Clinical trials: Chronic Lower Back Pain
Low Back Pain
Trial of Scrambler Therapy or Sham Treatment for Low Back Pain
This pilot study will evaluate Scrambler therapy and Sham treatment on levels of low back pain, pain sensitivity and mRNA expression of pain sensitivity candidate genes.
- Trial name
- NCT01896687
- Testing
- Scrambler
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Virginia Commonwealth University
Chronic Low-back Pain
VANISH for Chronic Low Back Pain
The program, called TMC-CP01, will use a combination of virtual reality, biofeedback, and psychological exercises to manage pain associated with Chronic Low Back Pain.
- Trial name
- VANISH (NCT04236804)
- Testing
- Flowly (TMC-CP01)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ajay Wasan, MD, Msc
Chronic Low Back Pain
Transcranial Alternating Current Stimulation in Back Pain- Pilot Sudy
Chronic pain is a severe disabling problem within society, affecting 25-30% of the United States population.. Transcranial alternating current stimulation (tACS) has the potential to provide a treatment option that is safe…
- Trial name
- BPS (NCT03243084)
- Testing
- XCSITE100 Stimulator tACS
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of North Carolina, Chapel Hill
Chronic Low-back Pain
Persica 002 Phase 1b PP353 vs Placebo in the Treatment of Low Back Pain
A Phase 1b study to investigate the efficacy of PP353 compared to placebo in the treatment of chronic low back pain associated with bone oedema.
- Trial name
- NCT04238676
- Testing
- PP353
- Where
- 10 sites in Denmark, New Zealand and 2 more
- Volunteers
- 43 people
- Sponsor
- Persica Pharmaceuticals Ltd
Pain, Low Back Pain
Efficacy and Safety Study of Buprenorphine HCl Buccal Film in Subjects With Low Back Pain
The purpose of this study is to determine whether buprenorphine hydrochloride (HCl) buccal film is effective and safe in the treatment of chronic low back pain (CLBP).
- Trial name
- NCT01256450
- Testing
- Buprenorphine
- Where
- 24 sites in United States
- Volunteers
- 334 people
- Sponsor
- BioDelivery Sciences International
Lower Back Pain
Neurosteroids as Novel Therapeutic Agents for Chronic Pain in OEF/OIF Veterans
The study design is a randomized, double-blind, two-arm trial of pregnenolone and placebo to determine the possible analgesic effects in OEF/OIF Veterans with chronic low back pain.
- Trial name
- NCT01898013
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Durham VA Medical Center
Back Pain Lower Back Chronic
Safety and Efficacy of Buprenorphine Transdermal System (BTDS) in Subjects With Moderate to Severe Low Back Pain
The objective of this study is to demonstrate the effectiveness and tolerability of the buprenorphine transdermal system (BTDS) 20 in comparison to the buprenorphine transdermal system (BTDS) 5 and oxycodone immediate-release in…
- Trial name
- NCT00313014
- Testing
- Buprenorphine, Oxycodone Immediate-Release
- Where
- 85 sites in United States
- Volunteers
- 660 people
- Sponsor
- Purdue Pharma LP
Back Pain Lower Back Chronic
Examining Racial and SocioEconomic Disparities (ERASED) in Chronic Low Back Pain Study
It remains unclear whether certain disadvantaged subgroups of society may be at heightened risk for poor chronic low back pain (cLBP) outcomes.
- Trial name
- ERASED (NCT03338192)
- Testing
- QST
- Where
- United States
- Volunteers
- 281 people
- Sponsor
- University of Alabama at Birmingham
Low Back Pain, Radiating Pain
Effect of Nitrous Oxide in Treating Neuropathic Pain: A Study in Chronic Low Back Pain Patients
Epidural injection will be completed under fluoroscopy and all patients will receive 1-4 mg of Midazolam for relaxation before procedure and, if needed, 50-100 mcg of Fentanyl intravenous (IV).
- Trial name
- NCT01172600
- Testing
- Entonox, Oxygen
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- The Cleveland Clinic
Chronic Low Back Pain
Visceral Manipulation in Patients With Chronic Low Back Pain
Non-specific chronic low back pain is a common multifactorial condition common to the world population. It is defined as a pain and discomfort located below the ribs and above the gluteal folds that may or may not have referred…
- Trial name
- NCT03101020
- Testing
- Active Visceral Manipulation, Standard care physiotherapy
- Where
- 2 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sorocaba
Chronic Pain, Chronic Low Back Pain
Pain Research: Innovative Strategies With Marijuana
This study tests the effects of cannabinoid levels in blood on pain relief, inflammation, and cognitive dysfunction in chronic pain patients who choose to use edible cannabis.
- Conditions
- Chronic Pain, Chronic Low Back Pain, Cannabis Use
- Trial name
- PRISM (NCT03522324)
- Testing
- Cannabis Edible
- Where
- United States
- Volunteers
- 268 people
- Sponsor
- University of Colorado, Boulder
Chronic Low-back Pain
Virtual Reality Guided Acupuncture Imagery Treatment for Chronic Low Back Pain
Testing the effect of Virtual Reality - guided imagery acupuncture
- Trial name
- NCT06814470
- Testing
- Virtual reality guided imagery acupuncture treatment (VRGAIT), Virtual reality guided imagery acupuncture treatment control
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Massachusetts General Hospital
Pain
A Pilot Study of Switching From One Pain Medication to Another (Opioid Rotation)
The purpose of this study is to see if changing from one pain medication like morphine or oxycodone to another pain medication, oxymorphone (OPANA®), will be helpful to patients.
- Trial name
- NCT00580294
- Testing
- Oxymorphone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Back Pain Lower Back Chronic
MOTIVATE: Moving to Improve Outcomes for Older Adults
The overarching goal of this study is to evaluate a tele-based behavioral change intervention for older adults (aged 50 years and older) with chronic low back pain (cLBP) and comorbid depression, and to ultimately assess its…
- Trial name
- NCT03914469
- Testing
- Behavioral Intervention Group
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Texas Southwestern Medical Center
Low Back Pain
Efficacy of the Quell Wearable Device for Chronic Low Back Pain
This is a 1-year trial designed to gather information about the use of the Quell for persons with chronic musculoskeletal low back pain.
- Trial name
- NCT02944513
- Testing
- Quell
- Volunteers
- 68 people
- Sponsor
- Brigham and Women's Hospital
Low Back Pain
RN624 In Adult Patients With Chronic Low Back Pain
The primary objective of this study is to evaluate the analgesic efficacy of RN624 compared with placebo and compared with naproxen in the treatment of adult patients with chronic low back pain.
- Trial name
- NCT00584870
- Testing
- Naproxen, PF-04383119 (RN624)
- Where
- 38 sites in United States
- Volunteers
- 220 people
- Sponsor
- Pfizer
Low Back Pain, Back Pain With Radiation
Evaluating the Role of Neuroinflammation in Low Back Pain
In this research, the study team will use brain imaging to evaluate the presence of neuroinflammation in the brains and spinal cords of patients with low back pain.
- Conditions
- Low Back Pain, Back Pain With Radiation, Back Pain Without Radiation, Back Pain Lower Back Chronic
- Trial name
- IGNITE (NCT03106740)
- Testing
- Minocycline Hydrochloride 100mg Capsule, Magnetic Resonance-Positron Emission Tomography Imaging
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Marco Loggia
Pain
An Efficacy and Safety Study of Acetaminophen Plus Tramadol Hydrochloride (JNS013) in Participants With Chronic Pain
The purpose of this study is to evaluate the efficacy and safety of tramadol hydrochloride plus acetaminophen (JNS013) in participants with chronic pain accompanied by osteoarthritis (a progressive and degenerative joint disease…
- Trial name
- NCT00736853
- Testing
- Tramadol Hydrochloride Plus Acetaminophen (Open-Label), Tramadol Hydrochloride Plus Acetaminophen (Double-Blind)
- Where
- 20 sites in Japan
- Volunteers
- 321 people
- Sponsor
- Janssen Pharmaceutical K.K.
Pain, Chronic Pain
Effect of Pulse Width With Spinal Cord Stimulation
The primary objective of this study is to assess the effects of varying pulse width in suprathreshold dorsal column stimulation in patients with low back pain.
- Conditions
- Pain, Chronic Pain, Back Pain
- Trial name
- NCT00399516
- Testing
- Precision
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Boston Scientific Corporation
Chronic Pain, Low Back Pain
Meditation-CBT for Opioid-treated Chronic Low Back Pain
Chronic low back pain (CLBP) is one of the most common, costly and disabling conditions. It is often refractory to treatment, with patients requiring long-term opioid therapy.
- Trial name
- NCT01775995
- Testing
- Meditation-CBT Intervention + Usual Care, Usual Care Alone
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Wisconsin, Madison