Clinical trials: Cognitive Dysfunction
Cognitive Deficits, Depression
Attentional Bias Modification Through Eye-tracker Methodology (ABMET)
Cognitive biases are a hallmark of depression but there is scarce research on whether these biases can be directly modified by using specific cognitive training techniques.
- Conditions
- Cognitive Deficits, Depression, Alteration of Cognitive Function
- Trial name
- ABMET (NCT02847793)
- Testing
- Gaze training
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Universidad Complutense de Madrid
Major Depression
Effectiveness of Repetitive Transcranial Magnetic Stimulation in Depressed Patients
The purpose of this study is to evaluate clinical efficacy (affective and cognitive) in patients with moderate depression between TMS over the left Dorsolateral Prefrontal Cortex (DLPFC) with simulated TMS, as well as clinical…
- Trial name
- NCT02213016
- Testing
- Transcranial Magnetic Stimulation
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Universidad Nacional Autonoma de Mexico
Healthy, Mild Cognitive Impairment
Supporting Episodic Memory With Transcranial Direct Current Stimulation in Healthy Controls and Dementia Patients
Previous studies showed that anodal tDCS applied over the dorsolateral prefrontal cortex (DLPFC) improved episodic memory performance, indicating a possible use as an intervention for patients suffering from memory impairments.
- Conditions
- Healthy, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT03227185
- Testing
- real anodal transcranial direct current stimulation (tDCS)
- Where
- Switzerland
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Bern
Mild Cognitive Impairment
Art Therapy and Music Reminiscence Activity in the Prevention of Cognitive Decline
The objective of this study is to determine the impact of Art Therapy and Music Reminiscence Activity on cognition in community living elderly with Mild Cognitive Impairment (DSM V: Mild Neurocognitive Disorder) using a…
- Trial name
- NCT02854085
- Testing
- Art Therapy, Music Reminiscence Activity
- Where
- Singapore
- Volunteers
- 68 people
- Sponsor
- National University of Singapore
Insomnia, Cognitive Impairment
RESET-BRAIN: REhabilitation of SleEp and CogniTive Impairment in BReast Cancer Survivors Using an App-based Intervention
The goal of the study is to investigate whether treating insomnia using app-based cognitive behavioral therapy for insomnia (CBT-I) can improve cognitive impairment in breast cancer survivors compared to an active control group…
- Conditions
- Insomnia, Cognitive Impairment, Breast Cancer
- Trial name
- RESET-BRAIN (NCT06553235)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I), Sleep hygiene education
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Aarhus University Hospital
Chronic Traumatic Encephalopathy, Traumatic Encephalopathy
Tau And Connectomics In TES Study
This pilot study aims to assess if participants that meet the criteria for a TES diagnosis have a specific tau deposition profile on PET scanning using the PET tau binding ligand - [18F] PI-2620.
- Conditions
- Chronic Traumatic Encephalopathy, Traumatic Encephalopathy, Head Injury Trauma, Cognitive Impairment
- Trial name
- TACIT (NCT05490576)
- Testing
- [18F] PI-2620 Tau Ligand
- Where
- Australia
- Volunteers
- 12 people
- Sponsor
- Macquarie University, Australia
Chronic Obstructive Pulmonary Disease COPD
Pulmonary Rehabilitation: Effects on Cognitive Functioning, Mood, Anxiety, and Quality of Life in Patients With COPD
The purpose of this project is to investigate whether a 12-week, fulltime pulmonary rehabilitation program can enhance cognitive functioning, mood, anxiety, and quality of life in patients with Chronic Obstructive Pulmonary…
- Trial name
- NCT01682447
- Testing
- Extensive Pulmonary Rehabilitation Program
- Where
- Netherlands
- Volunteers
- 261 people
- Sponsor
- Tilburg University
Alzheimer Disease (AD)
Daridorexant for Alzheimer Disease Prevention
This study will evaluate whether daridorexant, a DORA sleep medication, can support brain health by promoting the clearance of proteins linked to the development and progression of Alzheimer's disease.
- Trial name
- PAD-DORA (NCT07213349)
- Testing
- Daridorexant 50 mg
- Where
- Canada
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Hemodialysis, Cognitive Impairment
Influencing Factors of Cerebrovascular Disease and Cognition in Hemodialysis Patients
In this observational study, the investigators evaluate the influencing factors of cerebrovascular disease and cognition in hemodialysis patients.
- Conditions
- Hemodialysis, Cognitive Impairment, Cerebrovascular Disorders
- Trial name
- NCT04433455
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Huashan Hospital
Mental Health (Depression), Mental Health and General Well-being
Thrive at Home: A Virtual Reality Social Intervention for Older Adults
The goal of this clinical trial is to evaluate whether a virtual reality (VR) based social platform can improve mental health and social connection for older adults who receive in-home care.
- Conditions
- Mental Health (Depression), Mental Health and General Well-being, Loneliness, Well Being
- Trial name
- Thrive at Home (NCT07835568)
- Testing
- Full Virtual Reality Social Intervention, Abbreviated Virtual Reality Social Intervention
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of California, Santa Barbara
Dementia, Cognitive Impairment
Effect of Circadian Light on Hospitalized Persons With Dementia and Older Adults With Cognitive Impairments.
Light stimulates the human visual system and the biological functions in the retina, also referred to as non-visual responses, e.g. hormone production.
- Trial name
- NCT05535790
- Testing
- Naturalistic LED light, Standard/traditional lighting
- Volunteers
- 80 people
- Sponsor
- Zealand University Hospital
Thoracic Surgery, Cognitive Dysfunction
Cerebral Desaturation and Postoperative Dysfunction After Thoracic Surgery
The purpose of this study prospective observational study is to determine cognitive dysfunction incidence after thoracic surgery.
- Trial name
- NCT03805880
- Testing
- cerebral desaturation monitoring and cognitive examination
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Cognitive Impairment, Hematologic Malignancies
Cognitive Impairment in Older Adults With Hematologic Malignancies
This cross-sectional study aims to determine the prevalence of cognitive impairment and evaluate its relationship with activities of daily living among older adults with hematologic malignancies receiving chemotherapy.
- Conditions
- Cognitive Impairment, Hematologic Malignancies, Chemotherapy Effect
- Trial name
- NCT07842679
- Volunteers
- 120 people
- Sponsor
- Assiut University
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies, Lewy Body Disease
- Trial name
- MARKERS-NDD (NCT06596746)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Casa di Cura San Raffaele Cassino
Cognitive Disorder, Metabolic Disease
Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency
Background: Creatine transporter deficiency (CTD) is a genetic disorder that mainly affects the brain in males. CTD causes intellectual disability that can be mild to severe.
- Conditions
- Cognitive Disorder, Metabolic Disease, Autism Spectrum Disorder
- Trial name
- NCT05600946
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Cognitive Dysfunction, Postoperative, Cognitive Dysfunction
Assessment of Brain Oxygen Drops During Surgery and Related Risk Factors for Cognitive Problems After Heart Surgery
This study examines whether decreases in brain oxygen levels during cardiac surgery are linked to postoperative cognitive dysfunction and identifies other factors that may increase the risk of cognitive impairment.
- Conditions
- Cognitive Dysfunction, Postoperative, Cognitive Dysfunction, Cardiac Surgery
- Trial name
- NCT07361068
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Cognitive Impairment, Cardiovascular Risk Factor
The Active Mind Study
The purpose of this study is to explore whether physical exercise, mindfulness training, or both interventions together can improve cognitive function in individuals with multiple risk factors for the development of dementia in…
- Trial name
- NCT03289546
- Testing
- Mindfulness training, Aerobic training
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- The Miriam Hospital
Cognitive Decline
An Investigation Into the Effects of a Wild Blueberry Powder and a Wild Blueberry Extract on Cognition in Older Adults
The purpose of this study is to determine whether a 6 month dietary intervention with wild blueberry powder and extract stabilised with L-cysteine and L-glutathione have an effect on cognitive performance in participants aged…
- Trial name
- NCT02446314
- Testing
- Wild Blueberry Powder - 450mg, Wild Blueberry Powder - 900 mg, Wild Blueberry extract 100mg
- Where
- United Kingdom
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Reading
Mild Cognitive Impairment, Alzheimer Disease
Understanding Brain Mechanisms Involved in Autobiographical Memory
The overall objective of this project is to characterize the spatiotemporal dynamics of brain oscillations underpinning autobiographical memory (ABM) and the modulation of the memory network using non-invasive brain stimulation.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Memory Loss
- Trial name
- NCT05710549
- Testing
- high-density electroencephalography (hdEEG), Transcranial alternating current stimulation (tACS)
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lucie Bréchet
Metabolic Disorders and Cognitive Decline
Effects of Whole Grain Rye on Metabolic Risk Markers and Mood
The purpose of the study is to investigate, in healthy middle age subjects, effects of whole grain rye on cognitive functions, mood, and cardiovasculair risk markers
- Trial name
- NCT03275948
- Testing
- whole grain, reference
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Lund University