Clinical trials: Cluster Detection
Pre-Eclampsia, Eclampsia
An mHealth Strategy to Reduce Pre-Eclampsia and Infant Death in Tanzania
The core of this study is a cluster randomized controlled trial (RCT) of antenatal clinics which are located in four districts in Tanzania.
- Conditions
- Pre-Eclampsia, Eclampsia, Hypertension, Pregnancy-Induced
- Trial name
- NCT03978429
- Testing
- Community-based Pre-eclampsia/Eclampsia Detection and Management, Strengthened Referral Network from Community to Referral hospital levels
- Where
- Tanzania
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Dr. Karen Yeates
Tuberculosis (TB), Pulmonary TB
Xpert MTB/RIF Ultra Trial
Tuberculosis (TB) is the leading cause of death caused by infectious agent globally. Estimated 10 million people get ill with TB every year and in 2022 globally there was an increase in Tuberculosis cases, first time since 2010.
- Trial name
- NCT07135622
- Testing
- Xpert® MTB/RIF Ultra, Referral to the specialized TB clinics
- Where
- Georgia
- Volunteers
- 778 people
- Sponsor
- Nestani Tukvadze
Cluster Headache, Trigeminal Autonomic Cephalgia
Detection of Local Field Potentials in the Ventral Tegmental Area of the Midbrain in Chronic Cluster Headache Patients
The physiopathology of trigeminal-autonomic cephalalgia, and more particularly of cluster headache (CH) is still partially unknown.
- Trial name
- DETECT (NCT05857098)
- Testing
- Local Field potential recording
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Autism Spectrum Disorder, Neurodevelopmental Disorders
Early Detection and Referral for Autism and Neurodevelopmental Disorders at the Maternal and Child Protection Services
This study aims to compare two screening strategies for identifying infants with a potential risk of Autism Spectrum and Neurodevelopmental Disorders to provide early access to care and increase the likelihood of a favorable…
- Trial name
- NCT05815095
- Testing
- PREAUT grid
- Where
- France
- Volunteers
- 10,400 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Diabetes Mellitus, Pre-diabetes
Improving T2DM Detection Using Spot cHbA1c Test
Objectives: To evaluate the effectiveness of active opportunistic screening using point-of-care capillary Hemoglobin-A1c (POC-cHbA1c) testing, compared to venous HbA1c (vHbA1c) testing, in improving detection of type 2 diabetes…
- Trial name
- DM-REACH (NCT06382363)
- Testing
- POC-cHbA1c testing
- Where
- 8 sites in Hong Kong
- Volunteers
- 852 people
- Sponsor
- The University of Hong Kong
Atrial Fibrillation Paroxysmal
The Effect of a Case-finding App on the Detection Rate of Atrial Fibrillation in Primary Care Patients
Atrial fibrillation is a cardiac arrhythmia commonly encountered in a primary care setting. Current screening is limited to pulse palpation and ECG confirmation when an irregular pulse is found.
- Trial name
- NCT04545723
- Testing
- FibriCheck
- Volunteers
- healthy volunteers welcome
- Sponsor
- KU Leuven
Clostridium Difficile
Effectiveness of Isolating Clostridium Difficile Asymptomatic Carriers on the Incidence of Infections
Background: There is an urgent need to develop new strategies to prevent Clostridium difficile infections (CDI). A recent study suggests that a novel infection control bundle (IC bundle) can lead to a significant decrease in the…
- Trial name
- EFFICACI (NCT03223415)
- Testing
- Detection and isolation of C. difficile carriers
- Where
- 5 sites in Canada
- Volunteers
- 4,138 people, healthy volunteers welcome
- Sponsor
- Yves Longtin
Tuberculosis (TB)
Effectiveness of Computer-Aided Detection Chest X-Ray Screening for Improving Tuberculosis Diagnostic Yield in Chinese Primary Health Care Settings: Study Protocol for a Prospective Cluster Randomized Controlled Trial
The global incidence rate and mortality of tuberculosis (TB) pose a challenge to achieving the goals set out in the tuberculosis eradication strategy and the SDGs by 2030.
- Trial name
- NCT06963606
- Testing
- Artificial intelligence-assisted chest X-ray in TB screening, Routine doctors analyze the process of chest X-rays
- Where
- China
- Volunteers
- 22,000 people, healthy volunteers welcome
- Sponsor
- Xuelin Yang
Malaria
Evaluation of Reactive Focal Mass Drug Administration (rfMDA) +/- Reactive Focal Vector Control (RAVC) in Namibia
This is a cluster randomised controlled trial with factorial study design comparing the impact of reactive community-based malaria interventions: 1) presumptive treatment (or rfMDA, reactive focal mass drug administration) versus…
- Trial name
- NCT02610400
- Testing
- RACD, RAVC, rfMDA
- Where
- Namibia
- Volunteers
- 9,845 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cluster Detection
CLUSTER Trial for Outbreak Detection and Response
Despite the critical importance of identifying hospital-associated outbreaks as early as possible in order to limit their spread, there are currently no standardized methods for cluster detection.
- Trial name
- CLUSTER (NCT04053075)
- Testing
- Routine cluster detection, Enhanced cluster detection
- Where
- 82 sites in United States
- Volunteers
- 2,905,455 people
- Sponsor
- Harvard Pilgrim Health Care
Dengue
Combating Dengue With Innovative, Paradigm-shift-Strategies: Early Dengue Surveillance in Adult Aedes Mosquitoes
During dengue outbreaks, the Ministry of Health Malaysia employs various methods to control the spread of disease, including killing the larvae of Aedes mosquitoes, fogging, together with educating and disseminating information…
- Trial name
- NCT03799237
- Testing
- GOS trap and dengue NS1 antigen kit
- Where
- Malaysia
- Volunteers
- 7,979 people, healthy volunteers welcome
- Sponsor
- Jonathan Liew Wee Kent
Chronic Kidney Diseases
Electronic Decision-support System to Improve Detection and Care of Patients With Chronic Kidney Disease in Stockholm
One in 10 adults in Region Stockholm have chronic kidney disease (CKD), which dramatically increases healthcare costs and the risk of medication errors or adverse health outcomes, including cardiovascular disease and death.
- Trial name
- ALMA-CKD (NCT06386172)
- Testing
- Clinical decision support trigger
- Where
- Sweden
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Familial Hypercholesterolemia
Familial Hypercholesterolemia Interpretive Comment - Nudging to Detection.
Familial hypercholesterolemia is the most common inherited disease of the lipid metabolism, however it remains underdiagnosed. Only 15 % of 30.000 possible patients have been found in Denmark.
- Trial name
- FIND (NCT05614219)
- Testing
- Biochemistry interpretive comment on elevated LDL-C levels
- Where
- 2 sites in Denmark
- Volunteers
- 2,000 people
- Sponsor
- Odense University Hospital
HIV/AIDS, Depression
Collaborative Care for the Detection and Management of Depression Among Adults Receiving Antiretroviral Therapy in South Africa
With increasing access to antiretroviral therapy (ART) in South Africa, HIV has transitioned from a terminal illness to a long-term condition.
- Conditions
- HIV/AIDS, Depression, Chronic Diseases of Lifestyle
- Trial name
- COBALT (NCT02407691)
- Testing
- Primary care 101 plus mental health, Standard Primary Care 101
- Where
- 2 sites in South Africa
- Volunteers
- 2,002 people
- Sponsor
- University of Cape Town
Malaria
Community-led Responses for Elimination: Controlled Trial of Reactive Case Detection Versus Reactive Drug Administration
This study is designed to compare the effectiveness of reactive focal drug administration (RFDA) using dihydroartemisinin+piperaquine (DHAP) versus reactive focal test and treat (RFTAT) using artemether+lumefantrine (AL) as a…
- Trial name
- CORE Zambia (NCT02654912)
- Testing
- Reactive Focal Drug Administration
- Where
- Zambia
- Volunteers
- 8,682 people, healthy volunteers welcome
- Sponsor
- PATH
Dyslipidemia
Statins at the Primary Care Level
Hypercholesterolemia, a major cause of disease burden in both the developed and developing world, is estimated to cause 2.6 million deaths annually (4.5% of all deaths) and one third of ischemic heart diseases., and result in…
- Trial name
- EPRINA (NCT02380911)
- Testing
- Educational Intervention
- Where
- 10 sites in Argentina
- Volunteers
- 357 people
- Sponsor
- Institute for Clinical Effectiveness and Health Policy
Smoking, Lung Cancer
Centralized Lung Cancer EARly Detection Among Smokers (CLEAR Study)
This trial studies how well a centralized care strategy works in improving the quality of smoking cessation and shared decision making among patients who smoke and are considering lung cancer screening.
- Trial name
- NCT04200534
- Testing
- Best Practice, Nicotine Patch, Quality-of-Life Assessment
- Where
- 3 sites in United States
- Volunteers
- 358 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Tuberculosis
Increased Tuberculosis Case Detection - DiOpTB
As estimated by the WHO 10.6 million new Tuberculosis (TB) cases were identified in 2022- while more than three million went undetected and untreated.
- Trial name
- DiOpTB (NCT06437184)
- Testing
- ODP
- Where
- 2 sites in Ethiopia, Guinea-Bissau
- Volunteers
- 1,584 people
- Sponsor
- Aarhus University Hospital
Colorectal Cancer, Healthy
Computerized Feedback in Colonoscopy
In a cluster-randomized study compare if feedback from two computerized feedback systems doing a colonoscopy (CoPS and CoRS) can improve the adenoma detection rate and decrease patient discomfort.
- Trial name
- NCT04862793
- Testing
- Colonoscopy Progression Score (CoPS), Colonoscopy Retraction Score (CoRS)
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Copenhagen Academy for Medical Education and Simulation
Pulmonary Nodule, Clinical Decision Support
AI-Assisted Management of Pulmonary Nodules Found on Low-Dose CT in Health Screening
Pulmonary nodules are frequently found during low-dose computed tomography (LDCT) health screening. The main challenge is not only detecting nodules, but also recommending the appropriate next step, such as routine follow-up…
- Trial name
- AI-NoduleCare (NCT07841600)
- Testing
- AI-Assisted Pulmonary Nodule Reporting Workflow, Conventional Pulmonary Nodule Reporting Workflow
- Volunteers
- 2,000 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University