Clinical trials: Chronic Obstructive Pulmonary Disorder
Chronic Obstructive Pulmonary Disease, Urinary Incontinence
Urinary Incontinence Amongst Women With Chronic Obstructive Pulmonary Disease
The primary aim of the study is to investigate whether pelvic floor muscle training or cough-suppression therapy reduces symptoms of urinary incontinence amongst women with chronic obstructive pulmonary disease grade 1-4 (mild to…
- Trial name
- UriCO (NCT02614105)
- Testing
- Pelvic floor muscle training, Cough-suppression therapy, Control
- Where
- 2 sites in Norway
- Volunteers
- 35 people
- Sponsor
- Ostfold Hospital Trust
Lung Neoplasms, Emphysema
Computed Tomography Assessment of Regional Ventilation (CURVE)
This study uses CT scans to assess airflow in the lung, the scan is quick, cheap and painless. The information from the scan may help doctors tell which patients are suitable to have surgery to cure early stage lung cancer.
- Conditions
- Lung Neoplasms, Emphysema, Lung Diseases, Interstitial, Pulmonary Disease, Chronic Obstructive
- Trial name
- CURVE (NCT02879773)
- Testing
- CTPVe
- Where
- United Kingdom
- Volunteers
- 131 people
- Sponsor
- Heart of England NHS Trust
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Safety of Indacaterol Plus Tiotropium Versus Tiotropium Alone in Patients With Chronic Obstructive Pulmonary Disease
This study assessed the efficacy and safety of indacaterol (150 µg once daily [od]) when combined with tiotropium (18 µg od) versus tiotropium (18 µg od) treatment alone in patients with chronic obstructive pulmonary disease…
- Trial name
- INTRUST2 (NCT00877383)
- Testing
- Indacaterol 150 μg, Tiotropium 18 μg
- Where
- 176 sites in United States, Canada and 7 more
- Volunteers
- 1,142 people
- Sponsor
- Novartis Pharmaceuticals
COPD (Chronic Obstructive Pulmonary Disease), Endoscopy, Gastrointestinal
Risk Indicators and IPI Performance in Sedation-Related Respiratory Deterioration in COPD
This prospective observational clinical study investigates two key questions in COPD patients undergoing sedated endoscopic procedures.
- Trial name
- IPI-COPD (NCT07262905)
- Testing
- Sedation Analgesia and Respiratory Monitoring (Integrated Pulmonary Index - IPI)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Umran Karaca
Pulmonary Disease, Chronic Obstructive
Tiotropium Inhalation Capsules and Salmeterol Inhalation Aerosol on Muscular Efficiency and Resting Energy Expenditure (REE) in Patients With Stable Chronic Obstructive Pulmonary Disease (COPD)
The primary objective of this study is to evaluate the effect of tiotropium on gross muscular efficiency
- Trial name
- NCT02172794
- Testing
- Tiotropium, Salmeterol
- Volunteers
- 48 people
- Sponsor
- Boehringer Ingelheim
Chronic Graft Versus Host Disease
A Study of Belumosudil in Children With Chronic Graft Versus Host Disease (schoolROCK)
This is an open-label, single group, Phase 1/2, 1-arm study for treatment of children aged 1 to <18 years with active moderate-to-severe cGVHD that is refractory to or recurred after at least 2 prior lines of systemic therapy for…
- Trial name
- schoolROCK (NCT07116031)
- Testing
- Belumosudil
- Where
- 35 sites in United States, Belgium and 11 more
- Volunteers
- 37 people
- Sponsor
- Sanofi
Chronic Obstructive Pulmonary Disease
Molecular, Cytological Features and Genetic Susceptibility of COPD Attributable to Different Environmental Exposures 2
The objective of this study is to investigate molecular, cytological and genetic features of occupational chronic obstructive pulmonary disease (COPD) in conditions of different occupational exposures.
- Trial name
- NCT02284295
- Testing
- exposure to respirable silica dust, exposure to aromatic hydrocarbons
- Where
- Russia
- Volunteers
- 352 people
- Sponsor
- Novosibirsk City Hospital #2
COPD
Respiratory Pathogens of Patients With Asthma and COPD Exacerbations
To assess the infective etiologies by quantitative polymerase chain reaction (qPCR) of acute exacerbation of COPD and asthma who required hospitalization.
- Trial name
- NCT02866357
- Testing
- No intervention
- Where
- Hong Kong
- Volunteers
- 1,000 people
- Sponsor
- Chinese University of Hong Kong
Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency
Сohort Study to Evaluate Exacerbations, Respiratory Symptoms, Physical Exercise Intolerance and Lung Functions Among Participants Who Use IQOS With Heatsticks Compared to Smokers of Conventional Cigarettes
This study evaluates frequency of exacerbations, respiratory symptoms, physical exercise intolerance and abnormal lung functions among participants who use IQOS with heatsticks compared to smokers of conventional cigarettes
- Conditions
- Pulmonary Disease, Chronic Obstructive, Respiratory Insufficiency, Physical Disability, Respiratory Disease
- Trial name
- NCT03383601
- Testing
- Heated Tobacco product IQOS/heatstick, Smoking combustible cigarettes
- Where
- Kazakhstan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Kazakhstan Academy of Preventive Medicine
Emphysema
Efficacy of Osteopathic Manipulation in Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine if osteopathic manipulative treatment (OMT) is effective for persons with emphysema as a component of their chronic obstructive pulmonary disease.
- Trial name
- NCT00034112
- Testing
- osteopathic manipulative treatment
- Where
- United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Chronic Obstructive Pulmonary Disease
The Oxidative Stress, Inflammatory Markers, and Metabolomics Response to Exercise in Patients With COPD
The effect of different physical exercise protocols on inflammatory markers, antioxidant balance, and metabolomics has not been fully elucidated.
- Trial name
- NCT04117412
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Hacettepe University
Pulmonary Disease, Chronic Obstructive
Change in Symptom and Quality of Life in COPD by Budesonide/Glycopyrronium/Formoterol Fumarate Pressurized Metered Dose Inhaler (BGF pMDI)
This study is primarily aimed to investigate whether PROs can be improved after the initiation of BGF pMDI in real world clinical settings.
- Trial name
- EBISU (NCT05219630)
- Where
- 17 sites in Japan
- Volunteers
- 106 people
- Sponsor
- AstraZeneca
Gingivitis; Chronic, Gingivitis and Periodontal Diseases
Comparision of Enzymatic and Active Salt Toothpaste
Dental plaque is a major etiological factor in the development of gingivitis. Mechanical plaque control through toothbrushing is essential for maintaining oral hygiene, while toothpaste formulations containing active ingredients…
- Conditions
- Gingivitis; Chronic, Gingivitis and Periodontal Diseases, Dental Plaque
- Trial name
- Enzyme T/P (NCT07880483)
- Testing
- Enzyme toothpaste, active salt toothpaste, standard fluoridated toothpaste
- Where
- India
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Uttar Pradesh University of medical sciences
Chronic Respiratory Disease, COPD
The Effect of Spontaneous Respiration on Pulse-oximetry Measurements
This is a study designed to measure, characterize and describe changes on pulse-oxymetry values produced as a result of deep breaths in patients with stable chronic hypoxemic respiratory failure.
- Conditions
- Chronic Respiratory Disease, COPD, Interstitial Lung Disease
- Trial name
- NCT04139356
- Testing
- Deep breaths
- Where
- Mexico
- Volunteers
- 45 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
COPD
24-hour Lung Function in Subjects With Moderate to Very Severe COPD After Treatment With PT003, Open-Label Spiriva® Respimat® as an Active Control, and Placebo
Randomized, Phase IIIb, Three-period, Three-treatment, Double-blind, Multi-center, Crossover Study to Evaluate the 24-hour Lung Function Profile in Subjects with Moderate to Very Severe COPD after 4 Weeks of Treatment with PT003…
- Trial name
- NCT02347072
- Testing
- GFF MDI (PT003), Spiriva® Respimat® (Tiotropium Bromide)
- Volunteers
- 80 people
- Sponsor
- Pearl Therapeutics, Inc.
Asthma, Small Airway Disease
The Prevalence Of Small Airways Dysfunction In Asthma Patients And The Impact On The Asthma Control
Asthma, which are one of the most important causes of morbidity and mortality both in the world and in our country, constitute a very serious social and economic burden.
- Trial name
- NCT04375995
- Testing
- Impulse oscillometry, Spirometric pulmonary function test, Fractional exhaled nitric oxide (FENO) test
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Sibel Naycı
Chronic Obstructive Pulmonary Disease, Depression
The Effect on Depressive Symptoms in ECF Residents With COPD
The purpose of this study is to assess the effect of treatment with Advair Diskus on depression using the Cornell depression scale in COPD patients in the nursing home.
- Trial name
- DISK-02 (NCT00974246)
- Testing
- Advair diskus
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Valley Medical Research
Chronic Hypersecretions
Efficacy of Temporary Positive Expiratory Pressure (TPEP) in Chronic Hypersecretion
Mechanical devices to increase the individual's bronchial hygiene are commonly used in patients with chronic retention of secretions and abnormal cough reflex.
- Trial name
- UNIKO (NCT00700388)
- Testing
- TPEP device (UNIKO), MABT (Manually assisted breathing techniques)
- Where
- 6 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Villa Pineta Hospital
Chronic Obstructive Pulmonary Disease, COPD
A 7-Day Cross-over Study of QD (Once Daily) and BID (Twice Daily) TD-4208 in Chronic Obstructive Pulmonary Disease (COPD)
This study evaluated the safety and efficacy of once and twice daily TD-4208 and placebo when administered using a jet nebulizer for 7 days in a cross-over design to patients with moderate to severe chronic obstructive pulmonary…
- Trial name
- NCT02109172
- Testing
- TD-4208
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Mylan Inc.
Chronic Obstructive Pulmonary Disease
Oxygen Portable Concentrator During Exercises in Patients With COPD
The purpose of this study is to compare differences in oxygen delivery between portable oxygen concentrators (POCs) and liquid oxygen (LOs) portable units, pose a question if POCs are equally effective as LOs in reducing…
- Trial name
- NCT00875719
- Testing
- Oxygen concentrators versus constant flow axygen, oxygen concentrator
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche