Clinical trials: Cognitive Changes
Psychotic Disorders, Schizophrenia
Development and Pilot Evaluation of Modified Cognitive Behavioural Therapy for Adolescents With Early Onset Psychosis
In the last decade cognitive behavioural therapy (CBT) approaches for patients with schizophrenia have been developed, which where especially designed to reduce severity of positive symptoms, readmission rates, treatment…
- Conditions
- Psychotic Disorders, Schizophrenia, Schizoaffective Disorder, Delusional Disorder
- Trial name
- mCBT (NCT00465920)
- Testing
- modified cognitive behavioural therapy (mCBT)
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- University of Cologne
Persistent Physical Symptoms
PRINCE Primary: Integrated GP Care for Persistent Physical Symptoms - a Feasibility & Cluster Randomised Controlled Trial
PRINCE primary is cluster randomised waiting list controlled trial to evaluate the feasibility of an integrated approach to care in general practice for adults with persistent physical symptoms (PPS).
- Trial name
- PRINCE Primary (NCT02444520)
- Testing
- Integrated GP Care
- Where
- United Kingdom
- Volunteers
- 161 people
- Sponsor
- King's College London
Alcohol Use Disorder (AUD), Cocaine Use Disorder (CUD)
Web-based Alcohol- or Cocaine-specific Inhibition Training in Adolescents and Young Adults With Substance Use Disorder
Substance misuse is one of the most common risk factors for health problems and premature death among adolescents and young adults worldwide.
- Conditions
- Alcohol Use Disorder (AUD), Cocaine Use Disorder (CUD), Substance Use Disorder (SUD)
- Trial name
- WAIT-AYA (NCT07071779)
- Testing
- Substance-specific inhibition training, Control training
- Where
- Switzerland
- Volunteers
- 210 people
- Sponsor
- University of Bern
Overweight and Obesity, Cognitive Change
The Effect of Ketone Ester Supplementation and Ketogenic Diet on Brain Plasticity in Overweight/Obese Adults
This project comprises an initial crossover placebo-controlled neurophysiological study to ascertain the effect of acute ketone ester ingestion on motor cortex plasticity, followed by a second 2-week intervention study aimed to…
- Conditions
- Overweight and Obesity, Cognitive Change, Psychophysiologic Reaction
- Trial name
- NCT06368297
- Testing
- Ketone Monoester Supplementation, Ketogenic diet
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Macau
Cognitive Change
Vestibular-Based Exercises vs. Calisthenic Exercises for Cognitive Functions
This study was planned to determine the effects of vestibular-based exercises (VBE) and calisthenic-based exercises (CBE) on the cognitive functions of the older individuals.
- Trial name
- NCT05925582
- Testing
- vestibular based exercise program, calisthenic based exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Biruni University
Huntington Disease, Parkinson Disease
Measurement and Modification of Threat Interpretation Bias in Neurodegenerative Movement Disorders (Aims 2 & 3)
The purpose of this study is conduct a pilot open trial of a web-based cognitive bias modification intervention to reduce anxiety symptoms in persons with Huntington's disease and persons with Parkinson's disease.
- Trial name
- NCT05126862
- Testing
- MindTrails
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Virginia
Alteration of Cognitive Function, Ageing
Health Behaviors and Time-of-Day: Older Adult Cognitive Function
This is a single-center, observational study design. Enrolled participants will be typically, healthy older adults. Participants will complete daily computerized measures, in addition to continuously wearing an Actiwatch device.
- Trial name
- OA-TIME (NCT02300272)
- Testing
- Polysomnograph, Actiwatch
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cognitive Change
Effect of Alpha Hope Dietary Supplement on Health and Cognitive Performance
The purpose of the present research study is to evaluate the claims about the supplement influencing cognitive function that may impact performance on cognitive task and related biochemical measures.
- Trial name
- NCT05589051
- Testing
- Drink
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Memphis
Prolonged Grief Disorder
A Swedish Internet CBT for Prolonged Grief Disorder: a Three-armed RCT
The goal of this clinical trial is to evaluate the effectiveness of internet-delivered Cognitive Behavioral Therapy (iCBT) in reducing symptoms of prolonged grief in adults diagnosed with prolonged grief disorder.
- Trial name
- NCT06667674
- Testing
- iCBT for prolonged grief, Active control
- Where
- 2 sites in Sweden
- Volunteers
- 270 people
- Sponsor
- Uppsala University
Major Depressive Disorder
The Relationship Among Changes in Brain Network Activation in Adult Outpatients With Major Depressive Disorder
The purpose of this study is to explore patterns of Brain Network Activation (BNA) changes from baseline to endpoint on 1) efficacy of core symptoms of Major Depressive Disorder (MDD) and 2) improvement of cognitive dysfunction…
- Trial name
- NCT02749721
- Testing
- vortioxetine
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Rush University Medical Center
Frail Elderly Subjects
Omega-3 Fatty Acids and/or Multi-domain Intervention in the Prevention of Age-related Cognitive Decline
Epidemiological and fundamental research carried out in recent years has highlighted the role played by omega-3 fatty acids in the process of cognitive decline that accompanies advancing age and Alzheimer's disease.
- Trial name
- MAPT (NCT00672685)
- Testing
- omega-3, multi-domain intervention
- Where
- 13 sites in France, Monaco
- Volunteers
- 1,680 people
- Sponsor
- University Hospital, Toulouse
Postoperative Cognitive Dysfunction, Delirium
Cohort Study to Investigate the Association Between Changes in Brain Volume and Postoperative Cognitive Dysfunction
Despite an ongoing controversy in the scientific literature, the link between anesthesia and dementia and/or cerebral atrophy remains unclear.
- Conditions
- Postoperative Cognitive Dysfunction, Delirium, Dementia
- Trial name
- POCD-MRI (NCT02045004)
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nicolai Goettel
Caffeine, Diet, Healthy
Acute Effects of Fitness Drink Formulas on Energy Expenditure and Fat Metabolism
The purpose of this investigation was to examine the acute effects of consuming two different fitness drink formulas on the physiological response at rest and to exercise in healthy men and women.
- Conditions
- Caffeine, Diet, Healthy, Fat Burn, Cognitive Change
- Trial name
- NCT04455009
- Testing
- Fitness Drink Formula
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Depression, Unipolar, Depression Moderate
The Cerebral and Cognitive Changes After Intermittent Theta Burst Stimulation (iTBS) Treatment for Depression
The present project aims to assess the neurocognitive impact of a two-week once-a-day regimen of intermittent theta burst stimulation (iTBS) compared to sham iTBS, when targeting the left dorsolateral prefrontal cortex (LDLPFC)…
- Trial name
- NCT06534684
- Testing
- Intermittent Theta Burst Stimulation
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University Hospital of North Norway
CABG-Patients
Changes in Cerebrovascular Reactivity During Cognitive Activation After Cardiopulmonary Bypass: Relation With Intraoperative Embolic Load and Postoperative Neuropsychological Dysfunctions
The study aims to evaluate neuropsychological disorders in CABG patients. Measurements are performed 1 day before, 6 days, 6 months and 3-5 years after the surgery.
- Trial name
- NCT00394108
- Testing
- Determination of neuropsychological status
- Where
- Belgium
- Volunteers
- 66 people
- Sponsor
- University Ghent
Cognitive Impairment, Coginitive Assessment
A Modified Test of Goal-directed Behaviour: a Feasibility Study
Cognitive assessment plays an important part in decision making in acute neurological settings, partly because difficulties with cognitive skills such as attention, memory and executive functioning (which includes planning and…
- Trial name
- NCT07484048
- Testing
- Five cognitive tasks
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Binge Eating Disorder, Obesity
Treatment for Obesity and Binge Eating Disorder
This study is a test of cognitive behavioral therapy(CBT) and behavioral weight loss (BWL) treatments for obese patients with binge eating disorder (BED).
- Trial name
- NCT00537758
- Testing
- Cognitive Behavior Therapy, CBT and BWL, Behavioral Weight Loss Treatment
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Yale University
Stroke, Ischemic, Cognitive Decline
Post-stroke Immunological Changes in Young Stroke Patients
In the present study, the investigators aim to elucidate the role of T-cells on cognitive decline in younger stroke patients, using repeated cognitive testing, brain imaging, and immunological analyses in the first 6 month after…
- Trial name
- NCT03725137
- Testing
- Analysis of T-lymphocytes
- Volunteers
- 77 people
- Sponsor
- University Medicine Greifswald
Stroke, Cognitive Impairment
Cognitive Rehabilitation and Galantamine for Post Stroke Cognitive Impairment
The investigators would like to conduct a double blind placebo-controlled prospective study to show the impact of a treatment combining a specific cognitive rehabilitation program and acetylcholinesterase inhibitors on executive…
- Trial name
- COGICRehab (NCT01508494)
- Testing
- Galantamine
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Physician Well-being, Cognitive Function
Performance Nutrition for Residents and Fellows
Currently, residents commonly experience dehydration and poor nutrition during nighttime duty hours as a result of heavy work load, lack of time to take nutrition and hydration breaks, or limited or no access to healthy food and…
- Conditions
- Physician Well-being, Cognitive Function, Diet Modification, Diet Habit
- Trial name
- NCT03698123
- Testing
- Dietary Modification
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Stanford University