Clinical trials: Chronic Coronary Occlusion
Cardiac Surgery
Efficacy of Ultrasound Guided PIFB Versus Lidocaine Infusion on Postoperative Pain After Sternotomy
Chronic pain is a common complication after cardiothoracic surgery. The prevalence of post-sternoyomy pain syndrome (PSPS) ranges from 33% to 91%.
- Trial name
- NCT05885230
- Testing
- pecto intercostal fascial block using bupivacaine 0.25%, lidocaine infusion
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Metabolic Syndrome, Coronary Artery Disease
Brain, Cardiac Hemodynamics and Cognition During Exercise in Subjects With Various Cardiovascular Profiles
People with cardiovascular risk (CV) factors (obesity, diabetes, etc...) or established heart disease (such as coronary heart disease or chronic heart failure) often have cognitive dysfunction as compared to people without CV…
- Conditions
- Metabolic Syndrome, Coronary Artery Disease, Heart Failure
- Trial name
- COGNEX (NCT03018561)
- Testing
- Exercise and Cognitive testing
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Cardiovascular Risk Factor, Insulin Resistance
Chronic Cardiovascular Risk Outpatient Management in South Asians Using Digital Health Technology
This platform will enable investigation the cardiovascular risk reduction and the increase in participant engagement in their heart-healthy goals, through the use of virtual care/telemedicine with a digital platform that connects…
- Conditions
- Cardiovascular Risk Factor, Insulin Resistance, PreDiabetes, Diabetes
- Trial name
- HealthPals (NCT03167996)
- Testing
- Use of HealthPals (Telemedicine supported by digital health platform)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Stanford University
Coronary Artery Disease, Ischemic Heart Disease
Volatilome and Single-Lead Electrocardiogram Optimize Ischemic Heart Disease Diagnosis Using Machine Learning Models
This is a prospective, case-control, single-center, observational, non-randomized study. It is designed to evaluate the diagnostic accuracy of functional tests involving physical exertion monitored via a 12-lead ECG, combined…
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease, Chronic Coronary Disease, Angina Pectoris
- Trial name
- NCT06181799
- Testing
- Mass spectrometry using the PTR TOF-1000 (IONICON PTR-TOF-MS - Trace VOC Analyzer, Eduard-Bodem-Gasse 3, 6020 Innsbruck, Austria (Europe).
- Where
- Russia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Heart Diseases, Cardiovascular Diseases
Risk Factors in the Initial Presentation of Specific Cardiovascular Disease Syndromes
Cardiovascular disease (CVD) is an important public health problem that affects millions of people worldwide. Associations between risk factors, such as smoking, dyslipidaemia or hypertension, and prevalent CVD are well…
- Conditions
- Heart Diseases, Cardiovascular Diseases, Acute Myocardial Infarction, Unstable Angina
- Trial name
- NCT01804439
- Volunteers
- 2,240,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Heart Diseases
Health Electronic Assessment of Risks and Trends Using Biometric Equipment and Technology
This is a phase 0, non-interventional, longitudinal, electronic data capture (EDC) study to facilitate the HEARTBEAT Study project has set out to explore the potential use of smartwatches in collecting and analyzing biometric…
- Trial name
- HEARTBEAT (NCT06753045)
- Testing
- Smartwatch
- Where
- 3 sites in United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Tulane University
CORONARY ARTERY DISEASE
"Potential Effect of Acute and Chronic Caffeine Administration on Platelet Reactivity in Patient With Coronary Artery Disease on Dual Antiplatelet Therapy"
Prasugrel is a potent thienopyridine antiplatelet agent that selectively and irreversibly inhibits ADP-induced platelet aggregation mediated by the P2Y12 receptor.
- Trial name
- CyCLOPS (NCT02054988)
- Testing
- caffeine, not caffeine
- Where
- Italy
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Atrial Fibrillation, Coronary Heart Disease
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
Health inequality and genetic disparity are a significant issue in the United Kingdom (UK). This study focuses on diseases that are associated with significant morbidity and mortality in the UK, and specifically examines the…
- Conditions
- Atrial Fibrillation, Coronary Heart Disease, Cardiovascular Diseases, Heart Failure
- Trial name
- EMPOWER (NCT03987633)
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Future Genetics Limited
Coronary Artery Disease
Platelet Aggregation and Adenosine Levels Among Patients Taking Ticagrelor or Prasugrel
Prospective, single-center, double blind, double dummy, randomized trial. Platelet function tests and adenosine levels were assessed at baseline and 15 days after taking Ticagrelor with Prasugrel placebo or Prasugrel with…
- Trial name
- NCT05247385
- Testing
- Prasugrel, Ticagrelor
- Where
- Brazil
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cardiovascular Diseases, Diabetes
Kuopio Ischaemic Heart Disease Risk Factor Study (Nutrition Component)
To determine associations between dietary factors and risk of major chronic diseases and their risk factors
- Conditions
- Cardiovascular Diseases, Diabetes, Metabolic Syndrome, Cancer
- Trial name
- NCT03221127
- Volunteers
- 2,682 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Chronic Stable Angina, Vascular Dementia
The Effect of Danzhu Fuyuan Granule as Adjunctive Therapy for Chronic Stable Angina, Vascular Dementia and Idiopathic Membranous Nephropathy: A Bayesian Basket Trial
This study is designed as a bayesian basket trial , which aims to evaluate the efficacy of Danzhu Fuyuan Granule in patients with Chronic Stable Angina, Vascular Dementia and Idiopathic Membranous Nephropathy
- Conditions
- Chronic Stable Angina, Vascular Dementia, Idiopathic Membranous Nephropathy
- Trial name
- NCT04498962
- Testing
- Danzhu Fuyuan Granule
- Where
- 7 sites in China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Jingqing Hu
CAD - Coronary Artery Disease, Chronic Total Occlusion (CTO)
Chronic Total Occlusion and Triglyceride-Glucose Index
We retrospectively analyzed 200 CAD patients undergoing coronary angiography between 2026-2027. Patients were grouped by CTO presence.
- Conditions
- CAD - Coronary Artery Disease, Chronic Total Occlusion (CTO), Triglycerid Glucose Index
- Trial name
- NCT07451860
- Testing
- triglyceride-glucose (TyG) index was calculated from routinely obtained blood samples using the formula: Triglyceride (mg/dL) × Glucose (mg/dL) / 2.
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Acne Vulgaris, Allergic Rhinitis
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use
The specific aim of this proposed pilot study is to compare two standardized processes (paper and electronic) to deliver a customized MedlinePlus health information prescription.
- Conditions
- Acne Vulgaris, Allergic Rhinitis, Anxiety, Asthma
- Trial name
- NCT01050465
- Testing
- health information prescription
- Volunteers
- 907 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Non-communicable Diseases (NCD), Neoplams
Health for Hungary (H4H) - Longitudinal Collection of Blood Samples and Corresponding Data
The Health for Hungary (H4H) study collects blood samples and corresponding health data to investigate healthy aging and health-to-disease transitions in middle-aged and elderly participants.
- Conditions
- Non-communicable Diseases (NCD), Neoplams, Cancer, Lung Cancer (NSCLC)
- Trial name
- H4H (NCT07743021)
- Where
- 33 sites in Hungary
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Center for Molecular Fingerprinting Research Nonprofit LLC
Arterial Hypertension, Heart Rhythm Disorders
Screening for Cardiac and Cardiac-associated Pathology Using Single-channel Electrocardiogram
It is a prospective, controlled, single-center, observational, non-randomized study. The study is planned to include at least 4000 patients 18 years old and older in the training sample and 1000 patients over 18 years old in the…
- Conditions
- Arterial Hypertension, Heart Rhythm Disorders, Valvular Heart Diseases, Heart Failure
- Trial name
- NCT07396792
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Chronic Total Occlusion of Coronary Artery
REduction of Contrast Via DyeVert Used in CTO Procedures
The is an observational, prospective study to evaluate the effect of the DyeVert System on contrast volume administration in patients undergoing clinically-indicated chronic total occlusion (CTO) percutaneous coronary…
- Trial name
- REDUCe (NCT03118544)
- Testing
- DyeVert System
- Where
- 3 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Minneapolis Heart Institute Foundation
Coronary Artery Disease (CAD), Chronic Total Occlusion (CTO)
AGECTO Study: PCI vs. Optimal Medical Therapy for CTO in the Octogenarian Patients
The study compares an interventional strategy (PCI) with optimal medical therapy (OMT) in ultra-octogenarians with chronic total occlusions (CTO).
- Conditions
- Coronary Artery Disease (CAD), Chronic Total Occlusion (CTO), Percutaneous Coronary Intervention (PCI), Optimal Medical Therapy
- Trial name
- AGECTO (NCT07442526)
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- San Luigi Gonzaga Hospital
Endothelial Dysfunction, FMD
Role of Oxygen for Vascular Dysfunction
Hypoxemia may contribute increased morbidity and mortality in chronic obstructive pulmonary disease (COPD) patients. We aim to characterize the role of acute and chronic hypoxemia for vascular function.
- Conditions
- Endothelial Dysfunction, FMD, IMT, Microcirculation
- Trial name
- NCT02127333
- Where
- Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
Chronic Coronary Syndrome, Coronary Artery Disease
Hyperemic mYocardial Perfusion by adEnosine at diffeRent Doses
Adenosine is a commonly used pharmaceutical stressor at cardiac magnetic resonance examinations to assess suspected chronic coronary syndrome (CCS).
- Conditions
- Chronic Coronary Syndrome, Coronary Artery Disease, Ischemic Heart Disease
- Trial name
- HYPER (NCT06578234)
- Testing
- Adenosine
- Where
- Sweden
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Region Skane
Coronary Artery Disease, Congestive Heart Failure
Prognostic Indicators as Provided by the EPIC ClearView
The objective of this study is to determine whether the finger tip images captured by the EPIC ClearView device, when analyzed via the ClearView software, produce a Response Scale that characterizes trends consistent with known…
- Conditions
- Coronary Artery Disease, Congestive Heart Failure, Valvular Heart Disease, Atrial Fibrillation
- Trial name
- GBMC (NCT01476995)
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Epic Research & Diagnostics, Inc.