Clinical trials: Cognitive Fatigue
Chronic Myelogenous Leukemia
Cognitive Behavioral Intervention for Targeted Therapy Fatigue (CBT-TTF) Intervention
The purpose of this study is to evaluate Cognitive Behavioral Intervention for Targeted Therapy Fatigue (CBT-TTF) with fatigued chronic myelogenous leukemia (CML) patients on tyrosine kinase inhibitors (TKIs) for feasibility…
- Trial name
- NCT02592447
- Testing
- Therapy for Targeted Therapy-related Fatigue (TTF), Wait-List Control Condition (WLC)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Brain Tumor
Effects of Methylphenidate Versus Sustained Release Methylphenidate on Cognitive Functioning
Primary Objective: To assess the efficacy of immediate release methylphenidate, sustained release methylphenidate, and the novel vigilance enhancing drug modafinil for the improvement of cognitive functioning in patients with…
- Trial name
- NCT00418691
- Testing
- IR Methylphenidate, Modafinil, SR Methylphenidate
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- M.D. Anderson Cancer Center
Multiple Sclerosis
Feasibility of Remote Exercise Training for Hispanics/Latinos With MS
The goal of this clinical trial is to investigate the potential benefits of a specially designed exercise program for Hispanics/Latinos with multiple sclerosis (MS).
- Trial name
- FERLAMS (NCT05998616)
- Testing
- Exercise Training Program, Flexibility Program
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Illinois Chicago
Brain Tumors, Metastatic Disease
Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors
RATIONALE: Donepezil may help lessen confusion and fatigue and improve mood and quality of life in patients who have undergone radiation therapy for brain tumors.
- Trial name
- NCT00369785
- Testing
- donepezil hydrochloride
- Where
- 16 sites in United States
- Volunteers
- 198 people
- Sponsor
- Wake Forest University Health Sciences
Traumatic Brain Injury, Fatigue
Treatment of Post-Traumatic Brain Injury (Post-TBI) Fatigue With Light Therapy
This study aims to evaluate the efficacy of 4 weeks of daily light exposure in reducing Post-Traumatic Brain Injury (TBI) Fatigue immediately post-treatment and at a one-month follow up.
- Trial name
- NCT01725750
- Testing
- Bright White Light (BWL), Dim Red Light (DRL)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Attention, Memory
Polyunsaturated Fatty Acids (PUFA) Status and Cognitive Function in Healthy Young Adults
To date, the relationship between omega-3 polyunsaturated fatty acids (n-3 PUFAs) in cognitively intact individuals has only been examined in a limited number of studies; it is at present unknown whether supplementation with n-3…
- Conditions
- Attention, Memory, Mood, Mental Fatigue
- Trial name
- NCT01075958
- Where
- United Kingdom
- Volunteers
- 283 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Multiple Sclerosis
Impact of Armodafinil on Neurocognition and Cognitive Fatigue in Multiple Sclerosis (MS)
The investigation will involve a double-blind, placebo controlled, cross-over study examining the efficacy of armodafinil in improving neurocognitive functioning and reducing cognitive fatigue in MS.
- Trial name
- NCT00981084
- Testing
- armodafinil
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Missouri, Kansas City
Multiple Sclerosis
Efficacy and Safety of 4-aminopyridine on Cognitive Performance and Motor Function of Patients With Multiple Sclerosis
Twenty four relapsing-remitting multiple sclerosis (RRMS) patients over the age of 18, with similar degree of disability, and with an evolution of at last 6 months, who are in first-line immunomodulatory therapy and have a stable…
- Trial name
- NCT02280096
- Testing
- 4-aminopyridine
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Multiple Sclerosis
Cognition and HRQoL in Adults With Highly-active RMS in Year 3 and 4 After Initial Mavenclad® Dose (CLARIFY MS Extension)
The purpose of the study was the evaluation of the effect of a treatment for highly-active relapsing multiple sclerosis (RMS). This was the extension study to CLARIFY MS (NCT03369665), to assess cognitive impairment and health…
- Trial name
- NCT04776213
- Testing
- Mavenclad®
- Where
- 60 sites in Austria, Czechia and 8 more
- Volunteers
- 280 people
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Insomnia, Sleep Initiation and Maintenance Disorders
Modafinil Treatment for Sleep/Wake Disturbances in Older Adults
Modafinil, trade named Provigil, is a medication approved by the Food and Drug Administration for the treatment of narcolepsy, obstructive sleep apnea/hypopnea syndrome, and shift work sleep disorder.
- Conditions
- Insomnia, Sleep Initiation and Maintenance Disorders, Alzheimer Disease
- Trial name
- NCT00626210
- Testing
- modafinil
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- VA Palo Alto Health Care System
Fibromyalgia
Repetitive Transcranial Magnetic Stimulation (rTMS) in Fibromyalgia
This study aims to evaluate the effectiveness of 10 Hz neuronavigated repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (DLPFC) on pain, stiffness, fatigue, depression/anxiety, quality…
- Trial name
- NCT03909009
- Testing
- rTMS + Neuronavigation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Izmir Katip Celebi University
Inflammation, Fatigue
Effects of Riluzole on CNS Glutamate and Fatigue in Breast Cancer Survivors With High Inflammation
The goal of the proposed research is to determine whether riluzole, a drug that increases glutamate reuptake, will decrease central nervous system (CNS) glutamate in breast cancer survivors with increased inflammation and…
- Trial name
- NCT02796755
- Testing
- Riluzole
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Insomnia, Fatigue
Cognitive Behavioral Therapy +/- Armodafinil for Insomnia and Fatigue Following Chemotherapy
This is a four-arm, randomized, controlled, clinical trial examining the efficacy of of cognitive behavioral therapy (CBT)-I and armodafinil in reducing insomnia in 226 female breast cancer patients who report sleep disturbances…
- Conditions
- Insomnia, Fatigue, Breast Cancer
- Trial name
- NCT01091974
- Testing
- armodafinil, CBT-I
- Where
- 2 sites in United States
- Volunteers
- 138 people
- Sponsor
- University of Rochester
Breast Cancer, Cognitive Dysfunction
Reducing Breast Cancer-related Fatigue and Improving Cognition With Non-Invasive Brain Stimulation
This study will test the preliminary efficacy of transcranial direct current stimulation (tDCS) to improve fatigue and cognition in women with a history of breast cancer and persistent fatigue.
- Conditions
- Breast Cancer, Cognitive Dysfunction, Fatigue
- Trial name
- NCT03143894
- Testing
- tDCS
- Where
- 3 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Multiple Sclerosis
Cognitive Behavioral Therapy, Modafinil, or Both for Multiple Sclerosis Fatigue
This clinical trial will compare the effectiveness of 3 treatments for fatigue in Multiple Sclerosis: 1) a commonly used behavioral treatment strategy (telephone-based cognitive behavioral therapy), 2) a commonly used medication…
- Trial name
- COMBO-MS (NCT03621761)
- Testing
- Telephone-based Cognitive Behavioral Therapy, Modafinil
- Where
- 2 sites in United States
- Volunteers
- 343 people
- Sponsor
- University of Michigan
Gulf War Illness
Cognitive Rehabilitation for Gulf War Illness
There are almost 700,000 Gulf War Veterans (GWV) with 25-30% suffering from a devastating multi-symptom illness coined Gulf War Illness (GWI).
- Trial name
- NCT02161133
- Testing
- Problem-Solving Therapy, Health Education
- Where
- 3 sites in United States
- Volunteers
- 268 people
- Sponsor
- VA Office of Research and Development
Brain Fog
Transcranial Direct Current Stimulation (tDCS)
Cognitive impairment refers to when an individual struggles to learn, concentrate, remember, or make decisions. This can be due to underlying neurological diseases (i.e.
- Trial name
- tDCS (NCT05524233)
- Testing
- Active Transcranial Direct Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor College of Medicine
Malignant Glioma
Nuvigil or Placebo in Newly Diagnosed Malignant Glioma
The purpose of this study is to determine if Nuvigil® improves fatigue experienced by people receiving external beam radiation therapy for the treatment of malignant gliomas.
- Trial name
- NCT01400958
- Testing
- Nuvigil®
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute