Clinical trials: Cognitive Dysfunction, open to volunteers
Childhood Brain Tumor
Cognitive Biomarkers in Pediatric Brain Tumor Patients
The investigators will focus on three cohorts of brain tumor patients aged, 4-18 years, to answer two critical questions: 1) Can the investigators acquire high quality data relevant to cognitive function during the…
- Trial name
- NCT02914067
- Testing
- Neurocognitive testing, rsfcMRI
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Washington University School of Medicine
Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischemic Disease
Testing of a System for Remote Ischemic Conditioning in Cerebral Small Vessel Disease and Pre-hospital Stroke Care
This early phase trial will address the following key objectives: 1. Completion of initial safety and tolerability testing of our viable prototype for remote ischemic conditioning (RIC) with patients with (a) CSVD and (b) acute…
- Conditions
- Cerebral Small Vessel Diseases, Cerebral Small Vessel Ischemic Disease, Ischemic Stroke, Vascular Cognitive Impairment
- Trial name
- TRIC-SVD (NCT05967728)
- Testing
- Remote ischemic conditioning (RIC) progammable device
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary
Cancer-related Cognitive Dysfunction, Primary Brain Neoplasm
Virtual Home-based Exercise Intervention (RISE) to Improve Cancer-Related Cognitive Impairment and Gut Microbiome in Adolescent and Young Adult Brain Tumor Survivors
This clinical trial evaluates the impact of a research intervention of virtually supervised exercise program (RISE) on cancer-related cognitive impairment (CRCI), physical activity in adolescent and young adult (AYA) brain tumor…
- Trial name
- NCT06799481
- Testing
- Aerobic Exercise, Behavioral Intervention, Follow-Up
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Emory University
Depressive Symptoms, Quality of Life
Non-pharmacological Care for Depression in Cancer Patients Using VR and TMS
Despite its significant impact on individuals and healthcare systems, substantial gaps remain in the clinical and rehabilitative management of depression in oncology patients.
- Conditions
- Depressive Symptoms, Quality of Life, Cognitive Impairment
- Trial name
- INCEPT (NCT06589544)
- Testing
- Virtual Reality-based Cognitive Remediation (VR-COG) + Treatment as Usual (TAU), Repetitive transcranial magnetic stimulation (rTMS) + Treatment as usual (TAU), Treatment as Usual (TAU)
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- University Hospital of Ferrara
Postoperative Cognitive Dysfunction
Timing of Transcutaneous Acupoint Electrical Stimulation on Postoperative Recovery in Geriatric Patients with Gastrointestinal Tumor
Postoperative cognitive dysfunction(POCD). is a central nervous system complication in cancer patients with a 8.9-46.1% incidence.
- Trial name
- TEAS (NCT05482477)
- Testing
- Transcutaneous acupoint electrical stimulation
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Subei People's Hospital of Jiangsu Province
Multiple Sclerosis, Electric Stimulation
Effectiveness of Personalized Alternating Current Stimulation for Treating Cognitive Impairment in CNS Demyelination Patients
Background: Central nervous system inflammatory demyelinating diseases often lead to significant cognitive impairment, presenting a critical challenge in patient management.
- Trial name
- NCT06968039
- Testing
- Neuroelectrics StarStim 32
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Xuanwu Hospital, Beijing
Breast Cancer Females, Oncology
Effects of a Group Versus Individual Cognitive Training Program on Chemotherapy-induced Cognitive Impairment (Chemobrain) in Breast Cancer Patients Undergoing Active Treatment
Introduction: The significant improvement in breast cancer survival, largely attributable to biomedical and technological progress, makes it increasingly necessary to investigate the secondary effects linked to this pathology.
- Trial name
- NCT07165912
- Testing
- Health Education Program, Individual Cognitive Training Program, Group training program
- Where
- 2 sites in Spain
- Volunteers
- 75 people
- Sponsor
- University of Salamanca
Cancer-related Cognitive Impairment, Cancer-related Cognitive Dysfunction
CanCOG®: Pilot Trial of Cognitive Rehabilitation for Cancer Survivors
Cancer-related cognitive impairment (CRCI) affects a large proportion of non-central nervous system cancer survivors and can negatively impact cognitive functioning and daily life.
- Conditions
- Cancer-related Cognitive Impairment, Cancer-related Cognitive Dysfunction, Cancer-related Cognitive Difficulties, Depression and Anxiety Symptoms
- Trial name
- CanCOG® (NCT07755839)
- Testing
- CanCOG® - Cogntive Rehabilitation in Cancer
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Aveiro University
Stroke, Cognitive Impairment
A Sitting Tai Chi Programme for Chronic Stroke Survivors With Post-stroke Cognitive Impairment
Introduction Stroke remains the third leading cause of death and disability combined. Post-stroke cognitive impairment (PSCI) is a common neurological sequela that may affect up to 80% of stroke survivors.
- Trial name
- NCT07512739
- Testing
- Tai Chi
- Where
- China
- Volunteers
- 176 people
- Sponsor
- Chinese University of Hong Kong
Sexual Interest/Arousal Disorder
Cognitive-Behavioural Couple Therapy for Sexual Interest/Arousal Disorder
Sexual health is a fundamental aspect of quality of life; a satisfying sexual relationship is linked to better physical, psychological, and relationship health and well-being.
- Trial name
- CBCT for SIAD (NCT06777277)
- Testing
- Cognitive-behavioral therapy
- Where
- 3 sites in Canada
- Volunteers
- 170 people
- Sponsor
- Dalhousie University
Cognitive Impairment, Dementia
Investigating Dynamic Interactions in Distributed Cognitive Control Networks
The purpose of this study is to investigate the brain activity associated with cognitive tasks (thinking, reasoning, remembering) in order to understand how the brain works during certain tasks and to improve treatment for…
- Conditions
- Cognitive Impairment, Dementia, ADD, Depression
- Trial name
- NCT05927974
- Testing
- Passive testing, Active testing
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Insomnia, Sleep
Artificial Intelligence (AI)-Assisted Sleep Intervention for Insomnia in Older Adults With Subjective Cognitive Decline
To assess the feasibility and acceptability of Artificial Intelligence (AI)-assisted sleep intervention on improving the insomnia of older adults with subjective cognitive decline.
- Trial name
- NCT07588035
- Testing
- Artificial Intelligence (AI)-assisted sleep intervention, Usual Care
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
Alzheimer Disease
A Study to Evaluate the Safety, Tolerability, and Efficacy of TML-6 in Participants With Early Alzheimer's Disease
The primary purpose of the study is to assess if treatment with TML-6 for 52 weeks will be effective in slowing, stopping, or improving cognitive and functional decline in participants with early Alzheimer's Disease (AD) as…
- Trial name
- NCT07612150
- Testing
- TML-6
- Volunteers
- 210 people
- Sponsor
- Merry Life Biomedical Co., Ltd.
PTSD, Cognitive Performance
Examining the Efficacy of Short-Term Intensive PTSD Treatment on Psychological and Cognitive Impairment Symptoms
Our long-term goal is to provide rapid and sustained reductions of trauma and cognitive-related symptoms among Special Operations personnel with PTSD or subthreshold PTSD.
- Trial name
- NCT07680517
- Testing
- Cognitive Processing Therapy, Eye-Movement Desensitization and Reprocessing
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Ohio State University
Psychological Stress, Anxiety
NeuroFinance Human Stress Trial During Financial and Informational Volatility
The NeuroFinance Human Stress Trial (NFHST-2026-001) is a decentralized observational clinical study designed to evaluate how financial market volatility, economic uncertainty, digital media exposure, and information-driven…
- Conditions
- Psychological Stress, Anxiety, Emotional Stress, Autonomic Nervous System Dysfunction
- Trial name
- NFHST (NCT07622589)
- Testing
- Wearable Physiologic Monitoring Platform
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Mild Cognitive Impairment (MCI)
Validation of Population Characteristics and Dosage Prescriptions for Cognitive Function Intervention Benefits of Different Doses of Tai Chi in Elderly Patients With Mild Cognitive Impairment: A Real-World Cross-Sectional Study
This is a companion real-world external validation study of two pre-registered parent randomized controlled trials (RCTs, protocol IDs: FujianUTCM-1 and FujianUTCM-2).
- Trial name
- NCT07608510
- Testing
- 24-form Simplified Tai Chi (Observational Behavioral Exposure)
- Volunteers
- 150 people
- Sponsor
- Lidian Chen
Neglect, Brain Injured Patients
Tridimensional Robotic Assessment of Neglect in Brain Injured Patients
The goal of this clinical trial is to assess the usability and feasibility of a robotic and virtual reality-based system called NeglectARm 3D for the three-dimensional assessment of unilateral spatial neglect (USN) in patients…
- Conditions
- Neglect, Brain Injured Patients, Stroke, Unilateral Spatial Neglect (USN)
- Trial name
- NEGLECTARM3D (NCT07290218)
- Testing
- Evaluation with a Non-CE-Marked Robotic Device
- Where
- 3 sites in Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Sleep, Mild Cognitive Impairment
Light and Sleep Fragmentation
This trial will examine scheduled exposure to bright light in the morning and afternoon as a countermeasure to sleep fragmentation in older individuals with mild cognitive impairment.
- Conditions
- Sleep, Mild Cognitive Impairment, Mood Disorders
- Trial name
- NCT06009289
- Testing
- Light therapy
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cognitive Dysfunction, Overweight and Obesity
Cognitive Effects of Hesperidin in Overweight/Obese Older Adults
A randomized, double-blind, placebo-controlled trial was designed to test whether two doses of hesperidin (a natural flavonoid from citrus fruits) improve cognitive function in overweight and obese older adults.
- Trial name
- NCT07750223
- Testing
- Hesperidin
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Min Hou
Mild Cognitive Impairment, Dementia
A Behavioural Sleep Intervention for People With Mild Cognitive Impairment and Mild Dementia
This is two arm pilot randomized controlled trial, with the intervention gorup receiving AI-supported behavioral sleep intervention and control group receiving usual care
- Conditions
- Mild Cognitive Impairment, Dementia, Sleep
- Trial name
- NCT07784946
- Testing
- AI-supported behavioral sleep intervention, control group
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The Hong Kong Polytechnic University
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