Clinical trials: Cognition Disorder
Schizophrenia
Effectiveness of Vitamin Supplementation in Treating People With Residual Symptoms of Schizophrenia
This study will evaluate the effectiveness of folate and B12 supplementation in reducing negative symptoms in people with schizophrenia.
- Trial name
- NCT00611806
- Testing
- Folic Acid, B12
- Where
- 3 sites in United States
- Volunteers
- 140 people
- Sponsor
- Massachusetts General Hospital
Borderline Personality Disorder
Ketamine in Borderline Personality Disorder
The purpose of this study is to test the potential of the rapid-acting anti-depressant ketamine to decrease suicidality in Borderline Personality Disorder (BPD).
- Trial name
- NCT03395314
- Testing
- Ketamine, Midazolam
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Yale University
Alzheimer's Disease
Rosiglitazone (Extended Release Tablets) As Adjunctive Therapy For Subjects With Mild To Moderate Alzheimer's Disease
Rosiglitazone (RSG) has been tested in clinical studies and is approved by the FDA as a treatment for type II diabetes mellitus, a disease that occurs when the body is unable to effectively use glucose.
- Trial name
- REFLECT-2 (NCT00348309)
- Testing
- Rosiglitazone Extended Release 2mg, Rosiglitazone Extended Release 8mg, Donepezil
- Where
- 249 sites in United States, Argentina and 17 more
- Volunteers
- 1,496 people
- Sponsor
- GlaxoSmithKline
Polypharmacy, Alzheimer's Disease and Related Dementias
ALIGN: Aligning Medications With What Matters Most (Demonstration)
The goal of this clinical trial is to test the effectiveness of a pharmacist-led, primary care-based de-prescribing intervention for people living with dementia (PLWD) and the person's care partners.
- Conditions
- Polypharmacy, Alzheimer's Disease and Related Dementias, Mild Cognitive Impairment
- Trial name
- NCT06335953
- Testing
- Pharmacist-led deprescribing intervention
- Where
- United States
- Volunteers
- 474 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Huntington's Disease
Coenzyme Q10 in Huntington's Disease (HD)
The goals of this trial are to determine if coenzyme Q10 is effective in slowing the worsening symptoms of Huntington's disease and to learn about the safety and acceptability of long-term coenzyme Q10 use by determining its…
- Trial name
- 2CARE (NCT00608881)
- Testing
- coenzyme Q10
- Where
- 49 sites in United States, Australia and 1 more
- Volunteers
- 609 people
- Sponsor
- Massachusetts General Hospital
Cognitive Impairment, Mild, Depressive Symptoms
Brain Stimulation and Enhancing Cognition in Older Adults
The aim of the current research is to evaluate the efficacy of a combination of Mindfulness-Based Stress Reduction (MBSR) and transcranial direct current stimulation (tDCS) to improve cognitive function in individuals with…
- Conditions
- Cognitive Impairment, Mild, Depressive Symptoms, Anxiety
- Trial name
- NCT03653351
- Testing
- Active Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Washington University School of Medicine
Depression, Mild Cognitive Impairment
Combination Treatment Study for Memory Impairment and Depression
Patients presenting with depression (DEP) and cognitive impairment (CI), represent a unique, understudied population that is difficult to diagnose, treat and estimate prognosis.
- Trial name
- DEP-CI (NCT01658228)
- Testing
- Donepezil, Citalopram, Venlafaxine
- Where
- 2 sites in United States
- Volunteers
- 86 people
- Sponsor
- New York State Psychiatric Institute
Mild Cognitive Impairment
Exercise Training to Improve Cognitive Function
This project is assessing the feasibility of a novel home-based exercise intervention to improve episodic memory in individuals with mild cognitive impairment.
- Trial name
- NCT03824639
- Testing
- Structured exercise, Health Education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Long-Term Memory Decline, Mild Cognitive Impairment
Wayfinding Intervention in High-Fidelity Long-Term Memory
Therapeutic treatment is yet available for declining memory, which is an impairment affecting the quality of life for many older adults and patients with cognitive impairment.
- Trial name
- LABYR (NCT04253587)
- Testing
- LabyrinthVR, Coherence, Tablet
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Heart Transplant Recipients
Intravenous Iron Supplement for Iron Deficiency in Cardiac Transplant Recipients
Iron deficiency is prevalent in heart transplant recipients, and may be associated with reduced functional capacity. The IronIC trial is designed to assess the effect of intravenous iron isomaltoside on exercise capacity, muscle…
- Trial name
- IronIC (NCT03662789)
- Testing
- Iron Isomaltoside 1000
- Where
- Norway
- Volunteers
- 102 people
- Sponsor
- Oslo University Hospital
Bipolar Disorder
Testing the Ability of JNJ-18038683 to Improve Cognition and Reduce Depressive Symptoms in Stable Bipolar Patients
The goals of this study are to evaluate the efficacy of JNJ-18038683 in an 8 week trial to ameliorate the cognitive deficit and reduce residual depressive symptoms in 60 stable bipolar outpatients receiving treatment for…
- Trial name
- NCT02466685
- Testing
- JNJ-18038683
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Herbert Meltzer
Alzheimer's Disease, Mild Cognitive Impairment
Cognition Platform Study in Participants at Risk for Alzheimer's Disease (AD) (MK-0000-413)
The main purpose of this study is to assess the ability of a repeated high-frequency site-based computerized cognitive assessment to evaluate the potential treatment effects of donepezil (MK-0000) compared with placebo among…
- Trial name
- NCT04730635
- Testing
- Donepezil
- Where
- 10 sites in United States, Australia
- Volunteers
- 44 people
- Sponsor
- Merck Sharp & Dohme LLC
Parkinson's Disease
Cognitive Rehabilitation for PD
To investigate the effectiveness of a novel compensatory cognitive rehabilitation program for individuals with Parkinson's disease (PD) and mild cognitive impairment (MCI).
- Trial name
- CogSMART-PD (NCT03335150)
- Testing
- CogSMART-PD, Supportive Care
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- VA Office of Research and Development
Aging, Healthy
ACTIVE: Advanced Cognitive Training for Independent and Vital Elderly
The purpose of the ACTIVE study was to test if cognitive training interventions could maintain functional independence in elders by improving basic mental abilities, with follow-up assessments through five years.
- Trial name
- ACTIVE (NCT00298558)
- Testing
- Cognitive Training
- Where
- 7 sites in United States
- Volunteers
- 2,832 people, healthy volunteers welcome
- Sponsor
- Carelon Research
Dementia, Cognition Disorders
Impact of Anticoagulation Therapy on the Cognitive Decline and Dementia in Patients With Non-Valvular Atrial Fibrillation
Patients will be screened at Intermountain Medical Center and at Intermountain-affiliated anticoagulation clinics in the Salt Lake City region. Patients with non-valvular atrial fibrillation will be considered for study.
- Conditions
- Dementia, Cognition Disorders, Cerebral Ischemic Events
- Trial name
- CAF (NCT03061006)
- Testing
- Dabigatran Etexilate, Warfarin
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Intermountain Health Care, Inc.
Depression, Anxiety
Epidemiology of Depression, Anxiety, and Cognitive Impairment
Many older adults have undetected health problems and lack basic prevention measures. Failure to identify and treat these conditions can lead to unnecessary morbidity and mortality and a decreased quality of life.
- Conditions
- Depression, Anxiety, Cognitive Impairment
- Trial name
- NCT00717041
- Where
- United States
- Volunteers
- 1,206 people
- Sponsor
- University of Rochester
Mild Cognitive Impairment
Interleaved TMS-fMRI for Hippocampal Stimulation: Modeling Dose-Response Relationship in Amnestic Mild Cognitive Impairment
Emerging evidence indicates that dysfunction of hippocampal synaptic plasticity, which precedes neuronal degeneration during the progression of Alzheimer's disease (AD), underlies the hallmark cognitive impairment.
- Trial name
- TMS-fMRI (NCT05515952)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Arizona
Chronic Cerebral Ischemia
Study on Efficacy and Safety of Divaza in Patients With Chronic Cerebral Ischemia and Cognitive Disorders
An open-label, prospective, observational, multicenter study. The study enrolls adult outpatients with CCI from 8 federal districts of the Russian Federation.
- Trial name
- DIAMANT (NCT04370028)
- Testing
- Divaza
- Volunteers
- 2,583 people
- Sponsor
- Materia Medica Holding
Renal Dialysis, Vitamin D Deficiency
Vitamin D Supplementation in Kidney Disease
This is a double-blind placebo controlled pilot study to determine if vitamin D supplementation in hemodialysis (HD) patients will improve physical function and cognition.
- Trial name
- NCT01229878
- Testing
- Cholecalciferol (Vitamin D)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Cognition Disorders in Old Age, Mild Cognitive Impairment
Crossover Trial for Nicotinamide Riboside in Subjective Cognitive Decline and Mild Cognitive Impairment
In this research study we want to learn more about whether taking Niagen, a daily supplement containing a form of Vitamin B3, will improve cognitive function, mood, and daily activity in people with Subjective Cognitive Decline…
- Conditions
- Cognition Disorders in Old Age, Mild Cognitive Impairment, Cognitive Decline
- Trial name
- NCT04078178
- Testing
- Niagen
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Steven E Arnold, MD