Clinical trials: Cirrhoses, Liver, open to volunteers
Liver Cirrhoses, Hepatocellular Carcinoma (HCC)
A Comparative Study of MRI and Ultrasound for Detection of Primary Hepatocellular Carcinoma, Body Composition and Risk Factors for Decompensation in Liver Cirrhosis
DETECT-HCC-ESLD is a prospective multicenter study designed to examine early detection and risk stratification of hepatocellular carcinoma (HCC) in individuals with advanced liver disease.
- Conditions
- Liver Cirrhoses, Hepatocellular Carcinoma (HCC), Sarcopenia in Liver Cirrhosis, Portal Hypertension Related to Cirrhosis
- Trial name
- DETECT-HCC (NCT07291141)
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Mattias Ekstedt
Cirrhoses, Liver, Hepatic Encephalopathy (HE)
Study on Proteomic and Microbiome Changes in Patients With Hepatic Encephalopathy (HE)
The objective of this observational study is to compare the differences in proteomics and gut microbiome between the liver cirrhosis group without hepatic encephalopathy and the hepatic encephalopathy group through proteomics and…
- Trial name
- NCT07150195
- Where
- China
- Volunteers
- 32 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Liver Cirrhoses
Umbilical Cord Mesenchymal Stem Cell for Liver Cirrhosis Patient Caused by Hepatitis B
The study aims to evaluate the effect of allogeneic mesenchymal stem cell therapy on patients who suffered from liver cirrhosis caused by Hepatitis B.
- Trial name
- NCT04357600
- Testing
- Allogeneic Umbilical Cord Mesenchymal Stem Cell
- Where
- Indonesia
- Volunteers
- 12 people
- Sponsor
- PT. Prodia Stem Cell Indonesia
Cirrhoses, Liver, Decompensated Cirrhosis of Liver
Role of Allopurinol in Prevention of Complications Related to Decompensated Cirrhosis of Liver
Cirrhosis, a leading cause of global mortality, progresses to life-threatening complications like ascites, hepatic encephalopathy, and hepatorenal syndrome.
- Trial name
- NCT07800598
- Testing
- Allopurinol Tablet
- Where
- 2 sites in Bangladesh
- Volunteers
- 54 people
- Sponsor
- Bangladesh Medical University
Diagnostic Techniques, Ophthalmological, Liver Transplantation
Evaluation of Chronic Liver Disease Condition and Transplant Prognosis Assisted by Eye Biological Parameters
This study investigates the correlation between ocular biological characteristics and overall conditions before and after liver transplantation by collecting ocular biological characteristics.
- Conditions
- Diagnostic Techniques, Ophthalmological, Liver Transplantation, Liver Cirrhoses
- Trial name
- NCT06756009
- Testing
- Ophthalmic examination, General Condition Examination
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Liver Cirrhoses
Non-Invasive Characterization of Focal Liver Lesions in Liver Cirrhosis
This study aims to analyze non-invasive characterization focal liver lesions in patients with liver cirrhosis. The diagnostic accuracy and predictive value of non-invasive methods is studied.
- Trial name
- NICETIES (NCT03746210)
- Testing
- Standard diagnostic procedures
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bonn
Cancer Diagnosis, Liver Cancer, Adult
Raman Spectroscopy-Based Deep Learning Model for Early Pan-Cancer Early Diagnosis
The goal of this observational study is to explore whether a Raman-based, deep learning-assisted approach can be used to develop an effective method for early pan-cancer screening.
- Conditions
- Cancer Diagnosis, Liver Cancer, Adult, Cancer Screening, Colorectal Cancer (CRC)
- Trial name
- NCT06822413
- Testing
- No Interventions
- Where
- 4 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cirrhoses, Liver
Evaluating the Efficacy of Vonoprazan in Preventing Post-Endoscopic Variceal Band Ligation Ulcers: A Randomized Controlled Trial
The goal of this clinical trial is to learn if the medicine vonoprazan can help prevent ulcers that may develop after endoscopic variceal band ligation (EVBL) in adults with liver cirrhosis.
- Trial name
- NCT07267260
- Testing
- Vonoprazan 20 mg
- Where
- Pakistan
- Volunteers
- 154 people
- Sponsor
- King Edward Medical University
Gastric Varix, Sepsis
Antibiotic Prophylaxis in Patients Undergoing GVO
We design a randomized trial to clarify the necessity of antibiotic prophylaxis for the patients chronic liver disease with gastric varices treated by elective GVO.
- Conditions
- Gastric Varix, Sepsis, Liver Cirrhoses, Fever
- Trial name
- ABX-GV (NCT04140578)
- Testing
- Ertapenem
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Liver Cirrhoses
Developing Viability Index for Machine Perfused Livers
Machine perfusion technology is nearing the point of rescuing discarded liver grafts in the hope of proving them to be or improving them to the point of being transplantable.
- Trial name
- NCT03694691
- Testing
- Liver Biopsy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Cirrhoses, Liver, Splenectomy; Status
Laparoscopic Partial Splenectomy for Hypersplenism in Liver Cirrhosis Patients
In this study,the researchers compared the changes in immune function-related indicators in patients with liver cirrhosis following laparoscopic partial splenectomy,to determine whether this surgical intervention can enhance…
- Conditions
- Cirrhoses, Liver, Splenectomy; Status, Partial
- Trial name
- LPSH (NCT07205471)
- Testing
- Laparoscopic Partial Splenectomy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Northern Jiangsu People's Hospital
Cirrhoses, Liver, Carcinoma Liver
ProspEXPO : Study of the Associations Between Hepatocellular Carcinoma and Chemical and Psychosocial Environmental EXPOsome
The aim of the study is to build up a bio-collection of biological samples from patients with cirrhosis. Further work using this bio-collection will permit to describe the influence of different exposome factors (nutrition…
- Trial name
- ProspEXPO (NCT07119957)
- Testing
- Blood, urine and stool biocollection
- Where
- 4 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Angers
Liver Cirrhoses, Portal Hypertension Related to Cirrhosis
Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease
Cirrhosis is a form of advanced liver disease that can lead to serious complications, especially when combined with severe obesity.
- Conditions
- Liver Cirrhoses, Portal Hypertension Related to Cirrhosis, Severe Obesity, TIPS
- Trial name
- OPTIMAL (NCT07058155)
- Testing
- Transjugular Intrahepatic Portosystemic Shunt (TIPS), Sleeve Gastrectomy, Anti-Obesity Pharmacotherapy (Class Effect)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The Cleveland Clinic
Cirrhoses, Liver
Nursing Needs of Patients With Cirrhosis
The primary objective of this study is to examine the quality of life, disease-related knowledge, and perceived nursing needs of adult patients diagnosed with liver cirrhosis who attend the outpatient clinic at Landspítali…
- Trial name
- NCT07273331
- Testing
- blood sample, blood samples for analysis of cirrhosis
- Where
- 2 sites in Iceland
- Volunteers
- 150 people
- Sponsor
- Landspitali University Hospital
Liver Diseases, Humans
Liver Disease and Other Systemic Diseases
Examine the association of chronic liver diseases (including hepatitis B, hepatitis C, alcoholic liver disease, fatty liver, liver cirrhosis, and hepatocellular carcinoma) with other systemic diseases by retrospectively analyzing…
- Conditions
- Liver Diseases, Humans, Progression, Carcinogenesis
- Trial name
- NCT04525833
- Where
- Taiwan
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Cirrhoses, Liver
The Application of Lifestyle Enhancing Validated Integrative Therapies for Everyday Pain in Cirrhosis
The goal of this clinical trial is to test a low-touch vs high-touch drug-free pain self-management program that may help lower pain and improve quality of life for adults with cirrhosis and pain.
- Trial name
- ALLEVIATE-C (NCT07792850)
- Testing
- High-touch self-management program, Low-touch self-management program
- Where
- 8 sites in United States
- Volunteers
- 625 people
- Sponsor
- University of Pennsylvania
Fatty Liver, NAFLD - Non-Alcoholic Fatty Liver Disease
Detecting Liver Fibrosis in Patients At-risk
The project will establish a research cohort (called STELIR; STEatotisk Liver-risk In Rogaland) based on a biobank with an associated health register.
- Conditions
- Fatty Liver, NAFLD - Non-Alcoholic Fatty Liver Disease, Nash, MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease)
- Trial name
- STELIR (NCT07775638)
- Testing
- Routine study procedure
- Where
- Norway
- Volunteers
- 1,200 people
- Sponsor
- Helse Stavanger HF