Clinical trials: Cocaine Use
Cocaine Dependence
Pharmaco-Magnetic Resonance Spectroscopy (MRS) Study of Clavulanic Acid
A dose-escalation study to determine the optimum dose of Clavulanic Acid (CLAV) for effects on craving and efficacy.
- Trial name
- NCT04411914
- Testing
- Clavulanic Acid
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Temple University
Cocaine Dependence, Cocaine Abuse
Quetiapine for the Reduction of Cocaine Use
This placebo-controlled trial will test the effectiveness of Seroquel XR™ for the treatment of cocaine dependence in non-psychotic individuals who are cocaine dependent.
- Conditions
- Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Drug Abuse
- Trial name
- AZC (NCT00631748)
- Testing
- quetiapine fumarate, Cognitive-behavioral Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Substance Abuse, Intravenous, HIV
Change the Cycle: An RCT to Prevent Injection Initiation
The study will test the efficacy of a hour long, one-on-one, active listening counseling session (called Change the Cycle or CTC) aimed at reducing behaviors among active people who inject drugs (PWID) that research has found to…
- Conditions
- Substance Abuse, Intravenous, HIV, Heroin Dependence, Opioid Dependence
- Trial name
- CTC (NCT02774954)
- Testing
- Change the Cycle
- Where
- 2 sites in United States
- Volunteers
- 979 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Stimulant Use & Co-occuring Opioid Use Disorders
Stimulant Oxytocin Study
This study will investigate the effects of intranasal administration of oxytocin, a social neuropeptide, on reducing stimulant use, enhancing therapeutic engagement, and susceptibility to stress-induced relapse in Veterans with…
- Trial name
- SOS (NCT03016598)
- Testing
- Intranasal oxytocin
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Cocaine Use Disorder
Cocaine Use Reduction and Health
Reduced drug use is a clinically meaningful target for treatment development, but few studies have evaluated the positive impacts produced by this behavioral change, preventing adoption of this endpoint in clinical trials.
- Trial name
- RCT (04) (NCT03224546)
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- William Stoops
Cocaine Use Disorder
A Study to Evaluate EMB 001 in Subjects With Cocaine Use Disorder
EMB-001 is a combination of 2 drugs: the cortisol synthesis inhibitor, metyrapone (Metopirone®), and the benzodiazepine receptor agonist, oxazepam (original trade name Serax®; now marketed as oxazepam (generic) only).
- Trial name
- NCT04501874
- Testing
- EMB-001
- Where
- 4 sites in United States
- Volunteers
- 82 people
- Sponsor
- Embera NeuroTherapeutics, Inc.
Cocaine Use, Unspecified
Behavioral Effects of Drugs (Inpatient): 38
The specific aim of this project is to demonstrate that the decisional analysis/craving regulation aspects of CBT reduce cocaine self-administration in subjects with cocaine use disorder through diminished craving responses.
- Trial name
- NCT03954938
- Testing
- Craving Manipulation, Cocaine
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- William Stoops
Substance Use Disorders
Adaptive Treatment for Alcohol and Cocaine Dependence
1. Primary objective #1: Determine the relative effectiveness of MI-IOP and MI-PC in the full study sample with regard to treatment engagement over weeks 1-12 and cocaine/alcohol use over weeks 1-24.
- Trial name
- NCT01032135
- Testing
- Motivational Interviewing, Telephone counseling, Cognitive Behavioral Therapy (CBT) Counseling
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Cocaine/Crack and Reduction of Compulsion With Biperiden
Considering the effects of the cholinergic system on the drug reward and self-administration mechanisms, acetylcholine (Ach) may play an important role on cocaine dependence process.
- Trial name
- NCT01251393
- Testing
- Biperiden
- Where
- Brazil
- Volunteers
- 111 people
- Sponsor
- Federal University of São Paulo
Cocaine-Related Disorders, Anhedonia
Targeting Anhedonia in Cocaine Use Disorder
The purpose of this study is to examine anhedonia as a potential moderator of treatment outcomes for Cocaine Use Disorder (CUD).
- Trial name
- NCT02773212
- Testing
- d-amphetamine, Contingency management
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Illinois Chicago
Cocaine Use Disorder
Drug Interaction and Self Administration Studies of Compounds for Cocaine Use Disorder
The overall goal of this project is to develop initial human data on effects of novel compounds on safety (interactions with cocaine) and efficacy (subjective response to cocaine and self administration data) in non-treatment…
- Trial name
- NCT02537873
- Testing
- Lorcaserin, Cocaine Intravenous (IV)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Virginia Commonwealth University
HIV/AIDS, Cocaine Use
Project SMART Automated Pillbox Study
The aim of this study is to examine the effect of mHealth tools on antiretroviral (ART) adherence and persistence among HIV-infected individuals with co-occurring cocaine use disorders (CUDs).
- Trial name
- SMART (NCT04418076)
- Testing
- Group A_No feedback, Group B_Automated feedback, Group C_Automated feedback + Clinician feedback
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Yale University
Opioid Use Disorder, Stimulant Use Disorder
Suvorexant for Opioid/Stimulant Co-use
This study will evaluate whether Suvorexant 20mg reduces drug use and craving, and improves sleep and stress among persons with co-occurring opioid use disorder and stimulant use disorder.
- Trial name
- NCT05546515
- Testing
- Suvorexant (dual orexin receptor antagonist)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Cocaine Use Disorder, Anxiety
Role of the Orexin Receptor System in Stress, Sleep and Cocaine Use
The purpose of this study is to determine the effectiveness of a medication called suvorexant in reducing anxiety, improving sleep, and reducing cocaine cravings or cocaine use.
- Trial name
- NCT02785406
- Testing
- suvorexant
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Use Disorder, Contingency Management
Extending Long-term Outcomes Through an Adaptive Aftercare Intervention
Reinforcement interventions have pronounced effects on reducing cocaine use. This study will evaluate a novel approach in which reinforcement frequency varies by patient performance.
- Trial name
- NCT02143063
- Testing
- prize contingency management on a traditional twice weekly schedule for cocaine abstinence, prize contingency management on a variable interval schedule for cocaine abstinence, standard care
- Where
- 4 sites in United States
- Volunteers
- 274 people
- Sponsor
- UConn Health
Cocaine Use Disorder
Identifying Electrophysiological Targets for Transcranial Magnetic Stimulation in Cocaine Use Disorder (Pilot Study)
The purpose of this study is to assess the effects of active intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal cortex (dmPFC) on electroencephalogram (EEG) measures of reward sensitivity and cue reactivity and…
- Trial name
- NCT05631548
- Testing
- iTBS to dmPFC
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine-Related Disorders, Opioid-Related Disorders
The Therapeutic Workplace Initiation Study
The primary purpose of the study is to determine if the central feature of the Therapeutic Workplace, the abstinence reinforcement contingency, is critical to initiate cocaine abstinence in injection drug using methadone patients…
- Conditions
- Cocaine-Related Disorders, Opioid-Related Disorders, Heroin Dependence, Substance Abuse, Intravenous
- Trial name
- NCT00249470
- Testing
- Abstinence & Work, Work Only
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Johns Hopkins University
Cocaine Use Disorders
Glutamatergic Modulation of Motivation Enhancement: A Pilot Feasibility Trial
This study evaluates the feasibility of a treatment paradigm that involves naturalistic cocaine use opportunities in the context of psychotherapy aimed at utilizing these opportunities therapeutically.
- Trial name
- NCT02373124
- Testing
- infusion of NMDA antagonist
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- New York State Psychiatric Institute
Addiction
Cognitive Enhancement as a Target for Cocaine Pharmacotherapy
Specific Aim #1: To determine if galantamine (8 or 16 mg/day) is more effective than placebo in reducing cocaine use as measured by cocaine urine results and self-report days of use.
- Trial name
- NCT01531153
- Testing
- Galantamine
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Yale University
Cocaine Use Disorder, Cocaine Dependence
Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use
Objective: The goal of this clinical trial is to assess the tolerability of an accelerated intermittent theta burst stimulation (iTBS), a form of transcranial magnetic stimulation, intervention in participants with cocaine use…
- Trial name
- NCT02927236
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)