Clinical trials: Chronic Osteoarthritis
Spondylosis Lumbar
Battlefield Acupuncture as an Adjunct to Electroacupuncture for Chronic Low Back Pain Due to Lumbar Spine Osteoarthritis
Chronic low back pain due to lumbar spine osteoarthritis is a common and disabling condition. Many patients do not get enough relief from standard treatments.
- Trial name
- NCT06874959
- Testing
- Battlefield Acupuncture (BFA), Electroacupuncture, Paracetamol 500 mg (as-needed)
- Where
- 2 sites in Vietnam
- Volunteers
- 60 people
- Sponsor
- Bui Pham Minh Man
Meniscus; Degeneration, Knee Osteoarthritis
NUsurface Implant Registry
The purpose of this active post-market surveillance clinical registry study is to further characterize the therapeutic effect, the long-term safety and effectiveness of the NUsurface® meniscus implant in the real-world…
- Conditions
- Meniscus; Degeneration, Knee Osteoarthritis, Knee Pain Chronic
- Trial name
- NIR (NCT03953846)
- Where
- 6 sites in Belgium, Germany and 2 more
- Volunteers
- 36 people
- Sponsor
- Phoenix Kinetics
Osteoarthritis, Rheumatoid Arthritis
Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-steroidal Anti-inflammatory Drug Treatment
The purpose of this study is to evaluate the safety of long-term treatment with HZT-501, a fixed-dose combination oral tablet of 800 mg ibuprofen and 26.6 mg famotidine for patients that require long-term NSAID treatment.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Chronic Low Back Pain, Chronic Regional Pain Syndrome
- Trial name
- NCT00984815
- Testing
- HZT-501
- Where
- 4 sites in United States
- Volunteers
- 86 people
- Sponsor
- Amgen
Joint Osteoarthritis, Atherosclerosis of the Distal Arteries, Without Gangrene
Evaluation of Impaired Mobility in Chronic Illness Constitution of a Cohort
Chronic illness is a public health issue and mobility loss is frequent in this population. Among its' multiple physical and psychological consequences, increased mortality and cardiovascular morbidity seem the main concern.
- Conditions
- Joint Osteoarthritis, Atherosclerosis of the Distal Arteries, Without Gangrene, Parkinson Disease, Chronic Obstructive Pulmonary Disease, Unspecified
- Trial name
- EVALMOB (NCT04375280)
- Testing
- Development of a screening algorithm designed to determine a "dysmobility" profile in patients with chronic illness.
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Clermont-Ferrand
Osteoarthritis
Systemic Effects of Chronic Metal Ion Exposure From Metal-on Metal Hip Resurfacing
In recent years hip resurfacing has become a very popular alternative treatment to total hip replacement for the treatment of hip arthritis.
- Trial name
- Metal Ions (NCT01493141)
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Pain, Chronic Postsurgical, Knee Osteoarthritis
Central Sensitization in Total Knee Arthroplasty Patients with Persistent Pain
Persistent post-surgical pain is a significant adverse effect after total knee arthroplasty, present in around 20% of the patients. Central sensitization may contribute to developing and maintaining pain.
- Conditions
- Pain, Chronic Postsurgical, Knee Osteoarthritis, Sensitization, Central
- Trial name
- NCT05575310
- Testing
- Total Knee Arthroplasty
- Where
- Spain
- Volunteers
- 117 people
- Sponsor
- University of Barcelona
Osteoarthritis, Chronic Pain
Imaging Pain Relief in Osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease and is the most common form of arthritis. Pain reduction and functional recovery are the key elements of the clinical management of OA.
- Trial name
- IPRO (NCT02208778)
- Testing
- Duloxetine, Remifentanil
- Where
- United Kingdom
- Volunteers
- 77 people
- Sponsor
- University of Nottingham
Knee Osteoarthritis, Knee Pain Chronic
Gabapentin Regimens and Their Effects on Opioid Consumption
The purpose of this study is to determine the best strategy of administering gabapentin in connection with our current approach to perioperative pain management.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Opioid Use, Opioid Dependence
- Trial name
- NCT03334903
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Rheumatoid Arthritis, Health Literacy
Health Literacy, Rational Drug Use, and Cyberchondria in Rheumatic Diseases
Purpose: This study aimed to evaluate rational drug use (RDU), health literacy (HL), and cyberchondria levels among individuals diagnosed with inflammatory rheumatic diseases, and to investigate the factors associated with these…
- Conditions
- Rheumatoid Arthritis, Health Literacy, Rational Drug Use, Cyberchondria
- Trial name
- NCT06993935
- Where
- Turkey (Türkiye)
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Gulseren Demir Karakilic
Hip Osteoarthritis, Hip Pain Chronic
Fast Track Total Hip Arthroplasty vs Standard Care
Fast-track total hip arthroplasty (THA) is a well-established concept including optimized logistics and evidence-based treatment, focusing on minimizing surgical stress and improved post-operative recovery.
- Trial name
- FastTrack-H (NCT04211987)
- Testing
- fast track care protocol, standard care protocol
- Where
- Italy
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli
Chronic Knee Pain, Osteoarthritis
Sequential Genicular Nerve Ablation Prior to Geniculate Artery Embolization in Knee Pain
The goal of this clinical trial is to evaluate whether performing genicular nerve ablation (GNA) before geniculate artery embolization (GAE) improves pain relief and knee function in patients with chronic knee pain.
- Trial name
- NCT06514755
- Testing
- GNA followed by GAE, GAE alone
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Zagazig University
Osteoarthritis of the Knee
A Phase 2 Study To Assess The Efficacy, Tolerability, And Safety OF NKTR-181 In Subjects With Chronic OA Knee Pain
NKTR-181 is being developed as an analgesic compound for the treatment of moderate to severe chronic pain - active as a mu agonist, but with inherent molecular properties designed to provide a unique clinical profile, including…
- Trial name
- NCT01619839
- Testing
- NKTR-181
- Where
- 34 sites in United States
- Volunteers
- 296 people
- Sponsor
- Nektar Therapeutics
Arthritis, Arthritis/Arthrosis
Combining Virtual Reality and Hypnosis to Alleviate Chronic Pain in Elderly Patients with Hand Arthritis
The goal of this pilot randomized clinical trial is to test the efficacy of an intervention combining virtual reality and hypnosis on decreasing pain and improving quality of life in elderly patients with hand arthritis.
- Conditions
- Arthritis, Arthritis/Arthrosis, Arthritis, Rheumatoid, Elderly
- Trial name
- VRHArthrisis (NCT06833905)
- Testing
- Virtual reality: Beach, Virtual Reality: Forest, Hypnosis: Magic Hand
- Volunteers
- 80 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Chronic Low Back Pain, Hip Ostearthritis
Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)
Back pain is a huge problem for millions of Americans, including nearly 11 million Veterans. Our older Veterans suffer the most. Citizens spend billions of dollars, yet consistently get poor results.
- Conditions
- Chronic Low Back Pain, Hip Ostearthritis, Myofascial Pain Syndrome, Fibromyalgia
- Trial name
- NCT02697435
- Testing
- Patient-Centered Care, Imaging-Directed Care
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Chronic Pain Syndrome
Thermal Micro-cautery for Painful Knee Osteoarthritis
To trial a traditional pain management technique from Ayurveda in a modern way - the technique involves micro - cautery to painful areas in knee osteoarthritis for patients on a waiting list for knee replacement.
- Trial name
- TMC-PKO (NCT03460717)
- Testing
- Peripheral Nerve Field Stimulation by Thermal Micro-Cautery
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- The National Children's Hospital, Tallaght
Chronic Knee Pain, Chronic Knee Osteoarthritis
Treating Chronic Pain of Peripheral Nerve Origin With the Novel Noninvasive Hypersound Neuromodulation System
First, the subject will undergo screening and provide informed consent. Baseline measurements are then taken. The subject remains seated with back support throughout the session.
- Conditions
- Chronic Knee Pain, Chronic Knee Osteoarthritis, Post Surgical Neuropathic Pain
- Trial name
- NCT06626854
- Testing
- RF-PNS
- Volunteers
- 5 people
- Sponsor
- Hypersound Medical Inc
Osteoarthritis, Chronic Pain
OASIS: Osteoarthritis Sensitivity Integration Study
The primary objective of this study is to evaluate the relative efficacy of a centrally-acting analgesic (duloxetine) versus a peripherally acting analgesic (topical diclofenac) for pain and associated symptom management in knee…
- Trial name
- OASIS (NCT01377038)
- Testing
- Phenotype assessment
- Where
- United States
- Sponsor
- University of Michigan
Osteoarthritis, Chronic Pain
Mindfulness for Osteoarthritis-related Knee Pain
The purpose of this project is to investigate the feasibility and acceptability of a Mindfulness based intervention for people who are attending secondary care with Osteoarthritis (OA)-related knee pain.
- Trial name
- NCT02595099
- Testing
- Mindfulness training
- Volunteers
- 15 people
- Sponsor
- University of Nottingham
Osteoarthritis (OA) of the Hip
PENG Block & PENG PRF
The primary aim of this study is to prospectively compare the effects of the pericapsular nerve group (PENG) block alone and the combination of PENG block with pulsed radiofrequency (PRF) on pain intensity in patients with…
- Trial name
- PENG-PRF (NCT07360093)
- Testing
- PENG Block Pulsed radiofrequency
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Ankara City Hospital Bilkent
Chronic Knee Pain
Effects of Photobiomodulation on Inflammation and Chronic Pain in Knee Osteoarthritis (EPIC-KO)
This study aims to determine analgesic and anti-inflammatory effects of dual-wavelength PBM in people with symptomatic knee OA.
- Trial name
- EPIC-KO (NCT07079969)
- Testing
- Photobiomodulation therapy (PBM) device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida