Clinical trials: Cirrhosis, Decompensated
Decompensated Cirrhosis
Management of Decompensated HCV Cirrhotic Patients
-The limited treatment varieties of decompensated cirrhosis due to hepatitis C virus (HCV) remain a challenge. In patients with reduced hepatic reserve, DAAs may be associated with complications as worsening decompensation.
- Trial name
- NCT03547895
- Testing
- Sofosbuvir 400mg (Sovaldi) + Daclatasvir 60 mg (Daklinza) + Ribavirin 200 mg (Rebetol), vitamin K (Phytomenadione) 10 mg+ furosemide and spironolactone (Lasilactone) 50 mg + milk thistle (Silymarin) 140 mg + Albumin infusion
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Liver Cirrhosis, Malnutrition
Establishment of a Model for Predicting the Prognosis of HBV-related Decompensated Liver Cirrhosis Based on RFH-NPT
For all countries, chronic liver disease and liver cirrhosis is one of the important disease burdens. Malnutrition is an important complication of liver cirrhosis, which always runs through the course of liver cirrhosis.
- Trial name
- NCT05513651
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Hepatic Impairment, Cirrhosis
Effect of Hepatic Impairment on the Pharmacokinetics and Safety of VIR-2218 and VIR-3434
In this study, a single dose of VIR-2218 up to 200 mg SC or VIR-3434 at 300 mg SC monotherapy or a combination of VIR-2218 and VIR-3434 will be administered to assess the pharmacokinetic (PK) exposure, safety, and tolerability of…
- Trial name
- NCT05484206
- Testing
- VIR-2218, VIR-3434
- Where
- 4 sites in United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Vir Biotechnology, Inc.
Decompensated Cirrhosis
Effect of Liver MSCs in Blood of Patients With Liver Disease.
Liver MSCs or Adult Derived Human Liver Stem/progenitor Cells (ADHLSCs) infusions are currently being developed as a therapeutic medicinal product for the treatment of different liver defects.
- Trial name
- CIRRHOTIQUE01 (NCT03632148)
- Where
- Belgium
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Portal Hypertension
The Effect of Probiotics (VSL) on Portal Hypertension
The investigators will address the hypothesis that portal hypertension is mediated in part by bacterial or endotoxin translocation and the production of inflammatory mediators (tumor necrosis factor-α (TNFα), etc.).
- Trial name
- NCT01032941
- Testing
- Probiotic
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Liver Cirrhosis, Experimental
Antiviral Therapy in Decompensated Hepatitis C Virus (HCV) Cirrhosis
To evaluate: 1. the impact of combined antiviral therapy (Peginterferon plus ribavirin) on natural history of patients affected with HCV decompensated cirrhosis, after sustained virological response. A controlled study. 2.
- Trial name
- NCT00301509
- Testing
- peginterferon and ribavirin
- Where
- Italy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
Cirrhosis of the Liver, Ascites
Evaluation of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects With Decompensated Cirrhosis With Ascites
This protocol represents an open-label pilot study to assess whether oral administration of SBI in subjects with decompensated cirrhosis with ascites can lead improvements in the management of the disease.
- Conditions
- Cirrhosis of the Liver, Ascites, Spontaneous Bacterial Peritonitis
- Trial name
- NCT02608658
- Testing
- Medical food, EnteraGam (Serum-Derived Bovine Immunoglobulin)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Hepatic Encephalopathy, Acute-On-Chronic Liver Failure
Immune Profile, Neuronal Dysfunction, Metabolomics and Ammonia in Therapeutic Response of HE in ACLF
There is very little data related to the natural history of disease from covert HE (MHE and grade 1 HE) to overt HE (grades II, III and IV) in ACLF, with implications on long-term neurological recovery after an episode of overt…
- Conditions
- Hepatic Encephalopathy, Acute-On-Chronic Liver Failure, Decompensated Cirrhosis
- Trial name
- NCT05421351
- Where
- India
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Liver Cirrhosis
Observational Prospective Study.at the End of the Study the Patients Will be Classified According to PH,Serum Bicarbonate and Serum Sodium Into 6 Groups and Statistical Analysis Will be Performed Using Spss
1-to identify the prognostic value of serum bicarbonate and serum electrolytes at time of admission and their association with development of complications ,length of hospital stay ,prognosis and mortality in hospitalized…
- Trial name
- NCT05082064
- Testing
- arterial blood gases and serum electrolytes
- Where
- Egypt
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Sohag University
Hepatocellular Carcinoma, Cirrhosis
Branched-chain Amino Acid Supplementation for Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the fifth most common cause of cancer death among men. While several new treatment options have recently become available, they are costly and have a potential for significant, adverse side…
- Conditions
- Hepatocellular Carcinoma, Cirrhosis, Liver Failure
- Trial name
- BCAA in HCC (NCT03908255)
- Testing
- Branch Chain Amino Acid, maltodextrin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Hemostasis in Decompensated Liver Cirrhosis, Inflammation in Decompensated Liver Cirrhosis
Hemostasis in Liver Cirrhosis and Hepatocellular Cancer
Evaluating hemostasis in decompensated liver cirrhosis with novel hemostatic assays.
- Trial name
- HELICS (NCT06212635)
- Testing
- T-TAS
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Region Stockholm