Clinical trials: Cirrhosis, Decompensated
End-stage Liver Disease (ESLD), Cirrhosis, Liver
RTX001 Autologous Engineered Macrophages for Liver Cirrhosis
The purpose of this study is to assess the safety and efficacy of RTX001 in patients with end-stage liver disease. This study is the first time RTX001, a macrophage cell therapy engineered to have an anti-inflammatory and…
- Conditions
- End-stage Liver Disease (ESLD), Cirrhosis, Liver, Cirrhosis, Decompensated, Liver Diseases
- Trial name
- EMERALD (NCT06823713)
- Testing
- RTX001
- Where
- 15 sites in Spain, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Resolution Therapeutics Limited
Hepatitis B, Decompensated Cirrhosis
Re-compensation and Its Clinical Characteristics in HBV Decompensated Cirrhosis
In this study, treatment-naïve HBV-related cirrhosis patients were retrospectively enrolled at the first episode of decompensation (ascites or variceal hemorrhage).
- Trial name
- NCT05086536
- Testing
- no intervention
- Where
- 7 sites in China
- Volunteers
- 600 people
- Sponsor
- Beijing Friendship Hospital
Exocrine Pancreatic Insufficiency
Prevalence of Exocrine Pancreatic Insufficiency in Patients With Decompensated Cirrhosis
Exocrine pancreatic insufficiency (EPI) is the inability of the pancreas to perform a normal digestive function. The prevalence of IPE in patients with decompensated hepatic cirrhosis (HC) is unknown and most published series are…
- Trial name
- (EPIIHC) (NCT03236038)
- Testing
- Labeled triolein urea breath test
- Where
- Spain
- Volunteers
- 125 people
- Sponsor
- Corporacion Parc Tauli
Hypertension, Portal, Liver Cirrhosis
A Study to Test Whether Avenciguat Helps People With Liver Cirrhosis and High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver) Who Had Bleeding in the Esophagus or Fluid Accumulation in the Belly
This study is open to adults with advanced liver cirrhosis caused by hepatitis B, hepatitis C, alcohol-related liver disease, non-alcoholic steatohepatitis or other causes.
- Trial name
- NCT06082843
- Testing
- Avenciguat
- Where
- 15 sites in United States, Austria and 8 more
- Volunteers
- 22 people
- Sponsor
- Boehringer Ingelheim
Decompensated Cirrhosis
Risk Stratification for Adverse Events in End-Stage Liver Disease
Study Goal The goal of this multicenter, prospective observational cohort study is to develop and validate a multimodal predictive model that integrates portal hypertension, inflammation, and liver function indicators to predict…
- Trial name
- D-TECT (NCT07880678)
- Testing
- Routine Clinical Care with Biospecimen Collection and Free MRE Testing
- Volunteers
- 2,235 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Liver Cirrhosis
Autologous Bone Marrow Derived Stem Cells in Decompensate Cirrhotic Patients
Liver cirrhosis (LC) is the final outcome for chronic liver diseases. The liver transplantation is the sole effective therapy available to these patients.
- Trial name
- NCT01120925
- Testing
- MNC, CD133, Control
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Royan Institute
Decompensated Cirrhosis, AKI - Acute Kidney Injury
Study to Evaluate the Efficacy of Intravenous Administration of Human Albumin Versus Saline Solution in Patients With descompénsate Cirrhosis Grade 1B or Higher Renal Failure
This is a phase IV, unicentric, open-label. Patients eligible for this study will be patients with AKI 1B or greater and decompensated cirrhosis from the hospital participating in the study
- Trial name
- LIVER-AKI (NCT07270874)
- Testing
- Saline solution (NaCl 0.9%)
- Volunteers
- 114 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Decompensated Cirrhosis
Fecal Microbiome Transplantation in Cirrhosis: Trial in Patients With Decompensated Cirrhosis
This is a phase III, multicenter, double-blind, placebo-controlled, randomized clinical trial to evaluate the safety and efficacy of Fecal Microbiota Transplantation (FMT) from healthy subjects to patients with decompensated…
- Trial name
- LiverGut (NCT06533852)
- Testing
- Fecal Microbiome Transplantation (FMT)
- Where
- 8 sites in Spain
- Volunteers
- 190 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Decompensated Cirrhosis
Human Umbilical Cord-derived Mesenchymal Stem Cells for Decompensated Cirrhosis (MSC-DLC-2)
Decompensated cirrhosis has a high overall mortality rate. There is a large unmet need for safe and alternative therapeutic potions.
- Trial name
- NCT05224960
- Testing
- UC-MSCs
- Where
- 7 sites in China
- Volunteers
- 140 people
- Sponsor
- Beijing 302 Hospital
Cirrhosis
To Study and Compare the Clinical Course and Development of Organ Failure in Severe Acute Hepatitis Without Ascites, Non-cirrhotic and Cirrhotic Patients With Ascites [Acute on Chronic Liver Failure] and Acute Deterioration of Previously Decompensated Cirrhosis.
The study will be conducted on patients admitted to Department of Hepatology from MARCH 2015 to DECEMBER 2016 at ILBS, New Delhi.All patients presenting to ILBS fulfilling the inclusion criteria will be included in the study and…
- Trial name
- NCT02465619
- Where
- India
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhosis, Liver, Rectal Colonization
Longitudinal Surveillance of Rectal Colonization and Transmission by Resistant Bacteria in Acutely Decompensated Cirrhosis
Antimicrobial resistance has emerged as a global threat, and multidrug resistance organisms (MDROs) form one of the foremost challenges in the setting of decompensated cirrhosis.
- Conditions
- Cirrhosis, Liver, Rectal Colonization, Multidrug Resistance Organisms
- Trial name
- NCT06511492
- Testing
- No intervention in this study
- Volunteers
- 1,289 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Liver Cirrhosis
Muscle Tissue Oxygenation in Patients With Decompensated Liver Cirrhosis
Patients with decompensated liver cirrhosis exhibit numerous hemodynamic and microvascular changes, i.e., low systemic blood pressure and peripheral vasodilatation.
- Trial name
- NCT00849641
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University of Regensburg
Liver Cirrhosis
Safety and Efficacy of SHED for Decompensated Liver Cirrhosis
This study is an prospective, randomized control study. Patients with decompensated cirrhosis will be randomly assigned to receive 4 times of SHED treatment plus standard medical care(treatment）or standard medical care (control).
- Trial name
- NCT03957655
- Testing
- SHED group
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Changhai Hospital
Decompensated Cirrhosis, Severe Ascites
Efficacy of Combination of Midodrine With Propranolol in Preventing First Bleed in Decompensated Cirrhotics With Severe Ascites.
Study population: Decompensated cirrhotics requiring primary prophylaxis with asciteswho are admitted to and attending the OPD at ILBS.
- Trial name
- NCT04208776
- Testing
- Propranolol, Midodrine
- Where
- India
- Volunteers
- 140 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhosis, Ascites Hepatic
Albumin Assisted Diuresis in Patients with Cirrhosis and Ascites
A small, pilot proof-of-concept placebo-controlled trial to explore the effects of albumin on diuresis in patients with cirrhosis, ascites and lower extremity edema.
- Trial name
- NCT06812390
- Testing
- Albumin infusion (25% albumin), Normal Saline (0.9% NaCl)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Anahita Rabiee MD MHS