Clinical trials: Clonal Hematopoiesis
Venous Thromboses, Thromboembolic Disease
Clonal Hematopoiesis and NETs Formation in Venous Thrombosis (CLODETTE)
Thrombo-embolic venous diseases are represented by deep venous thrombosis and/or pulmonary embolism. In some patients with repeated thrombosis or occurrence of thrombosis in unusual sites, the etiological workup remains negative…
- Conditions
- Venous Thromboses, Thromboembolic Disease, Neutrophil Extracellular Trap Formation, Clonal Hematopoiesis of Indeterminate Potential
- Trial name
- CLODETTE (NCT05711173)
- Testing
- Additional blood sampling
- Where
- 7 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Bordeaux
Anemia, Clonal Hematopoiesis
Aging of Hematopoietic Stem Cells - Molecular Architecture of Marrow Dysplasia and Clinical Contribution of Ineffective Hematopoiesis to Frailty in the Elderly
The prevalence and incidence of anemia tend to increase with advancing age. Relatively low hemoglobin concentrations are a common laboratory finding in the elderly, for the most part judged by physicians as a sign without…
- Trial name
- NCT03907553
- Testing
- targeted genome sequencing
- Where
- Italy
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Cancer
Identification of Patients With Age-Related Clonal Hematopoiesis (ARCH) Among Cancer Survivors
The purpose of this study is to see if patients with cancer have a certain amount of genetic mutations in their blood. If certain levels of mutations are found in specific genes, patients may have a condition known as ARCH.
- Trial name
- ARCH-001 (NCT03878407)
- Testing
- Monitoring of ARCH variants
- Where
- Canada
- Volunteers
- 2,400 people
- Sponsor
- University Health Network, Toronto
Heart Failure With Reduced Ejection Fraction
Exploration of Clonal Hematopoiesis of Indeterminate Potential in Non-ischemic Heart Failure With Reduced Ejection Fraction
Clonal hematopoiesis of indeterminate potential (CHIP) refers to a phenomenon in which blood cells with somatic mutation circulate in the peripheral blood due to abnormal proliferation and differentiation of mutant hematopoietic…
- Trial name
- NCT05981144
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Clonal Hematopoiesis
The Clonal Hematopoiesis & Inflammation in Vasculature Registry and Biorepository
This study will investigate the association between clonal hematopoiesis and other conditions. Clonal hematopoiesis (CH) refers to the mutations in a person's stem cells which commonly affect people as they get older.
- Trial name
- CHIVE (NCT06701214)
- Testing
- Blood collection, Saliva collection, Bone marrow collection
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Heart Failure
Clonal Hematopoiesis of Indeterminate Potential in Heart Failure.
This study is part of the Rico Macro-Project, a multidisciplinary research program promoted by FROM in collaboration with the ASST-PG23 and ATS Bergamo, aiming to investigate the role of clonal hematopoiesis on inflammation…
- Trial name
- RICO-HF (NCT06626685)
- Testing
- Clinical and instrumental examination
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS