Clinical trials: Clinical Deterioration
Stroke
Clinical Study on Screening of Nursing Evaluation Indicators of Stroke Patients
The purpose of this study was to use Delphi method to screen the nursing observation indexes of patients with stroke, and to screen the sensitive indexes with high correlation with the severity of stroke.It is used to guide…
- Trial name
- NCT03650751
- Testing
- Nursing observation indexes
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shenzhen Second People's Hospital
Aortic Valve Disease, Artificial Heart Valves
Post-market Clinical Monitoring of the Safety and Efficacy of the Aortic Valve Bioprothesis
The goal of this multicenter prospective cohort study is to evaluate the long-term safety and efficacy of clinical outcomes of aortic valve replacement using the "TiAra" prosthesis with or without concomitant procedures.
- Trial name
- TiAra (NCT05998694)
- Where
- Russia
- Volunteers
- 2,000 people
- Sponsor
- Closed Joint-Stock Company NeoCor
Aneurysmal Subarachnoid Hemorrhage
Clinical Research Study With Clazosentan to Evaluate Its Effects on Preventing Complications Due to the Narrowing of the Blood Vessels (Vasospasm) in the Brain, Caused by Bleeding Onto the Surface of the Brain
This study will evaluate if clazosentan (on top of normal routine medical care) can reduce the risk of developing complications related to cerebral vasospasm and permanent brain damage as compared to normal routine medical care…
- Trial name
- REACT (NCT03585270)
- Testing
- Clazosentan
- Where
- 80 sites in United States, Austria and 13 more
- Volunteers
- 409 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Sepsis, Deterioration, Clinical
Outcomes of Digital Alerting Systems in Secondary Care
Why? The investigators are trying to find out if participants that suddenly deteriorate on the ward can be identified sooner by wearing a wearable sensor.
- Trial name
- NCT04638738
- Testing
- SensiumVitals wearable patch sensor
- Where
- United Kingdom
- Volunteers
- 650 people
- Sponsor
- Imperial College London
Aortic Valve Stenosis, Structural Valve Deterioration
Comparison of Allegra vs Sapien Transcatheter Aortic Valves in Valve-In-Valve Indication
The VIVALL-2 study is a randomized trial to compare the self-expandable supra-annular Allegra and the balloon-expandable intra-annular Edwards transcatheter valve systems in patients with degenerated biological aortic surgical…
- Trial name
- NCT06049654
- Testing
- NVT ALLEGRA TAVI System TF, EDWARDS SAPIEN 3 or SAPIEN ULTRA SYSTEM
- Where
- 12 sites in Italy, Spain and 1 more
- Volunteers
- 104 people
- Sponsor
- Fundación EPIC
Pulmonary Embolism and Thrombosis, Deterioration, Clinical
An Observational Study About Adverse Outcomes in Acute Pulmonary Embolism Patients
This multi-center retrospective study collected clinical, laboratory, and CT pulmonary angiography parameters with acute pulmonary embolism patients from admission to predict adverse outcomes within 30 days after admission into…
- Trial name
- NCT05481242
- Testing
- retrospective observational study
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shengjing Hospital
Cerebral Infarction, Subcortical Infarction
Early Neurological Deterioration in Recent Small Subcortical Infarction
Recent small subcortical infarction (RSSI) is defined as a small deep infarction in the territory of a perforating artery with maximum axial diameters (MAD) of less than 20 mm.
- Conditions
- Cerebral Infarction, Subcortical Infarction, Deterioration, Clinical, Progression
- Trial name
- NCT05679986
- Testing
- no intervention
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Yuan Gao
Vital Signs, Clinical Deterioration
Image-based Remote Monitoring in Cardiac Surgery Patients
In this observational study, 100 patients admitted to the Cardiothoracic ward will be additionally monitored with video-cameras. The video-cameras will measure heart- and respiration rate continuously.
- Trial name
- FORSEE-3 (NCT06099327)
- Testing
- Image-based vital sign monitoring
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Clinical Deterioration, Hospital Medicine
Realtime Streaming Clinical Use Engine for Medical Escalation
The escalation of care for patients in a hospitalized setting between nurse practitioner managed services, teaching services, step-down units, and intensive care units is critical for appropriate care for any patient.
- Conditions
- Clinical Deterioration, Hospital Medicine, Monitoring, Physiologic
- Trial name
- ReSCUE-ME (NCT04026555)
- Testing
- MEWS++ Monitoring, Predictor Score
- Where
- United States
- Volunteers
- 2,780 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Vital Sign, Clinical Deterioration
WARD-Home - Continuous Monitoring of Vital Parameters After Discharge
The current pilot study aims to investigate the feasibility of wireless, continuous monitoring of patients in the days around discharge after an acute medical hospitalization, as well as occurrence of deviating vital signs in…
- Trial name
- NCT05223504
- Testing
- Continuously monitoring
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Clinical Deterioration
Prevention of Functional and Cognitive Impairment Through a Multicomponent Exercise Program in Hospitalized Older Adults
The goal of this clinical trial is to determine whether a multicomponent exercise program improves functional capacity and cognitive status in hospitalized elderly patients aged 75 and older.
- Trial name
- PREDISC (NCT06634147)
- Testing
- Exercise
- Where
- 2 sites in Spain
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Fundacion Miguel Servet
Sepsis, Septicemia
A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning
In this study, the investigators will deploy a software-based clinical decision support tool (eCARTv5) into the electronic health record (EHR) workflow of multiple hospital wards.
- Conditions
- Sepsis, Septicemia, Respiratory Failure, Hemodynamic Instability
- Trial name
- NCT05893420
- Testing
- eCARTv5 clinical deterioration monitoring, Standard of care control
- Where
- 3 sites in United States
- Volunteers
- 30,000 people
- Sponsor
- AgileMD, Inc.
Dementia of the Alzheimer Type, Age-related Cognitive Decline
Dosage and Efficacy of Probucol-induced apoE to Negate Cognitive Deterioration
DEPEND is an open-label but dosage-masked trial of the retired cholesterol-lowering drug probucol as an agent to increase availability of apolipoprotein E (apoE) in the cerebrospinal fluid (CSF) of cognitively intact older…
- Conditions
- Dementia of the Alzheimer Type, Age-related Cognitive Decline, Mild Cognitive Impairment Due to Alzheimer Disease
- Trial name
- DEPEND (NCT02707458)
- Testing
- Probucol
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Monitoring, Clinical Deterioration
Continuous Monitoring of Patients in and After the Acute Admission Ward to Optimize Clinical Pathways
Hospitals aim to hospitalize patients when necessary and discharge patients when possible. However, the triage process and discharge management of patients in e.g. the Acute Admission Ward, is not a trivial task.
- Conditions
- Monitoring, Clinical Deterioration, Acute Disease
- Trial name
- NCT05181111
- Testing
- Wearable Sensor, Usual Care
- Where
- Netherlands
- Volunteers
- 400 people
- Sponsor
- Rijnstate Hospital
Chronic Obstructive Pulmonary Disease, Dyspnea
Wireless Assessment of Respiratory and Circulatory Distress in Chronic Obstructive Pulmonary Disease
For patients admitted to the medical ward, it is usually difficult to predict if their clinical condition will deteriorate, however subtle changes in vital signs are usually present 8 to 24 hours before a life-threatening event…
- Trial name
- WARD-COPD (NCT03467815)
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Bispebjerg Hospital
Deterioration, Clinical
Feasibility and Initial Clinical Impressions of Predictive Monitoring Integrated With the RACE Team
Rapid response teams (RRTs) have been adopted by hospitals to provide urgent critical care to hospitalized patients who require quick intervention to prevent further deterioration.
- Trial name
- VSI (NCT05108376)
- Testing
- Visensia Safety Index (VSI)
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Ottawa Hospital Research Institute
Acute Respiratory Distress Syndrome, Coronavirus
Pemziviptadil (PB1046), a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Improvement to Hospitalized COVID-19 Patients at High Risk for Rapid Clinical Deterioration and Acute Respiratory Distress Syndrome (ARDS).
This is a multicenter, randomized, double-blind, parallel group study to investigate the efficacy of pemziviptadil (PB1046) by improving the clinical outcomes in hospitalized COVID-19 patients at high risk for rapid clinical…
- Conditions
- Acute Respiratory Distress Syndrome, Coronavirus, Hypoxic Respiratory Failure, Hypoxemic Respiratory Failure
- Trial name
- VANGARD (NCT04433546)
- Testing
- Pemziviptadil (PB1046), Low Dose (10 mg) Control
- Where
- 4 sites in United States
- Volunteers
- 54 people
- Sponsor
- PhaseBio Pharmaceuticals Inc.
Mitral Valve Disease
Management and Clinical Outcomes of Patients With Severe Mitral Valve Disease Not Suitable for Surgery
The objective of this study is to collect in a prospective registry all cases of French patients undergoing an assessment for percutaneous treatment of mitral valve disease on a native valve or due to deterioration after surgical…
- Trial name
- MITRAGISTER (NCT02925819)
- Where
- 3 sites in France
- Volunteers
- 500 people
- Sponsor
- French Cardiology Society
Early Clinical Deterioration, Early Warning Score
Usefulness of Early Warning Systems in Detecting Early Clinical Deterioration After Intensive Care Discharge
The VitalPac Early Warning Score (VIEWS) scoring system, developed by Prytherch et al., Is an early warning system that aims to predict the first 24-hour mortality in emergency patients.
- Trial name
- NCT03910777
- Testing
- Early Warning Score
- Where
- Turkey (Türkiye)
- Volunteers
- 390 people
- Sponsor
- Erzincan University
Clinical Deterioration
Predictive Monitoring - IMPact in Acute Care Cardiology Trial
Hypothesis: display of predictive analytics monitoring on acute care cardiology wards improves patient outcomes and is cost-effective to the health system.
- Trial name
- PM-IMPACCT (NCT04359641)
- Testing
- CoMET Display
- Where
- United States
- Volunteers
- 10,424 people
- Sponsor
- Jamieson Bourque, MD