Clinical trials: Cognitive Aging
Fibromyalgia
Subjective Ageing in Fibromyalgia
Subjective age or felt age is the term used for how the person feels; one can feel same, younger or older than their actual age.
- Trial name
- NCT03966820
- Where
- Turkey (Türkiye)
- Volunteers
- 262 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Aging, Memory Impairment
Neurocognitive Study for the Aging-a Longitudinal Study With a Greek Cypriot Cohort
The Neurocognitive Study for the Aging (NEUROAGE) was initially funded by the Cyprus Innovation Foundation and has received subsequent funding by the European Union Regional Development Fund.
- Conditions
- Aging, Memory Impairment, Cognitive Decline, Mild Cognitive Disorder
- Trial name
- NEUROAGE (NCT01481246)
- Testing
- Categorization training, Psychosocial and Psychoeducational Group training
- Where
- Cyprus
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Cyprus
Mild Cognitive Impairment, Spatial Navigation
Active Navigation Training
Pilot testing and development of an immersive virtual reality system for spatial navigation training in mild cognitive impairment syndrome.
- Trial name
- ANTaging (NCT05768620)
- Testing
- CAVE, TAU
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- Istituto Auxologico Italiano
Dementia
The Exercogs® Study
Background: Multidomain, technology-based interventions represent a promising approach to dementia prevention by simultaneously targeting cognitive, physical, and social domains.
- Trial name
- Exercogs (NCT07530315)
- Testing
- Exercogs®, Control
- Where
- Portugal
- Volunteers
- 150 people
- Sponsor
- Eduarda Oliosi, MS
Aging Well
Effects of Acute Exercise Intensity on Cerebral Blood Flow and Cognitive Function in Older Adults
This study will analyze the influence of acute bout exercise intensities (continuous moderate and HIIT) on middle cerebral artery velocity (MCAv) to identify which intensity elicits the greatest increase in CBF in older adults…
- Trial name
- NCT05131217
- Testing
- Acute bout of Continuous Moderate Intensity Exercise, Acute bout of High Intensity Interval Training, Control
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cognitive Decline
Trial of a Nutritional Blend to Prevent Cognitive Decline in Older Adults
To demonstrate the beneficial effects of 1-year intervention with a nutritional blend of ingredients on blood levels of nutritional biomarkers known to be linked with cognitive decline in non-demented adults with subjective…
- Trial name
- NCT03080675
- Testing
- Nutrional blend of ingredients including vitamins and fish oil, Control
- Where
- France
- Volunteers
- 362 people
- Sponsor
- Société des Produits Nestlé (SPN)
Aging, Balance
Sleepiness and the Risk of Falling
The purpose of this project is to examine the impact of sleeping pills and waking up in the middle of the night on walking balance and cognitive function, to identify risk factors for falls in older adults.
- Conditions
- Aging, Balance, Sleep
- Trial name
- NCT00383357
- Testing
- zolpidem
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Cholinergic Function
Assessment of Cholinergic and Cognitive Function Using Pharmacologic ASL-Perfusion MRI
This research study will look at how medications affect the pattern of blood flow in the brain. This study will use a special type of MRI (magnetic resonance imaging) scan called perfusion MRI to make measurements of cerebral…
- Trial name
- NCT01379001
- Testing
- Scopolamine, Donepezil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Prodromal Alzheimer's Disease, Preclinical Alzheimer's Disease
TMS for Cognitive Decline in Aging and Preclinical AD
In this research study we want to learn more about the effects of non-invasive brain stimulation on motivation, memory, and brain-network function in cognitively unimpaired older adults and individuals with preclinical…
- Conditions
- Prodromal Alzheimer's Disease, Preclinical Alzheimer's Disease, Healthy Aging, Cognitive Decline
- Trial name
- NCT06956300
- Testing
- Active rTMS
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alzheimer's Disease (AD)
Cognitive Health in Ageing Register: Investigational and Observational Trial Studies in Dementia Research (CHARIOT): Prospective Readiness Cohort (PRO) Longitudinal Study
Alzheimer's disease is a degenerative condition affecting the brain and is the most frequent form of dementia in older adults. Dementia is currently a major healthcare issue in the UK, affecting approximately a million people.
- Trial name
- CPLS (NCT06953167)
- Where
- United Kingdom
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Imperial College London
MCI, Alzheimer Disease
Cognitive Impairment in Ageing People
Mild cognitive impairment (MCI) and neurocognitive disorder such as Alzheimer's disease (AD) and Vascular dementia (VaD) have become common diseases in the elderly.
- Conditions
- MCI, Alzheimer Disease, VAD - Vascular Dementia, Cognitive Impairment
- Trial name
- NCT04360200
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Yamei Tang
Memory Decline, Cognitive Decline
Anti-inflammatory Probiotics in Cognitive Functioning
The goal of this study is to explore the potential impact of an anti-inflammatory probiotic mixture of psychobiotics including Bifidobacterium longum Rosell®-175 and Lactobacillus helveticus Rosell®-52 on cognitive functions in…
- Conditions
- Memory Decline, Cognitive Decline, Cognitive Aging
- Trial name
- CoProM (NCT07165977)
- Where
- Poland
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Social Sciences and Humanities, Warsaw
Alzheimer's Disease, Dementia With Lewy Bodies
Imaging of Brain Amyloid Plaques in the Aging Population
This is a prospective, open label, non-therapeutic, diagnostic imaging study. The purpose of this study is to utilize Pittsburgh Compound B positron emission imaging (PiB PET) to ascertain the relationship between change in…
- Conditions
- Alzheimer's Disease, Dementia With Lewy Bodies, Frontotemporal Dementia, Vascular Dementia
- Trial name
- NCT00950430
- Testing
- Pittsburgh Compound B (C-11 PiB), F-18 FDG, Tau (18-F-AV-1451)
- Where
- United States
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Aging, Cognitive Performance
Development, Validity, and Reliability of the Reactive Skill Test in Older Adults
Aging is associated with cognitive and physical decline, leading to an increased risk of falls in older adults. Recent evidence highlights the critical role of cognitive functions-such as attention, memory, and executive…
- Trial name
- NCT07103837
- Testing
- Reactive Skill Test
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Healthy Aging, Sarcopenia
Plant-based Diets and Healthy Aging
This prospective study investigates the health effects of vegetarian and plant-based diets in middle-aged and older adults in Taiwan, specifically, recruiting 5000 Tzu Chi volunteers.
- Conditions
- Healthy Aging, Sarcopenia, Frailty, Cognitive Decline
- Trial name
- TCAS (NCT07151365)
- Where
- Taiwan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Aging
Theory-Driven Manualized Approach to Improving New Learning and Memory in Healthy Aging and MCI
The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in an aging population.
- Trial name
- NCT06269939
- Testing
- STEM
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Frailty Syndrome
TrackFrailty Project
The TRACKFRAILTY project aims to answer the following main research questions: i) What is the prevalence of physical frailty in individuals living in residential care facilities (RCF) from Portugal's Cova da Beira subregion…
- Trial name
- TrackFrailty (NCT06812286)
- Testing
- Less-volume, More-volume, Control
- Where
- 6 sites in Portugal
- Volunteers
- 45 people
- Sponsor
- University of Beira Interior
Mild Cognitive Impairment (MCI), Cognition
LpD3.5 Intervention Study in Older Adults- LISA-I Trial
This randomized placebo-controlled clinical study, called the LpD3.5 Intervention Study in Older Adults (LISA), aims to evaluate whether a heat-inactivated postbiotic of human origin (LpD3.5) can serve as a non-pharmacological…
- Conditions
- Mild Cognitive Impairment (MCI), Cognition, Brain Aging, Microbiome Dysbiosis
- Trial name
- Postbiotics (NCT07794956)
- Testing
- LpD3.5
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Healthy Ageing
Neuroplasticity: The Effects of Exercise Training on Cognitive and Affective Functioning of Older People
This study investigates the effects of exercise on older people's cognitive and affective functions, and the possible underlying neurobiological pathways.
- Trial name
- NCT04641429
- Testing
- Qigong exercise, Stretching exercise
- Where
- Hong Kong
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Cognitive Deterioration, Disorder of Aging
Exercise, Age-Related Memory Decline, And Hippocampal Function
The purpose of this study is to test the hypothesis that aerobic exercise leads increased cerebral blood volume in the dentate gyrus of the hippocampus in a sample of young and older adults.
- Trial name
- NCT01329653
- Testing
- aerobic training, Wait list
- Where
- United States
- Volunteers
- 233 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute