Clinical trials: Chronic Disease, open to volunteers
Liver Diseases, Acute on Chronic Hepatic Failure
Comparison of Inflammatory Profiles and Regenerative Potential in Alcoholic Liver Disease
The main objective of this study is the comparison of the profile of the pro-inflammatory cytokines at the patients suffering from an alcoholic hepatitis to that of two groups witnesses: patients suffering from an alcoholic…
- Trial name
- TargetOH (NCT03773887)
- Testing
- collection of liver biopsies collection of blood samples
- Where
- France
- Volunteers
- 450 people
- Sponsor
- University Hospital, Lille
COPD, Interstitial Pneumonia
Perioperative Risk Factors Related to the Prognosis of Lung Transplantation: A Retrospective Study
This study analyzes patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University from 2017 to 2024, focusing on anesthesia's impact on post-op results.
- Conditions
- COPD, Interstitial Pneumonia, Bronchiectasis, Respiratory Failure
- Trial name
- NCT06922916
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Zhejiang University
Chronic Kidney Diseases
miRNA in Chronic Kidney Diseases
Oxidative stress and endoplasmic reticulum (ER) stress play a key role in tubular damage in both acute kidney injury and chronic kidney disease (CKD).
- Trial name
- NCT06316284
- Where
- Croatia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Long COVID, Post Acute Sequelae of COVID-19
Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial - Effect of Hyperbaric Oxygen Therapy for the Treatment of Post COVID Condition
The RECLAIM study platform will be used to explore whether the use of Hyperbaric Oxygen therapy (HBOT) improves the symptoms of post covid cognitive dysfunction. Hyperbaric oxygen therapy is a well-established medical treatment.
- Conditions
- Long COVID, Post Acute Sequelae of COVID-19, Post-COVID-19 Condition
- Trial name
- RECLAIM-HBOT (NCT06452095)
- Testing
- Hyperbaric Oxygen therapy
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Chronic Kidney Diseases, Kidney Injury, Acute
Clinical Performance of a Point-of-Care Creatinine Testing System in Individuals With Kidney Disease
The goal of this clinical performance study is to evaluate the accuracy and usability of the Eaglenos Creatinine Test System（referred to as EG）, a point-of-care testing (POCT) system that consists of a handheld device and its…
- Trial name
- NCT07251075
- Testing
- Reference Creatinine Test System（Cobas c 111）, Investigational Creatinine Test System （EG）
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tingting Xu
Maxillary Sinusitis, Sinusitis, Chronic
Balloon Sinuplasty Efficiency in Maxillary Rhinosinusitis.
This study is a prospective, randomized, placebo-controlled, double-blinded clinical study. The balloon sinuplasty treatment is compared to placebo effect in chronic or recurrent maxillary sinusitis.
- Conditions
- Maxillary Sinusitis, Sinusitis, Chronic, Sinusitis Recurrent, Eustachian Tube Dysfunction
- Trial name
- NCT04645511
- Testing
- Balloon sinuplasty of maxillary sinuses
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- Tampere University Hospital
Chronic Conditions
NURsing-led FRAILty Prevention and Care
The goal of this quasi-experimental study is to learn if a nurse-led care program can help prevent or manage frailty in older adults living in the community.
- Trial name
- NUR-FRAIL (NCT07435064)
- Testing
- NUR-FRAIL
- Volunteers
- 200 people
- Sponsor
- University of Padova
Dialysis Patients
Intradialytic Exercise With Blood Flow Restriction in Hemodialysis Patients
The main objective is to evaluate in hemodialysis patients the effects of two intradialytic rehabilitation programs based on physical exercise, with or without the application of blood flow restriction, on myocardial stunning and…
- Trial name
- ERO-CARD (NCT07269379)
- Testing
- Chronic phase - HDEX/HDBFRE, Acute phase - HDEX/HDBFRE
- Where
- 2 sites in France
- Volunteers
- 108 people
- Sponsor
- University of Avignon
Chronic Kidney Disease With and Without Hemodialysis
Patterns of Cardiac Arrhythmia in Patients With Chronic Kidney Disease
Cardiovascular diseases remain the primary leading cause of death in patients on maintenance hemodialysis accounting for nearly 41% of deaths.
- Trial name
- Arrhythmia (NCT07640919)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sohag University
Hepatitis B Virus Infection, Children
Entecavir With or Without Pegylated Interferon α-2b in Children Aged 3-6 Years With Immune-Active Chronic Hepatitis B
This study aims to evaluate the efficacy and safety of entecavir monotherapy versus sequential entecavir plus pegylated interferon α-2b in achieving functional cure in immune-active, HBeAg-positive children aged 3-6 years with…
- Conditions
- Hepatitis B Virus Infection, Children, Chronic Hepatitis B
- Trial name
- NCT07345611
- Testing
- Entecavir, Entecavir + Pegylated interferon α-2b
- Volunteers
- 60 people
- Sponsor
- Qing-Lei Zeng
Subject Presenting Wheeze, Asthma
AeviceMD for Detection of Wheeze in Pediatric and Adult Populations
Respiratory signs and symptoms consisting of wheeze, cough, and breathlessness are obtained in a manual fashion through history taking and physical examination by the healthcare professional.
- Conditions
- Subject Presenting Wheeze, Asthma, Bronchial Disease, Respiratory Tract Diseases
- Trial name
- NCT06691971
- Testing
- AeviceMD
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Aevice Health Pte. Ltd.
Chronic Obstructive Pulmonary Disease Severe
Risk Prediction Model for Exacerbating Phenotype in Patients With Chronic Obstructive Pulmonary Disease
This study is planned to be conducted based on the cohort of patients with severe chronic obstructive pulmonary disease in our hospital.
- Trial name
- NCT06198309
- Where
- China
- Volunteers
- 365 people
- Sponsor
- Li An
Chronic Coronary Syndrome, Myocardial Ischemia
Perfusion Estimation For Optimal Treatment Strategy in Chronic Coronary Syndrome
We will establish a cohort of 570 symptomatic chronic coronary syndrome patients undergoing 15O-water PET and assess their symptoms through repeated questionnaires.
- Conditions
- Chronic Coronary Syndrome, Myocardial Ischemia, Stable Angina, Coronary Artery Disease
- Trial name
- PERFORM-CCS (NCT05865600)
- Testing
- Optimization of guideline-directed medical therapy, Immediate referral for invasive coronary angiography, 3-months delayed referral for invasive coronary angiography
- Where
- Denmark
- Volunteers
- 570 people
- Sponsor
- Gødstrup Hospital
Long COVID
A Study to Assess Anktiva in Patients With Long Covid-19.
This study will test the safety and tolerability of Anktiva in patients with Long Covid. Eligible patients will receive up to 2 doses of Anktiva and have follow-up exams and tests.
- Trial name
- INTERRUPT_LC (NCT07108036)
- Testing
- N-803 (IL-15 Superagonist)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- ImmunityBio, Inc.
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis (IPF)-Related Chronic Cough Reduction With Nalbuphine Extended-Release (NAL ER) Tablets
The primary purpose is to evaluate the safety and efficacy of NAL ER for the treatment of chronic cough in participants with Idiopathic Pulmonary Fibrosis (IPF).
- Trial name
- OCEAN-1 (NCT07671911)
- Testing
- NAL ER
- Where
- 22 sites in United States
- Volunteers
- 306 people
- Sponsor
- Trevi Therapeutics
Tenofovir, Tenofovir Alafenamide Fumarate
Tenofovir Exposures in Advanced Kidney Disease Study
Phamacokinetic study to evaluate tenofovir, emtricitabine and tenofovir alafenamide exposures in people with HIV who have chronic kidney disease stage 4 (estimated glomerular filtration rate [eGFR] 15-29 mL/min/1.73m2) or stage 3…
- Conditions
- Tenofovir, Tenofovir Alafenamide Fumarate, Chronic Kidney Diease, Kidney Failure
- Trial name
- TEAK (NCT07812571)
- Testing
- Plasma sampling for tenofovir and emtricitabine, Descovy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College Hospital NHS Trust
Chronic Kidney Disease (Stages 4 and 5)
Kidney RISE: Randomized Integrated Supportive CarE Trial
The purpose of study is to investigate whether adding palliative care to usual chronic kidney disease (CKD) care improves symptoms and quality of life for people with CKD.
- Trial name
- NCT07741357
- Testing
- Kidney RISE
- Where
- 2 sites in United States
- Volunteers
- 280 people
- Sponsor
- NYU Langone Health
Chronic Spontaneous Urticaria
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HS-10561 Capsule in Healthy Chinese Adults and Patients With Chronic Spontaneous Urticaria.
This is a randomized, double-blind, placebo-controlled phase 1/2 clinical study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of HS-10561 capsule in healthy Chinese adults and patients with…
- Trial name
- NCT06864507
- Testing
- HS-10561
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
Chronic Obstructive Pulmonary Disease, Asthma
A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine
Chronic inflammatory pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and interstitial lung diseases (ILD) are…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Bronchiectasis, Cystic Fibrosis
- Trial name
- PALMIRE (NCT07274631)
- Testing
- Non applicable
- Where
- France
- Volunteers
- 470 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Chronic Thromboembolic Pulmonary Hypertension
Change-a Multi-center Chronic Thromboembolic Pulmonary Hypertension （CTEPH） Database in China
The Change Database is a prospective, observational multi-center disease registry, which will collect data on patients with chronic thromboembolic pulmonary hypertension (CTEPH) in China.
- Trial name
- NCT05311072
- Testing
- pulmonary endarterectomy or balloon pulmonary angioplasty
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- China-Japan Friendship Hospital