Clinical trials: Cognitive Changes
Cognitive Change
Effectiveness of Cognitive Training in Older and Younger Adults
The proposed study will enroll 1600 participants to examine the effectiveness of cognitive training. Participants will be randomized into different experimental groups and can expect to participate for up to 15 hours of research…
- Trial name
- NCT06375681
- Testing
- Visual and / or Auditory Cognitive Tasks (1), Visual and / or Auditory Cognitive Tasks (2)
- Where
- 3 sites in United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Sleep, Sleep Deprivation
Resilience to Sleep Deprivation and Changes in Sleep Architecture in Shoonya Meditators
This study aims to investigate the effect of a 15-minute meditation practice on sleep architecture and high-frequency Heart Rate Variability (HF-HRV), as well as cognitive performance after both a well-rested and sleep-deprived…
- Conditions
- Sleep, Sleep Deprivation, Cognitive Change
- Trial name
- REST (NCT05026541)
- Testing
- Nap Practitioners, Shoonya Meditation
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Major Depressive Disorder, Neuroticism
Predictors of Cognitive Outcomes in Geriatric Depression
This study will focus on examining effects of stress on long-term mood and cognitive outcomes of late-life depression. It will also example the neural underpinnings of these changes using structural and functional brain imaging.
- Conditions
- Major Depressive Disorder, Neuroticism, Cognitive Change, Stress
- Trial name
- NBOLD (NCT05273996)
- Testing
- Sertraline, bupropion, desvenlafaxine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- David Steffens
Cognitive Wellness, Healthy Aging
MEVA Cognitive Wellness Platform Study for Adults
The goal of this observational study is to evaluate the reliability, usability, and feasibility of the MEVA Cognitive Wellness Platform in community-dwelling adults aged 55 to 75.
- Conditions
- Cognitive Wellness, Healthy Aging, Age-Related Cognitive Change, Aging
- Trial name
- MEVA (NCT07595250)
- Testing
- MEVA Cognitive Wellness Platform
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mentage LLC
Dementia Prevention, Subjective Cognitive Impairment
The Brain Health PRO Online Risk Factor Reduction Study to Prevent Dementia
This study will recruit participants at risk for dementia to participate in an online educational program called Brain Health PRO (BHPro).
- Conditions
- Dementia Prevention, Subjective Cognitive Impairment, Mild Cognitive Impairment, Cognitive Change
- Trial name
- BHPROOF (NCT07364019)
- Testing
- Brain Health PRO
- Where
- Canada
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Sickle Cell Disease, Cognitive Impairment
Minocycline In Neurocognitive Outcomes - Sickle Cell Disease
Sickle cell disease (SCD) is a common, inherited blood disorder that primarily affects people of African Ancestry. It has a lot of complications including neurological complications.
- Conditions
- Sickle Cell Disease, Cognitive Impairment, Cognitive Decline, Cognitive Change
- Trial name
- MINO-SCD (NCT05605366)
- Testing
- Minocycline
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Healthy Lifestyle, Home Environment Related Disease
HomeStyles-2: Shaping HOME Environments and LifeSTYLES to Prevent Childhood Obesity
Parents are children's primary role models, are food and physical activity gatekeepers, and create the structure/lifestyle environment within the home.
- Conditions
- Healthy Lifestyle, Home Environment Related Disease, Cognitive Change, Child Behavior
- Trial name
- HomeStyles-2 (NCT04802291)
- Testing
- HomeStyles-2: Obesity Prevention Program for Families with Children in Middle Childhood
- Where
- United States
- Volunteers
- 459 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Cognitive Change, Well-Being, Psychological
Acute Effects of Physical Activity on Cognition and Well-being in University Students
Previous studies in young adults have shown that physical activity can generate positive emotions and improve attention, among other cognitive functions.
- Trial name
- ActClass4Brain (NCT06168526)
- Testing
- Acute physical activity
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitat Jaume I
Breast Cancer, Locally Advanced Breast Cancer
Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer
This randomized, placebo-controlled trial aims to assess the feasibility, acceptability, and preliminary efficacy of memantine and the University of Carolina (UNC)'s Get Real \& Heel cancer exercise program (MEM+EX) in addressing…
- Conditions
- Breast Cancer, Locally Advanced Breast Cancer, Cognitive Impairment, Cognitive Decline
- Trial name
- NCT06727773
- Testing
- Memantine, Exercise Intervention, Exercise Control
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Parkinson Disease, Orthostatic Hypertension
Effects of Blood Pressure on Cognition and Cerebral Hemodynamics in PD
The goal of clinical trial is to learn about how blood pressure fluctuations affect cognitive performance (thinking abilities) and brain blood flow in persons with Parkinson's disease with and without orthostatic hypotension (low…
- Conditions
- Parkinson Disease, Orthostatic Hypertension, Cognitive Change, Cognitive Impairment
- Trial name
- NCT06252376
- Testing
- Head-up tilt table
- Sponsor
- University of California, San Diego
Cognitive Decline, Cognitive Change
Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient
The research team is creating a foundational infrastructure in order to develop a precision medicine approach for geriatric patients who require surgery with anesthesia.
- Conditions
- Cognitive Decline, Cognitive Change, Cognitive Impairment, Postoperative Delirium
- Trial name
- NCT03839784
- Testing
- Neurocognition Interventions
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Stanford University
Heat Stress, Physiological Stress
Impact of Indoor Overheating on Physiological Strain in Children
Communities worldwide are experiencing increasing heat extremes that challenge the limits of human thermoregulation, particularly among vulnerable populations such as children.
- Conditions
- Heat Stress, Physiological Stress, Cognitive Change
- Trial name
- NCT07261202
- Testing
- Simulated exposure to indoor overheating
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Heat Stress, Physiological Stress
Heat Stress in Individuals With Schizophrenia
Schizophrenia is a severe mental illness affecting approximately 24 million people worldwide and is associated with more than double the all cause mortality risk of the general population.
- Conditions
- Heat Stress, Physiological Stress, Cognitive Change
- Trial name
- NCT07383324
- Testing
- Simulated exposure to indoor overheating
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Ottawa
Cognitive Change
Oxygen as a Limiting Factor for Performing Multitasking
The aim of the present study was to evaluate whether hyperbaric oxygen (HBO) environment, with increased oxygen supply to the brain, will enable better performance of complex and/or multiple activities.
- Trial name
- NCT03126669
- Testing
- Hyperbaric oxygen, Hyperbaric chamber, normal air
- Where
- Israel
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Cognitive Change
Working Memory Training for People Aging With HIV
The present study investigates the feasibility of working memory training in people aging with HIV (PAWHIV). In a cross-over design this stage 1 feasibility trial, will evaluate acceptability, and estimate possible effect sizes…
- Trial name
- NCT06699927
- Testing
- Span
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Northeastern University
Healthy, Cognitive Change
Cognitive Augmentation Via Multimodal Sensing and Auricular Neurostimulation
The goal of this clinical trial is to extend this period of optimal cognitive performance by applying neurostimulation to buffer health volunteers against the effects of increased levels of stress, distraction, and cybersickness.
- Conditions
- Healthy, Cognitive Change, Effects of External Neurostimulation on Cognition
- Trial name
- CAMSAN (NCT06782360)
- Testing
- Active Neurostimulation
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- OpenBCI
Menopause, Cognitive Change
PhytoSERM to Prevent Menopause Associated Decline in Brain Metabolism and Cognition
This is a proof-of-concept phase 2 clinical trial to investigate the safety and effect of the phytoestrogenic supplement PhytoSERM on regional brain metabolism by fluorine-18 fluorodeoxyglucose positron emission tomography…
- Conditions
- Menopause, Cognitive Change, Brain Disorder, Metabolic
- Trial name
- NCT05664477
- Testing
- PhytoSERM
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Roberta Brinton
Cognitive Change, Inflammation
NAD+ Oral Supplement Pilot Intervention in Adult Females
The goal of this clinical trial is to learn whether Nicotinamide adenine dinucleotide (NAD+) can influence cognition and biomarkers in healthy, cognitively intact women aged 40-80.
- Conditions
- Cognitive Change, Inflammation, Neurodegenerative Diseases
- Trial name
- NCT06579209
- Testing
- Treatment
- Where
- 2 sites in United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Traumatic Brain Injury, Cognitive Change
Treating Word Finding Difficulties in Traumatic Brain Injury With HD-tDCS
The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., pre-supplementary motor area) thought to aid in memory will…
- Conditions
- Traumatic Brain Injury, Cognitive Change, Word Finding Difficulty, Acquired Brain Injury
- Trial name
- NCT06840808
- Testing
- Active Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- The University of Texas at Dallas
Aging, Alzheimer Disease
Exercise to Improve Brain Health in Older African Americans
The goal of this clinical trial is to test the effects of different types of exercise on brain health and Alzheimer's risk in older African Americans.
- Conditions
- Aging, Alzheimer Disease, Healthy Aging, Cognitive Change
- Trial name
- NCT05597124
- Testing
- Cardio-Dance Fitness, Strength, Flexibility & Balance
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey