Clinical trials: Chronic Opioid Use
Orthopaedic Trauma, Chronic Opioid Use
Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma Patients
The goal of this randomized clinical trial is to learn if the use of a low-dose nonsteroidal anti-inflammatory drug (NSAID), ketorolac, reduces the rate of chronic opioid use in orthopaedic trauma patients.
- Trial name
- NCT06201676
- Testing
- Ketorolac Injection, Standard of Care (SOC) Multimodal Analgesia
- Where
- 2 sites in United States
- Volunteers
- 458 people
- Sponsor
- Massachusetts General Hospital
Opioid Use Disorder, Cocaine Use Disorder
Cocaine Opioid Oxytocin Option - Limited
This is a pilot feasibility study assessing the tolerability of chronic administration of intranasal oxytocin to patients receiving methadone at an opioid replacement clinic who are actively using cocaine.
- Trial name
- COOOL (NCT02028533)
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Francisco
Pain, Chronic Pain
Negating Opioid and Pain Actively Through Intervention
Chronic pain is one of the most prevalent and debilitating medical conditions and opioid analgesics are a commonly prescribed class of medications in the United States.
- Conditions
- Pain, Chronic Pain, Opioid Use
- Trial name
- NOPAIN (NCT03306147)
- Testing
- Pain education with follow up encounters
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Opioid Use Disorder
Transition From Acute to Chronic Opioid Use and Chronic Pain
In the current opioid crisis, the use of opioids as the main pain management method is recognized as a consistent risk factor for chronic opioid use and the development of Opioid Use Disorder (OUD), as well as related…
- Trial name
- NCT07211399
- Testing
- Opioid-free anesthesia, Opioid-based anesthesia
- Where
- United States
- Sponsor
- Jacques E. Chelly
Opioid Use, Marijuana
Does Medical Cannabis Reduce Opioid Use in Adults With Pain
The study will examine how medical cannabis use affects opioid analgesic use. This landmark study will be among the first to examine the effect of medical cannabis with different THC/CBD (Tetrahydrocannibinol/Cannabidiol) content…
- Conditions
- Opioid Use, Marijuana, Chronic Pain
- Trial name
- ReLeaf-E (NCT04308148)
- Where
- United States
- Volunteers
- 217 people
- Sponsor
- Albert Einstein College of Medicine
Cancer, Chronic Pain
Prospective Multicentre Study of the Use of Ketamine in the Treatment of Refractory Chronic Pain in the French CLCC
The primary objective of this study is to describe the administration practices of the antalgic Ketamine in French CLCC (Centre de Lutte Contre le Cancer) in terms of indication (neuropathic sequelae pains, morphine additional…
- Conditions
- Cancer, Chronic Pain, Neuropathic Pain, Opioid Use
- Trial name
- KETACANCER (NCT04459234)
- Testing
- Ketamine use in CLCC sites (indication and administration protocol)
- Where
- 12 sites in France
- Volunteers
- 81 people
- Sponsor
- Centre Leon Berard
Opioid Dependence, Substance Abuse Disorders
The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care
The goal of this pilot clinical trial is to learn if a community informed designed program of addiction counseling with coordinated community peer navigator for people with Opioid Use Disorder (OUD) and other medical conditions…
- Conditions
- Opioid Dependence, Substance Abuse Disorders, Complex Medical Patients, Primary Care Patients With Chronic Conditions
- Trial name
- MOUD+ (NCT06837662)
- Testing
- MOUD "Plus" Intervention (treatment as usual + coordinated counseling and referral to community based peer), Treatment As Usual (primary care with low threshold MOUD prescribing)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Oregon Health and Science University
Chronic Pain, Tobacco Use
Opioids, Low Nicotine Cigarettes, and Chronic Pain
The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on craving, withdrawal, and pain among individuals with chronic pain…
- Conditions
- Chronic Pain, Tobacco Use, Opioid Substitution Treatment
- Trial name
- NCT06747871
- Testing
- Very Low Nicotine Cigarettes (VLNC), Normal Nicotine Cigarettes (NNC)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Narcotic Abuse, Opioid-related Disorders
Abuse Potential Assessment of Intranasally Administered EMBEDA Compared To Morphine Sulfate Controlled Release And Placebo
This was a single-dose, randomized, double-blind, placebo-controlled, 3 way crossover study designed to evaluate the relative abuse potential of crushed EMBEDA® compared to morphine sulfate CR tablets and placebo in healthy male…
- Conditions
- Narcotic Abuse, Opioid-related Disorders, Analgesia, Chronic Pain
- Trial name
- NCT01595867
- Testing
- EMBEDA - morphine sulfate/ naltrexone hydrochloride, morphine sulfate CR crushed.
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Pfizer
Opioid Use, Post Operative Pain
Assessment of the Development of Postoperative Persistent Postoperative Pain
During the postoperative period, it is possible to observe the development of acute pain, which lasts no longer than a week after surgery.
- Conditions
- Opioid Use, Post Operative Pain, Chronic Pain
- Trial name
- NCT05370924
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Obstetric Pain, Postpartum Depression
Ketamine to Improve Recovery After Cesarean Delivery - Part 1
The objective of this study is evaluate the breastmilk transfer and pharmacokinetics (Part 1) and effectiveness (Part 2) of a post-cesarean delivery intravenous ketamine bolus-and-infusion strategy, as a preventive analgesic…
- Conditions
- Obstetric Pain, Postpartum Depression, Breastfeeding, Pain, Acute
- Trial name
- KINETIC (NCT04037085)
- Testing
- Ketamine
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Opioid Use, Chronic Pain
Optimization and Multi-Site Feasibility of Yoga for Chronic Pain in People in YOGAMAT-II - Phase I
Phase 1 - MOST Preparation Phase: 1. To conduct a pilot trial at two opioid use disorder clinic sites, enrolling n=10 at both sites, for a total n=20. 2.
- Trial name
- YOGAMAT-II (NCT04646148)
- Testing
- Yoga classes
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Butler Hospital
Opioid Dependence, Chronic Pain
Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication
This is an open-label pilot trial to assess the safety and feasibility of a novel 8-week psilocybin-assisted psychotherapy intervention to facilitate successful tapering/discontinuation of opioid pain medication in adult patients…
- Trial name
- NCT05585229
- Testing
- Psilocybin-assisted Psychotherapy
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of British Columbia
Chronic Pain, Opioid Misuse
Mobile & Online-Based Interventions to Lessen Pain
The investigators will implement an international 2-arm online pragmatic feasibility randomized controlled trial (RCT) of a digital pain relief skills intervention "Empowered Relief: On-Demand" to reduce pain metrics, opioid…
- Conditions
- Chronic Pain, Opioid Misuse, Opioid Use Disorder
- Trial name
- NCT05152134
- Testing
- Empowered Relief On-Demand, Health Education
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Stanford University
Chronic Pain Syndrome, Opioid Use
Near-infrared Spectroscopy-based Neurofeedback as Adjunct to Mindfulness-Oriented Recovery Enhancement in Persons With Chronic Pain
The primary aim of this pilot trial is to enhance the efficacy of the Mindfulness-Oriented Recovery Enhancement (MORE) intervention by adding neurofeedback (NF) of the Orbitofrontal Cortex (OFC) as an adjunct to the savoring…
- Trial name
- NCT04902339
- Testing
- Mindfulness-Oriented Recovery Enhancement, Neurofeedback, Supportive Psychotherapy
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- University of Utah
Opioid-use Disorder, Opioid Use
PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Current Opioid-User Population
The objective of this research is to assess the effects of electronic health record (EHR)-based decision support tools on primary care provider (PCP) decision-making around pain treatment and opioid prescribing.
- Conditions
- Opioid-use Disorder, Opioid Use, Opioid Abuse
- Trial name
- PRINCE (NCT04601480)
- Testing
- Choice Architecture Nudge, PMP Integration & Nudge
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- University of Minnesota
Pain, Chronic, Opioid Use
Comparing the Impact of Mindful Interoceptive Mapping and Mindful Breathing on Pain and Opioid Use
This is a single site, two-arm, parallel group randomized clinical trial comparing the effect of two mindfulness-based interventions (Mindful Interoceptive Mapping vs.
- Trial name
- NCT04523766
- Testing
- Mindfulness of Breath, Mindful Interoceptive Mapping
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- University of Utah
Analgesia, CYP2D6 Polymorphism
Cytochrome P450's Pharmacogenomics in Chronic Pain Patients
The use of titrated drugs is at the base of a successful antalgic treatment in order to provide both an adequate relief and a satisfactory tolerability profile.
- Conditions
- Analgesia, CYP2D6 Polymorphism, Opioid Use, Chronic Pain
- Trial name
- FACIDOCRO (NCT03411759)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Bologna
Post Operative Pain, Acute, Post Operative Pain, Chronic
Naldebain for Control of Post-Cesarean Section Pain
Inadequate postoperative pain management can lead to physical and psychological distress in patients as well as impact surgical wound healing and increase the risk of developing postoperative delirium and cardiopulmonary and…
- Conditions
- Post Operative Pain, Acute, Post Operative Pain, Chronic, Cesarean Section
- Trial name
- NCT05187520
- Testing
- Patient-controlled epidural analgesia (PCEA), Naldebain®
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- E-DA Hospital
Pain, Chronic Pain
Developing rTMS Treatment Strategies for Pain in Opiate Dependence
The purpose of this study is to parametically evaluate two different types of repetitive Transcranial Magnetic Stimulation (rTMS) treatment strategies as a potential treatment for pain in individuals currently taking prescription…
- Conditions
- Pain, Chronic Pain, Opioid Dependence, Opioid Use
- Trial name
- NCT03576781
- Testing
- Real iTBS, Real cTBS
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina