Clinical trials: Coagulopathy
COVID 19 Associated Coagulopathy
A Study of the Efficacy of Troxerutin in Preventing Thrombotic Events in COVID-19 Patients
The goal of this clinical trial is to learn if troxerutin works to prevent thrombotic events in mild or severe COVID-19 patients. It will also learn about the safety of troxerutin.
- Trial name
- NCT06355258
- Testing
- Troxerutin, troxerutin + low molecular weight heparin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Westlake University
Coagulopathy
Comparison Between Colloids and Crystalloids on Coagulation and Blood Loss
Infusion of intravenous fluids is mandatory especially in major and prolonged surgeries. However, there is no available optimum ideal type of fluid nor a fixed amount suitable for transfusion but it must be individualized for…
- Trial name
- NCT06683079
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Snake Envenomation, Thrombi
Effects of Bothrops Spp. Snake Envenomation on Willebrand Factor Activity in Martinique and French Guiana
In 2017, the World Health Organization placed snakebites at the top of its list of neglected tropical diseases in an effort to facilitate funding for prevention programs, improve access to anti-venom, and stimulate new research…
- Conditions
- Snake Envenomation, Thrombi, Coagulopathy, Hemorrhage
- Trial name
- WBOTHROPS (NCT06304714)
- Testing
- Patients suffering from envenomation by Bothrops
- Where
- Martinique
- Volunteers
- 30 people
- Sponsor
- University Hospital Center of Martinique
Coagulopathy, Congenital Heart Disease
FFP Usage in Pediatric CV Surgery
When small children undergo heart surgery with the heart-lung machine, in the past, blood products to help the blood clot such as Fresh Frozen Plasma (FFP) was routinely used in children under 10kg.
- Trial name
- NCT05819788
- Where
- Canada
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Trauma Induced Coagulopathy
Pre-hospital Administration of Fibrinogen in Trauma-Induced Coagulopathy
A prospective, randomized controlled trial of fibrinogen concentrate (FC) plus standard of care versus standard of care alone in adult trauma patients with major bleeding or presumed major bleeding is developed to evaluate the…
- Trial name
- PAF-TIC (NCT06582420)
- Testing
- Fibrinogen concentrate, Standard trauma care
- Volunteers
- 52 people
- Sponsor
- Unidade Local de Saude do Arco Ribeirinho
Coagulopathy
Frequency, Predictors and Outcome of Sepsis Induced Coagulopathy in Critical Care Unit
In intensive care units , sepsis remains one of the common causes of mortality and morbidity . The average hospital length of stay for sepsis is twice as long as any other fatal condition .
- Trial name
- NCT06586346
- Volunteers
- 100 people
- Sponsor
- Assiut University
Hip Fractures, Pain, Postoperative
PENG Block vs FNB + ONB in Patients Undergoing Hip Fracture Surgery With Contraindications to Neuraxial Anesthesia
The aim of the study is to demonstrate the efficacy of PENG block as the main anesthetic technique to manage perioperative analgesia for hip fracture surgery compared to femoral and obturator nerve block in patients with…
- Conditions
- Hip Fractures, Pain, Postoperative, Coagulopathy, Comorbidities and Coexisting Conditions
- Trial name
- PENG/FNB+ONB (NCT06457880)
- Testing
- PENG BLOCK, Femoral Nerve Block, Obturator Nerve Block
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Campus Bio-Medico University
Sepsis-induced Coagulopathy
The Diagnostic and Prognostic Value of TAT, PIC, tPAI·C and TM in Sepsis-induced Coagulopathy
In order to evaluate the diagnostic and prognostic value of thrombin-antithrombin complex（TAT）, α2-plasmin inhibitor-plasmin complex（PIC）, tissue plasminogen activator-inhibitor complex（tPAI·C） and thrombomodulin（TM） in…
- Trial name
- NCT06379126
- Testing
- Test thrombin-antithrombin complex（TAT）, α2-plasmin inhibitor-plasmin complex（PIC）, tissue plasminogen activator-inhibitor complex（tPAI·C） and thrombomodulin（TM）
- Volunteers
- 210 people
- Sponsor
- The First Hospital of Jilin University
Cirrhosis, Liver, Coagulopathy
Thromboelastography Guided Blood Product Transfusion for Upper Gastrointestinal Bleeding in Cirrhosis
The goal of this clinical trial is to compare resuscitation strategies in patients with cirrhosis and gastrointestinal bleeding.
- Conditions
- Cirrhosis, Liver, Coagulopathy, GastroIntestinal Bleeding
- Trial name
- STRATEGIC (NCT05583539)
- Testing
- Thromboelastography
- Sponsor
- Vanderbilt University Medical Center
Snake Bites, Coagulopathy, Consumption
Hemostatic Variables In Snakebite Study
Background Novelty The global assays of coagulation, namely the viscoelastometric tests and clot waveform has never been studied in detail before in snakebite victims.
- Trial name
- HISS (NCT04520282)
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
COVID-19 (Coronavirus Disease 2019), COVID-19 Pandemic
University Hospital of Ioannina COVID-19 (Coronavirus Disease 2019) Registry
COVID-19 (Coronavirus Disease 2019) Registry of University Hospital of Ioannina. Retrospective datasource registry with quantitative and qualitative patient data from the hospital medical records.
- Conditions
- COVID-19 (Coronavirus Disease 2019), COVID-19 Pandemic, COVID-19 Pneumonia, COVID-19 Respiratory Infection
- Trial name
- NCT05534074
- Where
- Greece
- Volunteers
- 2,500 people
- Sponsor
- University Hospital, Ioannina
COVID 19 Associated Coagulopathy
Cardiovascular Complications in Children With COVID 19
Prevalance of cardiovascular complications in children with COVID 19 in Assuit university children hospital
- Trial name
- NCT06097403
- Testing
- Covid 19 swap
- Volunteers
- 100 people
- Sponsor
- Assiut University
Sepsis, Sepsis-induced Coagulopathy
Nafamostat Mesilate in the Treatment of Severe Infection-associated Coagulopathy
The objective of this study was to evaluate the therapeutic effect of nafamostat mesilate on patients with severe infection-related coagulation。
- Conditions
- Sepsis, Sepsis-induced Coagulopathy, Nafamostat Mesilate
- Trial name
- NMSICRCT (NCT06078839)
- Testing
- Nafamostat mesilate, 5% glucose
- Volunteers
- 778 people
- Sponsor
- Xu Li
Acute Bleeding on Long-Term Anticoagulation Therapy, Hemorrhage
Fixed Versus Variable Dosing of 4-factor Prothrombin Complex Concentrate for Emergent Warfarin Reversal
The goal of this study is to determine if a fixed dose of 4-factor prothrombin complex concentrate (4FPCC) is as effective as the current standard of care.
- Conditions
- Acute Bleeding on Long-Term Anticoagulation Therapy, Hemorrhage, Significant Bleeding in Patients With a Coagulopathy (Prolonged Thrombin Time), Urgent Reversal of Vitamin K Antagonist (VKA) Anticoagulation
- Trial name
- kcentra (NCT03064035)
- Testing
- 4-factor prothrombin complex concentrate (4FPCC)
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- HealthPartners Institute
Coagulopathy, Liver Transplantation
Clinical Evaluation of the Hemosonics Quantra® Coagulation Monitor in Liver and Multivisceral Transplantation
Severe coagulopathy and operative bleeding are common in liver and multivisceral transplant recipients. This is related to reduced synthesis and function of clotting proteins in end-stage liver disease, thrombocytopaenia…
- Trial name
- NCT04274699
- Testing
- Hemosonics Quantra coagulation monitor
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Snakebite, Coagulopathy, Consumption
Waveform Analysis In Snakebite Victims With Hematotoxicity
In hematotoxic snakebites, due to the lack of a better alternative, 20 minute whole blood clotting test (20'WBCT) or Clotting time remains the standard test in developing countries even though its reliability and sensitivity has…
- Trial name
- WISH (NCT03859154)
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
COVID 19 Associated Coagulopathy
Covid-19 Associated Coagulopathy
This prospective, randomized, open-label, multi-center interventional study is designed to compare the safety and efficacy of two LMWH dosing protocols in patients admitted to the University of Iowa Hospitals with COVID-19 who…
- Trial name
- NCT04360824
- Testing
- Intermediate dose thromboprophylaxis, Standard of Care thromboprophylaxis
- Where
- 2 sites in United States
- Volunteers
- 176 people
- Sponsor
- University of Iowa
Wounds and Injuries, Acute Coagulopathy
Pre-hospital Anti-fibrinolytics for Traumatic Coagulopathy and Haemorrhage (The PATCH Study)
The purpose of this research is to determine whether giving severely injured adults a drug called tranexamic acid (TXA) as soon as possible after injury will improve their chances of survival and their level of recovery at six…
- Trial name
- PATCH (NCT02187120)
- Testing
- Tranexamic Acid
- Where
- 33 sites in Australia, New Zealand
- Volunteers
- 1,310 people
- Sponsor
- Monash University
COVID 19 Associated Coagulopathy
Prevalence of Thrombophilic Gene Polymorphism (MTHFR C677T) in COVID-19patients
Aim of the study is to find the prevalence of thrombophilic gene methylene tetrahydrofolate reductase (MTHFR) gene polymorphism in a sample of COVID-19 patients, aiming at early detection of MTHFR mutant patients and guiding…
- Trial name
- (MTHFR)C677T (NCT05679414)
- Testing
- RT- PCR of 2 ml EDTA blood sample to determine MTHFR C677T genotypes
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Respiratory Failure, Shock
Comparing Post Cardiac Surgery Outcomes in ESRD Patient's With Early Dialysis Versus Standard Care
End-stage renal disease (ESRD) is an important risk factor for coronary and valvular cardiac disease leading to cardiac surgery.
- Conditions
- Respiratory Failure, Shock, Coagulopathy
- Trial name
- NCT04705701
- Testing
- Hemodialysis
- Sponsor
- Northwell Health