Clinical trials: Chronic Knee Pain
Osteoarthritis, Knee
The Effect of Therapeutic Methods for Chronic Knee Osteoarthritis Pain
Chronic osteoarthritis (OA) pain of the knee is not effectively abrogated by the available non-pharmacologic or pharmacologic treatments. Radiofrequency (RF) neurotomy is a therapeutic alternative for chronic pain.
- Trial name
- NCT00924677
- Testing
- radiofrequency neurotomy for genicular nerve
- Where
- South Korea
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Osteo Arthritis Knee, Pain, Chronic
Study of the Effects of Photobiomodulation in Patients With Osteoarthritis
PhotoBioModulation (PBM) is a mature science with therapeutic efficacy in humans and animals, and with excellent results in different medical specialties without side effects.
- Conditions
- Osteo Arthritis Knee, Pain, Chronic, Inflammation
- Trial name
- NCT03924128
- Testing
- Photobiomodulation
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Knee Osteoarthritis, Knee Pain Chronic
The Effect of PEMF for Patients With Knee OA
Health care costs are increasing alarmingly, which will impose an overwhelming economic burden to an aging society like that of Hong Kong.
- Trial name
- NCT05548712
- Testing
- Pulse Electromagnetic Field
- Where
- Hong Kong
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Knee Osteoarthritis, Knee Pain Chronic
iPACK Block for Total Knee Arthroplasty
This randomized, double-blinded, placebo-controlled trial seeks to evaluate the efficacy of the rehabilitation process of the Interspace between the Popliteal Artery and Capsule of the Posterior Knee (iPACK) block in total knee…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Disease
- Trial name
- NCT06087562
- Testing
- Ropivacaine 0.5% Injectable Solution 20mL, 0,9% normal saline 20mL
- Where
- Poland
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
Hip Pain Chronic, Knee Pain Chronic
Effect of Buglossoides Oil on Recent Chronic Non-injurious Hip and Knee Pain
The effect of Buglossoides oil emulsion on the intensity of recent chronic knee and hip pain, on plasma and mononuclear blood cells fatty acid profiles and on whole blood Eicosapentaenoic acid production will be investigated.
- Trial name
- NCT03576625
- Testing
- High Oleic Sunflower Oil, Buglossoides Oil
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Réseau de Santé Vitalité Health Network
Knee Osteoarthritis, Knee Arthritis
Rate of Torque Development and Voluntary Quadriceps Activation in Patients With Knee Osteoarthritis: A Quantitative Analysis Before and After a Single Session of Manual Physical Therapy
This is a randomized control trial to determine if there is a measurable change in voluntary quadriceps activation, RTD, pain, and function before and after a single session of manual physical therapy.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic, Knee Deformity
- Trial name
- NCT04234282
- Testing
- Manual Physical Therapy
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jennifer Moreno Clinic
Knee Osteoarthritis, Knee Pain Chronic
Kinematic Alignment vs Mechanical Alignment for Total Knee Arthroplasty
This is a prospective, randomized, single-blinded, multi-center trial comparing Kinematic Alignment vs Mechanical Alignment in TKA patients using patient reported outcomes, clinical and functional performance tests and…
- Trial name
- KA vs MA (NCT05461638)
- Testing
- Mechanical Alignment and Unrestricted Kinematic Alignment using Medacta GMK Sphere with MyKnee Custom guides, Mechanical Alignment and Restricted Kinematic Alignment using Medacta GMK Sphere with custom cutting guides
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medacta USA
Knee Osteoarthritis, Knee Pain Chronic
Evaluation of NMES for Reducing Pain and Improving Functional Outcomes in Knee OA Patients
The present prospective trial is designed to evaluate the efficacy of CyMedica Orthopedics e-vive™ system, a multifunctional electrotherapy device providing neuromuscular electrical stimulation (NMES) for reducing pain and…
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- NMES (NCT03980964)
- Testing
- Active NMES
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CyMedica Orthopedics, Inc
Acute Pain, Chronic Pain
The Use of Venlafaxine in Reducing Pain in Primary Total Knee Replacement
Patients experience pain after their knee replacement surgery - and some may continue to experience persistent pain long after their knee replacement surgery.
- Conditions
- Acute Pain, Chronic Pain, Knee Pain Chronic, Neuropathic Pain
- Trial name
- NCT05023278
- Testing
- Venlafaxine 37.5 MG
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Postoperative Delirium, Chronic Postsurgical Pain
Peripheral Blood Single Cell Sequencing Analysis of POD and CPSP in Elderly Patients After Total Knee Arthroplasty
Single-celled sequencing for evaluating differences in gene expression patterns in different cell types of the dynamics of a means of this research as a starting point, to study the postoperative delirium and chronic pain at the…
- Trial name
- NCT05572307
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Xuzhou Central Hospital
Chronic Pain, Knee Pain Chronic
Cognitive Flexibility Training for Persistent Pain: Neuroimaging Pilot (COFLEX-i)
To determine whether a 5-week computer-based cognitive training intervention results in changes in resting-state functional connectivity (rsFC) within the brain networks.
- Conditions
- Chronic Pain, Knee Pain Chronic, Hip Pain Chronic, Back Pain
- Trial name
- COFLEX-i (NCT03720821)
- Testing
- Cognitive Training + fMRI
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Acne Vulgaris, Allergic Rhinitis
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use
The specific aim of this proposed pilot study is to compare two standardized processes (paper and electronic) to deliver a customized MedlinePlus health information prescription.
- Conditions
- Acne Vulgaris, Allergic Rhinitis, Anxiety, Asthma
- Trial name
- NCT01050465
- Testing
- health information prescription
- Volunteers
- 907 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Chronic Pain
Intra-Articular 0.5 % Lidocaine Injection for Osteoarthritis
In this study, investigators compared the efficacy of intra-articular 0.5% lidocaine and saline injection on pain, stiffness and physical function in patients with osteoarthritis.
- Trial name
- NCT02632565
- Testing
- Lidocaine, Saline
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- H. Evren Eker
Musculoskeletal Pain, Musculoskeletal Pain Disorder
Dutch Version Fear-Avoidance Component Scale (FACS)
Chronic musculoskeletal disorders such as low back and neck pain are responsible for an enormous global burden. Fear-avoidance (FA) can be a predictor for the transition from subacute to chronic low back pain.
- Conditions
- Musculoskeletal Pain, Musculoskeletal Pain Disorder, Fear of Pain, Fear of Injury
- Trial name
- NCT03994861
- Testing
- Assessment of disability and behavior (by questionnaires)
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Autoimmune Diseases, Systemic Inflammatory Process
Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee Pain
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is a randomized clinical trial in 25,871 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids (Omacor® fish…
- Conditions
- Autoimmune Diseases, Systemic Inflammatory Process, Knee Pain Chronic, Osteoarthritis
- Trial name
- VITAL (NCT01351805)
- Testing
- Fish Oil, Vitamin D
- Where
- United States
- Volunteers
- 25,871 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Chronic Pain, Chronic Knee Pain
Brain Biomarker of Endogenous Analgesia in Patients With Chronic Knee Pain
This case-control study in patients with knee osteoarthritis and pain-free control individuals aims to develop a brain biomarker of endogenous analgesia that may be used in subsequent clinical trials.
- Conditions
- Chronic Pain, Chronic Knee Pain, Knee Osteoarthritis, Analgesia
- Trial name
- NCT05003323
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Knee Osteoarthritis, Knee Arthritis
Performance of MOTO Medial® Unicompartmental Knee Arthroplasty
This is a prospective, multi-center study, designed to assess mid-term performance of the MOTO Medial® Unicompartmental Knee Arthroplasty (UKA), with patient report outcomes, clinical findings and radiographic analysis.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic
- Trial name
- NCT03211663
- Testing
- MOTO Medial® UKA
- Where
- 5 sites in United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Chronic Musculoskeletal Pain
Network Modeling in Knee Osteoarthritis
This project seeks to understand inter-individual differences in chronic musculoskeletal pain (cMSKP). Our long-term objective is to develop clinically-feasible decision tools that enable whole-person assessment and management of…
- Trial name
- NCT07746284
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- George Mason University
Patello Femoral Syndrome, Patellofemoral Pain
Comparison of Concentric-eccentric Exercises in Patellofemoral Pain Syndrome
Patellofemoral pain syndrome is due to dysfunctional dynamic knee valgus resulting from decrease in strength of hip abductors or abnormal rear-foot eversion with pes pronatus valgus.
- Conditions
- Patello Femoral Syndrome, Patellofemoral Pain, Knee Pain Chronic
- Trial name
- NCT06197958
- Testing
- eccentric exercises, concentric exercises
- Where
- Pakistan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Analgesia
Radiofrequency in Knee Osteoarthritis
Knee osteoarthritis is one of the most common causes of chronic pain and disability worldwide, particularly in middle-aged and elderly populations.
- Trial name
- NCT07700784
- Testing
- Laser genicular nerve ablation, Conventional radiofrequency genicular nerve ablation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Zagazig University