Clinical trials: Cognitive Enhancement
Neuropathic Pain
Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot Trial
The purpose of the study is to investigate new therapies to alleviate pain on neuropathic chronic pain. At this time, the main purpose is to complete a feasibility or pilot study with 30 participants suffering from neuropathic…
- Trial name
- PSYKED-NP (NCT05639322)
- Testing
- Ketamine Hydrochloride, Cognitive Behavioral Therapy, Ketamine + Cognitive Behavioral Therapy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Multiple Sclerosis, Relapsing-Remitting
tDCS to Enhance Cognitive Training in Multiple Sclerosis
Expected results: an improvement in cognitive performance in both groups, boosted in the experimental arm and not confined to general frontal-cognitive abilities; potential changes would be reflected also by neurophysiological…
- Trial name
- REHACOG-MS (NCT04261556)
- Testing
- Real tDCS + CCT
- Where
- Italy
- Sponsor
- University of Milano Bicocca
Severe Acute Malnutrition, Cognitive Impairment
Choline to Improve Malnutrition and Enhance Cognition
The goal of this clinical trial is to test adding choline to ready-to-use therapeutic food (RUTF) in children with severe acute malnutrition (SAM) in Malawi.
- Conditions
- Severe Acute Malnutrition, Cognitive Impairment, Wasting, Kwashiorkor
- Trial name
- CHIME-SAM (NCT06154174)
- Testing
- C-RUTF (Ready-to-Use Therapeutic Food with added choline), S-RUTF (Ready-to-Use Therapeutic Food without added choline), Amoxicillin
- Where
- 10 sites in Malawi
- Volunteers
- 1,500 people
- Sponsor
- Washington University School of Medicine
Schizophrenia
TMS for Inhibition Enhancement in Schizophrenia
This study purpose is to perform a pilot mechanistic trial repetitive transcranial magnetic stimulation (rTMS) clinical trial in 34 people with schizophrenia (Sz).
- Trial name
- TIES (NCT06155682)
- Testing
- repetitive transcranial magnetic stimulation (active)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Maryland, Baltimore
Psychiatric Illness, Healthy
Effects of GLYX-13 on Learning and Memory in Healthy Individuals and Those With Psychiatric Illness
The present study proposes to evaluate the potential cognitive enhancing effects of GLYX-13, an NMDAR partial agonist, among a group of healthy adults and those with psychiatric illness on a series of functional magnetic…
- Trial name
- NCT01844726
- Testing
- GLYX-13
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Parkinson Disease, Mild Cognitive Impairment
Auditory Slow Wave Enhancement in Parkinson Disease and Mild Cognitive Impairment
The study aims to assess the efficacy of auditory slow-wave sleep (SWS) enhancement in PD patients and patients with amnestic MCI.
- Trial name
- PDMCI-TS (NCT04736017)
- Testing
- TSB Axo
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- University of Zurich
Mild Cognitive Impairment
Efficacy of Ubiquitous SR-based Memory Advancement and Rehabilitation Training (U-SMART)
The purpose of this study is to examine the efficacy of the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (U-SMART) in the elderly individuals with mild cognitive impairment (MCI) by an…
- Trial name
- U-SMART (NCT01688128)
- Testing
- Phase I U-SMART (4 wks), Washout (2 wks), Phase II U-SMART (4 wks)
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Bundang Hospital
Healthy Volunteer, HV
High-Density Direct Current Brain Polarization
Background: Direct current (DC) brain polarization is a technique in which very weak electricity is applied to the head. Doctors have used DC polarization for many years on patients and healthy people with no known serious side…
- Trial name
- NCT00944931
- Testing
- DC Brain Polarization
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Aging, Physical Activity
NEUROmuscular Training for Enhanced AGE Longevity
In recent years the research group on Prevention and Health in Exercise and Sport (PHES) has carried out numerous studies that have provided current and convincing evidence of the benefits of physical activity and exercise for…
- Conditions
- Aging, Physical Activity, Training
- Trial name
- NEUROAGE (NCT06620666)
- Testing
- Water-based power resistance training + Dietary supplement I (WPowDSI), Elastic band-based power resistance training + Dietary supplement I (EBPowDSI), Elastic band-based eccentric resistance training + Dietary supplement II (EBEccDSII)
- Where
- Spain
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Bipolar I Disorder
L-Carnosine for Bipolar I Disorder
Our hypothesis is that oral L-carnosine treatment (as compared with placebo) will enhance cognitive abilities (specifically: measures of attention, executive function, working memory, visuospatial ability and language) in persons…
- Trial name
- NCT00177463
- Testing
- L-carnosine
- Where
- 3 sites in United States
- Volunteers
- 47 people
- Sponsor
- University of Pittsburgh
Frontotemporal Dementia
Gamma-Induction in FrontoTemporal Dementia Trial
This is an interventional, sham controlled, double-blind study designed to investigate the safety, tolerability and efficacy of 40 Hz transcranial alternating current stimulation (tACS), a form of noninvasive brain stimulation…
- Trial name
- GIFTeD (NCT04425148)
- Testing
- Transcranial Alternating Current Stimulation (tACS)
- Where
- 2 sites in United States, Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Anesthesia, Hip Fractures
Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial)
The ANDES Platform Trial is a pragmatic, multicenter, adaptive randomized controlled platform trial in patients aged 65 years or older undergoing surgery for hip fracture.
- Conditions
- Anesthesia, Hip Fractures, Dementia, Cognitive Impairment
- Trial name
- ANDES platform (NCT06452147)
- Testing
- Nerve block, Standard anesthesia care, Bupivacaine liposome
- Where
- 13 sites in China
- Volunteers
- 1,860 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Binge Eating, Binge-Eating Disorder
Identifying Effective Technological-based Augmentations to Enhance Outcomes From Self-help Cognitive Behavior Therapy for Binge Eating
The purpose of this study is to test the feasibility, acceptability and efficacy of two technology-based intervention systems (including an Advanced Digital Data Sharing (ADDS) with Coaches or a smartphone-based just-in-time…
- Conditions
- Binge Eating, Binge-Eating Disorder, Bulimia Nervosa, Bulimia
- Trial name
- CONQUER (NCT05937243)
- Testing
- Base self-help CBT program, Just-in-time, adaptive intervention (JITAIs) system, Advanced Digital Data Sharing (ADDS) with Coaches
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Drexel University
Type 1 Diabetes
Effects of Acute Intake of Caffeinated Beverages in Type 1 Diabetes
The aim of this pilot study is to determine the impact of caffeine-enhanced energy drinks on blood glucose excursion on heart rate, blood pressure, cardiac output and cognitive performance in patients with type 1 diabetes.
- Trial name
- REDBULL (NCT01805700)
- Testing
- Caffeine enhanced energy drink, Glucose drink
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- The Royal Bournemouth Hospital
Cognitive Enhancement
Effect of a Plant Based Nootropic on Perceptual Decision Making.
Nootropics are a group of medicinal substances purported to improve important cognitive functions such as learning, focus and memory.
- Trial name
- NCT06689644
- Testing
- Nootropics (ginkgo biloba, nicergoline, piracetam, or others), Perceptual decision-making performance, Electroencephalography
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Pregnancy
Prenatal Music Exposure to Enhance Postnatal Language Development
The goal of this randomized controlled study is to evaluate the effect of prenatal music exposure on infants through two years of age.
- Trial name
- NCT07699536
- Testing
- High dose music Exposure, Education, Low dose music exposure
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Mild Cognitive Impairment
Transcranial Direct Current Stimulation to Enhance Cognition in Mild Cognitive Impairment
The study will examine whether the effects of computerized brain training are enhanced when training is combined with mild brain stimulation in patients with mild cognitive impairment.
- Trial name
- NCT01653431
- Testing
- Transcranial direct current stimulation
- Where
- Australia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- The University of New South Wales