Clinical trials: Ciprofol
Fiberoptic Bronchoscopy
Comparison of Efficacy and Safety Between Ciprofol and Remimazolam During Fiberoptic Bronchoscopy
Both ciprofol and remimazolam have been found to be potential alternatives to propofol (a commonly used anesthesia) during fiberoptic bronchoscopy, while the efficacy and safety between ciprofol and remimazolam have not been…
- Trial name
- NCT06531915
- Testing
- Ciprofol, Remimazolam
- Volunteers
- 190 people
- Sponsor
- Anhui Provincial Hospital
Respiratory Failure, Critical Illness
Comparison of the Efficacy and Safety of Ciprofol Versus Propofol for Sedation in ICU Patients Undergoing Non-Invasive Ventilation
Sedation is frequently required in critically ill patients admitted to the intensive care unit (ICU), including those receiving non-invasive respiratory support such as high-flow nasal cannula (HFNC), non-invasive ventilation…
- Trial name
- CALM-ICU (NCT07536750)
- Where
- China
- Volunteers
- 1,680 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Intracranial Tumors
The Effect of Ciprofol Versus Propofol Anesthesia on Postoperative Neurological Complications
Postoperative delirium and postoperative ischemic stroke are common neurological complications in clinical practice. The incidence of these complications is further increased in patients undergoing neurosurgical procedures.
- Trial name
- NCT07805876
- Testing
- Ciprofo, Propofol
- Where
- China
- Volunteers
- 434 people
- Sponsor
- Beijing Tiantan Hospital
Bariatric Surgery
Efficacy and Safety of Ciprofol in Laparoscopic Sleeve Gastrectomy
To evaluate the efficacy and safety of ciprofol for the induction of general anesthesia in obese patients undergoing laparoscopic sleeve gastrectomy.
- Trial name
- NCT05522998
- Testing
- Ciprofol, Propofol
- Where
- China
- Volunteers
- 212 people
- Sponsor
- The Third People's Hospital of Chengdu
Gastric Ulcer, Gastric Cancer
Hypoxia During Gastroenterological Endoscope Procedures Sedated With Ciprofol In Overweight Or Obesity Patients
Ciprofol is a new general anesthetic, which combine with γ- Aminobutyric acid-a (GABAA) receptor. Ciprofol has shown equivalent anesthetic efficacy of propofol at 1/4 to 1/5 of the dosage.
- Conditions
- Gastric Ulcer, Gastric Cancer, Gastrointestinal Polyp
- Trial name
- SpO2 (NCT05518929)
- Testing
- Ciprofol, Propofol
- Where
- 5 sites in China
- Volunteers
- 1,090 people
- Sponsor
- RenJi Hospital
Intraoperative Neurophysiological Monitoring, Spine Surgery
Ciprofol and Remimazolam for Intraoperative Neurophysiological Monitoring During Spine Surgery
Intraoperative neurophysiological monitoring, including motor evoked potentials and somatosensory evoked potentials, is commonly used during spine surgery to help detect impending neurological injury.
- Conditions
- Intraoperative Neurophysiological Monitoring, Spine Surgery, Anesthesia
- Trial name
- CIRIONM (NCT07718152)
- Testing
- Ciprofol, Remimazolam
- Volunteers
- 60 people
- Sponsor
- Affiliated 2 Hospital of Nantong University
Anesthesia
A Study to Evaluate the Differences in Pharmadynamics, Pharmacokinetics, and Safety Between Ciprofol and Propofol
This is a single-center, open-label, randomized, two-stage, two-way crossover Phase I study in healthy male subjects.The main objective is to evaluate the differences in pharmadynamics (PD), pharmacokinetics (PK), and safety…
- Trial name
- NCT04294056
- Testing
- Ciprofol, Propofol
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Elderly Patients
Ciprofol EC50 for Inducing Loss of Consciousness in Elderly Patients
ciprofol is a recently introduced novel sedative drug. In comparison to the traditional propofol, ciprofol exhibits a higher affinity for GABA A receptors, approximately 4-5 times that of propofol, and possesses fewer side…
- Trial name
- NCT06253078
- Testing
- Ciprofol dose 0.4mg/Kg, Ciprofol dose 0.3mg/Kg, Ciprofol dose 0.2mg/Kg
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Zhejiang Cancer Hospital
Brain Neoplasms, Delirium - Postoperative
Ciprofol, Propofol and Sevoflurane for Postoperative Delirium in Elderly Brain Tumor Patients
This study will compare three anesthesia medicines used to put people into a deep sleep during surgery: ciprofol, propofol, and sevoflurane. All three are commonly used for general anesthesia, but they work in different ways.
- Trial name
- NCT07799623
- Testing
- Ciprofol, Propofol, Sevoflurane
- Where
- China
- Volunteers
- 381 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Intraoperative Hypotension
A Comparative Study Protocol Investigating the Association Between Intraoperative Hypotension and the Use of Ring- Versus Propofol-Based Anesthesia in Elderly Patients Undergoing Non-Cardiac Surgery
we conducted this multicentre retrospective cohort study to evaluate the association between the choice of induction agent (ciprofol versus propofol) and the incidence of IOH in geriatric patients having non-cardiac surgery.
- Trial name
- NCT07808125
- Where
- China
- Volunteers
- 85,000 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Hemodynamic Stability, Ischemic Strokes
Ciprofol vs Propofol for Hemodynamic Stability in Patients Having General Anesthesia for Endovascular Thrombectomy After Ischemic Stroke
Endovascular therapy (EVT) improves the prognosis of patients with acute ischemic stroke (AIS). EVT has been established as a standard of care for AIS caused with large vessel occlusion based on numerous randomized controlled…
- Trial name
- NCT07696208
- Testing
- Ciprofol, Propofol
- Where
- China
- Volunteers
- 124 people
- Sponsor
- RenJi Hospital
Painless Abortion, Artificial Intelligence (AI)
Reinforcement Learned Automated Anesthesia Systems During Painless Abortion
This study compares the automated anesthesia systems for painless abortion (AAS-PA) with traditional anesthesia in painless abortions.
- Conditions
- Painless Abortion, Artificial Intelligence (AI), Ciprofol
- Trial name
- AAS-PA (NCT07132151)
- Testing
- AI Controlled General Anesthesia, General Anesthesia
- Where
- 8 sites in China
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.
Anesthesia; Adverse Effect, Biliary Tract Diseases
Ciprofol vs Propofol for Reducing Hypoxia Incidence in ERCP
Intravenous anesthesia has been widely used in endoscopic retrograde cholangiopancreatography (ERCP). In the past decade, many practices have been carried out under the propofol-based monitored anesthesia care without…
- Trial name
- NCT06015074
- Testing
- Propofol, Ciprofol
- Where
- China
- Volunteers
- 136 people
- Sponsor
- RenJi Hospital
Hemodynamics, Transcatheter Aortic Valve Replacement
Efficacy and Safety of Ciprofol for General Anaesthesia in Patients Undergoing Transcatheter Aortic Valve Replacement
Aortic valve stenosis is the most common debilitating valvular heart lesion in old patients. Transcatheter aortic valve replacement (TAVR) is an emergent technique for high-risk patients with aortic stenosis.
- Conditions
- Hemodynamics, Transcatheter Aortic Valve Replacement, General Anesthesia, Post-induction Hypotension
- Trial name
- NCT05881291
- Testing
- ciprofol, propofol
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Anesthesia, Sedation
Efficacy and Safety of Anricofen Combined With Ciprofol for Deep Sedation in Elderly Patients Undergoing ERCP
Background: Endoscopic retrograde cholangiopancreatography (ERCP) is a key technique for treating pancreatobiliary diseases in the elderly.
- Conditions
- Anesthesia, Sedation, ERCP, Ciprofol
- Trial name
- Anricofen Cipr (NCT07376577)
- Testing
- Sufentanil, Anricofen, Ciprofol
- Where
- China
- Volunteers
- 141 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Insomnia, Digestive Endoscopy
Changes in Ciprofol Dosage in Patients With Insomnia Undergoing Intravenous Anesthesia
To compare the dosage requirement of ciprofol under intravenous anesthesia between patients with insomnia and those with normal sleep pattern.
- Trial name
- NCT06897007
- Testing
- No interventions, it is a observational study
- Where
- China
- Volunteers
- 840 people
- Sponsor
- Beijing Tiantan Hospital
Hypotension
Propofol vs. Ciprofol for Anesthesia Induction in Frail Elderly Patients
Post-induction hypotension (PIH) is a common and critical complication during general anesthesia, particularly in frail elderly patients whose physiological reserves are significantly diminished.
- Trial name
- NCT07663695
- Testing
- Ciprofol, Propofol
- Where
- China
- Volunteers
- 96 people
- Sponsor
- General Hospital of Ningxia Medical University
Post Induction Hypotension, Elderly
Ciprofol Titrated Induction in Reducing Post-induction Hypotension in Geriatric Patients
Geriatric patients undergoing general anesthesia face a significant challenge, with the induction phase contributing to 50% of hypotensive events.
- Trial name
- CTIH (NCT06258967)
- Testing
- ciprofol, propofol
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Drug Drug Interaction
Drug-drug Interaction Between Ciprofol and Mefanamic Acid or Valproate
study the effect of mefanamic acid or valproate on ciprofol
- Trial name
- NCT05181007
- Testing
- Mefanamic Acid, Valproate
- Where
- China
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Intraoperative Hypotension, Ciprofol
Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors
The prevention of intraoperative hypotension could reduce postoperative organ injury and mortality, particularly in elderly patients receiving long-term renin-angiotensin system inhibitors.
- Conditions
- Intraoperative Hypotension, Ciprofol, Renin-angiotensin System Inhibitors
- Trial name
- NCT06952608
- Testing
- Ciprofol group, Propofol group
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine