Clinical trials: Chronic Postsurgical Pain
Post-operative Chronic Pain
Shifting Pain Modulation From Pro-to Anti-nociceptive
To create a data base that will facilitate the enrichment of the insights regarding post-operative pain development, and to identify those individuals with the potential to develop this kind of pain.
- Trial name
- NCT02672202
- Testing
- Duloxetine, Pregabalin
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Pain, Postoperative
Chronic Pain Following Thoracic Surgery
Pain that persists after the healing of a surgical wound has previously been described as an important, but often unrecognized clinical problem.
- Trial name
- PTPS-18 (NCT01144845)
- Testing
- Thoracic surgery
- Where
- Denmark
- Volunteers
- 702 people
- Sponsor
- University of Aarhus
Pain
Prospective Randomized Study of TPS + CBT VS TPS Alone: Readmission, Opioid Use, and Chronic Pain
This study aims to evaluate the impact of a Transitional Pain Service (TPS) on hospital readmission rates, opioid consumption, and chronic post-surgical pain(CPSP), Despite increasing recognition of the benefits of integrated…
- Trial name
- NCT07783672
- Testing
- Transitional Pain Service
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- M.D. Anderson Cancer Center
Postoperative Pain, Opioid Use
SPSIP Block Versus ESP Block for Chronic Pain After Unilateral Breast Surgery
This prospective, randomized, assessor-blinded study will compare serratus posterior superior intercostal plane block and erector spinae plane block in adult female patients undergoing unilateral breast surgery.
- Trial name
- SPES-CPSP (NCT07674836)
- Testing
- Serratus Posterior Superior Intercostal Plane Block, Ultrasound-guided Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Engin Çetin
Pain, Postoperative, Pain, Acute
Opioid Sparing Anesthesia in Lumbar Spine Surgery
The aim of this double blind randomized study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus remifentanil analgesia in lumbar…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Nociceptive
- Trial name
- NCT05594407
- Testing
- dexmedetomidine-ketamine-lidocaine, Remifentanil
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aretaieion University Hospital
Phantom Limb Pain
Study of Phantom Limb Pain Suppression Using Neuromodulation Methods
This study assesses the effectiveness of neuromodulation in alleviating pain through the stimulation of peripheral nerves. The research involves implanting electrodes for test stimulation of peripheral nerves (PNS - Peripheral…
- Trial name
- NCT06644807
- Testing
- Motor Cortex Stimulation, Spinal cord stimulation, Peripheral Nerve Stimulation
- Where
- 2 sites in Russia
- Volunteers
- 50 people
- Sponsor
- Skolkovo Institute of Science and Technology
Erector Spinae Plane Block, Pain Control
Intravenous(IV) vs. Erector Spinae Plane Blocks in Cardiac Surgery
Interfascial plane blocks have been developed for analgesia, among which the erector spinae plane (ESP) has gained popularity. The ESP block has been hypothesized to provide truncal analgesia by spread of local anesthetic into…
- Conditions
- Erector Spinae Plane Block, Pain Control, Post-Operative Pain, Chronic
- Trial name
- NCT04995497
- Testing
- Intravenous Administration of Lidocaine Post Cardiac Surgery, Administration of Lidocaine Post Cardiac Surgery via ESP Catheter
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Archit Sharma
Post-Surgical Pain, Chronic, Post-traumatic Pain, Chronic
Uncovering the Mechanism of Pain Relief by Peripheral Transcutaneous Magnetic Stimulation
This research aims to uncover the Mechanisms of pain relief through the FDA-cleared peripheral transcutaneous magnetic stimulation (pTMS) device by MagVenture.
- Trial name
- NCT07199361
- Testing
- Peripheral Transcutaneous Magnetic Stimulation from MagVenture
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Florida International University
Chronic Pain, Surgery
Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain
The investigators will approach elective cardiac and thoracic surgery patients in the preoperative consultation clinic. Consenting individuals will be administered, before surgery validated pain, psychological and sleep…
- Trial name
- CT-Pain (NCT04798573)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- University Health Network, Toronto
Breast Cancer, Chronic Pain
Persistent Post-Surgical Pain in Women With BrCA
Women with early-stage breast cancer (BrCA) are surviving longer, but many experience symptoms after curative treatments. Approximately 50% of BrCA survivors experience persistent pain post-surgery.
- Trial name
- NCT02266082
- Testing
- No intervention
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Breast Neoplasms, Pain,Postoperative
Chlorhydrate of Ropivacaine and Breast Cancer Surgery
The aim of the study is to evaluate the effect of local anesthetic (chlorhydrate of ropivacaine) to prevent chronic pain after breast surgery for cancer.
- Trial name
- NCT00370240
- Testing
- Chlorhydrate de Ropivacaine
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Institut Curie
Pain
Selective Neurectomy and Mesh Removal for Chronic Postherniotomy Pain
Chronic postherniotomy pain affects every day activities in 5-8% of patients. However, no established treatment for this pain syndrome exists and previous reports on the effect of surgical intervention suffer from methodological…
- Trial name
- NCT00627289
- Where
- 2 sites in Denmark
- Volunteers
- 21 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pain, Postoperative, Post-Mastectomy Chronic Pain Syndrome
Prevention of Post Mastectomy With Intraoperative Ketamine
Aim 1: To determine the effectiveness of perioperatively administered ketamine to decrease acute and persistent postmastectomy pain (PPMP).
- Trial name
- NCT03090776
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 264 people
- Sponsor
- Brigham and Women's Hospital
Coxarthrosis, Pain, Postoperative
Lumbar ESPB in Hip Replacement Surgery
In this study, continuous erector spinae plane block (ESPB) will be compared to continuous epidural analgesia in patients undergoing elective hip replacement surgery.
- Conditions
- Coxarthrosis, Pain, Postoperative, Pain, Acute, Pain, Chronic
- Trial name
- ESPB_HIP (NCT06282666)
- Testing
- Spinal anesthesia, lumbar erector spinae plane block, Epidural analgesia
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Lublin
Post Operative Pain, Acute, Chronic Post Surgical Pain
Continuous Epidural With Dexmedetomidine Adjuvant in Gynecologic Laparotomy
The goal of this clinical trial is to learn if adding a medication called dexmedetomidine to an epidural block works better than a standard epidural to control pain in women undergoing gynecologic laparotomy (abdominal surgery).
- Conditions
- Post Operative Pain, Acute, Chronic Post Surgical Pain, Gynecologic Disease
- Trial name
- NCT07292324
- Testing
- Dexmedetomidine & Bupivacaine., Bupivacain
- Where
- Indonesia
- Volunteers
- 62 people
- Sponsor
- Udayana University
Chronic Pain, Postoperative, Quality of Life
Quality of Life and Pain After Appendectomy in Children
Acute appendicitis is one of the most common emergency general surgical conditions worldwide and represents the leading cause of emergency abdominal surgery in children.
- Conditions
- Chronic Pain, Postoperative, Quality of Life, Functional Ability, Appendectomy
- Trial name
- CAPA-Peds (NCT07629362)
- Where
- Turkey (Türkiye)
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- Kocaeli City Hospital
Oxycodone, Chronic Pain, Postoperative
Effect of Preventive Analgesia with Oxycodone and Parecoxib Sodium on the Chronification of Acute Post-operative Pain
The goal of this clinical trial is to learn if the administration of oxycodone for preventive analgesia works to reduce the chronification of acute postoperative pain in adult participants undergoing major abdominal surgery.
- Trial name
- AOPC (NCT06721988)
- Testing
- oxycodone and parecoxib sodium combinations
- Volunteers
- 1,316 people
- Sponsor
- Ailin Luo
Acute Postoperative Pain, Trajectory
Pain Trajectories and Predictors After Noncardiac Surgery in Elderly Patients
This study will use group-based trajectory modeling to identify the different postoperative pain trajectory groups that exist in a mixed surgical population (non-cardiac surgery) of elderly patients during the first seven days…
- Trial name
- NCT05865366
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Feng Gao
Phantom Limb Pain After Amputation, Chronic Pain Due to Injury
Negative Pressure Wound Therapy as a Predictor of Persistent Pain After War-Related Trauma
War-related trauma frequently causes complex soft tissue injuries that require repeated surgical treatment and advanced wound management techniques such as Negative Pressure Wound Therapy (NPWT).
- Conditions
- Phantom Limb Pain After Amputation, Chronic Pain Due to Injury, Postoperative Pain, Trauma (Including Fractures)
- Trial name
- NPWT-Pain Stud (NCT07475897)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Pain, Pain Syndrome
Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06071949
- Testing
- Adezunap
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH