Clinical trials: Cocaine Related Disorders
Cognitive Dysfunction, Stimulant Use
Change in Cognitive Function in Stimulant Users
In Hong Kong, methamphetamine use is common and cocaine use has increased steadily over the past few years. While the use of ketamine decreased from 35.8% in 2015 to 13.9% in 2017, methamphetamine and cocaine have become the most…
- Conditions
- Cognitive Dysfunction, Stimulant Use, Methamphetamine Abuse, Cocaine Use
- Trial name
- SToP-S_CogFx (NCT04061941)
- Testing
- Cognitive Assessment
- Where
- Hong Kong
- Volunteers
- 93 people
- Sponsor
- The University of Hong Kong
Cocaine-Related Disorders
Psychostimulant Abuse - Novel Treatment Approaches - 1
To determine if acute assessments of profasi and factrel affect plasma cocaine levels and cocaine-induced behavioral changes in men.
- Trial name
- NCT00000325
- Testing
- Gonadorelin
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine Dependence, Opiate Dependence
A Drug Treatment for Cocaine Users Who Are Also on Methadone Maintenance Treatment
The main goal of this study is to evaluate the safety and tolerability of 40 or 80 mg atomoxetine as a treatment for cocaine dependence.
- Trial name
- NCT01802515
- Testing
- Atomoxetine, low dose, Atomoxetine, high dose
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Yale University
Cocaine Dependence, Cocaine Use Disorder
Neurobehavioral Measurement of Substance Users in Outpatient Treatment Setting
This study was an internal program effectiveness evaluation of the effects of a four-session weekly individualized cognitive therapy program (called the "Mind Freedom Plan" (MFP)) on substance use outcomes and substance abuse…
- Conditions
- Cocaine Dependence, Cocaine Use Disorder, Opiate Dependence, Opioid-use Disorder
- Trial name
- NCT03662529
- Testing
- Four-Session Mind Freedom Plan, Treatment as usual therapy
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Cocaine Use Disorder, Opioid Use Disorder
Behavioral Effects of Drugs (Inpatient): 43 (Opioids, Cocaine, n-Acetylcysteine)
The overarching hypotheses of this protocol are that (1) persistent brain glutamate changes induced by chronic opioid use will exacerbate use of cocaine during opioid physical dependence and withdrawal and (2) n-acetylcysteine…
- Conditions
- Cocaine Use Disorder, Opioid Use Disorder, Stimulant Use Disorder
- Trial name
- BED IN 43 (NCT05610072)
- Testing
- n-acetylcysteine, Hydromorphone
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- William Stoops
Cocaine Use Disorder
Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder
In The Netherlands, each year, about 15 thousand people come into treatment because of problems with cocaine use. There is no approved medication for treatment of cocaine addiction and the psychosocial treatment patients receive…
- Trial name
- NCT05529927
- Testing
- Sustained-release Dexamphetamine
- Where
- Netherlands
- Volunteers
- 204 people
- Sponsor
- Parnassia Addiction Research Centre
Cocaine-Related Disorders
Effects of Carvedilol on Cocaine Use in Humans - 11
The purpose of this study is to examine carvedilol effects in response to cocaine.
- Trial name
- NCT00000294
- Testing
- Carvedilol
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opiate Dependence
Employment-Based Depot Naltrexone Clinical Trial
The purpose of this study is to determine whether employment-based naltrexone treatment proves effective in promoting depot naltrexone adherence and drug abstinence.
- Trial name
- NCT00684788
- Testing
- employment-based reinforcement
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Johns Hopkins University
Cocaine Addiction
Deep Brain Stimulation of the Sub-Thalamic Nucleus to Treat Severe and Treatment-resistant Cocaine Addiction.
Cocaine addiction is a chronic condition with severe cardiac, neurologic, psychiatric and social complications. Cocaine is the second most consumed illicit drug in France.
- Trial name
- STUC (NCT02892851)
- Testing
- Deep brain stimulation of the subthalamic nuclei (STN-DBS)
- Where
- France
- Volunteers
- 2 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cocaine Dependence
Oxytocin in Cocaine Dependence
Stress is likely involved in relapse to cocaine use. This project will investigate the role oxytocin may play in the stress response in cocaine-dependent men and women and examine how oxytocin may impact brain activity in…
- Trial name
- NCT01573273
- Testing
- Oxytocin, Saline
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Medical University of South Carolina
Bipolar Disorder, Cocaine Dependence
Citicoline for Bipolar 1 Disorder and Cocaine Dependence
A 12-week, randomized, double-blind, parallel-group, placebo-controlled trial of citicoline as an add-on therapy will be conducted in 200 outpatients with bipolar I disorder and cocaine dependence.
- Trial name
- NCT00619723
- Testing
- Citicoline, Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Cocaine Use Disorder
Pioglitazone as an Adjunct to Cognitive-Behavioral Therapy for Cocaine Relapse Prevention
The purpose of this study is to see how well pioglitazone, when used with cognitive behavioral therapy, works at helping people who have recently stopped using cocaine to continue to not use cocaine.
- Trial name
- NCT04843046
- Testing
- Cognitive Behavioral Therapy (CBT), Pioglitazone
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine-Related Disorders
Bright Light Therapy During Inpatient Cocaine Detoxification
Cocaine is a major psychostimulant used to induce a state of euphoria, improved self-confidence and resistance to fatigue, with suppression of sleep.
- Trial name
- COKELUX (NCT07545798)
- Testing
- Medical light therapy device
- Where
- France
- Volunteers
- 256 people
- Sponsor
- Hôpital le Vinatier
Cocaine-Related Disorders
Treatment With Transcranial Magnetic Stimulation for Cocaine Addiction: Clinical Response and Functional Connectivity.
The purpose of this study is to investigate the short and long term clinical and cognitive effects of repetitive Transcranial Magnetic Stimulation (rTMS) at 5 Hz and/or 10 Hz frequencies on the left dorsolateral prefrontal cortex…
- Trial name
- TMS_COC_CONN (NCT02986438)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Cocaine Dependence
Pilot Study of Lisdexamfetamine for Treatment of Cocaine Dependence
The purpose of this study is to evaluate ideal dose or lisdexamfetamine and tolerability, plus reduction in cocaine use and craving.
- Trial name
- NCT01490216
- Testing
- lisdexamfetamine
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Minnesota
Cocaine-Related Disorders
IV Cocaine Abuse: A Laboratory Model - 3
The purpose of this study is to evaluate the effects of buprenorpine on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving in non-opiate dependent cocaine users.
- Trial name
- NCT00000214
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- New York State Psychiatric Institute
HIV, AIDS
Project RETAIN: Providing Integrated Care for HIV-Infected Crack Cocaine Users
This study will evaluate the efficacy of an integrated "Retention Clinic" in achieving virologic suppression among HIV-infected cocaine (including crack) users by using a two-group randomized, prospective trial.
- Conditions
- HIV, AIDS, Substance Abuse
- Trial name
- NCT01614106
- Testing
- Retention Clinic
- Where
- 2 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cocaine-Related Disorders, Infusions, Intravenous
Cocaine-Metyrapone Interaction Study - 1
The purpose of this study is to examine the safety of two consecutive days of metyrapone (MRP) in subjects who may use cocaine concurrently.
- Trial name
- NCT00033098
- Testing
- Metyrapone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cocaine-Related Disorders
Effectiveness of N-acetylcysteine in Treating Cocaine Dependent Individuals - 1
Recent findings have suggested that N-acetylcysteine (NAC) substantially reduces cocaine drug-seeking behavior in formerly cocaine dependent rats.
- Trial name
- NCT00136825
- Testing
- N-Acetylcysteine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)