Clinical trials: Cocaine Use
Cocaine Addiction, Opiate Addiction
Real Time Assessment of Drug Craving, Use, and Abstinence During Outpatient: A Development and Feasibility Study
Background: The treatment of addiction often hinges on preventing relapse into drug-using behaviors, which occurs at high rates even after prolonged abstinence.
- Trial name
- NCT00292136
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Abuse Problem, Pregnancy
Prenatal Cocaine, Nasal Oxytocin, and Maternal Psychophysiology
The purpose of this research is to study the effects of nasal oxytocin administration on maternal behaviors that may be influenced by cocaine use during pregnancy.
- Trial name
- NOX (NCT02872467)
- Testing
- Syntocinon treatment
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cocaine Use Disorder (CUD)
The Impact of Cobenfy Maintenance on Cocaine's Effects
The goal of this clinical trial is to learn if Cobenfy influences the effects of cocaine in people with cocaine use disorder. This trial will also provide information about the safety and tolerability of combining Cobenfy and…
- Trial name
- NCT07624227
- Testing
- Cobenfy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Joshua A. Lile, Ph.D.
Substance-Related Disorders, Alcohol-Related Disorders
Conflict Between Maternal Autonomy and Child Health in Substance-use
Qualitative project, comprising open-ended semi-structured interviews with healthcare workers, who provide antenatal care to substance-using women.
- Conditions
- Substance-Related Disorders, Alcohol-Related Disorders, Amphetamine-Related Disorders, Inhalant Abuse
- Trial name
- NCT02797990
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Opioid Use, Opioid Use Disorder
Treating Polysubstance Use Using a Novel Digital Technology
The goal of this clinical trial is to determine the effects of an app to reduce opioid and cocaine use when layered atop methadone treatment as usual among people using both opioids and cocaine.
- Conditions
- Opioid Use, Opioid Use Disorder, Cocaine Use, Cocaine Use Disorder
- Trial name
- POLY (NCT05766631)
- Testing
- DynamiCare Health, Methadone Treatment-As-Usual
- Where
- 5 sites in United States
- Volunteers
- 240 people
- Sponsor
- Friends Research Institute, Inc.
Cocaine Dependence
Efficacy of Caffeine, With and Without Biperiden, as a Maintenance Treatment for Cocaine Dependence
The aim of this study is to assess the efficacy of caffeine compared to placebo as a maintenance treatment for cocaine dependence. Caffeine potentiation with biperiden will be also studied.
- Trial name
- NCT00495183
- Testing
- caffeine, Biperiden
- Where
- Spain
- Volunteers
- 108 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Cocaine-Related Disorders
Effects of Carvedilol on Cocaine Use in Humans - 11
The purpose of this study is to examine carvedilol effects in response to cocaine.
- Trial name
- NCT00000294
- Testing
- Carvedilol
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Use Disorder
Cocaine Cue-reactivity Incubation Study
In this study, the research team proposes to longitudinally assess incubation of cue-reactivity, its reduction with cognitive reappraisal (CR; a self-regulation technique) and examine the impact of CR on clinical outcomes in…
- Trial name
- NCT07091877
- Testing
- Cognitive Reappraisal, Control cue-reactivity task
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cocaine Use Disorders
Impact of Buspirone Maintenance on the Reinforcing Effects of Cocaine
Cocaine use disorders are an unrelenting public health concern. Intensive research efforts have yielded behavioral interventions that reduce cocaine use, however, these interventions are not universally effective and treatment…
- Trial name
- NCT01639157
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- William Stoops
Cocaine Use Disorders
Combined Donepezil and Selegiline Effects on Cocaine-Reinforced Behavior
No medications are currently available for treatment of psychostimulant addiction, a compulsive preoccupation with use of cocaine and related compounds.
- Trial name
- SDC (NCT01495195)
- Testing
- High-dose donepezil, Low-dose donepezil, Selegiline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Midwest Biomedical Research
Addiction, Cocaine-Related Disorders
Benefits of Therapy With Virtual Reality Exposure in the Treatment of Cocaine Use Disorders
Cocaine addiction is a multifactorial disease with important consequences: somatic, psychiatric... The number of applications for treatment for cocaine addiction is gradually increasing from year to year but no conventional…
- Trial name
- CORVI (NCT04280900)
- Testing
- Virtual Reality-Enhanced Cognitive Behavioral Therapy (VR-CBT), Treatment as usual
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Cocaine Use Disorder
SXC-2023 Cocaine Interaction Study
The goal of this clinical trial is to determine whether there are any interactions between the study drug and cocaine. Researchers will compare a treatment group and a placebo group to see if they experience any effects when…
- Trial name
- NCT06343532
- Testing
- SXC-2023
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence
Pharmaco-Magnetic Resonance Spectroscopy (MRS) Study of Clavulanic Acid
A dose-escalation study to determine the optimum dose of Clavulanic Acid (CLAV) for effects on craving and efficacy.
- Trial name
- NCT04411914
- Testing
- Clavulanic Acid
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Temple University
Cocaine Addiction, Alcohol Addiction
Effect of N-acetylcysteine on Alcohol and Cocaine Use Disorders: A Double-Blind Randomized Controlled Trial.
This study evaluates the use of N-acetylcysteine in the treatment of alcohol and cocaine use disorders. Alcohol users will be split in two groups, one will receive the active N-acetylcysteine and the other placebo.
- Trial name
- NCT03018236
- Testing
- Alcohol N-acetylcysteine, Cocaine N-acetylcysteine
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cocaine Use Disorder
[C-11]NPA PET-amphetamine in Cocaine Use Disorders
This study uses [11C]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders (CUD).
- Trial name
- NCT05011760
- Testing
- Baseline [C-11]NPA PET Scan, d-amphetamine, Post-amphetamine [C-11]NPA PET Scan
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rajesh Narendran
Opioid Use Disorder, Stimulant Use Disorder
Suvorexant for Opioid/Stimulant Co-use
This study will evaluate whether Suvorexant 20mg reduces drug use and craving, and improves sleep and stress among persons with co-occurring opioid use disorder and stimulant use disorder.
- Trial name
- NCT05546515
- Testing
- Suvorexant (dual orexin receptor antagonist)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Substance Use Disorders, Opiate Dependence
The Effect of Self-Forgiveness on Self-Stigma in Addiction.
This study has an experimental design and will examine the difference in pre-test and post-test data on the Self-Forgiveness Dual Process Scale (SFDPS) (Griffin, Worthington, Davis, Hook, \& Maguen, 2018) and the Substance Abuse…
- Conditions
- Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder
- Trial name
- NCT03971097
- Testing
- Six Step Model of Self-Forgiveness, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pittsburgh
Cocaine Use
L-tetrahydropalmatine (l-THP) Treatment for Cocaine Use Disorder
Cocaine continues to be one of the most widely used substances of abuse around the world. In the US, an estimated 1.4 million individuals (0.5%) > 12 years were current (past month) cocaine users in 2011.
- Trial name
- NCT02139761
- Testing
- l-tetrahydropalmatine (l-THP)
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Cocaine Dependence, Substance Use Disorders
Transcranial Magnetic Stimulation for Cocaine Addiction
Background: Cocaine use disorders (CUD) is a complex brain disorder, involving several brain areas and neurocircuits. Effective treatments for CUD are still needed.
- Conditions
- Cocaine Dependence, Substance Use Disorders, Chemical Addiction, Mental Disorder
- Trial name
- BRAINSWITCH (NCT03333460)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
Cocaine Dependence
Cocaine Use Disorder and Cortical Dopamine
The goal of this study is to use [C-11]FLB 457 and amphetamine (oral, 0.5 mg/kg) to measure cortical dopamine transmission in cocaine dependent individuals and healthy controls
- Trial name
- NCT03349606
- Testing
- d-amphetamine, [C-11]FLB 457
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh