua Liu
Executive Function
Comparison Between Plyometrics and Calisthenics on Executive Function in School Going Children
The goal of this clinical trial is to compare the effects of calisthenics and plyometric exercises on executive functions in school-going children.
- Trial name
- NCT06770192
- Testing
- Calisthenics, Plyometric, Control
- Where
- Pakistan
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Chronic Pain, Nociplastic Pain
Internet-Delivered Psychological Treatments for Chronic Pain in Adolescents: ACT and Pain Education.
One in four children in Sweden experiences chronic pain. For many, the pain is temporary, but for about 5% it significantly affects daily life, leading to sleep problems, school absence, and reduced physical activity.
- Conditions
- Chronic Pain, Nociplastic Pain, Pain Management, Acceptance and Commitment Therapy
- Trial name
- NCT06981312
- Testing
- Acceptance and Commitment Therapy, Pain Science Education
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Region Stockholm
Healthy Aging, Cognitive Benefits
Cardiorespiratory Fitness and Acute High-Intensity Exercise Effects on Brain and Cognitive Function in Older Adults
The goal of this clinical trial is to learn whether a single session of high-intensity interval exercise (HIIT) affects cognitive performance and brain activity in older adults, and whether cardiorespiratory fitness influences…
- Conditions
- Healthy Aging, Cognitive Benefits, Cardio Respiratory Fitness, Brain Activity
- Trial name
- ExBrain (NCT07727577)
- Testing
- High-Intensity Interval Training
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Colby-Sawyer College
Cognitive Training, Subjective Cognitive Decline
Efficacy of Tinkering Activities in Individuals With Subjective Cognitive Decline
Given that preventing and delaying the onset of dementia is a crucial public health policy issues worldwide, it is essential to develop effective interventions and implement early interventions before the onset of dementia.
- Trial name
- NCT06110858
- Testing
- Tinkering Activities
- Where
- 2 sites in Taiwan
- Volunteers
- 12 people
- Sponsor
- National Taiwan University Hospital
Anorexia Nervosa, Parkinson Disease
Exploring Emotional Intelligence and Cognitive Flexibility in Anorexia Nervosa and Parkinson's Disease.
The main aim of this study is to demonstrate how disorders characterized by different types of "inflexibility", cognitive-affective type for Anorexia nervosa and motor one for Parkinson's disease, have an impact on how emotional…
- Trial name
- INTELLEGO (NCT06323564)
- Testing
- Neuropsychological tests in PD, Self-report questionnaires in PD, International Affective Picture System (IAPS)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituto Auxologico Italiano
Primary Dysmenorrhea
Exercise, Motor Imagery, and Pain Neuroscience Education for Primary Dysmenorrhea
The goal of this clinical trial is to find out whether exercise, motor imagery training, and pain neuroscience education can help reduce menstrual pain and improve well-being in young women with primary dysmenorrhea.
- Trial name
- NCT07196150
- Testing
- Exercise Program, Exercise plus Motor Imagery Training, Exercise plus Pain Neuroscience Education
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people
- Sponsor
- Muge Dereli
Healthy
Investigating Cognitive Flexibility Training
The investigators' previous research identified two distinct subtypes of Cognitive Flexibility (CF), termed CF1 (shifting flexibility) and CF2 (strategy flexibility).
- Trial name
- NCT07556250
- Testing
- Experimental (Implicit Training): Structure Learning Training, Active Control (Explicit Training): 'All You Can E.T.'
- Where
- Singapore
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Cognitive Flexibility, Rumination
The Effect of Cognitive Behavioral Therapy (CBT)-Based Psychoeducation on Cognitive Flexibility and Rumination in the Elderly
This study aimed to investigate the effect of psychoeducation on rumination and cognitive flexibility in elderly individuals residing in nursing homes.
- Conditions
- Cognitive Flexibility, Rumination, Elderly (People Aged 65 or More), Psychoeducation
- Trial name
- NCT07139197
- Testing
- Cognitive Behavioral Approach-Based Psychoeducation Program
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Ataturk University
Chronic Cancer-related Pain
An N-of-1 Trial of an Internet-delivered CBT Program Based on the Psychological Flexibility Model of Chronic Pain for Cancer-related Difficulties
Chronic pain is a commonly occurring complication of cancer and can have negatively impact day-to-day functioning and well-being. The recommended treatment for all forms of chronic pain is cognitive behavioral therapy (CBT).
- Trial name
- NCT06749964
- Testing
- Internet-delivered, therapist-assisted, pain-focused CBT based on the psychological flexibility model for chronic pain
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Lund University