Clinical trials: Cholera
Cholera (Disorder)
Ondansetron to Prevent Oral Rehydration Failure in Children With Cholera
This Phase IIa randomized controlled trial will evaluate whether a single oral dose of ondansetron can reduce oral rehydration failure in children and adolescents with suspected or confirmed cholera and active vomiting.
- Trial name
- NCT07795060
- Testing
- Ondansetron, Standard Cholera Care
- Where
- Republic of the Congo
- Volunteers
- 120 people
- Sponsor
- Public Interest Science Center
Cholera
Evaluation of a Boosting Regimen With Oral Cholera Vaccine
Data demonstrates that Shanchol™ (killed bivalent oral cholera vaccine) provides protection over 3 years and data regarding the protective efficacy over five years is anticipated for 2012.
- Trial name
- Boost (NCT01579448)
- Testing
- Shanchol™, oral cholera vaccine, Shanchol™, killed, whole cell, bivalent, oral cholera vaccine, no intervention
- Where
- India
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Sachin Desai
Cholera
PXVX0200 (CVD103-HgR) vs Shanchol in Mali
To compare the ability of a single dose of PXVX0200 at two different dose levels, to placebo to elicit a significant antibody response 14 days after vaccination, compared to baseline.
- Trial name
- NCT02145377
- Testing
- PXVX0200 10E8, PXVX0200 10E9, Shanchol
- Where
- Mali
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Cholera, Diarrhea
Immunogenicity of One Versus Two Doses of Killed Oral Cholera Vaccine
The purpose of this study is to compare the safety and immunogenicity of one and two doses of the killed oral cholera vaccine.
- Conditions
- Cholera, Diarrhea, Vibrio Infections
- Trial name
- NCT00419133
- Testing
- Killed bivalent whole cell oral cholera vaccine
- Where
- India
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Cholera
A Study of Two Doses of Oral Cholera Vaccine (Shanchol™) in Subjects Aged 1 Year and Older in Dominican Republic
The aim of the study is to generate safety and immunogenicity data with Shanchol in The Philippines Objectives: To describe the safety after each dose of Shanchol vaccine.
- Trial name
- NCT02434822
- Testing
- Shanchol™: Oral Cholera Vaccine Killed Bivalent (O1 and O139) Whole Cell
- Where
- Dominican Republic
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Cholera, Water-Related Diseases
Preventative Intervention for Cholera for 7 Days
The first objective of our study is to develop a theory-driven evidence-based targeted water, sanitation, and hygiene (WASH) intervention for household members of diarrhea patients in South Kivu, Democratic Republic of the Congo…
- Conditions
- Cholera, Water-Related Diseases, Diarrhea Infectious
- Trial name
- PICHA-7 (NCT05166850)
- Testing
- PICHA7 mHealth program, Standard Arm
- Where
- 2 sites in Democratic Republic of the Congo
- Volunteers
- 2,900 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cholera, Diarrhea
Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7) Water, Sanitation, and Hygiene (WASH) Case Area Targeted Intervention (CATI)
Objective: The investigators objective is to develop and evaluate the effectiveness of a case area targeted water, sanitation, and hygiene (WASH) intervention in reducing cholera infections and increasing sustained WASH behaviors…
- Trial name
- NCT06003816
- Testing
- Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7) CATI, Standard message
- Where
- 2 sites in Bangladesh
- Volunteers
- 3,140 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cholera Vaccination Reaction
Dose Escalation Study to Evaluate the Safety and Immunogenicity of the Cholera Conjugate Vaccine in Healthy Adults
This Phase I, first-in-human study is intended to primarily determine the safety of the dose range with or without Aluminum phosphate adjuvant expected to be needed for later clinical studies, to determine the nature of adverse…
- Trial name
- NCT05559983
- Testing
- OSP:rTTHc Cholera Conjugate Vaccine Cohort A, OSP:rTTHc Cholera Conjugate Vaccine with Aluminum phosphate adjuvant Cohort A, OSP:rTTHc Cholera Conjugate Vaccine Cohort B
- Where
- 3 sites in South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Diarrhea, Cholera
Randomized Controlled Trial of Killed Oral Cholera Vaccine in Kolkata
The primary purpose of this study is to estimate the efficacy of a two-dose regimen of the oral killed bivalent cholera vaccine when administered to individual residing in a cholera-endemic area in India.
- Conditions
- Diarrhea, Cholera, Vibrio Infections
- Trial name
- NCT00289224
- Testing
- bivalent killed whole cell oral cholera vaccine
- Where
- India
- Volunteers
- 69,329 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Shock Hypovolemic, Shock, Septic
Management of Shock in Children With SAM or Severe Underweight and Diarrhea
Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths.
- Conditions
- Shock Hypovolemic, Shock, Septic, Blood Transfusion, Adrenaline
- Trial name
- NCT04750070
- Testing
- Blood and Dopamine, Blood and adrenaline
- Where
- Bangladesh
- Volunteers
- 135 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Cholera, Vibrio Cholerae Infection
Effect of Extended Dose Intervals on the Immune Response to Oral Cholera Vaccine
Cholera is a life-threatening disease if prompt actions are not taken. The most recent estimates of the global burden of cholera estimate that there are more than 1.3 billion people at risk.
- Trial name
- NCT03373669
- Testing
- Oral Cholera Vaccine, Adjusted Dose Oral Cholera Vaccine
- Where
- Zambia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cholera, Cholera Vaccine Toxicity
First in Human Phase 1 Ascending Dose Study of PanChol in Healthy Volunteers
This study is a first-in-human, Phase 1 study of the safety, tolerability, and immunogenicity of PanChol in healthy volunteers. There will be three modules in this clinical trial assessing dosing, safety, and immunogenicity: 1.
- Trial name
- NCT05657782
- Testing
- PanChol
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Vibrio Cholerae, Cholera
Bridging Study for Killed Oral Cholera Vaccine in Ethiopia
This is a randomized, double blind, placebo controlled trial to confirm the safety and determine the immune response of the killed oral cholera vaccine in healthy adults and children in Ethiopia.
- Trial name
- NCT01524640
- Testing
- Killed Bivalent (O1 and O139) whole cell oral cholera vaccine
- Where
- Ethiopia
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Vibrio Cholerae
A Study to Evaluate Safety and Immunogenicity of the Bivalent Killed Whole Cell Oral Cholera Vaccine in Adults and Children
The purpose of this study is to determine whether the killed bivalent (O1 and O139)whole cell oral cholera vaccine(Shanchol™) is safe and effective in the treatment of Vibrio cholerae.
- Trial name
- NCT00760825
- Testing
- killed bivalent (O1 and O139)whole cell oral cholera vaccine
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- International Vaccine Institute
Cholera
Ciprofloxacin Multiple Dose for Adult Cholera
Cholera is an important diarrhoeal disease and an important cause of death, particularly during epidemic outbreaks, in Bangladesh and many other developing countries.
- Trial name
- NCT00741052
- Testing
- Ciprofloxacin, Azithromycin
- Where
- Bangladesh
- Volunteers
- 218 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Diarrhea, Cholera
Next Generation ORS: Comparing ORS With Calcium vs Standard ORS in Reducing Severity of Acute Watery Diarrhea
Diarrhea remains a leading killer of children in need of better treatments.
- Trial name
- ORS (NCT05814042)
- Testing
- Current standard control ORS (oral rehydration solution)
- Where
- Bangladesh
- Volunteers
- 396 people
- Sponsor
- University of Florida
Typhoid and/or Cholera Vaccination
CVD 38000: Study of Responses to Vaccination With Typhoid and/or Cholera
This is an open-label, non-randomized study. The purpose of this study is to better understand how vaccines against typhoid fever and cholera affect the normal immune system and bacteria in the intestine.
- Trial name
- NCT03705585
- Testing
- Vivotif Typhoid Oral Vaccine, Vaxchora
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Cholera
A Phase 3 Lot to Lot Consistency Study of Live Oral Cholera Vaccine, PXVX0200 in Healthy Adults
The primary goal of this Phase III study is to compare 3 lots for consistency of manufacture.
- Trial name
- NCT02094586
- Testing
- PXVX0200 Lot A, PXVX0200 Lot B, PXVX0200 Lot C
- Where
- 25 sites in United States, Australia
- Volunteers
- 3,146 people, healthy volunteers welcome
- Sponsor
- Bavarian Nordic
Cholera
Zinc Supplementation in Cholera Patients
Cholera is one of the leading causes of morbidity and mortality among children and adult in developing countries. We will evaluate the effect of supplementation of zinc on reduction of duration and severity of cholera.
- Trial name
- NCT00226616
- Testing
- Zinc
- Where
- 2 sites in Bangladesh
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh