Clinical trials: Chronic Hypercapnic Respiratory Failure
COPD, Pre-Lung-Transplantation
Pulmonary Rehabilitation in Patients Before Lung Transplantation (LTx)
The purpose of this study is to study the effects of a complex pulmonary rehabilitation program on mobility measured by 6 minute walking distance (6MWD) and physical activity, measured via Dynaport and Actibelt Aktivitätsmonitor…
- Conditions
- COPD, Pre-Lung-Transplantation, Hypercapnia, Respiratory Insufficiency
- Trial name
- NCT00962078
- Testing
- continuous endurance training, interval training
- Where
- Germany
- Volunteers
- 71 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Pulmonary Disease, Chronic Obstructive (COPD), Hypercapnia
Effectiveness and Efficiency of Home Telemonitoring and Non-invasive Ventilation in Patients With COPD and Hypercapnia (EVALECO)
The purpose of this study is to evaluate the effectiveness and clinical efficiency of combining home non-invasive ventilation (NIV) with a continuous remote telemonitoring (TM) system in patients with Chronic Obstructive…
- Trial name
- EVALECO (NCT07679646)
- Testing
- Home Non-Invasive Ventilation and Telemonitoring
- Where
- Spain
- Volunteers
- 92 people
- Sponsor
- Air Liquide Healthcare Spain
Lung, Hyperlucent, Positive-Pressure Respiration, Intrinsic
Non Invasive Mechanical Ventilation Versus Respiratory Rehabilitation in Hypercapnic COPD
Objective: To analyze the additional benefits of exercise training application by the non-invasive home mechanical ventilation in patients with stable COPD and hypercapnic respiratory failure.
- Trial name
- COPD (NCT01377818)
- Testing
- ventilation, excecise training, Both
- Volunteers
- 45 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Acute-on-chronic Respiratory Failure
Prospective Trial of the Bilevel Positive Airway Pressure (by Boussignac) in Emergency Department of Non-invasive Patients Presenting With Acute Hypercapnic Respiratory Failure
The purpose of this study is to determine whether the new Boussignac-system of non-invasive ventilation is as good as the conventional non-invasive System in patients presenting with acute hypercapnic respiratory failure.
- Trial name
- Boussignac (NCT01788345)
- Testing
- non- invasive ventilation
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- Vygon GmbH & Co. KG
Pulmonary Disease, Chronic Obstructive, Hypercapnic Respiratory Failure
The Clinical Application and Popularization of Portable Home Noninvasive Ventilator
The subjects of this study are the chronic obstructive pulmonary disease (COPD) patients with chronic II respiratory failure. The participants will be divided into two groups: The Portable Home Noninvasive Ventilator treatment…
- Trial name
- NCT03238339
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Mingdong Hu
Postoperative Coronary Artery Bypass Grafting (CABG), Chronic Obstructive Pulmonary Disease (COPD)
The Effect of Neuromuscular Electrical Stimulation
The effect of neuromuscular electrical stimulation on muscle atrophy in sedated patients on intensive care was studied. The aim of this study was to explore if electrical stimulation could prevent muscle atrophy.
- Conditions
- Postoperative Coronary Artery Bypass Grafting (CABG), Chronic Obstructive Pulmonary Disease (COPD), Ventilatory Failure
- Trial name
- NCT00442728
- Testing
- ELECTRICAL STIMULATION
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- Provinciale Hogeschool Limburg
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
NPPV Added Inspiratory Muscle Training in Severe COPD
The aim of this study is to determine whether noninvasive positive pressure ventilation with inspiratory muscle training can improve quality of life and respiratory muscle strength than noninvasive positive pressure ventilation…
- Trial name
- NCT01926275
- Testing
- NPPV+IMT, NPPV, IMT
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Acute Respiratory Failure, Acute on Chronic Respiratory Failure
Treatment of Dyspnea in Do-not-intubate Patients
Patients with severe chronic diseases are often admitted to the hospital complaining of shortness of breath. Some of these patients decide that they do not want placement of a breathing tube in the windpipe to assist their…
- Conditions
- Acute Respiratory Failure, Acute on Chronic Respiratory Failure, Dyspnea
- Trial name
- NCT02114944
- Testing
- NIV, CPAP, Standard oxygen
- Where
- 2 sites in United States, Italy
- Volunteers
- 400 people
- Sponsor
- Tufts Medical Center
Acute Hypercapnic Respiratory Failure
Systematic Follow-up of Patients Surviving an Episode of Acute Hypercapnic Respiratory Failure in the ICU
There is currently no good description of patients surviving an episode of acute hypercapnic respiratory failure in the ICU. For instance, the prevalence of OSA and sleep hypoventilation in a stable clinical condition is not…
- Trial name
- NCT02111876
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Ligue Pulmonaire Genevoise
Chronic Obstructive Pulmonary Disease, Hypercapnic Respiratory Failure
Home Non Invasive Ventilation for COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) patients are more likely to develop acute hypercapnic respiratory failure. In the acute phase, non invasive ventilation has been shown to improve mortality and reduce intubation rate.
- Trial name
- NIVOLD (NCT03221101)
- Testing
- Home ventilator
- Where
- 4 sites in France
- Volunteers
- 86 people
- Sponsor
- University Hospital, Rouen
Hypercapnic Respiratory Failure, Pulmonary Disease, Chronic Obstructive
Detecting Systemic Carbon Dioxide Levels With a Novel Biosensor
The study is an open, prospective, single center clinical observational pilot investigation. The aim is to compare the carbon dioxide values measured by the IscAlert sensor, which is inserted in proximity to the nasal mucosa.
- Conditions
- Hypercapnic Respiratory Failure, Pulmonary Disease, Chronic Obstructive, Neuromuscular Diseases, Obesity Hypoventilation Syndrome (OHS)
- Trial name
- DISCO (NCT06367686)
- Testing
- IscAlert sensor
- Where
- Norway
- Volunteers
- 21 people
- Sponsor
- The Hospital of Vestfold
Emphysema
Endoscopic Lung Volume Reduction Coil Treatment in Patients With Chronic Hypercapnic Respiratory Failure
Endoscopic lung volume reduction coil treatment is a treatment option for selected patients with severe emphysema. In the advanced stages, emphysema may lead to chronic hypercapnic respiratory failure.
- Trial name
- NCT02996149
- Testing
- Endoscopic lung volume reduction coil treatment
- Where
- Germany
- Volunteers
- 1 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Respiratory Therapy, Respiration, Artificial
Initiation of Home Mechanical Ventilation at Home in Patients With Chronic Hypercapnic Respiratory Failure
Objective: To prove that initiation of chronic ventilatory support at home, in patients with chronic hypercapnic respiratory failure due to neuromuscular disease (NMD) or thoracic cage problem is not inferior compared to…
- Conditions
- Respiratory Therapy, Respiration, Artificial, Positive-Pressure Respiration, Neuromuscular Diseases
- Trial name
- Homerun (NCT03203577)
- Testing
- Initiation of mechanical ventilation
- Where
- Netherlands
- Volunteers
- 96 people
- Sponsor
- University Medical Center Groningen
Respiratory Insufficiency, Sleep Disordered Breathing
Adjustment of Mask Pressure, for Bilevel Positive Airways Pressure Therapy, by Automated Algorithm
The aim of the study is to test the hypothesis that an automated algorithm for desired mask pressure improves breathing pattern and sleep quality in patients with hypercapnic ventilatory failure.
- Trial name
- NCT01403584
- Testing
- AutoVPAP with addition of AutoEPAP, AutoVPAP with EPAP manually selected
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- ResMed
Chronic Obstructive Pulmonary Disease, Chronic Respiratory Hypercapnic Failure
A Study to Investigate the Effects of Heated Humidification During Non-Invasive Ventilation
Noninvasive ventilation (NIV) is a form of ventilation delivered by a mask and is an important mode of treatment in patients with both acute and chronic respiratory (breathing) failure.
- Conditions
- Chronic Obstructive Pulmonary Disease, Chronic Respiratory Hypercapnic Failure, Neuromuscular Disease, Obesity Hypoventilation Syndrome
- Trial name
- NCT01372072
- Testing
- non-invasive ventilation heated humidification (Fisher-Paykel MR810 and MR850 humidifiers)
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
COPD, COPD (Chronic Obstructive Pulmonary Disease)
How Nocturnal Hypoventilation Predicts Long-term Response to Non-invasive Ventilation in Hypercapnic COPD Patients
The study is an observational, single-center, prospective cohort study aiming to evaluate respiratory mechanics data, as well as clinical and functional parameters commonly used in clinical practice in patients with COPD and…
- Conditions
- COPD, COPD (Chronic Obstructive Pulmonary Disease), Hypercapnia, Hypercapnic Respiratory Failure, COPD
- Trial name
- HYPONIV (NCT07414108)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Exacerbation Copd, Acute Respiratory Distress
High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease
Chronic obstructive lung disease is a disabling disease that affects people usually after several years of smoke tobacco exposure and affects millions of patients worldwide.
- Conditions
- Exacerbation Copd, Acute Respiratory Distress, Acute Hypercapnic Respiratory Failure
- Trial name
- HiFOLD (NCT03033251)
- Testing
- Non Invasive Ventilation, High Flow Oxygen Cannula 50, High Flow Oxygen Cannula 30
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Copd, Chronic Obstructive Pulmonary Disease
Impact of Non-invasive Ventilation in Hypercapnic COPD
Chronic obstructive pulmonary disease (COPD) is a highly prevalent condition worldwide and is a cause of substantial morbidity and mortality. Unfortunately, few therapies have been shown to improve survival.
- Conditions
- Copd, Chronic Obstructive Pulmonary Disease, Hypercapnia, Chronic Respiratory Failure
- Trial name
- NCT03522805
- Testing
- High-intensity non-invasive ventilation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, San Diego
COPD Exacerbations, Acute Hypercapnic Respiratory Failure
HFNC vs. NIV in Acute COPD Exacerbations
The investigators investigated the efficacy and safety of High Flow Nasal Cannula (HFNC) at different flow rates compared to non-invasive ventilation (NIV) in patients presenting to the emergency department (ED) with acute…
- Conditions
- COPD Exacerbations, Acute Hypercapnic Respiratory Failure, Respiratory Failure
- Trial name
- HFNCstdy (NCT06495086)
- Testing
- NIV, HFNC-30, HFNC-50
- Where
- Turkey (Türkiye)
- Volunteers
- 137 people
- Sponsor
- Haseki Training and Research Hospital
COPD (Chronic Obstructive Pulmonary Disease)
HFNC Versus NIV in Hypercapneic COPD Patients
Aim: To compare gas exchange trends, clinical outcomes, and tolerability between HFNC and NIV in COPD patients with mild-to-moderate hypercapnic respiratory failure.
- Trial name
- NCT07854210
- Testing
- high flow nasal cannula, non invasive ventilation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mohammed Shehta