Clinical trials: Chronic Anal Fissure
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Anal Fissure
Topical Minoxidil Versus Topical Glyceryl Trinitrate in Treatment of Chronic Anal Fissure
This randomized trial aims to compare two topical treatments in the treatment of chronic anal fissure: minoxidil gel and glycreyl trintrate cream.
- Trial name
- NCT03528772
- Testing
- Minoxidil, Glyceryl trinitrate
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Mansoura University
Chronic Anal Fissure
AI-Assisted Written Information in Chronic Anal Fissure
This single-center, prospective, 1:1 randomized, parallel-group controlled superiority trial compares standard verbal counseling with AI-assisted written patient information in adults with primary chronic anal fissure receiving…
- Trial name
- AF-AI (NCT07701811)
- Testing
- AI-assisted written patient information, Standardized verbal counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people
- Sponsor
- Sanliurfa Education and Research Hospital
Chronic Anal Fissure
Percutaneous Tibial Nerve Stimulation - an Alternative Treatment Option for Chronic Therapy Resistant Anal Fissure
At a tertiary referral centre, 10 patients (4 male and 6 female; mean age 49.8 years) were given neuromodulation via the posterior tibial nerve to the sacral nerve for 30 min on 10 consecutive days.
- Trial name
- NCT03554421
- Testing
- Percutaneous tibial nerve stimulation
- Volunteers
- 10 people
- Sponsor
- Region Skane
Fissure in Ano, Pain
A Study to Determine the Effect of Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With Chronic Anal Fissures
Anal fissure is a solitary ulcer in the squamous epithelium of the anus causing intense anal pain especially during defecation and for 1 or 2 hours afterwards.
- Trial name
- NCT00522041
- Testing
- Cellegesic
- Volunteers
- 248 people
- Sponsor
- Forest Laboratories
Chronic Anal Fissure
Conventional Lateral Internal Sphincterotomy, V-Y Anoplasty and Tailored Lateral Internal Sphincterotomy With V-YF in Treatment of Chronic Anal Fissure(CAF)
The investigators compared conventional lateral internal sphincterotomy (CLIS), V-Y anal flap, and combined tailored lateral internal sphincterotomy with V-Y anal flap (TLIS with V-YF) in a randomized prospective study in…
- Trial name
- CAF (NCT01500889)
- Testing
- Group I: Conventional Lateral internal sphincterotomy:, GroupII: V-Y advancement flap, GroupIII: Tailored LIS with V-Y advancement flap
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Mansoura University
Focus: Anal Incontinence After Lateral Sphincterotomy for Chronic Anal Fissure
Ultrasound Guided Lateral Sphincterotomy: Long Term Results
Ultrasound guided placement of the knife intersphincteric increases accuracy and safety during sphincterotomy. Secondly 3-D ultrasound visualizes that the internal anal sphincter is divided.
- Trial name
- NCT02020915
- Testing
- lateral sphincterotomy, ultrasound guided lateral sphincterotomy
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Hvidovre University Hospital
Anal Fissure Chronic
Ultrasound Assessment After Surgery for Chronic Anal Fissure
Chronic anal fissure is a painful tear in the lining of the anal canal that may not heal with medication or other non-surgical treatments. Lateral internal sphincterotomy (LIS) is a commonly used surgical treatment.
- Trial name
- NCT07809711
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Hospital Clínico Universitario de Valencia
Chronic Anal Fissure
Comparison of Lateral Internal Sphincterotomy Techniques for Chronic Anal Fissure
This prospective randomized controlled trial compares three lateral internal sphincterotomy (LIS) techniques in patients with chronic anal fissure refractory to medical treatment: (1) Spasm-Controlled LIS (serial small…
- Trial name
- SPHINX (NCT07520552)
- Testing
- Spasm-Controlled Lateral Internal Sphincterotomy, Lateral Internal Sphincterotomy up to Fissure Apex, Lateral Internal Sphincterotomy up to Dentate Line
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Çanakkale Onsekiz Mart University
Anal Fissure Chronic
Pulsed Electromagnetic Field on Chronic Anal Fissure Healing
The purpose of this study is to find the effect of Pulsed Electromagnetic Field on chronic Anal fissure healing. Included both male and female aged 30-60 suffering from Anal fissure symptoms.
- Trial name
- PEMF (NCT07729709)
- Testing
- PEMS, Lidocaine and general advice, Lidocaine cream and general advice
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Galala University
Chronic Anal Fissure
The Effect of Intra-anal Nifedipine, Used As Add-on to Conservative Therapy, on Pain in Patients With Anal Fissure
The objective of the study is to examine the effect of Nifedipine, applied intra-anally through our drug delivery device, on rectal pain severity in anal fissure patients that are being managed with conservative treatment.
- Trial name
- NCT02527109
- Testing
- Nifedipine
- Where
- 24 sites in Bulgaria, Moldova and 2 more
- Volunteers
- 339 people
- Sponsor
- RDD Pharma Ltd
Chronic Anal Fissure
Combined Method of Surgical Treatment of Anal Fissure
The purpose of this study is to improve treatment outcomes for patients with chronic anal fissure.
- Trial name
- NCT07268261
- Testing
- excision of the anal fissure with further relaxation of the internal sphincter with botulinum toxin A
- Where
- Russia
- Volunteers
- 122 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Anal Fissure
A Novel Method for Chronic Anal Fissure Treatment
Investigators performed a prospective pilot study to test the feasibility and safety of autologous adipose derived regenerative cell (ADRC) transplantation in treatment of anal fissures.
- Trial name
- NCT02628522
- Testing
- ADRCs therapy, Celution, Tulip cannulas
- Volunteers
- 6 people
- Sponsor
- Clinical Centre of Serbia