Clinical trials: Cognitive Enhancement
Addiction
Cognitive Enhancement as a Target for Cocaine Pharmacotherapy
Specific Aim #1: To determine if galantamine (8 or 16 mg/day) is more effective than placebo in reducing cocaine use as measured by cocaine urine results and self-report days of use.
- Trial name
- NCT01531153
- Testing
- Galantamine
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Yale University
Cocaine Dependence
Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse
We are testing to see if Galantamine, a learning enhancing medication, will help methadone maintained cocaine abusers with their learning and memory specific to CBT using an innovative CBT computer program.
- Trial name
- NCT00809835
- Testing
- Galantamine, Computer Assisted Cognitive Behavioral Therapy (CBT)
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Yale University
Traumatic Brain Injury
Memantine for Neuroprotection and Cognitive Enhancement Following Traumatic Brain Injury
The purpose of this study is to determine if memantine can improve cognitive and neuropsychiatric outcomes after severe traumatic brain injury.
- Trial name
- NCT02240589
- Testing
- Memantine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Indiana University
Healthy, Young Adults
Remote Limb Ischemic Conditioning to Enhance Learning and Muscle Strength in Healthy Young Adults
The purpose of this research study is to determine if remote limb ischemic conditioning (RLIC) can enhance learning of a motor (balance) and an ecologically valid, complex cognitive-motor (driving) task, and increase skeletal…
- Trial name
- NCT03512028
- Testing
- RLIC, Muscle strength training, Driving training
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Multimorbidity, Cognitive Impairments
Video-Enhanced Care Management for Medically Complex Veterans
The purpose of this study is to examine the feasibility and acceptability of a 12-week care management program for medically complex Veterans with cognitive impairment, delivered via telephone or videoconferencing.
- Trial name
- NCT02962687
- Testing
- Care management via videoconference, Care management via telephone calls
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Autism, Autism Spectrum Disorder
Services to Enhance Social Functioning in Adults With Autism Spectrum Disorders
The purpose of this study is to test a novel, three-part cognitive behavioral treatment strategy to improve social functioning in adults with autism spectrum disorder.
- Conditions
- Autism, Autism Spectrum Disorder, Autistic Disorder, Asperger Syndrome
- Trial name
- NCT04788537
- Testing
- Training to Understand and Navigate Emotions and Interactions (TUNE In)
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Brain Concussion, Blast Injuries
Metacognitive Training to Enhance Strategy Use in Blast-Related TBI
Enhanced Goal Management Training (GMT) is a 10-week group or individual therapy that teaches strategies to improve an individual's ability to complete everyday tasks.
- Trial name
- NCT00857207
- Testing
- Goal Management Training
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- VA Office of Research and Development
Brain Injury
Training in Goal-directed Attention Regulation for Individuals With Brain Injury
Brain injuries affect the lives of numerous Veterans. This study examines how the brain is affected by injury and how rehabilitation training for attention dysfunction may change brain functioning.
- Trial name
- NCT01035606
- Testing
- training in goal-directed attention regulation, brain health education, computer-assisted training in goal-directed attention regulation
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- VA Office of Research and Development
Down Syndrome, Mild Cognitive Impairment
Nicotine Treatment of Cognitive Decline in Down Syndrome
This study will ascertain whether nicotine is safe and tolerable in DS patients, help with dose-ranging of nicotine in DS, look for evidence of enhancements in cognitive functioning, and establish evidence for biological and…
- Trial name
- NCT01778946
- Testing
- Low Dose Nicotine (7mg), Moderate Dose Nicotine (14mg)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Vanderbilt University Medical Center
Social Anxiety Disorder
Effect of D-cycloserine Plus Cognitive Behavioral Therapy on People With Social Phobia
This study will assess the effectiveness of D-cycloserine combined with cognitive-behavior therapy in treating people with social anxiety disorder.
- Trial name
- NCT00515879
- Testing
- D-cycloserine, Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Boston University Charles River Campus
Cocaine Addiction
Cognitive Enhancement and Relapse Prevention in Cocaine Addiction
For this project, the investigators are interested in exploring a new way to extend and maintain drug abstinence in people who are addicted to crack cocaine.
- Trial name
- NCT01067846
- Testing
- Seromycin (D-cycloserine, DCS), Computerized Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of Arkansas
Bipolar Disorder
Cognitive Enhancement in Bipolar Disorder
The purpose of this study is to examine whether the medication pramipexole (Mirapex) may be able to improve cognitive problems (i.e.
- Trial name
- NCT00597896
- Testing
- pramipexole
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Panic Disorder
Exposure, D-Cycloserine Enhancement, and Genetic Modulators in Panic Disorder
This is a 5-year double blind, randomized, controlled, trial conducted at three treatment sites, aimed at showing the acute and longer-term effects of DCS augmentation of exposure-based CBT for panic disorder relative to placebo…
- Trial name
- DCSPanic (NCT00790868)
- Testing
- d-cycloserine
- Where
- 4 sites in United States
- Volunteers
- 180 people
- Sponsor
- Boston University Charles River Campus
Alzheimer Disease, Dementia
Movement Intervention for Memory Enhancement
Dancing is a complex sensorimotor rhythmic activity that integrates cognitive, physical, and social components and is applicable to seniors with various fitness levels.
- Conditions
- Alzheimer Disease, Dementia, Cognitive Decline, Cognitive Impairment
- Trial name
- MIME (NCT03475316)
- Testing
- Social Dancing, Treadmill Walking
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Suicide, Suicidal Ideation
Brief Interventions for Short-Term Suicide Risk Reduction in Military Populations
The purpose of the proposed study is to identify the most effective brief interventions for reducing short-term risk for suicide attempts in "real world" military triage settings, and to identify potential mechanisms of change…
- Trial name
- BISSR (NCT02042131)
- Testing
- Treatment As Usual (TAU), Standard Crisis Response Plan (S-CRP), Enhanced Crisis Response Plan (E-CRP)
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- University of Utah
Traumatic Brain Injury, Depression
Feasibility Study of Duloxetine in the Treatment of Depression in Patients With Traumatic Brain Injury
The primary objective of the study is to compare the efficacy of duloxetine 60 mg by mouth daily with placebo in the prevention of depression associated with mild/moderate traumatic brain injury and to enhance cognitive function.
- Trial name
- Duloxetine (NCT01223001)
- Testing
- Duloxetine, Sugar pill
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rehabilitation Hospital of Indiana
Phobic Disorders
D-Cycloserine to Enhance Cognitive Behavioral Therapy (CBT) for Acrophobia
The purpose of this study is to investigate the utility of post-session administration of D-cycloserine to enhance fear extinction in a sample of people with acrophobia who will be treated with CBT.
- Trial name
- NCT01102803
- Testing
- Individual Cognitive Behavioral Therapy (CBT), D-Cycloserine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Southern Methodist University
Healthy Participants, Mild Cognitive Impairment
Cognitive Enhancement Through Transcranial Laser Therapy
This is a mechanism-driven translational project to test the efficacy of transcranial low-level light/laser therapy (LLLT), for enhancing cognitive function in middle-aged and older adults and participants with Mild Cognitive…
- Trial name
- LLLT (NCT02851173)
- Testing
- LLLT
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Schizophrenia, Schizoaffective Disorder
Effect of MMFS-202-302 on Cognitive Enhancement in Schizophrenia
The goals of this study are to study MMFS-202-302 in a double blind, randomized, placebo-controlled 9-week study of its effect on ameliorating cognitive deficits in 60 patients with schizophrenia or schizoaffective disorder with…
- Trial name
- NCT02237235
- Testing
- MMFS-202-302
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwestern University
Multiple Sclerosis, Encephalitis
tDCS and Cognition in Adults With Multiple Sclerosis or Encephalitis
This research is being done to determine whether transcranial direct current stimulation (tDCS) can improve certain mental abilities in individuals with multiple sclerosis (MS) or encephalitis.
- Trial name
- NCT02538094
- Testing
- Anodal Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Johns Hopkins University