Clinical trials: Chronic Disease Management, open to volunteers
Chronic Graft-versus-host-disease
A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)
This is a Phase 2 study to evaluate the efficacy, safety, and tolerability of axatilimab at 3 different dose levels in participants with recurrent or refractory active chronic graft versus host disease (cGVHD) who have received…
- Trial name
- AGAVE-201 (NCT04710576)
- Testing
- Axatilimab
- Where
- 121 sites in United States, Australia and 14 more
- Volunteers
- 296 people
- Sponsor
- Syndax Pharmaceuticals
Chronic Urticaria (CU): Chronic Inducible Urticaria (CINDU) and Chronic Spontaneous Urticaria (CSU)
Characteristics and Management of Patients With Severe Chronic Spontaneous and/or Inducible Urticaria Refractory to Optimized Omalizumab Treatment: A French Multicenter Observational Study.
The study is sponsored by the University Hospital of Besancon under the coordination of Dr. Julie Castagna from the Department of Dermatology and Allergology.
- Trial name
- OMADROP (NCT07833696)
- Testing
- drug effect
- Where
- France
- Volunteers
- 73 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Fibromyalgia
Safety and Efficacy of Ketamine Intravenous Infusions in the Treatment of Fibromyalgia
Previous studies of intravenous ketamine, which is a non-competitive N-methyl-D aspartate receptor antagonist, for fibromyalgia pain relief are limited to three studies.
- Trial name
- NCT06916403
- Testing
- Intravenous Ketamine Infusions
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Wilderman Medical Clinic
Epilepsy, Seizure
AI-Based Mobile Intervention on Medication Non-Adherence and Transition
This study aims to examine whether the AI-personalized version of the Medilepsy® app is more effective than the non-AI (standard version without AI personalization) can improve key outcomes, such as medical adherence and…
- Trial name
- NCT07445074
- Testing
- Medilepsy® Chatbot AI-Enhanced, Medilepsy® Chatbot Standard
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Central Florida
Chronic Refractory Plantar Fasciopathy
Multimodal Conservative Intervention Versus Surgery for Chronic Refractory Plantar Fasciopathy
Chronic refractory plantar fasciopathy is a common musculoskeletal condition that can cause persistent heel pain and functional limitations despite conservative treatment.
- Trial name
- NCT07654660
- Testing
- Multimodal Conservative Intervention, Endoscopic Plantar Fascial Release
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Universidad Europea de Valencia
Chronic Pain, Chronic Pain Syndrome
Interoceptive Awareness and Function in Adolescents With Chronic Pain
The main objectives of this study are to compare the levels of interoceptive awareness and self-reported function pre and post completion of an occupational therapy treatment plan.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Pain, Chronic
- Trial name
- NCT07325110
- Testing
- Occupational Therapy
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Connecticut Children's Medical Center
Chronic Constipation
Sacral Neuromodulation as Treatment for Chronic Constipation
The objective of this study is to study if low level laser therapy will do more good than harm for patients with severe chronic refractory constipation. It is a proof of concept study without a placebo arm.
- Trial name
- NCT03819062
- Testing
- Low Level Laser Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Cluster Headache
Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache
Cluster headache is a primary headache condition characterized by clusters of one-sided, high-intensity pain attacks. The headache may be episodic or chronic. Treatment options are limited and their effects unsatisfactory.
- Trial name
- BASIC (NCT03944876)
- Testing
- Botulinum toxin type A
- Where
- 5 sites in Germany, Italy and 3 more
- Volunteers
- 112 people
- Sponsor
- Norwegian University of Science and Technology
Diabetes Type 2
Connected Care for Type 2 Diabetes Self-Management
The primary objective of this Randomized Clinical Trial is to improve the self-management (SM) competencies of patients affected by Type 2 Diabetes Mellitus (T2DM) living in the Marche region (Italy) through the support of a…
- Trial name
- RCT_SM (NCT07149610)
- Testing
- M-health solution classified as Class I Medical Devices, equipped with a CE certificate. The m-health solution will be integrated with the EPR currently used by the CADs of the Marche region
- Where
- 11 sites in Italy
- Volunteers
- 388 people
- Sponsor
- Marche Region Regional Health Agency
Inflammatory Bowel Disease
The EDICT Trial - Therapy for Inflammatory Bowel Disease Flares
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions of the gastrointestinal tract that affect millions of people in the United States of America.
- Trial name
- EDICT (NCT07143188)
- Testing
- elemental diet (ED)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Wake Forest University Health Sciences
Neuropathic Pain, Chronic Pain
Analgesic Effectiveness of Capsaicin 8% Cutaneous Patch in Children
This study concerns children aged to 12 to 17-years with local chronic neuropathic pain after trauma or surgery. It is a multicentric randomized controlled superiority trial in parallel arms : experimental arm: Capsaicin 8%…
- Trial name
- CAPSAPED (NCT05997979)
- Testing
- Capsaicin 8% patch, Hydrocolloid dressing
- Where
- 10 sites in France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Brest
Chronic Low Back Pain, After Lumbar Spine Surgery
Efficacy of Cognitive Functional Therapy in Individuals With Chronic Low Back Pain After Spinal Surgery
Chronic low back pain after spinal surgery is a complex and disabling condition influenced by biopsychosocial factors. Cognitive Functional Therapy (CFT) is a promising intervention targeting these multidimensional aspects.
- Conditions
- Chronic Low Back Pain, After Lumbar Spine Surgery, Failed Back Surgery Syndrome (FBSS)
- Trial name
- NCT07576062
- Testing
- CFT
- Volunteers
- 90 people
- Sponsor
- Centro Universitário Augusto Motta
Chronic Sacroiliac Joint Pain
Cryoneurolysis vs Radiofrequency Ablation for Chronic Sacroiliac Joint Pain
This is a single-center, randomized, open-label, pilot study in adult subjects with chronic sacroiliac joint (SIJ) pain. Thirty (30) subjects are planned for initial enrollment and will be randomized 1:1 to receive ioveraº…
- Trial name
- NCT06935539
- Testing
- Cryoneurolysis, Radiofrequency ablation
- Volunteers
- 30 people
- Sponsor
- Medical Pain Management Services, PLLC
Chronic Lymphocytic Leukemia, Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Tafasitamab With Acalabrutinib and Venetoclax for the Treatment of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
This phase II trial tests the safety, side effects and how well giving tafasitamab with acalabrutinib and venetoclax works for the treatment of chronic lymphocytic leukemia (CLL)/small cell lymphoma (SLL).
- Conditions
- Chronic Lymphocytic Leukemia, Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Small Lymphocytic Lymphoma
- Trial name
- NCT07582159
- Testing
- Acalabrutinib, Biospecimen Collection, Bone Marrow Biopsy
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- City of Hope Medical Center
Acute Postoperative Pain, Chronic Postoperative Pain
Comparison of the Efficacy and Safety of Intravenous Buprenorphine Administered Via PCA System Versus Oxycodone in the Management of Postoperative Pain After Video-Assisted Thoracoscopic Surgery
The goal of this clinical trial is to learn whether intravenous buprenorphine administered via a patient-controlled analgesia (PCA) system provides effective and safer postoperative pain control than intravenous oxycodone PCA in…
- Conditions
- Acute Postoperative Pain, Chronic Postoperative Pain, Toracosurgery, Video-assisted Thoracis Surgery (VATS)
- Trial name
- NCT07434427
- Testing
- Group B (Buprenorphine), Group O (Oxycodone)
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Silesia
Chronic Fatigue Syndrome (CFS)
Controlled Trial of Hydrogen Water as a Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
This is a 16-week controlled treatment trial of an over-the -counter supplement, hydrogen water, for individuals with ME/CFS patients. An active treatment condition will be compared to a placebo-control condition.
- Trial name
- ME/CFS (NCT07753122)
- Testing
- Molecular hydrogen produced by a metallic magnesium tablet, consumed 3x a day dissolved in water. Treatment duration is 16 weeks.
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Fred Friedberg
Viral Infection, Hematopoietic Stem Cell Transplantation (HSCT)
Adoptive T Lymphocyte Administration for Chronic Norovirus Treatment in Immunocompromised Hosts
This is a Phase I dose-escalation study to evaluate the safety of norovirus -specific T-cell (NST) therapy for chronic norovirus infection in participants following hematopoietic stem cell transplantation (HSCT) or who are…
- Conditions
- Viral Infection, Hematopoietic Stem Cell Transplantation (HSCT), Primary Immunodeficiency Disorders (PID)
- Trial name
- ATLANTIC (NCT04691622)
- Testing
- Norovirus -specific T-cell (NST) therapy
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Children's National Research Institute
Spinal Cord Injuries
Study on Preliminary Safety and Efficacy of the ARC Therapy Using the ARC-IM Lumbar System to Support Mobility in People With Chronic Spinal Cord Injury (BoxSwitch)
The purpose of this pre-market clinical study is to assess the preliminary safety and efficacy of the ARC Therapy using the ARC-IM Lumbar System at supporting mobility in participants who have previously received a spinal array…
- Trial name
- BoxSwitch (NCT05942339)
- Testing
- Procedure/Surgery
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Chronic Interstitial Cystitis, Bladder Pain Syndrome
Pain Type and Interstitial Cystitis/Bladder Pain Syndrome Treatment
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a severe pain condition affecting 3-8 million people in the United States lacking treatments that work.
- Conditions
- Chronic Interstitial Cystitis, Bladder Pain Syndrome, Painful Bladder Syndrome, Cystitis, Interstitial
- Trial name
- NCT06299683
- Testing
- Psychosocial Treatment, Pelvic Floor Physical Therapy
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Vanderbilt University Medical Center
Chronic Respiratory Acidosis
Respiratory Stabilization in Chronic Acidosis Before Bronchofiberoscopy & Non-Invasive Ventilation Effectivenes
Bronchofiberoscopy (FOB) is a minimally invasive and safe procedure performed for diagnostic and therapeutic purposes. FOB frequently impairs respiratory function, which may lead to possible exacerbation of respiratory failure.
- Trial name
- NCT06970002
- Testing
- Use of NIV during FOB as a respiratory support method, Use of HFNC during FOB as a respiratory support method
- Volunteers
- 210 people
- Sponsor
- Medical University of Silesia