Clinical trials: Cigarette Smoking Behavior
Cigarette Smoking
Analysis of Lipid Biomarkers of Exposure and Host Response
The purpose of this prospective, open-label, clinical trial is to establish the feasibility and validity of exhaled breath condensate (EBC) biomarkers for use in studies designed to evaluate harm reduction strategies of smoking.
- Trial name
- NCT00493831
- Testing
- nicotine polacrilex, transdermal system or inhaler
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Nebraska
Schizophrenia, Cognition
Transcranial Direct Current Stimulation (tDCS) As A Treatment For Cigarette Craving and Cognitive Deficits in Schizophrenic
This is a study of the effects of tDCS on smoking, craving for cigarettes, cognition, and psychiatric symptoms in schizophrenic patients who are current smokers or have a history of regular cigarette smoking.
- Conditions
- Schizophrenia, Cognition, Cigarette Smoking
- Trial name
- TDCSSCHIZ (NCT02128919)
- Testing
- tDCS
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
E-Cig Use
Responses to E-Cigarette Advertising
While conventional cigarette use continues to decline among youth and young adults, e-cigarette (EC) use is on the rise. The use of ECs during young adulthood, particularly 18 years of age, is especially alarming because it is…
- Trial name
- NCT04249219
- Testing
- Viewing e-cigarette ads
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Smoking
Palatability of Experimental Cigarettes - Study 2
Smoking remains a leading cause of preventable disease and premature death worldwide. Approximately 1 out of every 5 deaths is associated with cigarette smoking, and roughly half of all daily smokers will die prematurely from…
- Trial name
- NCT01568905
- Testing
- Low level nicotine cigarette, Intermediate nicotine level cigarette, High level nicotine cigarette
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Smoking
User Acceptability of a Nicotine Lactate Delivery System (P3L)
This study will provide an initial assessment of the acceptability of the Nicotine Lactate Delivery System (P3L) after ad libitum use and the ability of combustible cigarette (CC) smokers to use P3L to maintain their customary…
- Trial name
- NCT02643693
- Testing
- P3L, VUSE, CC
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking, Nicotine Addiction
The END Perioperative Smoking Pilot Study
The purpose of this pilot randomized trial is to determine the feasibility of e-cigarettes and telephone counselling (compared to transdermal nicotine replacement and telephone counselling) as a harm-reduction tool that may lead…
- Conditions
- Smoking, Nicotine Addiction, Surgery
- Trial name
- NCT02482233
- Testing
- ENDD (NJOY), NRT (NicoDerm CQ), telephone counseling
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Cigarette Smoking, Tobacco Use
Gabapentin for Smoking Cessation
Gabapentin is an anti-epileptic agent that has shown preliminary evidence of efficacy for improving symptoms of cocaine and alcohol withdrawal in pilot studies.
- Trial name
- NCT00578552
- Testing
- Gabapentin - 1800 mg/day, Gabapentin - 2700 mg/day
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Attentional Bias, Smoking Cues
Trial on the Effect of E-cigarette Advertising on Cigarette Perceptions in Adolescents
This research aims to investigate how exposure to advertising for Electronic Nicotine Delivery Systems (commonly called e-cigarettes) may lead to combustible smoking initiation in adolescents.
- Conditions
- Attentional Bias, Smoking Cues, Positive Perceptions About Cigarette Smoking, Social Norms
- Trial name
- NCT03786042
- Testing
- E-cigarette ad exposure, non e-cigarette TV commercials
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Trustees of Dartmouth College
Smoking (Tobacco) Addiction
Addiction and Behavior Related to Menthol Cigarette Substitutes
The goal of the proposed study is to examine the abuse liability and substitutability of plausible menthol cigarette alternatives currently on the market, including menthol filtered little cigars (mFLC), menthol roll-your-own…
- Trial name
- MENTHOL (NCT04844762)
- Testing
- Menthol cigarettes substitutes, Usual brand menthol cigarettes and substitutes, Menthol cigarettes substitutes and menthol cigarettes
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cigarette Smoker, Current Smoker
18F-FSPG PET/CT in Diagnosing Early Lung Cancer in Patients With Lung Nodules
This phase II trial studies how well 18F-FSPG positron emission tomography (PET)/computed tomography (CT) work in diagnosing early lung cancer in patients with indeterminate lung nodules.
- Conditions
- Cigarette Smoker, Current Smoker, Former Smoker, Multiple Pulmonary Nodules
- Trial name
- NCT03824535
- Testing
- Computed Tomography, Fludeoxyglucose F-18, Fluorine F 18 L-glutamate Derivative BAY94-9392
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Andrei Iagaru
Smoking, Cigarette, Smoking Cessation
Health Systems Reach Interventions Project
This project seeks to identify ways to enhance the reach of evidence-based smoking cessation treatments among adult primary care patients who smoke daily and are not ready to start treatment at study enrollment.
- Trial name
- NCT04199117
- Testing
- Varenicline, Combination nicotine patch and nicotine mini-lozenge treatment, Monetary incentives for initiating treatment
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of Wisconsin, Madison
Smoking
Insular Inhibitory Neuromodulation to Reduce Cigarette Craving and Alter Brain Function in Smokers
The goal of this study is to determine if a specific experimental brain stimulation technique can be used as a non-invasive way to reduce cigarette cravings in current smokers.
- Trial name
- NCT02590640
- Testing
- Repetitive transcranial magnetic stimulation, MagStim Rapid2
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
E Cig Use
Young Adult EC Use and Respiratory Outcomes
E-cigarette (EC) use continues to increase among youth, and EC may be detrimental to youth respiratory health. Public health officials and the Food and Drug Administration (FDA) can now regulate ECs.
- Trial name
- NCT04395274
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cigarette Smoking
Effects of Smoking Environments on Brain Reactivity
The goal of this study is to evaluate correlations between brain reactivity (as assessed via functional magnetic resonance imaging (fMRI) following 24-h abstinence) and the amount of smoking in a specific location.
- Trial name
- CameraCue3 (NCT03421210)
- Testing
- Nicotine patch
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Duke University
Tobacco Smoking
Tobacco and Socioeconomic Disadvantage
Randomized clinical trial comparing 3 brief interventions designed to increase motivation to quit smoking in socioeconomically disadvantaged smokers.
- Trial name
- NCT03620708
- Testing
- Motivational Interviewing, Nicotine Replacement Therapy Sampling, Referral Only
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Cigarette Smoking
A Virtual Arm to Stop Smoking
The investigators reported in a pilot study presented at last year's Cybertherapy Conference (Girard \& Turcotte, 2007) that using an action-cue exposure strategy in virtual reality (ACE-VR; crushing virtual cigarettes) might be…
- Trial name
- NCT00639093
- Testing
- psychoeducational / motivational combined with crushing, psychoeducational / motivational combined with control
- Where
- Canada
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Universite du Quebec en Outaouais
Cigarette Smoking Toxicity
Smoking Topography and Harm Exposure in Menthol Cigarettes
This study will examine how menthol affects smoking when menthol smokers switch to non-menthol cigarettes. Participants will smoke their preferred brand (control) or Camel Crush cigarettes, which have the ability to be menthol or…
- Trial name
- MQAT (NCT01329263)
- Testing
- Menthol to non-menthol
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Smoking Cessation
Meclizine as a Potential Smoking Cessation Treatment
The purpose of this study is to evaluate whether meclizine, an antihistamine used to prevent or treat motion sickness, can help smokers quit smoking.
- Trial name
- NCT01443858
- Testing
- Meclizine, Nicotine Patch
- Where
- 4 sites in United States
- Volunteers
- 146 people
- Sponsor
- Duke University
Nicotine Dependence
Concurrent Bupropion / Varenicline for Smoking Cessation
This study focuses on the first step in developing an algorithm for maximizing quit-smoking success based on an adaptive approach, which changes treatment from the initial nicotine replacement therapy (NRT) when that treatment…
- Trial name
- ConNic4 (NCT01303861)
- Testing
- Varenicline, Bupropion, Nicotine patches
- Where
- 4 sites in United States
- Volunteers
- 702 people
- Sponsor
- Duke University
Tobacco Use, Tobacco Smoking
Persistence Targeted Smoking Cessation in Serious Mental Illness (SMI)
Due to the pandemic, this study was modified from a randomized clinical trial to test the feasibility, initial efficacy, and mechanisms of action of our PTSC-S intervention to a feasibility and acceptability test of our…
- Conditions
- Tobacco Use, Tobacco Smoking, Tobacco Use Cessation, Tobacco Use Disorder
- Trial name
- PTSC-S (NCT03873337)
- Testing
- Persistence Targeted Smoking Cessation in SMI (PTSC-S), Nicotine patch
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Rutgers, The State University of New Jersey