Clinical trials: Cholesterol
Obesity
Hydrogen-rich Water and Appetite in Obesity
The main goal of this study is to investigate how dihydrogen supplementation impacts body composition, appetite, quality of life specific to obesity, and levels of the hormone GLP-1 in men and women with obesity.
- Trial name
- HYDRAPPET (NCT06722326)
- Testing
- Dietary Supplement: Hydrogen-rich water, Dietary Supplement: Control water
- Where
- Serbia
- Volunteers
- 36 people
- Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
Fed
Bioequivalence Study of Lamotrigine Tablets 25 mg (2 x 25 mg Tablets) Under Fed Condition
This is an open Label, randomized, two-period, two-treatment, two-sequence, crossover, balanced, single dose pivotal study. The purpose of this study is to assess the bioequivalence between Test Product and the corresponding…
- Trial name
- NCT01618825
- Testing
- Lamotrigine Tablets 25 mg, Lamotrigine
- Where
- India
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- IPCA Laboratories Ltd.
HIV Infections
Safety, Effectiveness, and Tolerability of Ezetimibe Combined With Statins for the Treatment of High Cholesterol in HIV Infected Adults
Anti-HIV drugs, especially protease inhibitors (PIs), have been linked to lipid metabolism problems, including elevations in low density lipoprotein cholesterol (LDL-c), triglycerides, and total cholesterol.
- Trial name
- NCT00099684
- Testing
- Ezetimibe
- Where
- 42 sites in United States, Puerto Rico
- Volunteers
- 44 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Autism, Asperger Disorder
Cholesterol in ASD: Characterization and Treatment
Background: Autism spectrum disorders (ASD) are developmental disabilities characterized by impaired social interaction and repetitive and/or stereotypical behaviors.
- Conditions
- Autism, Asperger Disorder, PDD-NOS
- Trial name
- NCT00965068
- Testing
- Cholesterol
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Cholesterol Embolism
Clinical Study to Evaluate the Efficacy of Blood Purification Therapy on Cholesterol Crystal Embolism
The aim of this study is to evaluate efficacy and safety of blood purification therapy on renal dysfunction by cholesterol crystal embolism.
- Trial name
- NCT01726868
- Testing
- Liposorber LA-15 System
- Where
- Japan
- Volunteers
- 35 people
- Sponsor
- Japan Community Health Care Organization Sendai Hospital
Radiotracer, Hypertension
Positron Emission Tomography (PET) Imaging of Cholesterol Trafficking: Clinical Evaluation of [18F]FNP-59 in Normal Human Subjects (Groups 2, 3 & 4)
This study will evaluate the feasibility of using a sub-therapeutic dose of a fluorine-18 analogue of NP-59 ([18F]FNP-59) to image the adrenal gland.
- Conditions
- Radiotracer, Hypertension, Cholesterol
- Trial name
- NCT04546126
- Testing
- Dexamethasone (Group 2), Cosyntropin (Group 3), PET/CT Scan with FNP-59
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Benjamin Viglianti
Hyperlipidemia
Reduction of LDL-C With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder Study-2
The primary objective was to evaluate the effect of 12 weeks of evolocumab subcutaneously once every 2 weeks (Q2W) and once monthly (QM), compared with placebo, on percent change from baseline in low-density lipoprotein…
- Trial name
- RUTHERFORD-2 (NCT01763918)
- Testing
- Evolocumab
- Where
- 39 sites in United States, Australia and 12 more
- Volunteers
- 331 people
- Sponsor
- Amgen
ASCVD, Risk Factor, Cardiovascular
Inclisiran for Subjects With ASCVD or ASCVD-Risk Equivalents and Elevated Low-density Lipoprotein Cholesterol
This is a Phase III, placebo-controlled, double-blind, randomized study in participants with ASCVD or ASCVD-Risk equivalents and elevated LDL-C despite maximum tolerated dose of LDL-C lowering therapies to evaluate the efficacy…
- Conditions
- ASCVD, Risk Factor, Cardiovascular, Elevated Cholesterol
- Trial name
- ORION-11 (NCT03400800)
- Testing
- Inclisiran Sodium
- Where
- 70 sites in Czechia, Germany and 5 more
- Volunteers
- 1,617 people
- Sponsor
- The Medicines Company
Familial Hypercholesterolemia, Familial Hypercholesterolemia - Heterozygous
Early Detection of Familial Hypercholesterolemia in Children
Heterozigous FH is an underdiagnosed disease in the paediatric population. Its early detection, would allow us to initiate lifestyle therapeutical changes and early pharmacological therapy if necessary.
- Conditions
- Familial Hypercholesterolemia, Familial Hypercholesterolemia - Heterozygous, Familial Hypercholesterolemia - Homozygous
- Trial name
- DECOPIN (NCT04370899)
- Testing
- lifestyle assessment
- Where
- 2 sites in Spain
- Volunteers
- 400 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Dyslipidemias, High Cholesterol
Evaluate the Effect of Obicetrapib in Patients With HeFH on Top of Maximum Tolerated Lipid-Modifying Therapies.
This study will be a placebo-controlled, double-blind, randomized, phase 3 study to Evaluate the Efficacy, Safety, and Tolerability of Obicetrapib in Participants with a History of Heterozygous Familial Hypercholesterolemia…
- Conditions
- Dyslipidemias, High Cholesterol, Hypercholesterolemia, Familial Hypercholesterolemia
- Trial name
- BROOKLYN (NCT05425745)
- Testing
- Obicetrapib
- Where
- 96 sites in United States, Canada and 8 more
- Volunteers
- 354 people
- Sponsor
- NewAmsterdam Pharma
Autism Spectrum Disorder, Autism
Exome Sequencing in Autistic Spectrum Disorder
Background: Research into the genetic causes of autism spectrum disorder (ASD) involves studies of the DNA of children with autism.
- Conditions
- Autism Spectrum Disorder, Autism, Autistic Disorder
- Trial name
- NCT01059201
- Where
- 3 sites in United States
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Cardiovascular Diseases
The Effect of Dark Chocolate Consumption on Blood Parameters in Healthy Adult Individuals
In healthy individuals, the effect of regular dark chocolate consumption for 4 weeks on blood lipid parameters such as; total cholesterol, LDL cholesterol, HDL cholesterol and triglyceride levels, in addition to fasting blood…
- Trial name
- NCT05290012
- Testing
- Dark Chocolate
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Major Adverse Cardiovascular and Cerebrovascular Events (MACCE)
Observational Prospective Study OPTIMA II - Follow-up
The current follow-up study was planned to reveal the rates of Major Adverse Cardiovascular and Cerebrovascular Events (MACCE) during 4-year follow-up in patients participated in OPTIMA study.
- Trial name
- OPTIMAII (NCT02099565)
- Where
- Russia
- Volunteers
- 572 people
- Sponsor
- AstraZeneca
Healthy
Bioequivalence Study of Terbinafine Hydrochloride Tablets, 250 mg of Dr. Reddy's Under Fed Conditions
The purpose of this study is to compare the rate and extent of absorption of terbinafine hydrochloride 250 mg tablets versus Lamisil® 250 mg tablets administered as 1 x 250 mg tablet under fed conditions.
- Trial name
- NCT01286701
- Testing
- Terbinafine Hydrochloride Tablets, 250 mg
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Dr. Reddy's Laboratories Limited
Familial Hypercholesterolemia
Familial Hypercholesterolemia Interpretive Comment - Nudging to Detection.
Familial hypercholesterolemia is the most common inherited disease of the lipid metabolism, however it remains underdiagnosed. Only 15 % of 30.000 possible patients have been found in Denmark.
- Trial name
- FIND (NCT05614219)
- Testing
- Biochemistry interpretive comment on elevated LDL-C levels
- Where
- 2 sites in Denmark
- Volunteers
- 2,000 people
- Sponsor
- Odense University Hospital
Cholesterol; Lipidosis
Can Mindful Eating Improve Cholesterol and Glucose Level
This study aims to explore the effectiveness of mindful eating and its effect on cholesterol and glucose level. The participants will be required to get tested for their fasting total cholesterol and blood glucose level for two…
- Trial name
- NCT04833595
- Testing
- Mindfulness practice
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Monash University Malaysia
Hyperlipidemia
Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese(MEGA Study)
To evaluate the primary preventive effect of low-dose pravastatin against coronary heart disease (CHD) in Japanese hypercholesterolemic patients.
- Trial name
- NCT00211705
- Testing
- Diet, Diet+pravastatin
- Volunteers
- 8,000 people
- Sponsor
- Mitsukoshi Health and Welfare Foundation
Covert Brain Infarction
A EUROpean Randomized Study on Blood-thinners and Cholesterol-lowering Treatments to Prevent Future Vascular Events in People With Covert Brain Infarcts (CBI)
Magnetic resonance imaging (MRI) is commonly used in healthcare, and sometimes it shows small areas of brain damage called Covert Brain Infarcts (CBIs).
- Trial name
- EURO-CBI (NCT07012629)
- Testing
- acetylsalicyclic acid (ASA), Clopidogrel, Rosuvastatin
- Where
- 14 sites in Denmark, Germany and 3 more
- Volunteers
- 1,652 people
- Sponsor
- Aarhus University Hospital
Osteoarthritis
Anti-inflammatory Agents and Cholesterol Metabolism
We hypothesize that administration of anti-inflammatory medications such as celecoxib, naprosyn and diclofenac will cause changes in the blood plasma and white blood cells of patients such that they will be less able to…
- Trial name
- NCT01279395
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Winthrop University Hospital
Hypercholesterolemia
Safety and Effectiveness of Flaxseed for Reducing High Cholesterol
Flaxseed, a rich source of fiber, may be a significant component of a cholesterol-reducing diet. The purpose of this study is to evaluate the safety and effectiveness of flaxseed in reducing high cholesterol.
- Trial name
- NCT00051415
- Testing
- Flaxseed-supplemented diet
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)