Clinical trials: Cognitive Aging, open to volunteers
Healthy Aging
Uncovering the Cognitive and Neural Mechanisms Underlying Cognitive Time
Time processing, the ability to process and encode temporal information, is essential for cognitive functioning and for a large number of daily life activities.
- Trial name
- TIMES (NCT06349213)
- Testing
- FDOPA injection before PET imaging, Time perception tasks, fMRI imaging
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Mild Cognitive Impairment, MCI
Neuromodulation of Memory in Aging
The proposed research will use closed-loop transcranial magnetic stimulation (TMS) based on individualized brain networks to establish parameters that can reliably control brain states.
- Trial name
- TMS-AD (NCT05460468)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy Volunteer Study
A Multi-domain Intervention for Healthy Aging
This study aims to investigate the long-term impact of a non-pharmacological intervention including several activities (e.g., physical activity, choir, learning programs, horticulture, etc.) to prevent cognitive impairment in…
- Trial name
- MultiMusic (NCT06767410)
- Testing
- Multidomain Intervention, General activities
- Where
- 4 sites in Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Bari
Healthy Aging, Alzheimer's Disease (AD)
Improving Executive Control in Cognitively Healthy Older Adults: the MUltitasking STrategy (MUST) Study
Developing efficient cognitive intervention for cognitively health older adults is a major public health goal, due to its potential for reducing age-related cognitive decline and Alzheimer's disease/dementia risk.
- Trial name
- MUST (NCT06995638)
- Testing
- Web-based Cognitive Training (with strategy), Web-based Cognitive Training (without strategy)
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Neurodegenerative Diseases, Aging
Simulation-informed Modelling and Personalized Evaluation (SIMPLE) in Ageing Populations
Multimodal magnetic resonance imaging (MRI), detecting brain structural and functional changes, has emerged as a powerful and promising technique to study individual's brain, as T1-weighted scans can detect morphometric features…
- Conditions
- Neurodegenerative Diseases, Aging, Brain, Cognitive Dysfunction
- Trial name
- NCT06572332
- Where
- Hong Kong
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Imagery (Psychotherapy), Postural Control
The Effect of Motor Image Training on Balance Performance in Geriatric Individuals
The goal of this study [type of study: clinical trial] is to was planned to investigate the effect of motor imagery training given to geriatric individuals with action observation on their balance performance and to compare these…
- Conditions
- Imagery (Psychotherapy), Postural Control, Postural Balance, Virtual Reality Therapy
- Trial name
- NCT06056180
- Testing
- Balance Training, Motor İmagery Training, Action Observation Training
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Muğla Sıtkı Koçman University
Dementia Risk Factors, Prevention
The REMINDER4Care Program for Older Adults Supported by Residential and Daycare Facilities
Dementia incidence is rising, posing a public health challenge, but 45% of cases can be prevented by addressing modifiable risk factors.
- Conditions
- Dementia Risk Factors, Prevention, Cognitive Health
- Trial name
- REMINDER4Care (NCT06922071)
- Testing
- REMINDER4Care
- Where
- Portugal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Dementia, Parkinsonism
DaTSCAN Imaging in Aging and Neurodegenerative Disease
The investigators propose using DaTscan in patients with REM sleep behavior disorder (RBD), mild cognitive impairment (MCI), Parkinson's disease (PD), dementia with Lewy bodies (DLB), Alzheimer's disease (AD), and other…
- Conditions
- Dementia, Parkinsonism, Mild Cognitive Impairment, REM Sleep Behavior Disorder
- Trial name
- NCT01453127
- Testing
- I-123 Ioflupane solution injection prior to SPECT scan (DaTscan), Single photon emission computed tomography (SPECT) scan
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
Aging
The Effect of NAD Supplementation on Brain Vascular Health in Aging
Daily consumption of one of the forms of Vitamin B3, the Nicotinamide Riboside (NR), energizes the body and combats cellular aging. This study is designed to test whether NR can also improve brain health and memory.
- Trial name
- NCT05483465
- Testing
- Nicotinamide riboside
- Where
- United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Aging, Brain Metabolic Disorder
Monitoring of Brain Metabolites Using Proton and Deuterium MR Techniques
MR pulse for whole brain optimal Deuterium (2H) Metabolic Imaging and EPSI (echo planar spectroscopic imaging) based SLOW-edited 1H-MRSI will be developed and optimized for use at an UHF scanner at 7 Tesla.
- Conditions
- Aging, Brain Metabolic Disorder, Carotid Stenosis, Alzheimer Disease
- Trial name
- SIGNATURES2023 (NCT06705010)
- Testing
- Application of new pulse sequence package SIGNATURES2023 to healthy controls, Application of new pulse sequence package SIGNATURES2023 to 4 groups of patients (pilot)
- Where
- Switzerland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cerebral Small Vessel Diseases, Stroke
Stopping Cognitive Decline and Dementia by Fighting Covert Cerebral Small Vessel Disease
Cerebral small Vessel Disease (cSVD), characterized by an alteration of the structure and function of small penetrating brain arteries, is highly prevalent in older persons from the general population and represents a leading…
- Conditions
- Cerebral Small Vessel Diseases, Stroke, Dementia
- Trial name
- SHIVA (NCT05306834)
- Testing
- Retinal Imaging, Blood sample, Evaluation of cardiovascular risks
- Where
- 2 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Bordeaux
Alzheimer Disease, Aging
Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness
The study aims to evaluate the effects of a 9-month intervention combining yoga-based mindfulness techniques, cognitive training, and nutritional counseling on cognitive function, plasma markers of neurodegeneration (tau…
- Conditions
- Alzheimer Disease, Aging, Lifestyle Factors, Cognitive Impairment
- Trial name
- LIBRA REMIND (NCT07042087)
- Testing
- Mindfulness Yoga, Time-Restricted Eating with nutritional counseling promoting a flexitarian dietary pattern, Cognitive Training
- Where
- Czechia
- Volunteers
- 48 people
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Breast Cancer
Remotely-Delivered Cognitive Behavioral Stress Management for Breast Cancer (R-CBSM)
The purpose of this research study to find out if a program called Remotely-delivered Cognitive Behavioral Stress Management (R-CBSM) can help women with breast cancer in the period of survivorship after they have completed…
- Trial name
- NCT07502352
- Testing
- Remotely Delivered Cognitive Behavioral Stress Management Intervention (R-CBSM), Standard of Care Survivorship Care Planning
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- University of Miami
Hypertension, Elevated Blood Pressure
Feasibility of a Community-Integrated Isometric Handgrip Exercise Program and Its Preliminary Effects on Blood Pressure and Cognitive Function in Older Adults
The goal of this clinical trial is to evaluate whether a short, supervised isometric handgrip exercise program is feasible and acceptable for older adults with elevated blood pressure or hypertension.
- Trial name
- NCT07648498
- Testing
- Zona Plus 4-Week Isometric Handgrip Exercise Intervention, Squegg 4-Week Isometric Handgrip Exercise Intervention
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Cognitive Impairment, Dementia With Behavioral Disturbance
The Care for America's Aging Study
Care for America's Aging is a randomized pilot study investigating whether a home health aide training intervention consisting of enhanced dementia-specific curriculum content will improve: 1) behavioral symptoms of older adult…
- Conditions
- Cognitive Impairment, Dementia With Behavioral Disturbance, Dementia, Alzheimer Disease
- Trial name
- CfAA (NCT06021704)
- Testing
- Enhanced home health aide training in dementia and dementia-related behaviors
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Frailty, Pre-Frailty
In-Person, Online, and Hybrid Healthy-Aging Education for Pre-Frailty and Frailty in Older Adults
The goal of this clinical trial is to determine whether a 6-month healthy-aging education program delivered in person, online, or in a hybrid format reduces frailty and is cost-effective compared with usual care in…
- Trial name
- FRAGSALUD-ON (NCT07738393)
- Testing
- In-person healthy aging education program, Hybrid healthy aging education program, Online healthy aging education program
- Where
- Spain
- Volunteers
- 276 people
- Sponsor
- University of Cadiz
Cognitive Impairment, Cognitive Decline
A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients
The current study is a mechanistic study to evaluate working memory gains from application of transcranial direct current stimulation (tDCS) in older adults with mild cognitive impairments (MCI) compared to cognitively healthy…
- Trial name
- AIM (NCT05998031)
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Florida
Overweight (BMI > 25), Obesity & Overweight
WB-EMS Combined With Nutritional Guidance for a High-Protein Diet on Body Composition, Muscle Function, Psychological and Functional Outcomes in Older Adults With Excess Adiposity
This is a 16-week randomized controlled trial (RCT) with outcome assessor blinding. The objective is to investigate the effects of resistance training (RT) combined with whole-body neuromuscular electrical stimulation (WB-NMES)…
- Conditions
- Overweight (BMI > 25), Obesity & Overweight, Aging
- Trial name
- WB-EMS (NCT07859072)
- Testing
- Whole-Body Neuromuscular Electrical Stimulation (WB-NMES), Conventional Resistance Training, High-Protein Nutritional Guidance
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Universidade Cesumar (UNICESUMAR)
Age-Related Cognitive Decline
EMBRACE - From Vulnerable to Empowered: Implementation and Evaluation of a Multicomponent Program to Tackling Age-related Decline
EMBRACE is a randomized, controlled, multi-domain, blinded clinical trial involving 120 community-dwelling older adults at risk of cognitive decline, lasting 12 months.
- Trial name
- EMBRACE (NCT07628686)
- Testing
- EMBRACE Intervention
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Fernando Pessoa
Stroke, Aging
Walking and Thinking - Brain Activity During Complex Walking in Stroke
Everyday life requires individuals to function in complex environments and perform tasks that involve the integration of motor and cognitive abilities.
- Conditions
- Stroke, Aging, Neuro-Degenerative Disease, Gait Impairment in Stroke Patients
- Trial name
- NCT07624630
- Testing
- No Interventions
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet