Clinical trials: Chronic Rhinosinusitis (CRS), open to volunteers
Chronic Rhinosinusitis (CRS), Olfactory Dysfunction
Position-Directed Budesonide Nasal Drops for CRS-associated Olfactory Dysfunction
This single-center randomized controlled trial evaluates whether budesonide nasal drops delivered in the Wu's position (Wu's 45° Head-Hanging Reclination Position) improve olfactory function more effectively than conventional…
- Trial name
- NCT07386873
- Testing
- Nasal Drops, Nasal Spray
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Peking University Third Hospital
Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
CRS Questionnaire Validation Project
The 'CRS validation project' consists of a joint effort of 32 medical centers in Europe, the USA, and South Africa to carry out the validation of 2 novel questionnaires designated to measure self-perceived severity and control of…
- Trial name
- NCT06970977
- Where
- 32 sites in United States, Belgium and 9 more
- Volunteers
- 1,000 people
- Sponsor
- The European Forum for Research and Education in Allergy and Airway Diseases
Chronic Rhinosinusitis (CRS)
Pistacia Lentiscus Oil Nasal Spray With Reduced-Dose Mometasone in Chronic Rhinosinusitis
Chronic rhinosinusitis (CRS) is a persistent inflammatory disease of the nose and sinuses. Medical treatment is mainly based on topical therapies aimed at controlling mucosal inflammation and improving naso-sinus clearance…
- Trial name
- NCT07787494
- Testing
- Mometasone furoate - intranasal application, Bactorinol nasal spray
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Pain, Anxiety
Active vs. Passive VR During Office-based ENT Procedures
The purpose of this research is to evaluate whether active virtual reality reduces pain and anxiety more effectively than passive virtual reality during office-based ENT procedures.
- Conditions
- Pain, Anxiety, Chronic Rhinosinusitis (CRS), Nasal Obstruction
- Trial name
- NCT07599826
- Testing
- Passive virtual reality headset or goggles, Active virtual reality headset or goggles
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Cedars-Sinai Medical Center
Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
Paclitaxel-Coated Balloon Treatment of Chronic Rhinosinusitis
This is a prospective, multicenter, randomized, controlled, double-blind clinical trial enrolling 300 adult subjects with chronic rhinosinusitis (CRS) with and without nasal polyps (CRSwNP and CRSsNP) indicated for endoscopic…
- Trial name
- RESTORE-2 RCT (NCT07290140)
- Testing
- Airiver ESSpand DCB, ESS
- Where
- 10 sites in United States
- Volunteers
- 300 people
- Sponsor
- Airiver Medical, Inc.
Chronic Rhinosinusitis (CRS), Nasal Polyps
Triamcinolone Nanocapsules After Endoscopic Nasal Surgery
This randomised, single-masked, parallel-group clinical trial will evaluate the efficacy and safety of a topical triamcinolone acetonide-loaded polymeric nanocapsule formulation for postoperative care following endoscopic nasal…
- Conditions
- Chronic Rhinosinusitis (CRS), Nasal Polyps, Postoperative Healing After Endoscopic Nasal Surgery
- Trial name
- NCT07714525
- Testing
- Triamcinolone Acetonide-Loaded Polymeric Nanocapsules, Normal Saline Nasal Irrigation
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Deraya University
Smell Loss, Chronic Rhinosinusitis (CRS)
Cognitive and Immunologic Profiles of Patients With Olfactory Dysfunction After Smell Training
A research study to assess the baseline olfactory function, mental health status, clinical severity, and immunological profile in patients with smell loss.
- Trial name
- CIPOD (NCT07681973)
- Testing
- Smell Training
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Chronic Rhinosinusitis (CRS), Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
Evaluation of the Safety and Performance of a Bioresorbable Nasal Dressing Containing Mometasone Furoate (MF)
The primary objective of the study is to evaluate the safety and effectiveness of OCEAN as an adjunct aid in wound healing after nasal/sinus surgery and to demonstrate that OCEAN is non-inferior compared to a steroid-eluting…
- Trial name
- ENHANCE II (NCT07286201)
- Testing
- OCEAN, Steroid-eluting sinus stent
- Where
- 9 sites in United States
- Volunteers
- 110 people
- Sponsor
- Polyganics BV
Chronic Rhinosinusitis (CRS)
Propel Drug-Eluting Sinus Implant Family IBUKI Cohort
To confirm clinical safety and performance for the PROPEL family of products when used according to IFUs and standard of care in Japan.
- Trial name
- NCT07546682
- Testing
- None, observational standard of care study
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Medtronic
Chronic Rhinosinusitis (CRS)
Intra-Sinus Povidone-Iodine and Budesonide After Endoscopic Sinus Surgery for Chronic Rhinosinusitis
Endoscopic sinus surgery (ESS) is commonly performed in patients with chronic rhinosinusitis (CRS) to improve sinus drainage and allow better delivery of topical therapies after surgery.
- Trial name
- PVP-I (NCT07383402)
- Testing
- Povidone-Iodine and Budesonide Gel-Forming Suspension
- Volunteers
- 180 people
- Sponsor
- Amin Javer
Inferior Turbinate Hypertrophy, Chronic Rhinosinusitis (CRS)
Efficacy of Lavender Aromatherapy on Anxiety and Pain Reduction During Awake Otolaryngologic Procedures
The purpose of this study is to evaluate the efficacy of lavender aromatherapy in adult patients undergoing awake otolaryngologic procedures in the outpatient clinic setting.
- Conditions
- Inferior Turbinate Hypertrophy, Chronic Rhinosinusitis (CRS), Rhinitis, Vasomotor, Thyroid Nodules
- Trial name
- NCT07299474
- Testing
- Lavender Aromatherapy
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Chronic Rhinosinusitis (CRS)
Treatment Decision-Making Among Patients With Chronic Rhinosinusitis
This project aims to develop and pilot-test a bilingual, patient-centered clinical decision support (PC CDS) web application for individuals with chronic rhinosinusitis (CRS), a condition affecting 16% of U.S.
- Trial name
- CRS-AID (NCT07010679)
- Testing
- Patient Centered CRS Treatment Decision Support
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Southern California
Cystic Fibrosis (CF), Chronic Rhinosinusitis (CRS)
Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy
The investigators are doing this study to discover if it is appropriate for people with Cystic Fibrosis (CF) on highly effective modulator therapy (HEMT) to stop using certain standard Sino nasal therapies such as high-volume…
- Trial name
- NCT06996951
- Testing
- STOP NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID, CONTINUE NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Indiana University
URTI, Bronchiolitis
Assessement of Effectiveness of Seawater Nasal Sprays on Sinonasal Symptoms
The purpose of this post-market clinical investigation is to assess in a real-life setting, the effectiveness, usage, tolerance, safety and satisfaction of 4 isotonic and hypertonic seawater-based CE-marked nasal sprays.
- Conditions
- URTI, Bronchiolitis, COVID - 19, Allergic Rhinitis
- Trial name
- SeaBridge (NCT07262450)
- Testing
- Respimer® Hygiene-Prevention -Baby, kids, adults, Respimer® Hygiene-Prevention Kids, adults, Respimer® Decongestion Baby, kids, adults
- Where
- 32 sites in France
- Volunteers
- 1,065 people
- Sponsor
- Laboratoire de la Mer
Chronic Rhinosinusitis (CRS)
A Phase I Study Evaluating the Safety, Tolerability, and Pharmacokinetics of VVN432 Nasal Spray
The goal of this clinical study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of VVN432 Nasal Spray in healthy volunteers (Phase Ia) and in patients with chronic rhinosinusitis (Phase 1b).
- Trial name
- NCT07259538
- Testing
- 0.5% VVN432 Nasal Spray, 1% VVN432 Nasal Spray, Vehicle
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- VivaVision Biotech, Inc
Chronic Rhinosinusitis (CRS), Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
The German National CRS Registry (GenreCRS): Clinical Evaluation of the New European Academy for Allergy and Clinical Immunology (EAACI) Criteria for CRSwNP Disease Control, Remission and Cure in a Real-World Evidence Study Approach
The objective of the study is to establish a registry of patients diagnosed with Chronic Rhinosinusitis with and without Nasal Polyps (CRSwNP/CRSsNP) to collect comprehensive longitudinal real-world evidence from specialised…
- Trial name
- GenreCRS (NCT06815211)
- Volunteers
- 500 people
- Sponsor
- Ärzteverband Deutscher Allergologen e.V.
Chronic Rhinosinusitis (CRS)
Effectiveness of Penthrox vs Placebo in Sinus Procedures, a Clinical Trial
The goal of this randomized controlled trial is to evaluate the effectiveness of inhaled methoxyflurane (Penthrox) as an analgesic for patients undergoing minor rhinology and sinus procedures, specifically comparing it to a…
- Trial name
- NCT06750302
- Testing
- Methoxyflurane - Penthrox
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- St. Paul's Hospital, Canada
Chronic Rhinosinusitis (CRS)
Comparative Effects of Therapeutic Ultrasound and Sinus Massage in Chronic Rhinosinusitis: a Randomized Controlled Study
This is a randomized controlled trial. Previous studies show that both therapeutic ultrasound and sinus massage techniques have significant results in Chronic Rhinosinustis (CRS).
- Trial name
- NCT06960876
- Testing
- Therapeutic Ultrasound, Sinus Massage, Control group
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Foundation University Islamabad
Chronic Rhinosinusitis (CRS)
Impact of Structural and Microenvironmental Abnormalities in Olfactory Cleft on Olfaction in CRS
The purpose of this research is to investigate the impact of structural abnormalities and microenvironmental changes in the olfactory cleft on olfactory function in patients with chronic rhinosinusitis (CRS).
- Trial name
- NCT06834477
- Testing
- Computed Tomography
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Chronic Rhinosinusitis (CRS)
Real-life Evaluation of the Efficacy of Biologicals in Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)
The goal of this observational study is to learn more about the real-world efficacy of biologics in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).
- Trial name
- RELIBIO (NCT06683261)
- Testing
- Omalizumab, Dupilumab, Mepolizumab 100 mg
- Where
- 8 sites in Belgium
- Volunteers
- 300 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven