Clinical trials: Cognitive Disorders
Binge-Eating Disorder, Bulimia Nervosa
Building an Equitable and Accessible System of Eating Disorder Care for VA, DoD, and Underrepresented Americans
When untreated, eating disorders present with tremendous burdens to affected active duty Service members and Veterans and their families, and are very costly to the DoD and VA healthcare system.
- Conditions
- Binge-Eating Disorder, Bulimia Nervosa, Veterans Health, Cognitive Behavioral Therapy
- Trial name
- EASED (NCT05304104)
- Testing
- Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- VA Connecticut Healthcare System
Parkinson Disease, Cognitive Dysfunction
HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH)-Parkinson's Disease (HOBSCOTCH-Parkinson's)
The goal of this pilot study is to assess the feasibility of adapting and delivering the existing home-based epilepsy self-management intervention, HOBSCOTCH, for people with Parkinson's Disease (PD) The main questions it aims to…
- Conditions
- Parkinson Disease, Cognitive Dysfunction, Memory Disorders
- Trial name
- HOBSCOTCH-PD (NCT06260228)
- Testing
- HOme-Based Self-management and COgnitive Training CHanges lives (HOBSCOTCH)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Sickle Cell Disease, Executive Dysfunction
Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease
The purpose of this study is to determine if patients with sickle cell disease (SCD) can consistently take a drug called Methylphenidate (MPH) daily, once a day for 4 weeks to help with any thinking, attention or schoolwork…
- Conditions
- Sickle Cell Disease, Executive Dysfunction, Cognitive Impairment, Attention Deficit/Hyperactivity Disorder (ADHD)
- Trial name
- NCT07226219
- Testing
- Extended-Release Methylphenidate
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- St. Jude Children's Research Hospital
Delirium, Neurocognitive Disorders
Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders
The goal of this clinical trial is to compare the Hospital Elder Life Program (HELP) with a family-augmented version of HELP (FAM-HELP), that includes family members and care partners, for the prevention of delirium in older…
- Conditions
- Delirium, Neurocognitive Disorders, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- ENHANCE (NCT05929703)
- Testing
- HELP, FAM-HELP
- Where
- 7 sites in United States
- Volunteers
- 1,900 people
- Sponsor
- University of Michigan
Schizophrenia / Schizoaffective Disorder, TMS
Efficacy and Safety of Individualized Sequential Accelerated Theta Burst Stimulation in Improving Cognitive Function in Schizophrenia
The goal of this clinical trial is to learn if sequential dual-site accelerated theta burst stimulation (SD-aTBS) targeting the frontoparietal network and default mode network works to improve cognitive function in adults with…
- Conditions
- Schizophrenia / Schizoaffective Disorder, TMS, Cognitive, PET / MR
- Trial name
- NCT07806877
- Testing
- Sequential Dual-Site Accelerated Theta Burst Stimulation (SD-aTBS)
- Volunteers
- 60 people
- Sponsor
- Central South University
Mild Cognitive Impairment
Olfactory Training in Mild Cognitive Impairment
Sense of smell tends to decline in individuals with early Alzheimer's disease, typically earlier than when other senses and thinking abilities begin to decline.
- Trial name
- OTMCI (NCT06825403)
- Testing
- Olfactory Memory Training, Visual Memory Training
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Jeffrey Motter
Strength Training Adaptations, Stress
The Impact of 12-week Ashwagandha Supplementation Induced by Resistance Training on Strength, Levels of Neurotrophic and Stress Response Proteins, Oxidative and Psychological Stress, and Cognitive Function in Physically Active Male Adults
This clinical trial will study the effects of Ashwagandha (Withania somnifera), a natural plant extract, on physical and mental health in adult men.
- Conditions
- Strength Training Adaptations, Stress, Sleep Quality, Cognitive Functions
- Trial name
- NCT07803068
- Testing
- Ashwagandha, Resistance training
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Cognitive Deficit
Studying the Effects of Brain Stimulation on Cognitive Control and Associated EEG in Human Subjects.
This is a basic neuroscience study of modulating brain oscillations involved in cognitive control. We will record brain signals and stimulate specific regions of the brain in human participants who are undergoing monitoring for…
- Trial name
- NCT05251454
- Testing
- Brain Stimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Cincinnati
Mild Cognitive Impairment, Alzheimer Dementia (AD)
Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline
The goal of this clinical study is to investigate the effectiveness of non-invasive stimulation to enhance cognitive control abilities in older adults with and without cognitive impairment.
- Trial name
- NCT05907343
- Testing
- Closed-loop TBS, Open-loop TBS
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
MARKERS-NDD is a prospective, observational, longitudinal study, which aims to collect data from patients affected by neurodegenerative diseases (NDD) followed longitudinally for routine examinations performed as part of normal…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Synucleinopathies, Lewy Body Disease
- Trial name
- MARKERS-NDD (NCT06596746)
- Testing
- Observation
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Casa di Cura San Raffaele Cassino
Dementia (Diagnosis), Alzheimer Dementia (AD)
Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI)
The goal of this observational study is to learn if an artificial intelligence (AI)-based speech analysis tool can identify which patients with memory problems need specialist evaluation at a memory clinic.
- Conditions
- Dementia (Diagnosis), Alzheimer Dementia (AD), Vascular Dementia (VaD), Lewy Body Dementia (LBD)
- Trial name
- DetectAI (NCT07200739)
- Testing
- Mini-mental State Examination, Addenbrooke's Cognitive Examination, Speech Task - Picture Description
- Where
- Denmark
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Cognitive Dysfunction, Cognitive Disorder
MW151 and Whole-brain Radiotherapy in Patients With Intracranial Metastases
HYPOTHESIS: MW151 intervention during whole-brain radiotherapy for intracranial metastases is safe and well tolerated and will mitigate neurocognitive decline.
- Trial name
- MW151-102 (NCT05417282)
- Testing
- MW151
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- ImmunoChem Therapeutics, LLC
Psychosis, Schizophrenia
Cognitive Remediation for Social Cognition in Schizophrenia and Related Disorders
This study will investigate whether the remote administration of the cognitive remediation program RC2S+ acceptable and feasible in people with schizophrenia and related disorders.
- Conditions
- Psychosis, Schizophrenia, Cognitive Impairment
- Trial name
- RC2S (NCT05017532)
- Testing
- The program Remédiation Cognitive de la Cognition Sociale en Schizophrénie (RC2S+)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Douglas Mental Health University Institute
Post Intensive Care Syndrome (PICS)
Post Intensive Care Accelerometery to Study and Support Recovery Outcomes
The primary purpose of this study is to find out whether a wrist-worn activity monitor can help healthcare professionals understand how people recover after they leave the intensive care unit (ICU), where they were cared for when…
- Trial name
- PICASSO (NCT07466446)
- Where
- 3 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh
Post-Operative Cognitive Decline in Older Adults, Post-operative Cognitive Decline
Post-operative Cognitive Decline After Ambulatory Cataract Surgery in the Elderly Population
Postoperative cognitive decline is a recognized complication following anesthesia and surgery in older adults; however, its incidence after ambulatory cataract surgery performed under sedation is not well understood.
- Conditions
- Post-Operative Cognitive Decline in Older Adults, Post-operative Cognitive Decline, Perioperative Neurocognitive Disorders, Cataract Surgery Anesthesia
- Trial name
- NCT07714174
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Behavior Problems, Attention Problems
Effect of Sports Based Structured Cognitive Therapy Program on Attention, Memory and Behavior for School Going Children
This randomized controlled trial will evaluate the effect of a sports-based structured cognitive therapy program on attention, memory, and behavior in school-going children aged 8-12 years with mild to moderate attention or…
- Conditions
- Behavior Problems, Attention Problems, Cognitive Functions
- Trial name
- NCT07786532
- Testing
- Sports-Based Structured Cognitive Therapy Program, Conventional Physical Activity
- Where
- Pakistan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Psychological Stress, Anxiety
NeuroFinance Human Stress Trial During Financial and Informational Volatility
The NeuroFinance Human Stress Trial (NFHST-2026-001) is a decentralized observational clinical study designed to evaluate how financial market volatility, economic uncertainty, digital media exposure, and information-driven…
- Conditions
- Psychological Stress, Anxiety, Emotional Stress, Autonomic Nervous System Dysfunction
- Trial name
- NFHST (NCT07622589)
- Testing
- Wearable Physiologic Monitoring Platform
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
PARKINSON DISEASE (Disorder), Parkinson
The Role of METhanogens in the PROgression Of Parkinson's Disease and Related Neurological Conditions
Gut problems, such as constipation, can have an important impact on quality of life of people who have them, and have been associated with higher risk of developing neurological diseases such as Parkinson's or Alzheimer's…
- Conditions
- PARKINSON DISEASE (Disorder), Parkinson, Parkinson Disease, Parkinson s Disease
- Trial name
- Met-Pro (NCT07786116)
- Testing
- Probiotic Supplementation with L. reuteri
- Where
- United Kingdom
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Alzheimer Disease
A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
The main purpose of this study is to evaluate the safety of LY3954068 in participants with early symptomatic Alzheimer's Disease (AD).
- Trial name
- NCT06297590
- Testing
- LY3954068, Flortaucipir F18
- Where
- 10 sites in United States, Japan and 1 more
- Volunteers
- 48 people
- Sponsor
- Eli Lilly and Company
Opioid Use Disorder, Cognitive Ability General
Older Adults, Methadone, and Cognitive Function
The increasing prevalence of opioid use disorder (OUD) among older adults, coupled with high overdose rates and cognitive impairments associated with opioid use, highlights a critical gap in addiction treatment.
- Trial name
- NCT07153029
- Testing
- Smartphone based cognitive tasks
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Maryland, Baltimore