Clinical trials: Chronic Spinal Cord Injury
Cervical Spinal Cord Injury
A User-friendly, Non-invasive Neuro-orthosis That Restores Volitionally Controlled Grasp Functions for SCI Survivors With Tetraplegia
The goal of this pilot clinical study is to investigate the NeuroLife EMG-FES Sleeve System, a closed-loop approach to functional electrical stimulation, in adults (n=12) with chronic (>12 months) tetraplegia due to spinal cord…
- Trial name
- NCT06087445
- Testing
- NeuroLife EMG-FES Sleeve System
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Ohio State University
Spinal Cord Injuries (SCI), Paralysis, Lower Limbs
Epidural Electrical Stimulation to Restore Standing and Walking in Patients With Chronic Paralysis Due to Spinal Cord Injury: A Study on Motor Recovery, Spasticity Reduction, and Quality of Life Improvement Through Neuromodulation and Intensive Rehabilitation
Spinal cord injury (SCI) is a major cause of morbidity and disability worldwide, significantly impacting patients' quality of life and functional independence.
- Trial name
- EPISTIM-SCI (NCT06847295)
- Testing
- Epidural Electrical Stimulation (EES) using an implanted paddle lead and pulse generator combined with a 12-month intensive rehabilitation program.
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Sao Paulo General Hospital
Chronic Low Back Pain, Spinal Cord Injury
SERENITY Study of Chronic Pain Interference in Adults
SERENITY is a remote observational study designed to characterize inter-individual differences in chronic pain among adults with chronic low back pain and adults with spinal cord injury-related neuropathic pain.
- Conditions
- Chronic Low Back Pain, Spinal Cord Injury, Neuropathic Pain, Chronic Pain
- Trial name
- SERENITY (NCT07820475)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Minnesota
Spinal Cord Injury Cervical
Non-Invasive Neuromodulation for Upper Extremity Function in Spinal Cord Injury: A Crossover Trial
This study explores two promising therapies for restoring arm and hand function in people with chronic cervical spinal cord injury (SCI), a condition that affects independence and quality of life.
- Trial name
- NCT06903416
- Testing
- Transcutaneous Cervical Spinal Cord Stimulation, Paired Corticospinal Motoneuronal Stimulation, Functional Task Practice
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Alberta
Chronic Pain, Spinal Cord Injuries
Improving Functioning in Persons With Chronic Pain Post-SCI Through Virtual Classroom Education
Chronic pain (pain that is that is present for a long period of time) is very common among people with spinal cord injury (SCI).
- Trial name
- NCT02561676
- Testing
- Education Program Type 1, Education Program Type 2
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Kessler Foundation
Peripheral Nerve Disease, Peripheral Nerve Injury Lower Limb
Effect of Ankle-foot Orthoses on Balance Confidence
The patients at our Prosthetics and Orthotics Outpatient Clinic who have had an ankle-foot orthosis for at least one year will fill in the Activities-Specific Balance Confidence Scale (ABC Scale) for wearing the orthosis and for…
- Conditions
- Peripheral Nerve Disease, Peripheral Nerve Injury Lower Limb, Poliomyelitis, Cerebral Palsy
- Trial name
- ABCOGS (NCT04080687)
- Testing
- Ankle-foot orthosis
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Rehabilitation Institute, Republic of Slovenia
Spinal Cord Injuries, Spasticity, Muscle
Extracorporeal Shockwave Therapy for Spasticity in People With Spinal Cord Injury
People with spinal cord injury (SCI) experience a host of secondary complications that can impact their quality of life and functional independence.
- Conditions
- Spinal Cord Injuries, Spasticity, Muscle, Spastic Paraplegia, Spastic Quadriplegia
- Trial name
- NCT05432999
- Testing
- Extracorporeal Shockwave Therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Kessler Foundation
Spinal Cord Injuries
Daily Intermittent Hypoxia and Task-Specific Upper Limb Training in Persons With Chronic Incomplete SCI
The purpose of this research study is to investigate the effectiveness of a combinatorial therapy of breathing low oxygen in short bursts-acute intermittent hypoxia (AIH) and upper limb training on arm strength and function, and…
- Trial name
- NCT03262766
- Testing
- Acute Intermittent Hypoxia (AIH), Upper extremity training
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Disease, Spinal Cord Injuries (Complete and Incomplete)
Spinal Cord Stimulation Combined With Motor Training in Non-Traumatic SCI: A Prospective Interventional Study
Interventional prospective longitudinal on the evaluation of spinal cord stimulation (SCS) assisted by motor rehabilitation training for restoring motor function in patients with non-traumatic spinal cord injury (SCI).
- Trial name
- Neuro-scs-002 (NCT07412808)
- Testing
- Spinal cord stimulation surgery (device implant) and motor rehabilitation
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Albano Luigi
Spinal Cord Injury
Wheelchair Indoors Curling With SCI patients_RCT
This study investigates if, patients with diagnosed chronic spinal cord injury will benefit from an Indoor Curling Exercise program on their control capabilities of trunk movements and on their intrinsic motivation for physical…
- Trial name
- SCI-RCT (NCT02550834)
- Testing
- Wheelchair indoors curling training
- Where
- 2 sites in Switzerland
- Volunteers
- 32 people
- Sponsor
- HES-SO Valais-Wallis
Spinal Cord Injury, Traumatic Spinal Cord Injury
Pilot Study of Galantamine to Treat Metabolic Syndrome in People With Chronic Traumatic Spinal Cord Injury (SCI)
The purpose of this research study is to measure the tolerability and preliminary efficacy of a drug, galantamine, to treat metabolic syndrome (MetS) by reducing circulating inflammation in people with spinal cord injury (SCI).
- Conditions
- Spinal Cord Injury, Traumatic Spinal Cord Injury, Paraplegia and Tetraplegia, Metabolic Syndrome
- Trial name
- NCT07625332
- Testing
- Galantamine Hydrobromide Extended Release
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Northwell Health
Chronic Pain, Brain Injuries, Traumatic
Telehealth Pain Self-Management for Employed Adults
The E-TIPS trial will evaluate an evidence-based, telehealth pain self-management intervention compared to standard care (a waitlist) for chronic pain in adults with physical disabilities who are employed.
- Conditions
- Chronic Pain, Brain Injuries, Traumatic, Multiple Sclerosis, Spinal Cord Injuries
- Trial name
- E-TIPS (NCT04248725)
- Testing
- E-TIPS
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Washington
Xerosis
Safety and Efficacy of SQIN™ on Xerosis in Adults With Mobility Problems and Paralysis
In the general population, xerosis is often caused by external factors such as seasonal changes. In that case, the best way to relieve dry skin is to use a standard moisturizer.
- Trial name
- NCT02429206
- Testing
- SQIN, standard moisturizing cream (Glaxal Base)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Nordic Life Science Pipeline Inc.
Spinal Cord Injury
Different Efficacy Between Rehabilitation Therapy and Stem Cells Transplantation in Patients With SCI in China
The morbidity of spinal cord injury (SCI) is increasing year by year significantly in China. The methods to treat SCI patients in sequela stage update are poor.
- Trial name
- SCI-III (NCT01873547)
- Testing
- cell therapy, rehabilitation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- General Hospital of Chinese Armed Police Forces
Tetraplegia, Asthma
Exhaled Breath Condensate Biomarkers of Inflammation in Individuals With Chronic Cervical Spinal Cord Injury
The purpose of this study is to obtain markers of airway inflammation from the exhaled breath condensate (the moisture in exhaled air) for comparison to blood based markers.
- Trial name
- NCT02235714
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Spinal Cord Injuries
Umbilical Cord Blood Cell (MC001) Transplant Into Injured Spinal Cord Followed by the Locomotor Training
Umbilical cord blood mononuclear stem cells (UCBMSCs) transplant followed by the intensive locomotor training for up to 5±1 hours a day, 5±1 days a week, and for 3-6 months for treatment in patients with chronic, stable and…
- Trial name
- NCT03979742
- Testing
- Umbilical Cord Blood Mononuclear Cell, Locomotor Training
- Where
- 2 sites in Taiwan
- Volunteers
- 6 people
- Sponsor
- StemCyte, Inc.
Stroke, Peripheral Neuropathy
Arm Motor Control on Bi and Uni ADLs
This study is being performed to assess how certain chronic disabilities - stroke, upper extremity (UE) amputation, spinal cord injuries (SCI), cerebral palsy (CP) - differ from healthy subjects in their ability to perform ADLs.
- Conditions
- Stroke, Peripheral Neuropathy, Spinal Cord Injuries, Cerebral Palsy
- Trial name
- BiAs (NCT02778529)
- Testing
- Bilateral assessment robots (BiAS)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Chronic Spinal Cord Disorder
The Effects of rTMS and tDCS Combined With Robotic Rehabilitation In Patients With Spinal Cord Injury
The purpose of this study is to assess the effect of rTMS and tDCS combined with robotic therapy on motor functional recovery and gait parameters
- Trial name
- NCT06188130
- Testing
- active rTMS, active tDCS
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ankara City Hospital Bilkent
Neuropathic Pain, Spinal Cord Injury
Effectiveness of Controlled-Release Morphine for Chronic Neuropathic Pain After Spinal Cord Injury
We would like to learn if a medicine called "modified-release morphine sulfate" (Avinza) helps reduce Spinal Cord Injury (SCI)-related pain that has lasted a long time.
- Trial name
- NCT00488969
- Testing
- Modified-release morphine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Icahn School of Medicine at Mount Sinai